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Drug: Metformin
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Metformin attenuates chronic lung allograft dysfunction: evidence in rat models
CONCLUSIONS: Metformin attenuates CLAD in rat models, which could be attributed to the antifibrotic and immunomodulatory effects. AMPK activation suggests the potential molecular mechanism. Our study provides an experimental rationale for further clinical trials.PMID:37516880 | DOI:10.1186/s12931-023-02492-5
Source: Respiratory Care - July 29, 2023 Category: Respiratory Medicine Authors: Dong Tian Xiangyun Zheng Hongtao Tang Heng Huang Junjie Wang Lin Xu Caihan Li Haoji Yan Ruixuan Yu Jinzhu Nan Menggen Liu Xiaoguang Guo Shunhai Jian Tao Wang Senyi Deng Qiang Pu Lunxu Liu Source Type: research
Complex Case of Skull Base Osteomyelitis Secondary to Chronic Otitis Media
We present a case of a 58-year-old male with type II diabetes managed with metformin and insulin, who presented to the clinic with left chronic otitis media, persistent drainage, a stenotic meatus, and a prior history of 3 canal wall-down mastoidectomies and antibiotic therapy. A revision tympanoplasty with mastoidectomy was performed, and during the postoperative period, the patient had persistent pain and otorrhea, which were managed with opioids and several courses of antibiotic therapy. After symptoms persisted, imaging and culture ultimately led to the diagnosis of fungal skull base osteomyelitis, which was eventually...
Source: Ear, Nose and Throat Journal - July 29, 2023 Category: ENT & OMF Authors: Masa Petrovic Hannah G Landsberger Kevin A Peng Source Type: research
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models
CONCLUSIONS: Metformin attenuates CLAD in rat models, which could be attributed to the antifibrotic and immunomodulatory effects. AMPK activation suggests the potential molecular mechanism. Our study provides an experimental rationale for further clinical trials.PMID:37516880 | DOI:10.1186/s12931-023-02492-5
Source: Cell Research - July 29, 2023 Category: Cytology Authors: Dong Tian Xiangyun Zheng Hongtao Tang Heng Huang Junjie Wang Lin Xu Caihan Li Haoji Yan Ruixuan Yu Jinzhu Nan Menggen Liu Xiaoguang Guo Shunhai Jian Tao Wang Senyi Deng Qiang Pu Lunxu Liu Source Type: research
Pharmacological and Pathological Effects of Mulberry Leaf Extract on the Treatment of Type 1 Diabetes Mellitus Mice
This study investigated the pharmacological and pathological effects of aqueous mulberry leaf extract on type 1 diabetes mellitus mice induced with an intraperitoneal injection of streptozotocin (STZ). Diabetic mice were randomized into six groups: control (normal group), model, metformin-treated mice, and high-dose, medium-dose, and low-dose mulberry. The mulberry-treated mice were divided into high-, medium-, and low-dose groups based on the various doses of aqueous mulberry leaf extract during gavage. The efficacy of the six-week intervention was evaluated by measuring levels of fasting plasma glucose, alkaline phosphat...
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Liru Luo Wei Fan Jingping Qin Shiyin Guo Hang Xiao Zhonghai Tang Source Type: research
