Non-CGRP Antagonist/Non-Triptan Options for Migraine Disease Treatment: Clinical Considerations
Curr Pain Headache Rep. 2023 Aug 16. doi: 10.1007/s11916-023-01151-0. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Although the association between CGRP and migraine disease is well-known and studied, therapies can target other pathways to minimize migraine symptoms. It is important to understand the role of these medications as options for migraine treatment and the varied mechanisms by which symptoms can be addressed. In the present investigation, the role of non-CGRP antagonist/non-triptan options for migraine disease therapy is reviewed, including NSAIDs, ß-blockers, calcium channel blockers, antidepressants, and ...
Source: Pain Physician - August 16, 2023 Category: Anesthesiology Authors: Ellen E Ingram Brooke E Bocklud Sarah C Corley Mallory A Granier Elisa E Neuchat Shahab Ahmadzadeh Sahar Shekoohi Alan D Kaye Source Type: research
Non-CGRP Antagonist/Non-Triptan Options for Migraine Disease Treatment: Clinical Considerations
AbstractPurpose of ReviewAlthough the association between CGRP and migraine disease is well-known and studied, therapies can target other pathways to minimize migraine symptoms. It is important to understand the role of these medications as options for migraine treatment and the varied mechanisms by which symptoms can be addressed. In the present investigation, the role of non-CGRP antagonist/non-triptan options for migraine disease therapy is reviewed, including NSAIDs, ß-blockers, calcium channel blockers, antidepressants, and antiepileptics. Pharmacologic therapies for both acute symptoms and prophylaxis are evaluated,...
Source: Current Pain and Headache Reports - August 16, 2023 Category: Neurology Source Type: research
Non-selective beta-blockers and the incidence of hepatocellular carcinoma in patients with cirrhosis: a meta-analysis
Conclusion: Different types of NSBB have different effects on the incidence of patients with cirrhosis of the liver, where nadolol and carvedilol can reduce the risk. Also, the effect of NSBBs may vary in ethnicity. Propranolol can reduce HCC incidence in Europe and America.Systematic Review Registration: identifier https://CRD42023434175, https://www.crd.york.ac.uk/PROSPERO/. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 19, 2023 Category: Drugs & Pharmacology Source Type: research
Randomized Multicenter Clinical Trial Comparing 0.1% Brimonidine/0.5% Timolol Versus 1% Dorzolamide/0.5% Timolol as Adjuncts to Prostaglandin Analogues: Aibeta Crossover Study
ConclusionAs BTFC offered better tolerability than DTFC with comparable reduction in IOP, we recommend it as an alternative for patients who experience ocular discomfort with DTFC-prostaglandin analogue combination therapy.Trial Registration NumberjRCTs051190125. (Source: Advances in Therapy)
Source: Advances in Therapy - July 15, 2023 Category: Drugs & Pharmacology Source Type: research
Evaluation of antiglaucoma drug treatment awareness and patient-reported medication adherence: Determinants of glaucoma management
Conclusion: POAG patients did have adequate treatment awareness with good self-reported medication adherence and performance of eye drop instillation technique. Around 25% patients lacked awareness; hence, reinforcement education programs on medication regimens need to be implemented. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - July 10, 2023 Category: Internal Medicine Authors: RK Tripathi A Shah SV Jalgaonkar S Kerkar Source Type: research
Does Combination of Cryotherapy and Topical Timolol Solution Superior to Cryotherapy Alone in the Treatment for Epidermal Growth Factor Receptor Inhibitor-Induced Paronychia? A Double-Blinded, Left-to-Right Comparison, Randomized Controlled Trial
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - July 6, 2023 Category: Dermatology Authors: Ya-Wen Hsiao, Yu-Chen Huang Tags: Research Letter Source Type: research
Does the combination of cryotherapy and topical timolol solution superior to cryotherapy alone in the treatment of epidermal growth factor receptor inhibitor-induced paronychia? A double-blinded, left-to-right comparison, randomized controlled trial
To the Editor: Topical β-blockers are potentially effective treatments for epidermal growth factor receptor inhibitor (EGFRi)-induced paronychia. Previous studies investigating their efficacy were case series with conflicting results.1,2 Olamiju et al3 had demonstrated that topical β-blockers may have limited efficacy as monotherapy and should be used as an adjunctive therapy. Therefore, we conducted a double-blinded, left-to-right comparison, randomized controlled trial to investigate the efficacy of topical β-blocker combined with cryotherapy for the treatment of EGFRi-induced paronychia. (Source: Journal of the Amer...
Source: Journal of the American Academy of Dermatology - July 6, 2023 Category: Dermatology Authors: Ya-Wen Hsiao, Yu-Chen Huang Tags: Research letter Source Type: research
Is the combination of cryotherapy and topical timolol solution superior to cryotherapy alone in the treatment of epidermal growth factor receptor inhibitor-induced paronychia? A double-blinded, left-to-right comparison, randomized controlled trial
To the Editor: Topical β-blockers are potentially effective treatments for epidermal growth factor receptor inhibitor (EGFRi)-induced paronychia. Previous studies investigating their efficacy were case series with conflicting results.1,2 Olamiju et al3 had demonstrated that topical β-blockers may have limited efficacy as monotherapy and should be used as an adjunctive therapy. Therefore, we conducted a double-blinded, left-to-right comparison, randomized controlled trial to investigate the efficacy of topical β-blocker combined with cryotherapy for the treatment of EGFRi-induced paronychia. (Source: Journal of the Amer...
