Evaluation of Efficacy and Safety of Latanoprost/Timolol versus Travoprost/Timolol Fixed Combinations for Ocular Hypertension Associated with Uveitis.
CONCLUSIONS: Both LT and TT are safe and effective for the treatment of OHT associated with uveitis and greater IOP reduction may be achieved by TT than by LT treatment.
PMID: 26799307 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 17, 2016 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Sustainability of Intraocular Pressure Reduction of Travoprost Ophthalmic Solution in Subjects with Normal Tension Glaucoma
Conclusion
This multi-center collaborative study suggests that IOP-lowering efficacy of travoprost ophthalmic solution persists during the day at the clinically relevant level in subjects with NTG.
Funding
Alcon Japan Ltd.
Trial registration
University Hospital Medical Information Network, UMIN ID: 000011621. (Source: Advances in Therapy)
Source: Advances in Therapy - February 9, 2016 Category: Drugs & Pharmacology Source Type: research
Association between glaucoma eye drops and hyperemia
Conclusion
Our software program may be useful for evaluating the hyperemic effects of eye drops used for glaucoma. The particular type of prostaglandin analog seems to determine the level of conjunctival hyperemia during ocular hypotensive medical treatment. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - February 4, 2016 Category: Opthalmology Source Type: research
Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits
Conclusion: The prostaglandin analogs tafluprost BAK-free and travoprost BAK improved blood flow in the ophthalmic artery in healthy New Zealand white rabbits, which suggests that these drugs enhance the prevention of the progression the progression of glaucoma.RESUMO Objetivo: O objetivo deste estudo foi investigar os efeitos dos análogos da prostaglandina (PGAs) no fluxo sanguíneo da artéria oftálmica em coelhos. Métodos: Cinquenta e cinco coelhos da raça Nova Zelândia clinicamente saudáveis foram divididos em seis grupos para tratamento com formulação tópica de diferentes APGs (bimatoprosta BAK, tafluprosta...
Source: Arquivos Brasileiros de Oftalmologia - February 2, 2016 Category: Opthalmology Source Type: research
Comparison of 1-Site and 2-Site Phacotrabeculectomy in the Small Adult Eyes With Concomitant Cataract and Glaucoma
Abstract: The aim of this study was to compare the outcomes after phacotrabeculectomy at 1 or 2 sites in the small adult eyes with concomitant cataract and glaucoma.
Patients who had 1-site (n = 26) or 2-site (n = 14) phacotrabeculectomy over a 4-year period at an eye surgery center were included. Eighteen eyes of 18 patients with glaucoma using any 1 prostaglandin analogue (latanoprost, travoprost, or bimatoprost) were compared with 8 normal control patients. The records of patients were reviewed, and intraocular pressure, best-corrected visual acuity, axial length, anterior chamber depth, corneal endothelial cel...
Source: Medicine - February 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Reversible Conjunctival Pigmentation Associated With Prostaglandin Use
A 54-year-old Indian male with a diagnosis of ocular hypertension was started on a prostaglandin analog (PGA) in both eyes to lower intraocular pressure. Six years later, he developed progressively increasing bilateral limbal conjunctival hyperpigmentation. Travoprost was discontinued and replaced with brinzolamide and over the next year, the patient’s conjunctival pigmentation improved significantly in both the eyes. This case report documents with slit-lamp photography the first case of conjunctival pigmentation associated with PGA use that has been shown to have reversal with discontinuation of the PGA. Because of the...
Source: Journal of Glaucoma - December 22, 2015 Category: Opthalmology Tags: Online Articles: Case Reports Source Type: research
The Impact of Glaucoma Medications on Corneal Wound Healing
Conclusions: Corneal toxicity of Xalatan is most probably caused by BAC. Monoprost delays corneal healing, which is not well understood. The Monoprost effects could be caused by its additive, macrogolglycerolhydroxystearate 40. This excipient is a known skin irritant, and its concentration is relatively elevated in Monoprost, 50 mg/mL, compared with its active ingredient, latanoprost (0.05 mg/mL). (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - December 22, 2015 Category: Opthalmology Tags: Basic Science Reviews Source Type: research
Efficacy and safety of topical travoprost with sofzia preservative for Japanese glaucoma patients.
