Hiroshima Journal of Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Assessment of Outcome of Hepatic Arterial Infusion Chemotherapy in Patients with Advanced Hepatocellular Carcinoma by the Combination of RECIST and Tumor Markers.
Authors: Hatooka M, Kawaoka T, Aikata H, Honda F, Nakamura Y, Nakano N, Morio K, Fukuhara T, Kobayashi T, Nagaoki Y, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Awai K, Chayama K Abstract To assess the outcome of stable disease (SD) patients with advanced hepatocellular carcinoma (HCC) by tumor markers after the first course of hepatic arterial infusion chemotherapy (HAIC). The study subjects were 156 HCC patients treated with HAIC and classified as Child Pugh A, with no extrahepatic metastasis, and no history of sorafenib treatment. In the study and validation cohorts, the AFP and DCP ratios of patients ...
Source: Hiroshima Journal of Medical Sciences - July 13, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

High Initial-dose Dependency of Cerebrovascular Disease Mortality among Female Survivors of the Hiroshima Atomic Bomb Exposed in Teens: A Cohort Study, 1970-2010.
The objective of the present study was to examine whether the sex- and age ATB-specific cerebrovascular disease mortality among Hiroshima atomic bomb survivors can be explained by the initial radiation dose. At Hiroshima University, a cohort study has been conducted with Hiroshima Atomic Bomb Survivors (ABS) since 1970. We selected 30,378 subjects from the ABS who were exposed at 3.5 km or less from the hypocenter and still alive on January 1, 1970. These subjects were followed up until December 31, 2010. The cohort data were stratified with respect to sex and age ATB into 10-year age groups. For each stratum, using Cox re...
Source: Hiroshima Journal of Medical Sciences - July 13, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

High Excess Risk of Heart Disease Mortality among Hiroshima Atomic Bomb Male Survivors Exposed Near the Hypocenter.
Authors: Hara N, Satoh K, Otani K, Kawakami H, Ohtaki M Abstract Heart disease (HD) mortality is the second leading cause of death in Japan. The HD mortality risk among Atomic bomb survivors is slightly positive but shows a statistically significant dose-response relationship with initial radiation dose, as reported by the Radiation Effects Research Foundation. In that report, dosimetry was based on initial radiation only, with the effect of indirect radiation dose not taken into consideration. The atomic bomb radiation, however, consisted of both initial and residual radiation. We reevaluated the dose-res...
Source: Hiroshima Journal of Medical Sciences - July 13, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

Clinical Significance of Pharmacological Prophylaxis based on the Original Risk Classification of Venous Thromboembolism after Lower Abdominal Surgery.
Authors: Shimomura M, Kochi M, Hinoi T, Egi H, Adachi T, Kobayashi T, Tashiro H, Ohdan H Abstract Pharmacological prophylaxis was not routinely administrated following gastroenterological surgery because of concerns about bleeding complications. We tried to establish the original risk classification to determine the indication for pharmacological prophylaxis for selected patients at high risk of venous thromboembolism (VTE). One hundred and fifty-six consecutive patients who underwent lower abdominal elective surgery were divided into three groups (highest, high, and low risk groups) based on the original ...
Source: Hiroshima Journal of Medical Sciences - July 13, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

Ganglioneuroma of Spinal Nerve Root: A Rare Case Mimicking Herniated Lumbar Disc and Lumbar Radiculopathy.
We report a 34-year-old male patient who presented with typical lumbar radiculopathy. He had low back pain radiating to the right lower leg with numbness. His MRI revealed a herniated disc at L5-S1 compressing the right nerve root. Surgery was planned for microdiscectomy and nerve root decompression. Right L5 hemilaminotomy was performed and the nerve root was identified. Surprisingly the nerve root was markedly inflamed and there was no obvious disc tissue herniation. Considering it to be a spinal nerve root tumor, the dura of the nerve root was opened and nerve root mass exposed. Subtotal resection was performed. Biopsy ...
Source: Hiroshima Journal of Medical Sciences - July 13, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

A Case of Spontaneously Reduced Ileoileal Intussusception Caused by a Lipoma.
We describe herein a rare case of adult ileoileal intussusception caused by an ileal lipoma, which was diagnosed preoperatively and was confirmed at the operation to have reduced spontaneously. A 68-year-old woman experienced sudden-onset colicky pain in the upper abdomen accompanied by vomiting and was brought to our hospital by ambulance. Physical examination revealed a distended abdomen and tenderness in the upper abdomen. Laboratory findings showed slightly elevated inflammatory parameters. Abdominal computed tomography (CT) showed a target sign in the ileum, which is a typical sign of intussusception. Additional cauda...
Source: Hiroshima Journal of Medical Sciences - July 13, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

Russell Body Gastritis Concurrent with Eosinophilia: a case report.
Authors: Imai T, Sentani K, Yamashita K, Oue N, Yoshida K, Yasui W Abstract A 64-year-old male patient with a histological diagnosis of Russell body gastritis and with eosinophilic infiltrate in biopsy specimens is reported. The patient continued hemodialysis and pseudomembranous enteritis was contracted. Upper gastrointestinal endoscopy was performed due to poor appetite and blood eosinophilia. During endoscopy, a flare, swollen mucous membrane, and multiple verrucous erosions were noted in the gastric antrum. Biopsy and histopathological examination of gastric mucosa showed infiltration of plasma cells c...
Source: Hiroshima Journal of Medical Sciences - July 13, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

