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Infectious Disease: COVID-19
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Total 239975 results found since Jan 2013.
How does the Immunological System Change during the SARS-COV-2 Attack? A Clue for the New Immunotherapy Discovery
Curr Med Chem. 2023 Sep 18. doi: 10.2174/0929867331666230918092749. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) is one of the biggest unsolved global problems of the 21st century for which there has been no definitive cure yet. Like other respiratory viruses, SARS-COV-2 triggers the host immunity dramatically, causing dysfunction in the immune system, both innate and adaptive, which is a common feature of COVID-19 patients. Evidence shows that in the early stages of COVID-19, the immune system is suppressed while it is overactive in severe p...
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Mohammad Mahdi Hajihasani Najmeh Kaffash Farkhad Ali Mahmoudi Amirhossein Sahebkar Source Type: research
Addressing Opportunities and Barriers in Telehealth Neurologic Physical Therapy: Strategies to Advance Practice
This article highlights the potential and future of telehealth in neurologic PT practice. Our recommendations provide current clinical tools and resources for telehealth implementation following a knowledge-to-action framework and suggest areas for future research.Video Abstract available for more insights from the authors (see the Video, the Supplemental Digital Content, available at: http://links.lww.com/JNPT/A447).PMID:37725807 | DOI:10.1097/NPT.0000000000000454
Source: Physical Therapy - September 19, 2023 Category: Physiotherapy Authors: Aimee E Perron Hina Garg Sarah Gallagher Brittany Kennedy Sara Oxborough Emily Schultz Gregory Thielman Qing Zhang Source Type: research
Emergency Department waiting-time in the post pandemic era: new organizational models, a challenge for the future
CONCLUSIONS: data show an increase in the time spent in the EDs and an increase in the overcrowding, according to the NEDOCS index. New management models and a reorganization of EDs are needed as the workload has increased significantly.PMID:37724561 | DOI:10.23750/abm.v94iS3.14262
Source: Acta Bio-Medica : Atenei Parmensis - September 19, 2023 Category: General Medicine Authors: Giuseppe Stirparo Erika Kacerik Aida Andreassi Paolo Pausilli Francesca Cortellaro Anna Coppo Maurizio Migliari Andrea Albonico Giuseppe Maria Sechi Alberto Zoli Carlo Signorelli Source Type: research
Effect of interferon- α on COVID-19 in-hospital mortality: a large-scale propensity score-matched study
CONCLUSION: Our findings indicate that subcutaneous administration of IFN-α, with or without remdesivir, does not have any significant impact on COVID-19 mortality and ICU admission. Future clinical trials considering the time, subtype, and form of IFN-α administration are warranted to investigate the potential therapeutic effects of IFN-α on COVID-19.PMID:37724852 | DOI:10.1684/ecn.2023.0485
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Mohamad Amin Pourhoseingholi Amirreza Rafiei Javazm Naghmeh Asadimanesh Fatemeh Shojaeian Mehdi Azizmohammad Looha Seyed Amir Ahmad Safavi-Naini Benyamin Mohammadzadeh Parnian Jamshidi Fatemeh Gholampoor Omid Yazdani Nadia Zameni Zahra Azizan Amirhossein Source Type: research
Family physicians' questions about the COVID-19 pandemic: a content analysis of 2,272 helpline calls
CONCLUSIONS: This research provides unique insight on the effects the COVID-19 pandemic had on family medicine in Canada. These results provide insights on the needs and information gaps of family physicians in a public health crisis and can inform preparedness efforts by public health agencies, professional organizations, educators, and practitioners.PMID:37726697 | DOI:10.1186/s12875-023-02147-w
Source: Primary Care - September 19, 2023 Category: Primary Care Authors: Allan McDougall Jacqueline H Fortier Cathy Zhang Caroline Ehrat Kerri Best Heather Blois Gary Garber Source Type: research
Evaluation of the Impact of the COVID-19 Pandemic on Cystic Echinococcosis Indirect Hemagglutination Test Dynamics: A Single-center Experience
CONCLUSION: A significant decrease was observed in the rate of IHA positivity during the pandemic period. The status of no increase in positivity rates despite a significant decrease in IHA tests makes us think that the diagnosis may be missed in some patients or that there could be disruptions in their follow-up. For this reason, in order to continue the fight successfully against CE, which is an important public health problem for our country, early diagnosis and regular follow-ups should be emphasized with educations, and the laboratory-clinician communication should be strengthened in order to use tests more efficientl...
