Loss of Autophagy in Hematopoietic Cells Contributes to Osteoporosis
In this study, we showed that osteoporosis is highly associated with reduction in hematopoietic autophagy activity in humans. We showed that an autophagy defect in the hematological system leads to severe bone loss. The disturbed osteocyte homeostasis is apparently caused by impaired type H blood vessels and possibly an aberrant alteration in the extracellular matrix (ECM) pathways that govern osteocyte homeostasis in hematopoietic autophagy-defective mice. Our results thus suggest that autophagy in the adjacent hematopoietic cells is essential to maintain bone homeostasis, and chronic hematopoietic autophagy deficiency ca...
Source: Fight Aging! - April 7, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Actress Jordin Sparks Talks About Sickle Cell Disease in NIH MedlinePlus Magazine
The current issue of NIH MedlinePlus magazine brings you recording artist and Broadway actress Jordin Sparks sharing her family’s experience with sickle cell disease. Sparks opens up about honoring her late stepsister, giving more patients a voice, and reducing stigma. She says, “We need to end the stigma that can come with sickle cell disease.… (Source: NLM In Focus)
Source: NLM In Focus - January 16, 2020 Category: Databases & Libraries Authors: Guest Author Tags: Featured Articles People Source Type: blogs
Fight Aging! Newsletter, November 25th 2019
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis.
Against Senolytics
https://www.fightaging.org/archives/2019/11/against-senolytics/
There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a...
Source: Fight Aging! - November 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
7-Ketocholesterol as a Contributing Cause of Multiple Age-Related Diseases
One noteworthy difference between the biochemistry of young and old individuals is a greater presence of oxidative molecules, resulting from dysfunctional cells, inflammatory processes, and other issues. As a consequence, there are also many more oxidized molecules, changed from their original structure and now either broken or actively harmful. Cells clear out this sort of oxidative damage constantly, and are quite efficient at this sort of maintenance until levels of oxidization become high, but they nonetheless struggle with some particularly toxic or resilient oxidized molecules, even in smaller amounts. A good example...
Source: Fight Aging! - November 21, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Mandated Queries of the Florida Prescription Drug Monitoring Program: A Three-Month Experience from a Cancer Center-Based Outpatient Palliative Medicine Clinic
This article represents the findings from the queries over the first three months ’ queries and brings further clarity to our initial findings.Methods This quality improvement (QI) project was reviewed and approved by the Orlando Health/UFHealth Cancer Center Joint Oncology Committee for 2018-19. We began recording results of all E-FORSCE queries occurring after the law ’s implementation of July 1, 2018 through September 30, 2018. We informed each patient that the PDMP query had become mandatory in Florida, and we discussed the results of each query with each patient. Each query examined the last 12 months of the patie...
Source: Pallimed: A Hospice and Palliative Medicine Blog - November 18, 2019 Category: Palliative Care Tags: kollas opioid pain quality improvement statte Source Type: blogs
Viral Agents of Childhood Respiratory Tract Infection in the United States
As of October, 2019 Gideon www.GideonOnline.com and the Gideon e-book series contain details of 69,204 epidemiological surveys – of which 1,107 (1.6%) are related to the prevalence of specific viral species in patients with respiratory tract infection. [1-3]
The following chronology of published studies summarizes the relative proportion of viral agents associated with non-influenza childhood respiratory infection in the United States. Additional details and primary references are available on request.
1976 – 2001 Tennessee
hMPV accounted for 20% of acute respiratory illness among children ages 0 to 5 years having ...
Source: GIDEON blog - October 25, 2019 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: Ebooks Epidemiology ProMED Source Type: blogs
Part 6 - Why Is Cancer Pain So Special?
by Drew Rosielle (@drosielle)A Series of Observations on Opioids By a Palliative Doc Who Prescribes A Lot of Opioids But Also Has Questions.This is the 5th post in a series about opioids, with a focus on how my thinking about opioids has changed over the years. See also:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph.Part 2 – We Were Wrong 20 years Ago, Our Current Response to the Opioid Crisis is Wrong, But We Should Still Be Helping Most of our Long-Term Patients Reduce Their Opioid DosesPart 3 – Opioids Have Ceiling Effects, High-Doses are Rarely Therapeutic, and Another Hand-Cr...
Source: Pallimed: A Hospice and Palliative Medicine Blog - October 6, 2019 Category: Palliative Care Tags: cancer opioids pain rosielle The profession Source Type: blogs
Part 5 - Why Do We Lump the Non-Cancer Pain Syndromes Together?
by Drew Rosielle (@drosielle)A Series of Observations on Opioids By a Palliative Doc Who Prescribes A Lot of Opioids But Also Has Questions.This is the 5th post in a series about opioids, with a focus on how my thinking about opioids has changed over the years. See also:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph.Part 2 – We Were Wrong 20 years Ago, Our Current Response to the Opioid Crisis is Wrong, But We Should Still Be Helping Most of our Long-Term Patients Reduce Their Opioid DosesPart 3 – Opioids Have Ceiling Effects, High-Doses are Rarely Therapeutic, and Another Hand-Cr...
