Spatiotemporal analysis and hotspots detection of COVID-19 using geographic information system (March and April, 2020)
In conclusion, hot spot analysis coupled with Anselin local Moran ’sI provides a scrupulous and objective approach to determine the locations of statistically significant clusters of COVID-19 cases shedding light on the high-risk districts. (Source: Journal of Environmental Health Science and Engineering)
Source: Journal of Environmental Health Science and Engineering - October 12, 2020 Category: Environmental Health Source Type: research

Worldwide differences in COVID-19-related mortality
Abstract Mortality statistics due to COVID-19 worldwide are compared, by adjusting for the size of the population and the stage of the pandemic. Data from the European Centre for Disease Control and Prevention, and Our World in Data websites were used. Analyses are based on number of deaths per one million inhabitants. In order to account for the stage of the pandemic, the baseline date was defined as the day in which the 10th death was reported. The analyses included 78 countries and territories which reported 10 or more deaths by April 9. On day 10, India had 0.06 deaths per million, Belgium had 30.46 and San Marino 618....
Source: Ciencia e Saude Coletiva - June 5, 2020 Category: Occupational Health Source Type: research

Insomnia and hot flashes
In the epidemiology of sleep disorders, one of the most significant differences between genders is the frequency of insomnia, which in women is 1.2-2.0 times more common than in men. In this regard, a study conducted on the population of San Marino showed an increase in the prevalence of insomnia from 12 to 40% in women around 45-50 years of age, the age of transition to menopause [1]. In 2007 the Sleep in America Poll examined women ’s sleep throughout their lifespan, and found that almost 60% of women in perimenopause reported insomnia, about 40% reported symptoms of apnea or restless legs syndrome (RLS), and 20% suffe...
Source: Maturitas - May 13, 2019 Category: Primary Care Authors: Enrica Bonanni, Alessandro Schirru, Maria Caterina Di Perri, Ubaldo Bonuccelli, Michelangelo Maestri Source Type: research

Genetic Counseling in Huntington's Disease: Potential New Challenges on Horizon?
Conclusion and Recommendations In this review we attempt to summarize current knowledge about the HD mutation and how information about CAG repeats in the HTT gene can be used to provide sound genetic counseling, which can possibly extend to other neurodegenerative diseases (44). By involving families in observational (i.e., ENROLL-HD platform) and interventional trials, clinicians have an opportunity to include adult patients and their relatives (e.g., partners, symptomatic minors, premanifest adults) in research-based networks that provide current knowledge about developments in genetic testing and novel therapies in HD...
Source: Frontiers in Neurology - April 29, 2019 Category: Neurology Source Type: research

Epidemiology of inflammatory bowel disease in the Republic of San Marino: The “EPIMICI – San Marino” study
The burden of Crohn ’s disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest nation of the world. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 20, 2018 Category: Gastroenterology Authors: Anna Chiara Piscaglia, Loris Riccardo Lopetuso, Lucrezia Laterza, Viviana Gerardi, Elena Sacchini, Emanuele Leoncini, Stefania Boccia, Maria Loredana Stefanelli, Antonio Gasbarrini, Alessandro Armuzzi Tags: Alimentary Tract Source Type: research

Epidemiology of Inflammatory Bowel Disease in the Republic of San Marino: the “EPIMICI − San Marino” Study
The burden of Crohn ’s disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest Nation of the World. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 20, 2018 Category: Gastroenterology Authors: Anna Chiara Piscaglia, Loris Riccardo Lopetuso, Lucrezia Laterza, Viviana Gerardi, Elena Sacchini, Emanuele Leoncini, Stefania Boccia, Maria Loredana Stefanelli, Antonio Gasbarrini, Alessandro Armuzzi Source Type: research

Multiple sclerosis in the Republic of San Marino, Italian peninsula: an incidence and prevalence study from a high-risk area
AbstractEpidemiological studies on multiple sclerosis (MS) carried out in Southern Europe in the last years have shown a significant increase in the disease frequency. Previous surveys conducted in the Republic of San Marino, Northern Italian peninsula, identified  that the population is at high risk for MS, with a prevalence of 51.6 per 100,000 population in 1982 and of 166.7 in 2005 and with a mean annual incidence of 7.9 per 100,000 for the period 1990–2005. The present work is a community-based intensive prevalence and incidence survey, by a complete e numeration approach, to update the prevalence and incidence of ...
Source: Neurological Sciences - April 18, 2018 Category: Neurology Source Type: research

