Fight Aging! Newsletter, September 17th 2018

In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that TXNIP is a critical regulator of AKT-mediated cellular senescence under glucose-mediated stress in vitro and in vivo. Might Means of Reversing Atherosclerosis also Prevent Macular Degeneration? https://www.fightaging.org/archives/2018/09/might-means-of-reversing-atherosclerosis-also-prevent-macular-degeneration/ Atherosclerosis is characterized by growing lipid deposits that weaken and narrow blood vessels. Age-related macular degeneration is also characterized by a deposition of lipids in and around the retina in its early stage. One might therefore speculate as to whether age-related problems with the mechanisms responsible for clearing lipids might be at the root of both conditions. Macrophages are the cell responsible for gathering up unwanted lipids, which they then hand off to HDL particles for the journey back to the liver and con...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

In conclusion, this review reported that IL-37 has a crucial role in reducing infection-associated inflammation and has a good impact on inflammation-induced pathology. However, tight regulation that achieved balance between effector immune responses that required for pathogen elimination and limited tissue damage that resulted from excessive inflammation should be existed in the potential IL-37 therapy to prevent clinical complications of a disease. PMID: 31633447 [PubMed - as supplied by publisher]
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
Date: Monday, 10 28, 2019; Speaker: Xiangbo Ruan, Regulation of systemic lipid metabolism by human lncRNAs, The Cao group, CB, NHLBI; Ranganath Muniyappa, Hyperuricemia in insulin resistance, DEOB, NIDDK; Building: Building 10 (Clinical Center); Solarium Conference Room 9S233 (old Bunim Room)
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Tuesday, 11 12, 2019; Speaker: Meira Epplein, PhD, Associate Professor in Population Health Sciences, Associate Prof in Medicine, Department of Medicine, Duke University School of Medicine ; http://epi.grants.cancer.gov/events/infectious-age
Source: NIH Calendar of Events - Category: American Health Source Type: events
Low English proficiency puts patients with chronic conditions such as heart failure and COPD at much higher risk for returning to the hospital, new data show.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Hospital Medicine News Source Type: news
Conclusions: The results indicate that a possible mechanism behind an anastomotic leakage is an impaired circulation and thus insufficient saturation to the small intestine peroperatively. This develops into an inflammation both intraperitoneally and intravenously, which, if not reversed, spread within the gastrointestinal tract .The colorectal anastomosis is the most vulnerable part of the gastrointestinal tract postoperatively and hypoxia and inflammation may occur there, and an anastomosis leakage will be the consequence. PMID: 31630578 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
This article highlights the role of nuclear medicine in standardizing the diagnostic approach in patients with infectious/inflammatory diseases, in particular in peripheral osteomyelitis, septic arthritis, prosthetic joint infections, infected diabetic foot and spinal infections. The authors reveal the role of the most common radionuclides tests, with their advantages and clinical indications, to achieve an adequate diagnosis of infection and inflammation.ResumenLas enfermedades inflamatorias e infecciosas osteoarticulares pueden tener graves consecuencias para el paciente si no se diagnostican a tiempo. En las últi...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
Publication date: Available online 22 October 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Muhammad Younis, Wang Faming, Zhao Hongyan, Tan Mengmeng, Song Hang, Yuan LiudiAbstractGlioma is the most common neoplasm of the central nervous system, with the highest mortality rate. The present study was designed to examine the therapeutic effect of Iguratimod (IGU) encapsulated- poly (lactic-co-glycolic acid) PLGA nanoparticles (IGU-PLGA-NPs), which showed inhibition of glioma cells proliferation both in vitro and in vivo. IGU was encapsulated in PLGA nanoparticles with an average size of 100-200 nm w...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: Available online 21 October 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Duo Lin, Qiong Wu, Sufang Qiu, Guannan Chen, Shangyuan Feng, Rong Chen, Haishan ZengAbstractDevelopment of a sensitive, rapid and easy-to-use liquid biopsy method is of imperative clinical value for point-of-care caner diagnostics. Here, a label-free and modification-free nanotechnology based on surface-enhanced Raman spectroscopy (SERS) was employed for DNA analysis. Using the SERS signals of phosphate backbone as internal standard, quantitative detection for nucleobases was achieved even at single base l...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Authors: Baldi D, Colombo J, Robiony M, Menini M, Bisagni E, Pera P Abstract BACKGROUND: The purpose of this study was to analyze pulpal temperature increase generated by prosthodontic margin repositioning and finishing with ultrasonic and rotating instruments. The temperature changes recorded were also correlated with the residual dentin thickness. METHODS: A sample of 32 human extracted molars was selected. The teeth were endodontically treated and prepared with prosthetic round chamfer preparation. Then, they were inserted in plaster cubes up to the cement-enamel junction, leaving the apical portion pervious...
Source: Minerva Stomatologica - Category: Dentistry Tags: Minerva Stomatol Source Type: research
Publication date: Available online 21 October 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Mohammad-Taghi Bahreyni-Toossi, Elham Dolat, Hashem Khanbabaei, Navid Zafari, Hosein AzimianAbstractGlioblastoma (GBM) is the most lethal type of primary brain tumor. Currently, even with optimal and multimodal cancer therapies, the survival rate of GBM patients remains poor. One reason for inadequate response of GBM tumors to radiotherapy is radioresistance (RR). Thus, there is a critical need for new insights about GBM treatment to increase the chance of treatment. microRNAs (miRNAs) a...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - Category: Cytology Source Type: research
More News: Age-Related Macular Degeneration (AMD) | ALS | Alzheimer's | Antidoxidants | Biochemistry | Biology | Biotechnology | Blindness | Blogging | Brain | Brain Cancers | Cancer | Cancer & Oncology | Cancer Vaccines | Carbohydrates | Cardiology | Cardiovascular | Cataract Removal | Cataracts | Chemistry | Cholesterol | Clinical Trials | Czechia Health | Databases & Libraries | Dementia | Depression | Diabetes | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epidemiology | Expenditures | Eyes | Flavonoids | Funding | Fundraising | Gastroschisis Repair | Gene Therapy | Genetics | Germany Health | Government | Heart | Heart Failure | History of Medicine | Hypermetropia (long sighted) | Hypertension | Immunotherapy | Infectious Diseases | Insulin | Laboratory Medicine | Liver | Lyme Disease | Medical Devices | Medical Ethics | Men | Metabolic Syndrome | Mitochondria | Mitochondrial Disease | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Nutrition | Obesity | Opthalmology | Orthopaedics | Osteoarthritis | Osteoporosis | Parkinson's Disease | Pathology | Physiology | Research | Science | Skin | Sports Medicine | Statin Therapy | Study | Sugar | Suicide | Toxicology | Training | Transplants | Tuberculosis | Universities & Medical Training | Urology & Nephrology | Vaccines | Veterinary Vaccinations | Vitamin A | Vitamin B3 | Websites