Source: Turkish Society for Parasitology - September 19, 2023 Category: Parasitology Authors: Özlem Ulusan Bağcı Source Type: research
Student Perceptions of a New Course Using Argumentation in Medical Education
CONCLUSION: These findings support evidence from educational scholarship outside of medicine showing argumentation as a learning tool is well received by students. Further work is needed to determine whether it improves critical thinking skills and enhances learning in medical education.PMID:37724185 | PMC:PMC10505381 | DOI:10.2147/AMEP.S394219
Source: Adv Data - September 19, 2023 Category: Epidemiology Authors: Andrew J Foy Kent E Vrana Paul Haidet Bernice L Hausman Nancy E Adams Ira Ropson Daniel R Wolpaw David Rabago Richard B Mailman Xuemei Huang Source Type: research
Preclinical evaluation of a SARS-CoV-2 variant B.1.351-based candidate DNA vaccine
Vaccine. 2023 Sep 17:S0264-410X(23)01091-5. doi: 10.1016/j.vaccine.2023.09.021. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic revealed the critical shortfalls of global vaccine availability for emergent pathogens and the need for exploring additional vaccine platforms with rapid update potential in response to new variants. Thus, it remains essential, for the present evolving SARS-CoV-2/Covid-19 and future pandemics, to continuously develop and characterize new and different vaccine platforms. Here, we describe an expression-optimized DNA vaccine candidate based on the SARS-CoV-2 spike protein of the Beta variant (...
Source: Vaccine - September 19, 2023 Category: Allergy & Immunology Authors: Ria Lassauni ère Charlotta Polacek Jeanette Linnea Tingstedt Anders Fomsgaard Source Type: research
Patient-reported reactogenicity and safety of COVID-19 vaccinations vs. comparator vaccinations: a comparative observational cohort study
CONCLUSION: The rate of adverse reactions after established vaccinations was roughly comparable to previous studies. Two weeks after vaccination, participants in the SARS-CoV-2 vaccination group reported more local and systemic local reactions than participants in the comparator group. In the further course, however, there were no higher odds of medical consultations in either of the two groups. Thus, altogether, we assume comparable safety.TRIAL REGISTRATION: DRKS-ID DRKS00025881 and DRKS-ID DRKS00025373.PMID:37726711 | DOI:10.1186/s12916-023-03064-6
Source: Herpes - September 19, 2023 Category: Infectious Diseases Authors: Felix Werner Nikoletta Zeschick Thomas K ühlein Philipp Steininger Klaus Überla Isabelle Kaiser Maria Sebasti ão Susann Hueber Lisette Warkentin Source Type: research
Associations of polychlorinated biphenyl and organochlorine pesticide exposure with hyperuricemia: modification by lifestyle factors
Environ Sci Pollut Res Int. 2023 Sep 20. doi: 10.1007/s11356-023-29938-z. Online ahead of print.ABSTRACTRecent research has reported positive associations of exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) with hyperuricemia. However, most of these studies have primarily focused on the individual effects of PCB/OCP exposure. We aimed to explore the associations of both individual and combined PCB/OCP exposure with hyperuricemia and examine whether such associations could be modified by lifestyle factors. The cross-sectional study recruited 2032 adults between March and May 2019 in Wuhan, C...
