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Drug: Metformin
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Total 6422 results found since Jan 2013.
MiR-601-induced BMSCs senescence accelerates steroid-induced osteonecrosis of the femoral head progression by targeting SIRT1
CONCLUSIONS: Considering the role of BMSCs aging in the progression of SONFH, this provides a new idea for the prevention and treatment of SONFH.PMID:37597099 | DOI:10.1007/s00018-023-04903-8
Source: Cellular and Molecular Life Sciences : CMLS - August 19, 2023 Category: Cytology Authors: Boyu Tang Yu Chen Pei Zhao Wenlong Yan Xiao Huang Weiqian Jiang Mingjie Sun Hongrui Zhang Dulei Xiang Tingmei Chen Chengjie Lian Jian Zhang Source Type: research
Clinical presentation, diagnosis, and management of a primary cardiac tumor: A case report
CONCLUSIONS: For patients with malignant tumor, most of them had local invasion or had distant metastasis when the diagnosis was clear, and only conservative management could be done. Moreover, the prognosis of malignant tumor is poor, and the pathological morphology is diverse. The causes of death are due to widespread tumor metastasis, refractory heart failure, and various arrhythmias.PMID:37596232 | DOI:10.1016/j.asjsur.2023.07.099
Source: Asian Journal of Surgery - August 18, 2023 Category: Surgery Authors: Jianhua Xie Liang Yuan Yuxue Qin Jianxiong Liu Source Type: research
Updates on RPE cell damage in diabetic retinopathy (Review)
Mol Med Rep. 2023 Oct;28(4):185. doi: 10.3892/mmr.2023.13072. Epub 2023 Aug 18.ABSTRACTDiabetic retinopathy (DR) is a microvascular complication of diabetes. The retinal pigment epithelium (RPE) forms the outer layer of the blood‑retinal barrier and serves a role in maintaining retinal function. RPE cell injury has been revealed in diabetic animal models, and high glucose (HG) levels may cause damage to RPE cells by increasing the levels of oxidative stress, promoting pro‑inflammatory gene expression, disrupting cell proliferation, inducing the endothelial‑mesenchymal transition, weakening tight conjunctions and elev...
Source: Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Min Li Meimei Tian Yuling Wang Huijie Ma Yaru Zhou Xinli Jiang Yan Liu Source Type: research
Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in < em > db/db < /em > mice
This study aimed to determine the effect of loss of endothelial GR on organ fibrosis in the db/db model. Db/Db mice lacking endothelial GR showed more severe fibrosis in multiple organs compared to endothelial GR-replete db/db mice. Organ fibrosis could be substantially improved either through administration of a Wnt inhibitor or metformin. IL-6 is a key cytokine driving the fibrosis phenotype and is mechanistically linked to Wnt signaling. The db/db model is an important tool to study mechanisms of fibrosis and its phenotype in the absence of endothelial GR highlights the synergistic effects of Wnt signaling and inflammat...
Source: Am J Physiol Renal P... - August 17, 2023 Category: Urology & Nephrology Authors: Swayam Prakash Srivastava Julie E Goodwin Source Type: research
Case Report: Late-Onset Metformin-Associated Diarrhea
Am Fam Physician. 2023 Aug;108(2):Online.NO ABSTRACTPMID:37590844
Source: American Family Physician - August 17, 2023 Category: Primary Care Authors: Robert J Flaherty Source Type: research
Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in < em > db/db < /em > mice
This study aimed to determine the effect of loss of endothelial GR on organ fibrosis in the db/db model. Db/Db mice lacking endothelial GR showed more severe fibrosis in multiple organs compared to endothelial GR-replete db/db mice. Organ fibrosis could be substantially improved either through administration of a Wnt inhibitor or metformin. IL-6 is a key cytokine driving the fibrosis phenotype and is mechanistically linked to Wnt signaling. The db/db model is an important tool to study mechanisms of fibrosis and its phenotype in the absence of endothelial GR highlights the synergistic effects of Wnt signaling and inflammat...
Source: Am J Physiol Renal P... - August 17, 2023 Category: Urology & Nephrology Authors: Swayam Prakash Srivastava Julie E Goodwin Source Type: research
Metformin derivatives - Researchers' Friends or Foes?
Biochem Pharmacol. 2023 Aug 15:115743. doi: 10.1016/j.bcp.2023.115743. Online ahead of print.ABSTRACTMetformin has been used for ages to treat diabetes mellitus due to its safety profile and low cost. However, metformin has variable pharmacokinetics in patients, and due to its poor oral absorption, the therapeutic doses are relatively high, causing unpleasant gastrointestinal adverse effects. Therefore, novel derivatives of metformin have been synthesized during the past decades. Particularly, after the mid-2000s, when organic cation transporters were identified as the main metformin carriers, metformin derivatives have be...
Source: Biochemical Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Sema Tuna Torunoglu Agnieszka Zajda Janne Tampio Magdalena Markowicz-Piasecka Kristiina M Huttunen Source Type: research