Source: Journal of the American Academy of Dermatology - July 6, 2023 Category: Dermatology Authors: Ya-Wen Hsiao, Yu-Chen Huang Tags: Research letter Source Type: research
RNA-seq analysis of human trabecular endothelial cells after treatment with timolol maleate
ConclusionTimolol exerts various effects on human trabecular endothelial cells. The increase in MMP expression may contribute to the decrease in the aqueous humor outflow facility. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - June 14, 2023 Category: Opthalmology Source Type: research
Supporting wound healing by mesenchymal stem cells (MSCs) therapy in combination with scaffold, hydrogel, and matrix; State of the art
Pathol Res Pract. 2023 May 26;248:154575. doi: 10.1016/j.prp.2023.154575. Online ahead of print.ABSTRACTNon-healing wounds impose a huge annual cost on the survival of different countries and large populations in the world. Wound healing is a complex and multi-step process, the speed and quality of which can be changed by various factors. To promote wound healing, compounds such as platelet-rich plasma, growth factors, platelet lysate, scaffolds, matrix, hydrogel, and cell therapy, in particular, with mesenchymal stem cells (MSCs) are suggested. Nowadays, the use of MSCs has attracted a lot of attention. These cells can in...
Source: Pathology, Research and Practice - June 7, 2023 Category: Pathology Authors: Bayu Indra Sukmana Ria Margiana Yasir Qasim Almajidi Sami G Almalki Ahmed Hjazi Sana Shahab Rosario Mireya Romero-Parra Adeeb Abdulally Abdulhussien Alazbjee Afa Alkhayyat Vivek John Source Type: research
Supporting wound healing by mesenchymal stem cells (MSCs) therapy in combination with scaffold, hydrogel, and matrix; State of the art
Pathol Res Pract. 2023 May 26;248:154575. doi: 10.1016/j.prp.2023.154575. Online ahead of print.ABSTRACTNon-healing wounds impose a huge annual cost on the survival of different countries and large populations in the world. Wound healing is a complex and multi-step process, the speed and quality of which can be changed by various factors. To promote wound healing, compounds such as platelet-rich plasma, growth factors, platelet lysate, scaffolds, matrix, hydrogel, and cell therapy, in particular, with mesenchymal stem cells (MSCs) are suggested. Nowadays, the use of MSCs has attracted a lot of attention. These cells can in...
Source: Pathology, Research and Practice - June 7, 2023 Category: Pathology Authors: Bayu Indra Sukmana Ria Margiana Yasir Qasim Almajidi Sami G Almalki Ahmed Hjazi Sana Shahab Rosario Mireya Romero-Parra Adeeb Abdulally Abdulhussien Alazbjee Afa Alkhayyat Vivek John Source Type: research
Supporting wound healing by mesenchymal stem cells (MSCs) therapy in combination with scaffold, hydrogel, and matrix; State of the art
Pathol Res Pract. 2023 May 26;248:154575. doi: 10.1016/j.prp.2023.154575. Online ahead of print.ABSTRACTNon-healing wounds impose a huge annual cost on the survival of different countries and large populations in the world. Wound healing is a complex and multi-step process, the speed and quality of which can be changed by various factors. To promote wound healing, compounds such as platelet-rich plasma, growth factors, platelet lysate, scaffolds, matrix, hydrogel, and cell therapy, in particular, with mesenchymal stem cells (MSCs) are suggested. Nowadays, the use of MSCs has attracted a lot of attention. These cells can in...
Source: Pathology, Research and Practice - June 7, 2023 Category: Pathology Authors: Bayu Indra Sukmana Ria Margiana Yasir Qasim Almajidi Sami G Almalki Ahmed Hjazi Sana Shahab Rosario Mireya Romero-Parra Adeeb Abdulally Abdulhussien Alazbjee Afa Alkhayyat Vivek John Source Type: research
Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangiomas
CONCLUSION: The use of topical 0.5% timolol maleate hydrogel is a promising therapeutic option for the treatment of superficial IHs. Anwar F, Mahmood E, Sharif S, et al. Topical application of 0.5% timolol maleate hydrogel for the treatment of superficial infantile hemangiomas. J Drugs Dermatol. 2023;22(6):594-598. doi:10.36849/JDD.7054.PMID:37276157 | DOI:10.36849/JDD.7054 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - June 5, 2023 Category: Dermatology Authors: Fariha Anwar Emaan Mahmood Shawana Sharif Rohan Shah Marielle Jamgochian Samantha Ouellette Muhammad Umar Babar Rao Source Type: research
