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Drug: Metformin
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Total 6422 results found since Jan 2013.
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes
In conclusion, the findings suggest that metformin-induced inhibition of pyruvate oxidation combined with altered cellular redox state, shifts the equilibrium of the lactate dehydrogenase (LDH) reaction leading to a dose-dependent lactate production in primary human myotubes.PMID:37694284 | DOI:10.1152/ajpcell.00186.2023
Source: American Journal of Physiology. Cell Physiology - September 11, 2023 Category: Cytology Authors: Jennifer Maurer Xinjie Zhao Martin Irmler Anders Gudiksen Nanna S Pilmark Qi Li Thomas Goj Johannes Beckers Martin Hrab ě de Angelis Andreas Birkenfeld Andreas Peter Rainer Lehmann Henriette Pilegaard Kristian Karstoft Guowang Xu Cora Weigert Source Type: research
Metformin and Covid-19: a systematic review of systematic reviews with meta-analysis
Conclusions More in-depth studies on the use of metformin, compared to other molecules, may be required to understand the real protective potential of the drug against negative outcomes caused by COVID-19 infection in DM2 patients.PMID:37695186 | DOI:10.23750/abm.v94iS3.14405
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Fabio Petrelli Iolanda Grappasonni Cuc Thi Thu Nguyen Marina Tesauro Paola Pantanetti Sonila Xhafa Giovanni Cangelosi Source Type: research
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes
In conclusion, the findings suggest that metformin-induced inhibition of pyruvate oxidation combined with altered cellular redox state, shifts the equilibrium of the lactate dehydrogenase (LDH) reaction leading to a dose-dependent lactate production in primary human myotubes.PMID:37694284 | DOI:10.1152/ajpcell.00186.2023
Source: Am J Physiol Cell Ph... - September 11, 2023 Category: Cytology Authors: Jennifer Maurer Xinjie Zhao Martin Irmler Anders Gudiksen Nanna S Pilmark Qi Li Thomas Goj Johannes Beckers Martin Hrab ě de Angelis Andreas Birkenfeld Andreas Peter Rainer Lehmann Henriette Pilegaard Kristian Karstoft Guowang Xu Cora Weigert Source Type: research
Metformin and Covid-19: a systematic review of systematic reviews with meta-analysis
Conclusions More in-depth studies on the use of metformin, compared to other molecules, may be required to understand the real protective potential of the drug against negative outcomes caused by COVID-19 infection in DM2 patients.PMID:37695186 | DOI:10.23750/abm.v94iS3.14405
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Fabio Petrelli Iolanda Grappasonni Cuc Thi Thu Nguyen Marina Tesauro Paola Pantanetti Sonila Xhafa Giovanni Cangelosi Source Type: research
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes
In conclusion, the findings suggest that metformin-induced inhibition of pyruvate oxidation combined with altered cellular redox state, shifts the equilibrium of the lactate dehydrogenase (LDH) reaction leading to a dose-dependent lactate production in primary human myotubes.PMID:37694284 | DOI:10.1152/ajpcell.00186.2023
Source: Am J Physiol Cell Ph... - September 11, 2023 Category: Cytology Authors: Jennifer Maurer Xinjie Zhao Martin Irmler Anders Gudiksen Nanna S Pilmark Qi Li Thomas Goj Johannes Beckers Martin Hrab ě de Angelis Andreas Birkenfeld Andreas Peter Rainer Lehmann Henriette Pilegaard Kristian Karstoft Guowang Xu Cora Weigert Source Type: research
Metformin and Covid-19: a systematic review of systematic reviews with meta-analysis
Conclusions More in-depth studies on the use of metformin, compared to other molecules, may be required to understand the real protective potential of the drug against negative outcomes caused by COVID-19 infection in DM2 patients.PMID:37695186 | DOI:10.23750/abm.v94iS3.14405
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Fabio Petrelli Iolanda Grappasonni Cuc Thi Thu Nguyen Marina Tesauro Paola Pantanetti Sonila Xhafa Giovanni Cangelosi Source Type: research
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ultra-efficient radio-immunotherapy for reprogramming the hypoxic and immunosuppressive tumor microenvironment with durable innate immune memory
Biomaterials. 2023 Sep 5;302:122303. doi: 10.1016/j.biomaterials.2023.122303. Online ahead of print.ABSTRACTRadiosensitization efficacy of conventional tumor radiosensitizers has been frequently limited by insufficient competence for tumor microenvironment (TME) regulation and unfavorable cellular uptake at biological barriers. Here, we reported an ultra-efficient radiotherapy (RT) strategy by synthesizing an extracellular vesicles (EVs)-encapsulated hollow MnO2 to load metformin (Met@HMnER). It demonstrated significant RT enhancement by morphological control of catalyst and cellular respiratory depression against conventi...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Jichun Yang Chong Zhang Xiaohui Chen Daijun Zhou Zixin Sun Ruyan Niu Ying Zhu Hengyi Chen Liu Wang Yi Chen Yuhan Wang Yunqian Fu Ningyu Ma Jianjun Li Yang Luo Source Type: research
Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea
Chemosphere. 2023 Sep 7:140070. doi: 10.1016/j.chemosphere.2023.140070. Online ahead of print.ABSTRACTThe antidiabetic drug metformin (MET) and its metabolite guanylurea (GUA) have been frequently and ubiquitously detected in surface water. Consequently, there has been a consistent rise in studying the toxicity of MET and GUA in fish over the past decade. Nonetheless, it is noteworthy that no study has assessed the harmful effects both compounds might trigger on fish blood and organs after chronic exposure. Taking into consideration the data above, our research strived to accomplish two primary objectives: Firstly, to asse...