Source: Environmental Science and Pollution Research International - September 19, 2023 Category: Environmental Health Authors: Gaojie Fan Qing Liu Jianing Bi Qing Fang Xiya Qin Mingyang Wu Yongman Lv Surong Mei Youjie Wang Zhengce Wan Lulu Song Source Type: research
Evolution of the surgical procedure gap during and after the COVID-19 pandemic in Ontario, Canada: cross-sectional and modelling study
Br J Surg. 2023 Sep 19:znad289. doi: 10.1093/bjs/znad289. Online ahead of print.NO ABSTRACTPMID:37724806 | DOI:10.1093/bjs/znad289
Source: The British Journal of Surgery - September 19, 2023 Category: Surgery Authors: Rachel Stephenson Vahid Sarhangian Jangwon Park Ashwin Sankar Nancy N Baxter Therese A Stukel Andrea N Simpson Duminda N Wijeysundera Andrew S Wilton Charles de Mestral Stephen W Hwang Daniel Pincus Robert J Campbell David R Urbach Jonathan Irish David Go Source Type: research
Clinical Utility of Sero-Immunological Responses Against SARS-CoV-2 Nucleocapsid Protein During Subsequent Prevalence of Wild-Type, Delta Variant, and Omicron Variant
In conclusion, nucleocapsid antibody provides instructive clues about the immunogenicity of nucleocapsid proteins by different seroconversion rates and titers according to the severity of infection, host immune status, and different variants of concern.PMID:37724496 | DOI:10.3346/jkms.2023.38.e292
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Beomki Lee Jae-Hoon Ko Jin Yang Baek Haein Kim Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Kyong Ran Peck Eun-Suk Kang Source Type: research
Physician and administrator experience of preparing to implement Ontario's intensive care unit Triage Emergency Standard of Care during the COVID-19 pandemic: a qualitative study
CMAJ Open. 2023 Sep 19;11(5):E838-E846. doi: 10.9778/cmajo.20220168. Print 2023 Sep-Oct.ABSTRACTBACKGROUND: As the COVID-19 pandemic created a surge in demand for critical care resources, the province of Ontario, Canada, released the Adult Critical Care Clinical Emergency Standard of Care for Major Surge (Emergency Standard of Care [ESoC]), a triage framework to guide the allocation of critical care resources in the expectation that intensive care units would be overwhelmed. Our aim was to understand physicians' and administrators' experiences and perceptions of planning to implement the ESoC, and to identify ways to impro...
Source: cmaj - September 19, 2023 Category: General Medicine Authors: Brandon A Heidinger Ariane Downar Andrea Frolic James Downar Sarina R Isenberg Source Type: research
Addressing Opportunities and Barriers in Telehealth Neurologic Physical Therapy: Strategies to Advance Practice
This article highlights the potential and future of telehealth in neurologic PT practice. Our recommendations provide current clinical tools and resources for telehealth implementation following a knowledge-to-action framework and suggest areas for future research.Video Abstract available for more insights from the authors (see the Video, the Supplemental Digital Content, available at: http://links.lww.com/JNPT/A447).PMID:37725807 | DOI:10.1097/NPT.0000000000000454
Source: Health Physics - September 19, 2023 Category: Physics Authors: Aimee E Perron Hina Garg Sarah Gallagher Brittany Kennedy Sara Oxborough Emily Schultz Gregory Thielman Qing Zhang Source Type: research
Maternal Mental Health, COVID-19-Related Distress, and Disruptions in Lifestyle Behaviors Among Postpartum Mothers With a Previous Hypertensive Disorder of Pregnancy
CONCLUSION: Monitoring PTSD symptoms may be vital in supporting mothers with hypertensive disorders of pregnancy in making lifestyle changes to prevent cardiovascular disease.PMID:37723619 | DOI:10.1097/JCN.0000000000001038
Source: The Journal of Cardiovascular Nursing - September 19, 2023 Category: Nursing Authors: Jewel Scott Alisse Hauspurg Esa M Davis Samantha Bryan Janet M Catov Source Type: research
