Effects of Ripasudil, a Rho-Kinase Inhibitor, on Scar Formation in a Mouse Model of Filtration Surgery
CONCLUSIONS: These results suggest that ripasudil, ROCK inhibitor may inhibit excessive fibrosis after glaucoma filtering surgery vis inhibition the transdifferentiation of tenon fibroblast into myofibroblast and may have a potential effect as anti-scarring for glaucoma filtration surgery.PMID:37216470 | DOI:10.1080/02713683.2023.2217367 (Source: Current Eye Research)
Source: Current Eye Research - May 22, 2023 Category: Opthalmology Authors: Ji-Ae Ko Kaori Komatsu Akira Minamoto Satomi Kondo Hideaki Okumichi Kazuyuki Hirooka Yoshiaki Kiuchi Source Type: research
Effects of Ripasudil, a Rho-Kinase Inhibitor, on Scar Formation in a Mouse Model of Filtration Surgery
CONCLUSIONS: These results suggest that ripasudil, ROCK inhibitor may inhibit excessive fibrosis after glaucoma filtering surgery vis inhibition the transdifferentiation of tenon fibroblast into myofibroblast and may have a potential effect as anti-scarring for glaucoma filtration surgery.PMID:37216470 | DOI:10.1080/02713683.2023.2217367 (Source: Current Eye Research)
Source: Current Eye Research - May 22, 2023 Category: Opthalmology Authors: Ji-Ae Ko Kaori Komatsu Akira Minamoto Satomi Kondo Hideaki Okumichi Kazuyuki Hirooka Yoshiaki Kiuchi Source Type: research
Effects of Ripasudil, a Rho-Kinase Inhibitor, on Scar Formation in a Mouse Model of Filtration Surgery
CONCLUSIONS: These results suggest that ripasudil, ROCK inhibitor may inhibit excessive fibrosis after glaucoma filtering surgery vis inhibition the transdifferentiation of tenon fibroblast into myofibroblast and may have a potential effect as anti-scarring for glaucoma filtration surgery.PMID:37216470 | DOI:10.1080/02713683.2023.2217367 (Source: Current Eye Research)
Source: Current Eye Research - May 22, 2023 Category: Opthalmology Authors: Ji-Ae Ko Kaori Komatsu Akira Minamoto Satomi Kondo Hideaki Okumichi Kazuyuki Hirooka Yoshiaki Kiuchi Source Type: research
The rational design of novel 5-amino-2-oxindole derivatives with antiglaucomic activity
Bioorg Med Chem Lett. 2023 May 17:129334. doi: 10.1016/j.bmcl.2023.129334. Online ahead of print.ABSTRACTCompounds with a 2-oxindole scaffold play an important role in organic synthesis and especially in the synthesis of bioactive organic compounds, therefore, the development of new methods for modifying this scaffold is a very interesting and urgent task. In the framework of this study, we have created a rational approach to the synthesis of 5-amino-substituted derivatives of 2-oxindole. The approach is characterized by good total yield and a small number of steps. One-stage modification of obtained 5-amino-2-oxindoles le...
Source: Bioorganic and Medicinal Chemistry Letters - May 19, 2023 Category: Chemistry Authors: Roman O Eremeev Olga V Beznos Alexander M Efremov Natalia B Chesnokova Natalia A Lozinskaya Source Type: research
The rational design of novel 5-amino-2-oxindole derivatives with antiglaucomic activity
Bioorg Med Chem Lett. 2023 May 17:129334. doi: 10.1016/j.bmcl.2023.129334. Online ahead of print.ABSTRACTCompounds with a 2-oxindole scaffold play an important role in organic synthesis and especially in the synthesis of bioactive organic compounds, therefore, the development of new methods for modifying this scaffold is a very interesting and urgent task. In the framework of this study, we have created a rational approach to the synthesis of 5-amino-substituted derivatives of 2-oxindole. The approach is characterized by good total yield and a small number of steps. One-stage modification of obtained 5-amino-2-oxindoles le...
