Efficacy of travoprost for the treatment of patients with glaucoma
Conclusion:
The findings of the present study will summarize the updated evidence of travoprost for patients with glaucoma.
PROSPERO registration number: PROSPERO CRD42019126956. (Source: Medicine)
Source: Medicine - July 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Prospective randomized clinical trial on the effects of latanoprost, travoprost and bimatoprost on latanoprost non-responders.
CONCLUSION: There is no added benefit of switching latanoprost to another topical prostaglandin for patients who are initially non-responders. Regression towards the mean and the Hawthorne effect are probably important factors explaining the additional IOP reduction obtained after randomization and explain the result of most switch studies.
PMID: 31164290 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - June 6, 2019 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Randomized crossover trial comparing effectiveness and tolerability of generic and brand-name travoprost.
CONCLUSION: This study is the first to compare a brand-name travoprost with one of its generic forms and adds to the body of evidence that generic glaucoma eye drops are as effective and well-tolerated as their brand name counterparts. The intraocular pressure lowering effect of generic Sandoz travoprost is equivalent to that of Travatan Z. Patient tolerance of generic and brand-name travoprost is similar.
PMID: 30975346 [PubMed - in process] (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - March 31, 2019 Category: Opthalmology Authors: Ta Kim D, Daigle P, Carbonneau M Tags: Can J Ophthalmol Source Type: research
Effects of anti-glaucoma prostaglandin ophthalmic solutions on cultured human corneal epithelial cells.
CONCLUSIONS: Xalatan and Lumigan 0.01% ophthalmic solutions demonstrated potent cytotoxicity compared with Lumigan 0.03%, Travatan, Taflotan and Taflotan UD. Taflotan UD, compared to Taflotan 0.0015%, induced less oxidative stress and apoptotic signalling. The cytotoxicity might be partly associated with benzalkonium chloride.
PMID: 30884982 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - March 17, 2019 Category: Opthalmology Authors: Tong L, Matsuura E, Takahashi M, Nagano T, Kawazu K Tags: Curr Eye Res Source Type: research
New insights in vitiligo treatments using bioactive compounds from Piper nigrum.
This study shows that Piper nigrum (PN) extract and its main alkaloid, piperine, promote melanocyte proliferation in vivo, being consistent with previous study. A PN fruit extract and pure piperine were integrated in two different ointments and tested on human subjects affected by vitiligo. A number of 9 areas were treated: 3 using the extract, 3 using pure piperine, 1 using travoprost solution, and 2 using an association of travoprost (prostaglandin F2α analogue) solution and our products. Pigmentation was achieved in all the treated areas. The extract caused faster and more remarkable results than the pure piperine. The...
Source: Experimental and Therapeutic Medicine - January 28, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
Variation in Prostaglandin Analog Prices Paid for Through Medicare Part D
Conclusions:
There is substantial variation in PGA prices when purchased by Medicare Part D enrollees across the United States and within each state itself. Simultaneously, the prices and total expenditure on these medications are increasing yearly. Physicians should be cognizant of this price variation for these expensive and chronically used drugs and should educate patients to optimize their Part D supplemental plan. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - December 28, 2018 Category: Opthalmology Tags: Online Articles: Brief Report Source Type: research
In vitro effects of benzalkonium chloride and prostaglandins on human meibomian gland epithelial cells.
CONCLUSIONS: BAC showed cytotoxic effects on HMGECs starting with a concentration of 0.1μg/ml. The combination of BAC and prostaglandin-analogs might have a synergistic effect which results in higher toxicity than BAC alone. Unpreserved eye drops and eye drops preserved with Polyquaternium-1 are less damaging to HMGECs.
PMID: 30580056 [PubMed - as supplied by publisher] (Source: Annals of Anatomy)
Source: Annals of Anatomy - December 20, 2018 Category: Anatomy Authors: Rath A, Eichhorn M, Träger K, Paulsen F, Hampel U Tags: Ann Anat Source Type: research
Washout Duration of Prostaglandin Analogues: A Systematic Review and Meta-analysis.
Conclusion: A significant IOP-lowering effect of latanoprost was not observed beyond 4 weeks, suggesting this may be an appropriate washout period for latanoprost. We could not identify appropriate washout periods for either travoprost or bimatoprost, although a majority of articles had 4-week washout durations for the two drugs. Despite the widespread use of this class of medication, there is a paucity of literature on the effects of PGA washout in patients that are treatment naïve to other topical medications.