Source: Chemosphere - September 9, 2023 Category: Chemistry Authors: Gustavo Axel Elizalde-Vel ázquez Selene Elizabeth Herrera-V ázquez Leobardo Manuel G ómez-Oliván Sandra Garc ía-Medina Source Type: research
Metformin induces tolerogenicity of dendritic cells by promoting metabolic reprogramming
In this study, metformin was added to a culture system of LPS-induced DC maturation. The results revealed that metformin shifted DC into a tolerant phenotype, resulting in reduced surface expression of MHC-II, costimulatory molecules and CCR7, decreased levels of proinflammatory cytokines (TNF-α and IFN-γ), increased level of IL-10, upregulated immunomodulatory molecules (ICOSL and PD-L) and an enhanced capacity to promote regulatory T-cell (Treg) differentiation. Further results demonstrated that the anti-inflammatory effects of metformin in vivo were closely related to remodeling the immunophenotype of DCs. Mechanistic...
Source: Cellular and Molecular Life Sciences : CMLS - September 9, 2023 Category: Cytology Authors: Xianmei Liu Peng Yu Yujun Xu Yun Wang Jin Chen Fuzhou Tang Zuquan Hu Jing Zhou Lina Liu Wei Qiu Yuannong Ye Yi Jia Weijuan Yao Jinhua Long Zhu Zeng Source Type: research
Ultra-efficient radio-immunotherapy for reprogramming the hypoxic and immunosuppressive tumor microenvironment with durable innate immune memory
Biomaterials. 2023 Sep 5;302:122303. doi: 10.1016/j.biomaterials.2023.122303. Online ahead of print.ABSTRACTRadiosensitization efficacy of conventional tumor radiosensitizers has been frequently limited by insufficient competence for tumor microenvironment (TME) regulation and unfavorable cellular uptake at biological barriers. Here, we reported an ultra-efficient radiotherapy (RT) strategy by synthesizing an extracellular vesicles (EVs)-encapsulated hollow MnO2 to load metformin (Met@HMnER). It demonstrated significant RT enhancement by morphological control of catalyst and cellular respiratory depression against conventi...
Source: Biomaterials - September 9, 2023 Category: Materials Science Authors: Jichun Yang Chong Zhang Xiaohui Chen Daijun Zhou Zixin Sun Ruyan Niu Ying Zhu Hengyi Chen Liu Wang Yi Chen Yuhan Wang Yunqian Fu Ningyu Ma Jianjun Li Yang Luo Source Type: research
Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea
Chemosphere. 2023 Sep 7:140070. doi: 10.1016/j.chemosphere.2023.140070. Online ahead of print.ABSTRACTThe antidiabetic drug metformin (MET) and its metabolite guanylurea (GUA) have been frequently and ubiquitously detected in surface water. Consequently, there has been a consistent rise in studying the toxicity of MET and GUA in fish over the past decade. Nonetheless, it is noteworthy that no study has assessed the harmful effects both compounds might trigger on fish blood and organs after chronic exposure. Taking into consideration the data above, our research strived to accomplish two primary objectives: Firstly, to asse...
Source: Chemosphere - September 9, 2023 Category: Chemistry Authors: Gustavo Axel Elizalde-Vel ázquez Selene Elizabeth Herrera-V ázquez Leobardo Manuel G ómez-Oliván Sandra Garc ía-Medina Source Type: research