Coronary heart disease differences in Eastern versus Western Europe: a demanding situation
There are more than 4 million cardiovascular disease (CVD) related deaths each year in Europe, thus representing the main cause of deaths (47% of total: 52% of deaths in women and 42% in men). Notably, the main forms of CVD are coronary heart disease (CHD: about half of all CVD) and stroke (about 1/4 in men and 1/3 in women). If one considers geographic distribution of CVD deaths, CVD is the main cause of death for women in all countries of Europe for which we have mortality data and it is the main cause of death for men in all but 6 of these countries (exceptions are France, Israel, the Netherlands, San Marino, Slovenia a...
Source: International Journal of Cardiology - June 27, 2016 Category: Cardiology Authors: Paolo Emilio Puddu, Alessandro Menotti Source Type: research

Coronary heart disease differences in Eastern versus Western Europe: A demanding situation
There are more than 4 million cardiovascular disease (CVD) related deaths each year in Europe, thus representing the main cause of deaths (47% of total: 52% of deaths in women and 42% in men). Notably, the main forms of CVD are coronary heart disease (CHD: about half of all CVD) and stroke (about 1/4 in men and 1/3 in women). If one considers geographic distribution of CVD deaths, CVD is the main cause of death for women in all countries of Europe for which we have mortality data and it is the main cause of death for men in all but 6 of these countries (exceptions are France, Israel, the Netherlands, San Marino, Slovenia a...
Source: International Journal of Cardiology - June 27, 2016 Category: Cardiology Authors: Paolo Emilio Puddu, Alessandro Menotti Source Type: research

Colorectal cancer screening in countries of European Council outside of the EU-28.
CONCLUSION: Cancer screening should be viewed as a key health care tool, also because investing in screening protects the weakest in the population, decreases the social burden of cancer, and reduces all types of health care costs, including those for radical surgery, long-term hospitalisation, and chemotherapy. PMID: 27239121 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 27, 2016 Category: Gastroenterology Authors: Altobelli E, D'Aloisio F, Angeletti PM Tags: World J Gastroenterol Source Type: research

Estimation of the Prevalence of Asymptomatic Pancreatic Cysts in the Population of San Marino
There has been a dramatic increase in the number of pancreatic cystic lesions observed in the past two decades but data regarding the prevalence of cysts in the general population are lacking. (Source: Pancreatology)
Source: Pancreatology - May 20, 2015 Category: Gastroenterology Authors: Nicola Zanini, Marco Giordano, Elia Smerieri, Giulio Cipolla d’Abruzzo, Marilyn Guidi, Giorgio Pazzaglini, Fiorella De Luca, Giorgia Chiaruzzi, Giovanni Vitullo, Paolo Piva, Raffaele Lombardi, Elio Jovine, Marino Gatti, Giovanni Landolfo Tags: Original Article Source Type: research

Lifestyle changes associated with a new antioxidant formulation in non-alcoholic fatty liver disease: a case series.
Authors: Abenavoli L, Peta V, Milic N Abstract Non-alcoholic fatty liver disease (NAFLD) is a relevant issue in public health owing to its epidemiological burden. It represents the most common chronic liver disease in the general population and is expected to increase in future as a result of an ageing population. The only currently recommended treatment for NAFLD is lifestyle modification. However, literature reports pre-clinical and clinical studies on the use of antioxidant supplementation in NAFLD. A new antioxidant complex, called Bilirel (BIL) (Pharmaluce, Republic of San Marino), have recently intro...
Source: Annals of Hepatology - December 25, 2014 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The bottom quartile for health indices in America vs Europe
Summary: The inequities in health outcomes in different parts of the developed world merit further analysis. An index comprising mortality and morbidity factors was composed for American states and European nations. Multiple factors and bottom quartile status were analyzed by regression methodology. The 51 American states (and District of Columbia) showed a “Health Index” value based on life expectancy at birth and morbidity determined by rates of cardiac disease and cancer that ranged from 63 (Mississippi and West Virginia) to 94 (Utah). The 48 of 51 European states with assessable data showed a Health Index based on ...
Source: Journal of Infection and Public Health - July 18, 2014 Category: Global & Universal Authors: Wayne Xavier Shandera Tags: Original Articles Source Type: research

Mass population screening for celiac disease in children: the experience in Republic of San Marino from 1993 to 2009
Conclusions: Prevalence of celiac disease in children of Republic of San Marino is comparable to other North-European Countries. Sensitivity of ATTG proved much higher than that of anti-gliadin antibodies. Concordance between ATTG and EMA was 100%. Concordance between serology and histology was approximately 100%. Cost of screening was yearly about 5000 euros (250 children screened every year). (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - October 23, 2013 Category: Pediatrics Authors: Alessandrini SusannaGiacomoni ElisaMuccioli Fausto Source Type: research