Source: Pallimed: A Hospice and Palliative Medicine Blog - October 6, 2019 Category: Palliative Care Tags: opioid pain rosielle The profession Source Type: blogs
For some with chronic pain, the problem is not in their backs or knees but their brains - The Washington Post
After 36 agonizing years with sickle cell disease, Tesha Samuels is in complete remission — free, at least for now, of one of the most painful disorders known to medicine. Yet Samuels's body still hurts almost every day.The question that perplexes her doctors at the National Institutes of Health is why, after her blood disorder has been vanquished, she is still in pain.Perhaps her newly healed red blood cells are not yet bringing enough oxygen to her tissues. Perhaps the emotional toll of a lifetime of constant pain has left her prepared to feel little else. Or perhaps the pain signals that have flooded her brain for...
Source: Psychology of Pain - September 24, 2019 Category: Anesthesiology Source Type: blogs
What's new in midwifery - 4th September 2019
Some things you might like to know about.StatisticsMaternity statisticsApril 2019May 2019 Quarterly conceptions to women aged under 18 years (England)April to June 2018Public Health EnglandGeneration genome and the opportunities for screening programmesIncludes opportunities in screening for fetal anomalies, sickle cell and thalassemia, infectiosu diseases in pregnancy, and newborn blood spot screening and newborn hearing screening.NewsLots this time...The man who gave birth (Guardian podcast)Freddy McConnell is a trans man who decided to begin the process of conceiving and delivering his own child. The fil...
Source: Browsing - September 4, 2019 Category: Databases & Libraries Tags: midwifery Source Type: blogs
The Lunate That Died
Everyone who works with me knows that I love joint radiographs, and the wrist is my favorite. It was no surprise when I came on shift that someone exclaimed, "I have an x-ray for you. I bet you will know exactly what it is! This 30-ish-year-old lady came in with atraumatic wrist pain."I did know exactly what it was. My eyes were drawn to the lucent lunate target. The patient was still in the ED, so I went to examine her hand. She had increased pain when I walked my fingers proximally down the metacarpal, which dipped into the carpal space. She was also not a fan of volar flexion or dorsiflexion. It made sense....
Source: Lions and Tigers and Bears - September 3, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Lipid Nanoparticles Deliver CRISPR/Cas9 into Organs with High Efficiency
Researchers at Tufts University and the Chinese Academy of Sciences have developed a new lipid nanoparticle which can deliver CRISPR/Cas9 gene editing tools into organs with high efficiency, suggesting that the system is promising for clinical applications.
The CRISPR/Cas9 system is currently being investigated as a way to treat a variety of diseases with a genetic basis, including Duchenne muscular dystrophy, Huntington’s, and sickle cell disease. While the system has significant promise, there are some issues that need to be resolved before it can be used clinically. CRISPR/Cas9 is a large complex, and it is diffic...
Source: Medgadget - July 15, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Source Type: blogs
The Causes of Schizophrenia: It ’ s Probably Not Genetics
For more than a century, researchers have had a deeply-held belief that schizophrenia is one form of mental illness that has its basis in genetics. In the intervening years, hundreds of millions of person-hours and billions of dollars have been funneled pursuing the genetic theory of schizophrenia.
Despite all of this enormous effort, researchers are starting to understand that perhaps the genetic component of schizophrenia has been overemphasized. And, in fact, the heritability estimates are not the 80-85 percent that some researchers claimed, but instead are far less.
A new review article published in Psychiatry Researc...
Source: World of Psychology - July 10, 2019 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: General Research Schizophrenia Causes Of Schizophrenia Schizophrenia Causes Source Type: blogs
Microfluidic Impedance Sensor Can Monitor Sickle Cell Disease
Researchers at Florida Atlantic University have developed a microfluidic chip that can rapidly assess blood samples from sickle cell disease patients to help monitor the disease. The technique is much faster and more convenient than traditional optical microscopy assessments.
Sickle cell disease affects approximately 100,000 individuals in the U.S. and millions of people throughout the world. Red blood cells in those affected become misshapen (forming a “sickle” shape) and sticky, and can block blood flow and break down. This can lead to a variety of serious symptoms, such as organ failure, stroke, and severe pain, bot...
Source: Medgadget - June 14, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Source Type: blogs
Fenwal Amicus Red Blood Cell Exchange System
Fresenius Kabi, a company based in Bad Homburg, Germany, announced that its Fenwal Amicus Red Blood Cell Exchange (RBCx) system won clearance from the FDA. The device can automatically remove patient’s blood cells and replace them with another fluid, particularly useful when treating sickle cell disease. The system can perform exchange, depletion/exchange, and depletion procedures, depending on each patient’s needs and for blood centers that stock up on platelet and plasma fluids.
The system has been approved in Europe for three years now, and as in the United States it is indicated for “therapeutic plas...
Source: Medgadget - March 6, 2019 Category: Medical Devices Authors: Editors Tags: Medicine Oncology Source Type: blogs