PMID: 30363694 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 27, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research
Objective ocular surface tolerance in patients with glaucoma treated with topical preserved or unpreserved prostaglandin analogues.
CONCLUSION: Overall, this study suggests a better subjective and objective ocular tolerance when patients were treated with preservative-free latanoprost than with other preserved prostaglandin analogues monotherapy. Switching to preservative-free latanoprost maintained intraocular pressure at the same level as preservative prostaglandin analogue, but improved ocular surface tolerance.
PMID: 30301370 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - October 10, 2018 Category: Opthalmology Authors: El Ameen A, Vandermeer G, Khanna RK, Pisella PJ Tags: Eur J Ophthalmol Source Type: research
Experimental Evaluation of Travoprost-Induced Changes in Biomechanical Behavior of Ex-Vivo Rabbit Corneas.
CONCLUSIONS: Significant reductions in corneal stiffness, that are associated with the use of travoprost, were observed experimentally under low applied stresses. This stiffness-reduction effect should be considered in clinical management, especially in primary open angle glaucoma treatment.
PMID: 30273056 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - October 1, 2018 Category: Opthalmology Authors: Zheng X, Wang Y, Zhao Y, Cao S, Zhu R, Huang W, Yu A, Huang J, Wang Q, Wang J, Bao F, Elsheikh A Tags: Curr Eye Res Source Type: research
The Effect of Prostaglandin Analogues on the Ciliary Zonular Fibers of the Rabbit Crystalline Lens.
CONCLUSIONS: PG analogues may induce zonular change in rabbits microscopically. There was no association between zonular changes and the levels of certain types of MMP or TIMP in the aqueous humor or crystalline lens after topical treatment with PG analogues.
PMID: 30015523 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - July 17, 2018 Category: Opthalmology Authors: Hwang HB, Kim SY Tags: Curr Eye Res Source Type: research
Comparison of Efficacy and Ocular Surface Disease Index Score between Bimatoprost, Latanoprost, Travoprost, and Tafluprost in Glaucoma Patients.
Conclusion: All prostaglandin analogues equally and significantly reduce the IOP in patients with POAG. According to the results of the OSDI score, latanoprost seems to be the least tolerated among the four drugs.
PMID: 29707390 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 2, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research
Association of Postoperative Topical Prostaglandin Analog or Beta-Blocker Use and Incidence of Pseudophakic Cystoid Macular Edema
Conclusions:
To the best of our knowledge this is the largest study that has investigated the association between postoperative topical PGA or topical beta-blocker use and the incidence of pseudophakic CME. Postoperative use of both topical PGAs and topical beta-blockers was found to be associated with the incidence of pseudophakic CME. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - May 1, 2018 Category: Opthalmology Tags: Original Studies Source Type: research
Meibomian Gland Features and Conjunctival Goblet Cell Density in Glaucomatous Patients Controlled With Prostaglandin/Timolol Fixed Combinations: A Case Control, Cross-sectional Study
Purpose:
To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs).
Materials and Methods:
In this cross-sectional study, 60 white patients were treated with PTFCs, 15 with latanoprost+timolol (L+T) unfixed combination, and 15 controls were enrolled. Patients underwent the Ocular Surface Disease Index questionnaire, tear film breakup time, corneal staining, Schirmer test I, and IVCM of MGs and goblet cells. The main outcome measures were: mean Meibomian ...
Source: Journal of Glaucoma - April 1, 2018 Category: Opthalmology Tags: Original Studies Source Type: research
Comparative cost evaluation of brand name and generic ophthalmology medications in Ontario.
Abstract
Medication cost for the same indication can vary considerably and can affect patient compliance. In this comparative cost analysis of commonly prescribed ophthalmology medications, the differences in cost between generic and brand name medications as well as different medications within an individual drug class were evaluated. Eye preparations from the Ontario Drug Benefit Formulary were identified, and further agents commonly prescribed by ophthalmologists were included. The standardized prescription drug cost, which includes the cost of the medication, mark-up, and dispensing cost, was provided ...
Source: Canadian Journal of Ophthalmology - April 1, 2018 Category: Opthalmology Authors: Popovic M, Chan C, Lattanzio N, El-Defrawy S, Schlenker MB Tags: Can J Ophthalmol Source Type: research
