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Effectiveness and infectious complications of BCMA T ‐cell engagers in treating multiple myeloma: Real‐world evidence from Sweden
ConclusionsDespite the risk of infectious complications, the prognosis of MM patients can be significantly improved with vigilant monitoring and proactive management of infections. This real-world data highlight the potential of BCMA T-cell engagers in treating MM, emphasizing the need for careful patient monitoring to mitigate infection risks. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Katarina Uttervall, Love T ätting, Konstantinos Lemonakis, Mousa Majd, Jacob Crafoord, Mikael Olsson, Ulf‐Henrik Mellqvist, Markus Hansson, Hareth Nahi Tags: RESEARCH ARTICLE Source Type: research

Continued decline in the incidence of myocardial infarction beyond the COVID-19 pandemic: a nationwide study of the Swedish population aged 60 and older during 2015 –2022
This study aims to shed light on the seemingly paradoxical relationship between COVID-19 and myocardial infarction occurrence on the population level by exploring long-term trends in incidence rates, case fatality, and proportion of patients dying before reaching a hospital. Our work is based on a linkage of administrative registers covering the entire population aged 60 + in Sweden. Considering both long-term trends since 2015 and seasonal variability, we compared observed incidence, case fatality, and proportions of patients hospitalized to expected values during 2020–2022. Despite more than 200 laboratory-confirm...
Source: European Journal of Epidemiology - April 23, 2024 Category: Epidemiology Source Type: research

Gender Difference in sidE eFfects of ImmuNotherapy: a possible clue to optimize cancEr tReatment (G-DEFINER): study protocol of an observational prospective multicenter study
Acta Oncol. 2024 Apr 21;63:213-219. doi: 10.2340/1651-226X.2024.24179.ABSTRACTBACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in various cancers. ICI treatment is associated with the incidence of immune-related adverse events (irAEs) which can affect any organ. Data on irAEs occurrence in relation to sex- differentiation and their association with gender-specific factors are limited.AIMS: The primary objective of the G-DEFINER study is to compare the irAEs incidence in female and male patients who undergo ICI treatment. Secondary objectives are: to compare the irAEs incidence in pre- an...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Rosalba Miceli Hanna Eriksson Giuseppe Lo Russo Salvatore Alfieri Maria Moksnes Bjaan æs Filippo Pietrantonio Loris De Cecco Arsela Prelaj Claudia Proto Johan Franz én Deirdre McDonnell Jos é Javier Berenguer Pina Teresa Beninato Laura Mazzeo Patrizia Source Type: research

Does losing family members in midlife matter for late-life mental and cognitive health? A longitudinal study of older Swedes spanning 30 years
CONCLUSION: Midlife bereavement might have gendered implications on LLD and cognitive impairment, but associations need to be confirmed by well-powered studies. Further research is warranted to elucidate the association between multiple midlife losses and reduced LLD risk.PMID:38644675 | DOI:10.1080/13607863.2024.2341877 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 22, 2024 Category: Geriatrics Authors: Valeria Cecchini Neda Agahi Source Type: research

Procedural factors associated with successful recanalization in patients with acute ischemic stroke treated with endovascular thrombectomy-a nationwide register-based observational study
CONCLUSION: This study illustrates factors associated with procedural success in endovascular thrombectomy on a nationwide scale including the use of general anesthesia, BGC, annual center volumes >50 cases per year and the overall success rate of the individual operator. It highlights the potential benefit of systematic performance measurements, benchmarking, and continuous training to bring all centers and operators to the highest level of performance.PMID:38646674 | DOI:10.1177/15910199241248268 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - April 22, 2024 Category: Radiology Authors: Johan Wass élius Emma Hall Birgitta Ramgren Tommy Andersson Teresa Ullberg Source Type: research

Trends in incidence and treatments of spontaneous subarachnoid hemorrhage- a 10 year hospital based study
ConclusionsThe incidence of patients with SAH gradually decreased in our material, in line with national data. The treatment policy in our unit has been shifting to more use of endovascular methods. During the study period the use of hemicraniectomies decreased. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 22, 2024 Category: Neurosurgery Source Type: research

Remote neuropsychological assessment of patients with neurological disorders and injuries--a study protocol for a cross-sectional case-control validation study
This study protocol describes a cross-sectional study aimed at validating the newly developed digitalized neuropsychological test battery Mindmore Remote in patients with neurological disorders and injuries. Diagnoses comprise traumatic brain injury, stroke, Parkinson’s disease, multiple sclerosis, brain tumour and epilepsy. 50 patients in each patient group will be included. In addition, 50 healthy controls will be recruited. All participants will undergo both testing with Mindmore Remote at home and traditional neuropsychological assessment face-to-face in a randomised order. The primary outcome is the association ...
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Berginström, N., Andersson, L. Tags: Open access, Neurology Source Type: research

First-line Treatment Patterns and Outcomes in Advanced Non-Small Cell Lung Cancer in Sweden: A Population-based Real-world Study with Focus on Immunotherapy
Acta Oncol. 2024 Apr 21;63:198-205. doi: 10.2340/1651-226X.2024.20309.ABSTRACTBACKGROUND AND PURPOSE: The treatment landscape for patients with advanced non-small cell lung cancer (NSCLC) has evolved significantly since the introduction of immunotherapies. We here describe PD-L1 testing rates, treatment patterns, and real-world outcomes for PD-(L)1 inhibitors in Sweden.MATERIALS AND METHODS: Data were obtained from the Swedish National Lung Cancer Registry for patients with advanced NSCLC and Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2 who initiated first-line -systemic treatment from 01 April 201...
Source: Acta Oncologica - April 21, 2024 Category: Cancer & Oncology Authors: Gunnar Wagenius Anders Vikstr öm Anders Berglund Stina Salomonsson Goran Bencina Xiaohan Hu Dana Chirovsky Hans Brunnstr öm Source Type: research

Promising therapeutic targets for the treatment of urine storage dysfunction: what ’s the status?
. (Source: Expert Opinion on Therapeutic Targets)
Source: Expert Opinion on Therapeutic Targets - April 21, 2024 Category: Drugs & Pharmacology Authors: Karl-Erik Anderssona Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USAb Department of Laboratory Medicine, Lund University, Lund, Sweden Source Type: research