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Drug: Metformin
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Total 6422 results found since Jan 2013.
Metformin and exercise effects on postprandial insulin sensitivity and glucose kinetics in pre-and-diabetic adults
Am J Physiol Endocrinol Metab. 2023 Aug 16. doi: 10.1152/ajpendo.00118.2023. Online ahead of print.ABSTRACTThe potential interaction between metformin and exercise on glucose-lowering effects remains controversial. We studied the separated and combined effects of metformin and/or exercise on fasting and postprandial insulin sensitivity in individuals with pre- and - type 2 diabetes (T2D). Eight T2D adults (60±4 years) with overweight/obesity (32±4 kg·m-2) under chronic metformin treatment (9±6 years; 1281±524 mg·day-1) underwent four trials; a) taking their habitual metformin treatment (MET), b) substituting during 9...
Source: Am J Physiol Endocri... - August 16, 2023 Category: Endocrinology Authors: Alfonso Moreno-Caba ñas Felix Morales-Palomo Laura Álvarez-Jimenez Diego Mora-Gonzalez Juan Fernando Ortega Ricardo Mora-Rodriguez Source Type: research
Approach to the Patient with Youth-Onset Type 2 Diabetes
J Clin Endocrinol Metab. 2023 Aug 16:dgad482. doi: 10.1210/clinem/dgad482. Online ahead of print.ABSTRACTYouth-onset type 2 diabetes is a growing epidemic with a rising incidence worldwide. Although the pathogenesis and diagnosis of youth-onset type 2 diabetes are similar to adult-onset type 2 diabetes, youth-onset type 2 diabetes is unique, with greater insulin resistance, insulin hypersecretion, and faster progression of pancreatic beta cell function decline. Individuals with youth-onset type 2 diabetes also develop complications at higher rates within short periods of time compared to adults with type 2 diabetes or yout...
Source: The Journal of Clinical Endocrinology and Metabolism - August 16, 2023 Category: Endocrinology Authors: Talia A Hitt Tamara S Hannon Sheela N Magge Source Type: research
GAL3 Mediates Vascular Dysfunction in Obesity by Regulating NOX1
CONCLUSIONS: Deletion of GAL3 normalizes microvascular endothelial function in obese db/db mice, likely through an NOX1-mediated mechanism. Pathological levels of GAL3, and in turn NOX1, are amenable to improvements in metabolic status, presenting a potential therapeutic target to ameliorate pathological cardiovascular consequences of obesity.PMID:37586054 | DOI:10.1161/ATVBAHA.123.319476
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 16, 2023 Category: Cardiology Authors: Caleb A Padgett R óbert K Bátori Andrew C Speese Cody L Rosewater Weston B Bush Cassandra C Derella Stephen B Haigh Hunter G Sellers Zachary L Corley Madison A West James D Mintz Brittany B Ange Ryan A Harris Michael W Brands David J R Fulton David W St Source Type: research
Metformin and exercise effects on postprandial insulin sensitivity and glucose kinetics in pre-and-diabetic adults
Am J Physiol Endocrinol Metab. 2023 Aug 16. doi: 10.1152/ajpendo.00118.2023. Online ahead of print.ABSTRACTThe potential interaction between metformin and exercise on glucose-lowering effects remains controversial. We studied the separated and combined effects of metformin and/or exercise on fasting and postprandial insulin sensitivity in individuals with pre- and - type 2 diabetes (T2D). Eight T2D adults (60±4 years) with overweight/obesity (32±4 kg·m-2) under chronic metformin treatment (9±6 years; 1281±524 mg·day-1) underwent four trials; a) taking their habitual metformin treatment (MET), b) substituting during 9...
Source: Am J Physiol Endocri... - August 16, 2023 Category: Endocrinology Authors: Alfonso Moreno-Caba ñas Felix Morales-Palomo Laura Álvarez-Jimenez Diego Mora-Gonzalez Juan Fernando Ortega Ricardo Mora-Rodriguez Source Type: research
Tracking contaminants of concern in wet-weather sanitary sewer overflows
The objective was to identify the risks posed by sewage contaminants to aquatic biota in the receiving waters, to aid in prioritising management actions. Twelve organic contaminants were identified in influents across the four sites under rainfall ingress diluted conditions, with measurements showing that the highest concentrations were restricted to the anti-inflammatory acetaminophen and the diabetes medication metformin. Lesser contaminants included theobromine, ibuprofen, sucralose, and three benzotriazoles (mainly 1-H benzotriazole). An assessment of the toxicity of the identified organic chemicals indicated that none...
Source: Environmental Science and Pollution Research International - August 15, 2023 Category: Environmental Health Authors: Colin H Besley Graeme E Batley Michele Cassidy Source Type: research
Salvia Officinalis Improves Glucose Uptake and Suppresses Ectopic Lipid Deposition in Obese Rats with Metabolic Syndrome
CONCLUSION: The findings imply that SAGEAE could be used as a new pharmaceutical formula in the treatment of obesity.PMID:37581324 | DOI:10.2174/1389201024666230811104740
Source: Current Pharmaceutical Biotechnology - August 15, 2023 Category: Biotechnology Authors: Diana A ALsherif Mohammed A Hussein Suzan S Abuelkasem Soha A Hassan Michael Wink Source Type: research
Tracking contaminants of concern in wet-weather sanitary sewer overflows
The objective was to identify the risks posed by sewage contaminants to aquatic biota in the receiving waters, to aid in prioritising management actions. Twelve organic contaminants were identified in influents across the four sites under rainfall ingress diluted conditions, with measurements showing that the highest concentrations were restricted to the anti-inflammatory acetaminophen and the diabetes medication metformin. Lesser contaminants included theobromine, ibuprofen, sucralose, and three benzotriazoles (mainly 1-H benzotriazole). An assessment of the toxicity of the identified organic chemicals indicated that none...
Source: Environmental Science and Pollution Research International - August 15, 2023 Category: Environmental Health Authors: Colin H Besley Graeme E Batley Michele Cassidy Source Type: research
