Fight Aging! Newsletter, November 5th 2018
In conclusion, weight cycling significantly increased life-span relative to remaining with obesity and had a similar benefit to sustained modest weight loss.
Support for Oxidized Cholesterol as a Primary Cause of Atherosclerosis
https://www.fightaging.org/archives/2018/11/support-for-oxidized-cholesterol-as-a-primary-cause-of-atherosclerosis/
In the paper I'll point out today, the authors provide evidence in support of the concept that it is specifically oxidized cholesterol that is the primary cause of atherosclerosis rather than the condition resulting from too much cholesterol in general. In atherosc...
Source: Fight Aging! - November 4, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Grander Lessons from a Failure of Robotic Surgery
This week on my podcast, I deviated briefly from cardiology to discuss a shocking and sad study highlighting the vital nature of doing randomized controlled trials in the practice of medicine.
The reason I mentioned a trial comparing 2 types of hysterectomy (removal of the uterus) in women with early stage cervical cancer was not to opine on matters of cancer, but because the tragic story shows the harm doctors can do if we incorporate therapies without proper testing.
The New England Journal of Medicine published a trial in which women with early cervical cancer were randomized to two types of hysterectomy:
One was the...
Source: Dr John M - November 4, 2018 Category: Cardiology Authors: Dr John Source Type: blogs
Final Stretch Goal for the Lifespan.io NAD+ Mouse Study Crowdfunding Event
The latest Lifespan.io crowdfunding project launched last month and is already closing in on the final stretch goal of $75,000; congratulations to everyone involved. The funds will be used to run a mouse study of nicotinamide mononucleotide (NMN) supplementation, one of a number of similar approaches that can increase NAD+ levels in older animals. This in turn improves mitochondrial function, though without addressing any of the underlying causes of mitochondrial decline with aging - it is a way to narrowly compensate for some of the metabolic consequences of aging, or to selectively override some of the reactions to the b...
Source: Fight Aging! - November 1, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Niacin hasn ’t lived up to its original promise in cardiovascular prevention
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - September 21, 2018 Category: Internal Medicine Tags: cardiovascular pharmacology Source Type: blogs
Fight Aging! Newsletter, September 17th 2018
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - September 16, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How to Organize and Run a Comparatively Simple Self-Experiment to Assess the Impact of MitoQ and Niagen on Cardiovascular Aging
The objective here is a set of tests that (a) match up to the expected outcome based on human trials of MitoQ and Niagen, and (b) that anyone can run without the need to involve a physician, as that always adds significant time and expense. These tests are focused on the cardiovascular system, particularly measures influenced by vascular stiffness, and some consideration given to parameters relevant to oxidative stress and the development of atherosclerosis.
A standard blood test, with inflammatory markers.
An oxidized LDL cholesterol assessment.
Resting heart rate and blood pressure.
Pulse wave velocity.
Biolog...
Source: Fight Aging! - September 10, 2018 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
Fight Aging! Newsletter, August 20th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - August 19, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Napa Therapeutics Formed to Develop Drugs to Influence NAD Metabolism
The involvement of In Silico Medicine in the formation of Napa Therapeutics to run drug discovery based on advances in understanding of mitochondrial metabolism in aging is an example of the premium placed on any approach that might plausibly reduce the cost and time involved in finding drug candidates. We will no doubt see a lot more of this sort of thing as computational methodologies become a plausible replacement for greater portions of the existing costly, hands-on, mechanical screening processes.
Draw a triangle in the present field of aging research with the three points set at calorie restriction mimetics, e...
Source: Fight Aging! - August 17, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 16th 2018
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur.
Over the course of the ...
Source: Fight Aging! - July 15, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More than You Wanted to Know About NAD+ in Metabolism and Aging
Manipulating levels of nicotinamide adenine dinucleotide (NAD+) so as to improve mitochondrial function in older individuals is a popular topic these days, particularly now that numerous groups are selling supplements alleged to raise NAD+ levels usefully. These might be thought of as a form of exercise mimetic drug, in the cases where they actually perform. Even given an intriguing early human trial, this is most likely a road to only minor benefits in the matter of aging. At 90, even the best of former athletes looks like a 90-year old, with a significant degree of dysfunction, and a high chance of failing to live to see...
Source: Fight Aging! - July 11, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 2nd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 1, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Improving the Understanding of Chronic Inflammation in Atherosclerosis
Atherosclerosis is an inflammatory condition. Oxidized lipids//en.wikipedia.org/wiki/Lipid_peroxidation">Oxidized lipids lead to the formation of fatty plaques that narrow and weaken blood vessels, the growth of those plaques driven by the activities of macrophages that try and fail to repair the damage. They become overwhelmed and die: plaques are a mix of fat and the cellular debris from dead macrophages. Prior to their destruction, macrophages generate inflammatory signaling as atherosclerosis worsens, but how is it that other sources of age-related chronic inflammation can accelerate the progression of atherosclerosis?...
Source: Fight Aging! - June 25, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Skin serum: What it can and can ’t do
Many things improve with age; unfortunately, your skin is not one of them. Wrinkles, brown spots, and general dullness often start to creep in as the years tick by. To reverse these problems many women are turning to a skin serum. Serums are light, easily absorbed oil- or water-based liquids that you spread on your skin. They typically come in small bottles with a dropper, and you only need a few drops to treat your whole face. A skin serum is not a moisturizer, like a lotion or cream, says Dr. Abigail Waldman, instructor of dermatology at Harvard Medical School. Rather, they are highly concentrated formulations that are d...
Source: Harvard Health Blog - June 12, 2018 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Health Healthy Aging Skin and Hair Care Source Type: blogs
Fight Aging! Newsletter, June 11th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 10, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Arguing for Nicotinamide Riboside to Improve Hematopoietic Stem Cell Function
Researchers here argue for enhanced levels of NAD+ to boost stem cell function through improved mitochondrial function. This is an area of metabolism that has gained increasing attention of late, a second pass at the whole topic of sirtuins, mitochondrial function, and metabolism in aging. I'd say the jury is still out on whether it is worth pursing aggressively in human medicine. One or two early trials seem promising, in the sense of obtaining benefits that look similar to those derived from exercise, but the magnitude and reliability of those benefits is the important question.
The bone marrow stem cell populatio...
Source: Fight Aging! - June 5, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
