Do topical antiglaucoma drugs affect the cornea?
Eur J Ophthalmol. 2021 May 13:11206721211016981. doi: 10.1177/11206721211016981. Online ahead of print.ABSTRACTTo investigate effects of beta blocker (BB; timolol or betaxolol), latanoprost, and latanoprost-timolol combination (LTC) drugs on corneal endothelial cell density (ECD) and central corneal thickness (CCT) in primary open-angle glaucoma (POAG) patients. Sixty-one patients in BB group, 64 patients in latanoprost group, 59 patients in LTC group, and 58 healthy cases in control group were included. Intraocular pressures (IOP), ECDs, and CCTs of groups were recorded at initial (pre-treatment) period, first and third y...
Source: European Journal of Ophthalmology - May 14, 2021 Category: Opthalmology Authors: İrfan Botan Güneş Hakan Öztürk Bediz Özen Source Type: research

Do topical antiglaucoma drugs affect the cornea?
Eur J Ophthalmol. 2021 May 13:11206721211016981. doi: 10.1177/11206721211016981. Online ahead of print.ABSTRACTTo investigate effects of beta blocker (BB; timolol or betaxolol), latanoprost, and latanoprost-timolol combination (LTC) drugs on corneal endothelial cell density (ECD) and central corneal thickness (CCT) in primary open-angle glaucoma (POAG) patients. Sixty-one patients in BB group, 64 patients in latanoprost group, 59 patients in LTC group, and 58 healthy cases in control group were included. Intraocular pressures (IOP), ECDs, and CCTs of groups were recorded at initial (pre-treatment) period, first and third y...
Source: European Journal of Ophthalmology - May 14, 2021 Category: Opthalmology Authors: İrfan Botan Güneş Hakan Öztürk Bediz Özen Source Type: research

Topical Timolol Combined Intralesional Injection of Diprospan in the Treatment of Elevated Localized Mixed Infantile Hemangiomas and a Discussion for Proper Timing for Injection
Conclusion: Topical timolol combined with intralesionally injected diprospan is an effective and safe treatment for elevated, localized mixed IH. The injection is needed only when we forecast the elevated tissue may remain after regression. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - May 1, 2021 Category: Surgery Tags: Original Articles Source Type: research

Using Topical Citric Acid to Treat an Infected Ulcerated Hemangioma in an Infant: A Case Study
Conclusions. The efficacy, ease of application, and absence of notable adverse effects of using citric acid suggest it may be an effective option for the treatment of hemangiomas in children.PMID:33914691 (Source: Wounds)
Source: Wounds - April 29, 2021 Category: General Medicine Authors: Basavraj Nagoba Milind Davane Basavraj Warad Nawab Jamadar Ajay M Gavkare Source Type: research

Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: UK and Ireland Results from the VISIONARY Study
ConclusionsTreatment with PF Taf-T FC resulted in significant reductions in mean IOP over 6  months. Patients and physicians reported that treatment was well tolerated. These data demonstrate real-world efficacy of PF Taf-T FC for the treatment of OAG and OHT in routine clinical practice in the UK and Ireland.Trial registrationEuropean Union electronic Register of Post-Authorisation Studies (EU PAS) register number, EUPAS22204. (Source: Advances in Therapy)
Source: Advances in Therapy - April 22, 2021 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Topical Timolol for Infantile Hemangioma in the Early Proliferative Stage
This randomized clinical trial evaluates the efficacy and safety of timolol maleate solution, 0.5%, for the early treatment of infantile hemangioma in infants younger than 60 days. (Source: JAMA Dermatology)
Source: JAMA Dermatology - April 7, 2021 Category: Dermatology Source Type: research

Morphological, genetic and clinical correlations in infantile hemangiomas and their mimics
Rom J Morphol Embryol. 2020 Jul-Sep;61(3):687-695. doi: 10.47162/RJME.61.3.07.ABSTRACTInfantile hemangiomas (IHs) are the most frequent pediatric benign vascular tumors, with a reported incidence of 5% to 10%. They have self-limiting evolution pattern divided into a growth phase in the first 12 months and a regression one, that may take up to 10 years. Occasionally, hemangiomas might lead to local or systemic complications, depending on their morphological characteristics. The first line of treatment is β-blockers, such as Propranolol, Timolol, Nadolol, administered either locally or systemically. Newer therapeutic st...
Source: Romanian Journal of Morphology and Embryology - April 5, 2021 Category: General Medicine Authors: Alina Costina Luca Ingrith Crengu ţa Miron Laura Mihaela Trandafir Elena Cojocaru Ioana Alexandra P ădureţ Mioara Florentina Trandafirescu Alin Constantin Iordache Elena Ţarcă Source Type: research

Timolol induces necroptosis, apoptosis and senescence concentration-dependently in rabbit Limbal stem cells in vitro
Publication date: Available online 31 March 2021Source: Life SciencesAuthor(s): Guo-Jian Jiang, Bei-Bei Li, Ting-Jun Fan (Source: Life Sciences)
Source: Life Sciences - March 31, 2021 Category: Biology Source Type: research

Comparison of the Intraocular Pressure-Lowering Effect and Safety of Preservative-Free And Preservative-Containing Brimonidine/Timolol Fixed-Combination Ophthalmic Solutions in Patients with Open-Angle Glaucoma
This study was conducted as a multicenter, randomized, open-label, parallel-group clinical trial to evaluate the efficacy and safety of PF BTFC as compared with PC BTFC in adult patients (aged ≥ 19 years) with open-angle glaucoma (OAG) and ocular hypertension (OHT). A total of the 106 patients were enrolled, with 53 patients each randomized to the two treatment groups and included in the analysis of the safety set (SS).After a washout period, patients with an IOP below 35 mmHg at 9 a.m. were enrolled. After a full ophthalmic and glaucoma examination, a total of 106 OAG and OHT patients were randomized to the PF group or...
Source: Seminars in Ophthalmology - March 18, 2021 Category: Opthalmology Authors: Joon Mo Kim Tae-Woo Kim Sang-Woo Park Hae-Young Lopilly Park Young Hoon Hwang Jin Wook Jeoung Chan Yun Kim Source Type: research