Source: Bioorganic and Medicinal Chemistry Letters - May 19, 2023 Category: Chemistry Authors: Roman O Eremeev Olga V Beznos Alexander M Efremov Natalia B Chesnokova Natalia A Lozinskaya Source Type: research
The rational design of novel 5-amino-2-oxindole derivatives with antiglaucomic activity
Bioorg Med Chem Lett. 2023 May 17:129334. doi: 10.1016/j.bmcl.2023.129334. Online ahead of print.ABSTRACTCompounds with a 2-oxindole scaffold play an important role in organic synthesis and especially in the synthesis of bioactive organic compounds, therefore, the development of new methods for modifying this scaffold is a very interesting and urgent task. In the framework of this study, we have created a rational approach to the synthesis of 5-amino-substituted derivatives of 2-oxindole. The approach is characterized by good total yield and a small number of steps. One-stage modification of obtained 5-amino-2-oxindoles le...
Source: Bioorganic and Medicinal Chemistry Letters - May 19, 2023 Category: Chemistry Authors: Roman O Eremeev Olga V Beznos Alexander M Efremov Natalia B Chesnokova Natalia A Lozinskaya Source Type: research
Hot-melt extruded in situ gelling systems (MeltDrops Technology): Formulation development, in silico modelling and in vivo studies
In this study, we demonstrate novel application of hot-melt extrusion (HME) technology for continuous manufacturing of ISGS (MeltDrops Technology). Timolol maleate (TIM) and dorzolamide hydrochloride (DRZ) loaded MeltDrops were successfully developed using HME for glaucoma management, thereby resolving issues with batch manufacturing of ISGS, prolonging retention time thus improving bioavailability. The MeltDrops technology involves one-step, i.e., passing all the ingredients through an extruder at a screw speed between 20-50 rpm and barrel temperature of 80 °C. The comparative evaluation of MeltDrops and batch-processed ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 14, 2023 Category: Drugs & Pharmacology Authors: Srushti M Tambe Divya D Jain Chetan Hasmukh Mehta T Ashwini Usha Yogendra Nayak Purnima D Amin Source Type: research
Hot-melt extruded in situ gelling systems (MeltDrops Technology): Formulation development, in silico modelling and in vivo studies
In this study, we demonstrate novel application of hot-melt extrusion (HME) technology for continuous manufacturing of ISGS (MeltDrops Technology). Timolol maleate (TIM) and dorzolamide hydrochloride (DRZ) loaded MeltDrops were successfully developed using HME for glaucoma management, thereby resolving issues with batch manufacturing of ISGS, prolonging retention time thus improving bioavailability. The MeltDrops technology involves one-step, i.e., passing all the ingredients through an extruder at a screw speed between 20-50 rpm and barrel temperature of 80 °C. The comparative evaluation of MeltDrops and batch-processed ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 14, 2023 Category: Drugs & Pharmacology Authors: Srushti M Tambe Divya D Jain Chetan Hasmukh Mehta T Ashwini Usha Yogendra Nayak Purnima D Amin Source Type: research
Hot-melt extruded in situ gelling systems (MeltDrops Technology): Formulation development, in silico modelling and in vivo studies
In this study, we demonstrate novel application of hot-melt extrusion (HME) technology for continuous manufacturing of ISGS (MeltDrops Technology). Timolol maleate (TIM) and dorzolamide hydrochloride (DRZ) loaded MeltDrops were successfully developed using HME for glaucoma management, thereby resolving issues with batch manufacturing of ISGS, prolonging retention time thus improving bioavailability. The MeltDrops technology involves one-step, i.e., passing all the ingredients through an extruder at a screw speed between 20-50 rpm and barrel temperature of 80 °C. The comparative evaluation of MeltDrops and batch-processed ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 14, 2023 Category: Drugs & Pharmacology Authors: Srushti M Tambe Divya D Jain Chetan Hasmukh Mehta T Ashwini Usha Yogendra Nayak Purnima D Amin Source Type: research
Primary Open-Angle Glaucoma Progression in Glaucoma Patients with Unchanged Topical Treatment over 3 Years - Retrospective Observational Cohort Analysis
CONCLUSION: Both groups had comparable baseline, as well as mean overall IOP. However, the course of IOP levels over time was different in the two groups, showing earlier and more pronounced long-term drift in the prostaglandin analog-treated group. RNFL thickness was comparable at baseline, however, RNFL thinning over time was more pronounced in the prostaglandin analog-treated group. There were no statistical differences between the groups in terms of VF MD at baseline and over time.PMID:37164404 | DOI:10.1055/a-2004-4943 (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - May 10, 2023 Category: Opthalmology Authors: Yasemin Saruhan Pascal W Hasler Konstantin Gugleta Source Type: research
