Rho kinase inhibitor for primary open-angle glaucoma and ocular hypertension
CONCLUSIONS: The current evidence suggests that in people diagnosed with OHT or (P)OAG, the hypotensive effect of netarsudil may be inferior to latanoprost and slightly inferior to timolol. Combining netarsudil and latanoprost probably further reduces IOP compared with monotherapy. Netarsudil as mono- or combination therapy may result in more ocular AEs. However, the certainty of evidence was very low or low for all comparisons except timolol. In general, AEs were described as mild, transient, and reversible upon treatment discontinuation. ROKi was not associated with any particular serious AEs. Future trials of sufficient...
Source: Cochrane Database of Systematic Reviews - June 10, 2022 Category: General Medicine Authors: Josefine Clement Freiberg Alexander von Spreckelsen Miriam Kolko Augusto Azuara-Blanco Gianni Virgili Source Type: research
Contact Palpebral Dermatitis and Conjunctivitis Due to Delayed Hypersensitivity to Timolol
Dermatitis. 2022 Jun 8. doi: 10.1097/DER.0000000000000902. Online ahead of print.NO ABSTRACTPMID:35674513 | DOI:10.1097/DER.0000000000000902 (Source: Dermatitis)
Source: Dermatitis - June 8, 2022 Category: Dermatology Authors: Miriam Sobrino Esther M Moreno Elena Laffond Francisco J Mu ñoz-Bellido Maria Teresa Gracia-Bara Cristina Mart ín Eva M Mac ías Sonia de Arriba Alicia Gallardo Rosita Castillo Adelaida Cabrera Ignacio D ávila Source Type: research
Contact Palpebral Dermatitis and Conjunctivitis Due to Delayed Hypersensitivity to Timolol
Dermatitis. 2022 Jun 8. doi: 10.1097/DER.0000000000000902. Online ahead of print.NO ABSTRACTPMID:35674513 | DOI:10.1097/DER.0000000000000902 (Source: Dermatitis)
Source: Dermatitis - June 8, 2022 Category: Dermatology Authors: Miriam Sobrino Esther M Moreno Elena Laffond Francisco J Mu ñoz-Bellido Maria Teresa Gracia-Bara Cristina Mart ín Eva M Mac ías Sonia de Arriba Alicia Gallardo Rosita Castillo Adelaida Cabrera Ignacio D ávila Source Type: research
Contact Palpebral Dermatitis and Conjunctivitis Due to Delayed Hypersensitivity to Timolol
Dermatitis. 2022 Jun 8. doi: 10.1097/DER.0000000000000902. Online ahead of print.NO ABSTRACTPMID:35674513 | DOI:10.1097/DER.0000000000000902 (Source: Dermatitis)
Source: Dermatitis - June 8, 2022 Category: Dermatology Authors: Miriam Sobrino Esther M Moreno Elena Laffond Francisco J Mu ñoz-Bellido Maria Teresa Gracia-Bara Cristina Mart ín Eva M Mac ías Sonia de Arriba Alicia Gallardo Rosita Castillo Adelaida Cabrera Ignacio D ávila Source Type: research
Contact Palpebral Dermatitis and Conjunctivitis Due to Delayed Hypersensitivity to Timolol
Dermatitis. 2022 Jun 8. doi: 10.1097/DER.0000000000000902. Online ahead of print.NO ABSTRACTPMID:35674513 | DOI:10.1097/DER.0000000000000902 (Source: Dermatitis)
Source: Dermatitis - June 8, 2022 Category: Dermatology Authors: Miriam Sobrino Esther M Moreno Elena Laffond Francisco J Mu ñoz-Bellido Maria Teresa Gracia-Bara Cristina Mart ín Eva M Mac ías Sonia de Arriba Alicia Gallardo Rosita Castillo Adelaida Cabrera Ignacio D ávila Source Type: research
Contact Palpebral Dermatitis and Conjunctivitis Due to Delayed Hypersensitivity to Timolol
Dermatitis. 2022 Jun 8. doi: 10.1097/DER.0000000000000902. Online ahead of print.NO ABSTRACTPMID:35674513 | DOI:10.1097/DER.0000000000000902 (Source: Dermatitis)
Source: Dermatitis - June 8, 2022 Category: Dermatology Authors: Miriam Sobrino Esther M Moreno Elena Laffond Francisco J Mu ñoz-Bellido Maria Teresa Gracia-Bara Cristina Mart ín Eva M Mac ías Sonia de Arriba Alicia Gallardo Rosita Castillo Adelaida Cabrera Ignacio D ávila Source Type: research
Contact Palpebral Dermatitis and Conjunctivitis Due to Delayed Hypersensitivity to Timolol
Dermatitis. 2022 Jun 8. doi: 10.1097/DER.0000000000000902. Online ahead of print.NO ABSTRACTPMID:35674513 | DOI:10.1097/DER.0000000000000902 (Source: Dermatitis)
Source: Dermatitis - June 8, 2022 Category: Dermatology Authors: Miriam Sobrino Esther M Moreno Elena Laffond Francisco J Mu ñoz-Bellido Maria Teresa Gracia-Bara Cristina Mart ín Eva M Mac ías Sonia de Arriba Alicia Gallardo Rosita Castillo Adelaida Cabrera Ignacio D ávila Source Type: research
Synthesis of 2-chloropurine ribosides with chiral amino acid amides at C6 and their evaluation as A < sub > 1 < /sub > adenosine receptor agonists
Bioorg Chem. 2022 May 18;126:105878. doi: 10.1016/j.bioorg.2022.105878. Online ahead of print.ABSTRACTA series of purine ribonucleosides bearing chiral amino acid amides at the C6 position of 2-chloropurine was synthesized. Molecular docking of the synthesized analogs of 2-chloroadenosine by their affinity for A1 adenosine receptors (A1ARs) was conducted. The investigation of A1AR stimulating activity of synthesized nucleosides was carried out in a model of an isolated mouse atrium. We have shown that derivatives with tyrosine, valine, and serine residues exhibit the properties of A1AR partial agonists. Animal experiments ...