Authors: Kanamoto T, Kiuchi Y, Suehiro T, Nakano T, Nakano Y, Hirota A, Miyata A
Abstract
The purpose of this study is to evaluate the intraocular pressure (IOP) -lowering effect and safety of topical travoprost with sofzia and without benzalkonium chloride on Japanese patients with glaucoma. Topical travoprost (0.04%) was used on 39 glaucoma patients with no prior use of topical prostaglandin F2alpha analogues (Beginning group). The IOP, number of conjunctival follicules, degrees of conjunctival hyperemia, and degrees of superficial punctate keratitis (SPK, AD-classification) were determined at the beginn...
Source: Hiroshima Journal of Medical Sciences - December 12, 2015 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research
Effect of benzalkonium chloride–free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study
Background:
Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK).
Methods:
This was an open-label, single-arm study conducted in Latin America from February 2012 to May 2013. Patients with open-angle glaucoma or ocular hypertension who were intolerant of latanoprost 0.005 % were transitioned to receive once-daily BAK-free travoprost 0.004 % containing polyquaternium-1 (Travatan® preserved with POLYQUAD® [PQ], Alcon Laborator...
Source: BMC Ophthalmology - November 12, 2015 Category: Opthalmology Authors: Joao LopesDouglas HubatschPatricia Amaris Source Type: research
Hypertrichosis and Hyperpigmentation in the Periocular Area Associated with Travoprost Treatment.
Authors: Lee HE, Lim SK, Im M, Kim CD, Seo YJ, Lee JH, Lee Y
PMID: 26512190 [PubMed] (Source: Annals of Dermatology)
Source: Annals of Dermatology - October 31, 2015 Category: Dermatology Tags: Ann Dermatol Source Type: research
Safety and Efficacy of Adding Fixed-Combination Brinzolamide/Timolol Maleate to Prostaglandin Therapy for Treatment of Ocular Hypertension or Glaucoma.
Conclusion. Adjunctive BTFC + PGA therapy was effective and well tolerated. IOP decreased by 6 mmHg at weeks 4 and 12.
PMID: 26495134 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 25, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research
Fixed Combination of Travoprost and Timolol Maleate Reduces Intraocular Pressure in Japanese Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: A Prospective Multicenter Open-Label Study
Conclusion
Our findings confirm that switching to Duotrav® in PGA monotherapy patients shows IOP-lowering effect with minimal safety concerns.
Funding
Japan Association of Health Service and Alcon Japan. Ltd.
Trial registration
UMIN Clinical Trials Registry identifier, UMIN000007028. (Source: Advances in Therapy)
Source: Advances in Therapy - September 30, 2015 Category: Drugs & Pharmacology Source Type: research
Unilateral Prostaglandin-Associated Periorbitopathy: A Syndrome Involving Upper Eyelid Retraction Distinguishable From the Aging Sunken Eyelid
Conclusion: Prostaglandin analogue drops cause adnexal changes and orbital fat atrophy leading to eyelid redness, superior sulcus deformity, higher eyelid crease, and enophthalmos. In contrast to previous studies showing ptosis in PAP, relative upper eyelid retraction was seen in most of our treated eyes. Our novel PAP grading scale may help objectify and categorize this syndrome. Awareness of these signs is critical, as the eyelids and eyes may be affected even in the absence of patient recognition. (Source: Ophthalmic Plastic and Reconstructive Surgery)
Source: Ophthalmic Plastic and Reconstructive Surgery - September 1, 2015 Category: Opthalmology Tags: Original Investigations Source Type: research
In Vivo Effects of Preservative-free and Preserved Prostaglandin Analogs: Mouse Ocular Surface Study.
CONCLUSIONS: Corneal damage, increased inflammation and apoptosis and low cell viability were observed in BAC-containing groups. PF or alternatively preserved glaucoma medications seem to be a reasonable and viable alternative to those preserved with BAC.
PMID: 26240512 [PubMed - in process] (Source: Korean Journal of Ophthalmology : KJO)
Source: Korean Journal of Ophthalmology : KJO - August 5, 2015 Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
Polyquaternium-1–Preserved Travoprost 0.003% or Benzalkonium Chloride–Preserved Travoprost 0.004% for Glaucoma and Ocular Hypertension
To demonstrate equivalence of polyquaternium-1–preserved travoprost 0.003% with benzalkonium chloride–preserved travoprost 0.004% in patients with open-angle glaucoma or ocular hypertension (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - April 29, 2015 Category: Opthalmology Authors: James H. Peace, Peter Ahlberg, Mathias Wagner, John M. Lim, David Wirta, James D. Branch Tags: Original Articles Source Type: research
