Fight Aging! Newsletter, July 16th 2018
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the 21st century, people will have access to an increasing array of options when it comes to enhancing the function of the mind and the body. The young of today will live to see all of that span, and more. Aging will soon become a treatable medical condition, its causes addressed by therapies that repair the molecular damage that accumulates in old tissues. The human genome will become fluid, the subject of any number of treatments that alter genes or gene expression in adult tissues in order to achieve specific benefits such as greater muscle mass or increased resistance to disease. Somewhere down the line, biotechnology and nanotechnology will merge to produce technologies such as artificial cells and cell-like machines, vastly more efficient at specific tasks than their biological counterparts. Biology will become an option, rather than the present mandate. P...
Re: Yang CJ, Kumar A, Gulack BC, Mulvihill MS, Hartwig MG, Wang X, et al. Long-term outcomes after lobectomy for non–small cell lung cancer when unsuspected pN2 disease is found: A National Cancer Data Base analysis. J Thoracic Cardiovasc Surg. 2016;151:1380-8.
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01189G, PaperTaichi Kusakabe, Tomoyuki Mochida, Tomohiro Ariyama, Dong Lee, Shin Ohkubo, Keisuke Takahashi, Keisuke Kato The PdII catalyzed carbonylation of allenyl ketones has been investigated. Carbonylative dimerization predominantly proceeded to afford bis(3-furanyl)methanones 2 as the major products. The use of DMSO strikingly changed the course... The content of this RSS Feed (c) The Royal Society of Chemistry
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01162E, PaperQuentin Pavic, Aline Pillot, Olivier Tasseau, Laurent Legentil, Sylvain Tranchimand Galactofuranoconjugates are rare compounds with interesting biological properties. Their syntheses by traditional approaches are however tedious. Glycosidases are nowadays often used to simplify such synthesis but no galactofuranosidase has been... The content of this RSS Feed (c) The Royal Society of Chemistry
Solid organ transplantation from hepatitis C virus–positive (HCV-positive) deceased donors into HCV-negative recipients is a recent approach aimed to expand the donor organ pool in the setting of severe shortage. Good short-term outcomes have been reported with this approach in combination with direct-acting antivirals. In this issue of the JCI, Zahid and colleagues have characterized early viral kinetics and the genetic landscape of donor-to-recipient HCV transmission using single-genome sequencing. In seven HCV-negative recipients of four HCV-positive donor organs, productive infection with a highly diverse viral p...
Gliomas account for approximately 80% of primary malignant tumors in the central nervous system. Despite aggressive therapy, the prognosis of patients remains extremely poor. Glioma stem cells (GSCs), considered a potential target of therapy for their crucial role in therapeutic resistance and tumor recurrence, are believed to be key factors in the disappointing outcome. Here, we took advantage of GSCs as the cell model to perform high-throughput drug screening, and the old antibiotic clofoctol was identified as the most effective compound, showing reduction of colony formation and induction of apoptosis of GSCs. Moreover,...
Highly effective direct-acting antivirals against hepatitis C virus (HCV) have created an opportunity to transplant organs from HCV-positive individuals into HCV-negative recipients, since de novo infection can be routinely cured. As this procedure is performed more widely, it becomes increasingly important to understand the biological underpinnings of virus transmission, especially the multiplicity of infection. Here, we used single genome sequencing of plasma virus in 4 genotype 1a HCV-positive organ donors and their 7 organ recipients to assess the genetic bottleneck associated with HCV transmission following renal and ...
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ01211G, Papermaryam monajati, Ali Tamaddon, Gholamhossein Yousefi, Samira Abolmaali, Rassoul Dinarvand Recently, numerous bioconjugation procedures were developed to promote the pharmacokinetic and immunological properties of L-asparaginase (ASNase), anti-leukemic enzyme. Here, compared with PEGylation, the influence of the protein conjugation with poly(HPMA)... The content of this RSS Feed (c) The Royal Society of Chemistry
J. Mater. Chem. A, 2019, Accepted Manuscript DOI: 10.1039/C9TA05252F, Review ArticleCuiping Han, Hongfei Li, Ruiying Shi, Tengfei Zhang, Jing Tong, Jun Qin Li, Baohua Li Redox active organic quinones are a class of potentially low cost, sustainable, and high energy density electroactive materials for energy storage applications due to their large specific capacity, high redox... The content of this RSS Feed (c) The Royal Society of Chemistry
J. Mater. Chem. A, 2019, Advance Article DOI: 10.1039/C9TA01810G, PaperZhangxin Chen, Ning Xu, Weijun Li, Ruiyang Zhao, Yujie Dong, Junlei Liu, Chang Su, Jianli Wang, Cheng Zhang A novel electrochemical test confirms the acid-doping of trace HF into N-heterocycle based polymers in a LiPF6 electrolyte. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Dalton Trans., 2019, Accepted Manuscript DOI: 10.1039/C9DT02009H, CommunicationS érgio Vilela, Thomas Devic, Alejandro Varez, Fabrice Salles, Patricia Horcajada A new robust Bi-carboxylate metal-organic framework (MOF) IEF-2 was hydrothermally prepared, acting as a proton carrier ( σ ~ 1.1 x 10-4 S cm-1). Such proton conductivity is among the highest... The content of this RSS Feed (c) The Royal Society of Chemistry
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