Source: Bioorganic Chemistry - June 6, 2022 Category: Chemistry Authors: Maria Ya Berzina Barbara Z Eletskaya Alexei L Kayushin Elena V Dorofeeva Olga I Lutonina Ilya V Fateev Alexander S Paramonov Maria A Kostromina Evgeniy A Zayats Yulia A Abramchik Dmitriy V Maltsev Ludmila V Naumenko Alena S Taran Dmitry S Yakovlev Alexand Source Type: research
Synthesis of 2-chloropurine ribosides with chiral amino acid amides at C6 and their evaluation as A < sub > 1 < /sub > adenosine receptor agonists
Bioorg Chem. 2022 May 18;126:105878. doi: 10.1016/j.bioorg.2022.105878. Online ahead of print.ABSTRACTA series of purine ribonucleosides bearing chiral amino acid amides at the C6 position of 2-chloropurine was synthesized. Molecular docking of the synthesized analogs of 2-chloroadenosine by their affinity for A1 adenosine receptors (A1ARs) was conducted. The investigation of A1AR stimulating activity of synthesized nucleosides was carried out in a model of an isolated mouse atrium. We have shown that derivatives with tyrosine, valine, and serine residues exhibit the properties of A1AR partial agonists. Animal experiments ...
Source: Bioorganic Chemistry - June 6, 2022 Category: Chemistry Authors: Maria Ya Berzina Barbara Z Eletskaya Alexei L Kayushin Elena V Dorofeeva Olga I Lutonina Ilya V Fateev Alexander S Paramonov Maria A Kostromina Evgeniy A Zayats Yulia A Abramchik Dmitriy V Maltsev Ludmila V Naumenko Alena S Taran Dmitry S Yakovlev Alexand Source Type: research
Uses of eye drops in dermatology, literature review
J Dermatolog Treat. 2022 Jun 2:1-13. doi: 10.1080/09546634.2022.2079598. Online ahead of print.ABSTRACTBackground: Since medication absorption through the skin and eye tissue seems similar, commercially available eye-drops could be used to treat skin diseases when topical therapies are unavailable or unaffordable. The FDA-approved and off-label applications of various eye drops used as topical treatments in dermatological clinical practice were highlighted in this review.Methodology: A thorough PubMed and Google Scholar library search using various combinations of the keywords (Eye drop, ocular solution, conjunctival insta...
Source: Journal of Dermatological Treatment - June 2, 2022 Category: Dermatology Authors: Sameh Magdy Sarsik Heba Saed El-Amawy Source Type: research
A comparison of country-level data from the VISIONARY study examining treatment outcomes with preservative-free tafluprost/timolol fixed-dose combination therapy
CONCLUSION: Subanalysis of VISIONARY study data revealed significant IOP reductions following a switch to the PF tafluprost/timolol FC from either PGA or beta-blocker topical monotherapy. Cross-country variation was likely due to baseline IOP differences. Within country, outcomes were consistent regardless of diagnosis, dosing or prior monotherapy. Treatment was generally well tolerated.PMID:35621005 | DOI:10.1080/03007995.2022.2083324 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 27, 2022 Category: Research Authors: G ábor Holló James Kirwan Fernando Lopez-Lopez Marina Zimina Claudia Fassari Francesco Oddone VISIONARY study group Source Type: research