Application of Compound Action Potential of Facial Muscles Evoked by Transcranial Stimulation as a Reference Waveform of Motor-evoked Potential in Spinal Surgery.
Authors: Morishige M, Takeda M, Yamaguchi S, Sugiyama K, Kurisu K Abstract Transcranial electrical stimulation motor-evoked potential (TES-MEP) has been widely used to monitor major motor pathways in cranial and spinal surgeries. However, the results of TES-MEP might be strongly influenced by anesthetic agents and muscle relaxants. To compensate for this effect, a technique using compound muscle action potentials of the abductor pollicis brevis (APB-CMAP) evoked by median nerve stimulation has recently been reported. In this article, we adopted the transcranial electrical stimulation motor-evoked potential...
Source: Hiroshima Journal of Medical Sciences - July 11, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

A Case of Holocord Leptomeningeal Dissemination from Cerebellar Hemangioblastoma without von Hippel-Lindau Disease.
Authors: Ohba H, Yamaguchi S, Magaki T, Takeda M, Kolakshyapati M, Sadatomo T, Kurisu K Abstract Hemangioblastoma disseminated along leptomeninges from the solitary cranial lesion without von Hippel-Lindau (VHL) disease is a quite rare instance with 23 cases reported in 40 years. We add a new case and discuss these rare instances. A 55-year-old female underwent surgery for total removal of cerebellar hemangioblastoma. Twenty months later, magnetic resonance (MR) images of the spinal cord revealed a tumor compressing the thoracic cord at T3-4 level which was removed en bloc by emergent spinal surgery. Howev...
Source: Hiroshima Journal of Medical Sciences - July 11, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

Hybrid Surgery for Portosystemic Encephalopathy in a Patient with Liver Cirrhosis: a case report.
In conclusion, this is a successful case of a hybrid operation for an extremely large and complicated portosystemic shunt, providing for intraoperative angiography as a safe and reliable surgical treatment for portosystemic encephalopathy in patients with liver cirrhosis. PMID: 29986123 [PubMed - in process] (Source: Hiroshima Journal of Medical Sciences)
Source: Hiroshima Journal of Medical Sciences - July 11, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

Portosystemic Encephalopathy without Liver Disease Masquerading as Dementia.
Authors: Honda Y, Kubo M, Takaki S, Mori N, Ishikawa M, Kakizawa H, Tsuji K, Furukawa Y Abstract An 84-year-old woman was hospitalized due to consciousness disorder as hyperammonemia. She had no etiology of liver disease. Twelve months before the current admission, she had been diagnosed with dementia based on her low level of daily perception and physical activity. Abdominal computed tomography revealed a large portosystemic shunt between the medial branch of the portal vein and middle hepatic vein. After the improvement of her consciousness disturbance by medical treatment, percutaneous shunt embolizatio...
Source: Hiroshima Journal of Medical Sciences - July 11, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

Spontaneous Celiac and Splenic Artery Dissection.
We describe a patient with dissection of the celiac and splenic arteries causing splenic circulatory impairment. A 55-year-old Japanese man was referred to our hospital for left back pain that suddenly occurred 3 days previously and spread to the left flank. He had complicated sleep apnea syndrome well controlled with continuous positive airway pressure, and had been prophylactically taking aspirin (100 mg/day) because of asymptomatic cerebral lacunar infarcts. Contrast-enhanced computed tomography (CT) in the arterial phase revealed dissection from the celiac root extending to the entire splenic artery, the caliber of whi...
Source: Hiroshima Journal of Medical Sciences - July 11, 2018 Category: General Medicine Tags: Hiroshima J Med Sci Source Type: research

The Sarin-like Organophosphorus Agent bis (isopropyl methyl)phosphonate Induces Apoptotic Cell Death and COX-2 Expression in SK-N-SH Cells.
In this study, we examined the toxicity of the sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate (BIMP) and the effects of BIMP on COX-2 expression in SK-N-SH human neuroblastoma cells. Exposure to BIMP changed cell morphology and induced caspase-dependent apoptotic cell death accompanied by cleavage of caspase 3, caspase 9, and poly (ADP-ribose) polymerase (PARP). It also increased COX-2 expression, while pretreatment with a COX inhibitor, ibuprofen, decreased BIMP-dependent cell death and COX-2 expression in SK-N-SH cells. Thus, our findings suggest that BIMP induces apoptotic cell death and upregulates ...
Source: Hiroshima Journal of Medical Sciences - July 1, 2016 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

A Case of Cutaneous Meningioma in the Rudimentary Meningocele.
We report a rare case of neonatal cutaneous meningioma derived from a rudimentary meningocele. This neonate had a congenital skin-covered hump in the thoracolumbar region. Computed tomography showed bifid laminae of T12 and L1 underneath the mass lesion. Magnetic resonance images showed the mass to have no cerebrospinal fluid space and that it had a stalk connecting to the spinal canal. Split cord malformation was also observed under the bifid laminae. Because of the increasing size of the lump and cosmetic reasons, the parents opted for surgical treatment. We operated on the patient 9 months after birth. Operative finding...
Source: Hiroshima Journal of Medical Sciences - July 1, 2016 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research

The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report.
In conclusion, the SACI test can enhance the accuracy of preoperative localization and diagnosis of invisible microgastrinomas, especially in the setting of severe duodenal stenosis. PMID: 27348901 [PubMed - in process] (Source: Hiroshima Journal of Medical Sciences)
Source: Hiroshima Journal of Medical Sciences - July 1, 2016 Category: Journals (General) Tags: Hiroshima J Med Sci Source Type: research