Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes

In conclusion, the findings suggest that metformin-induced inhibition of pyruvate oxidation combined with altered cellular redox state, shifts the equilibrium of the lactate dehydrogenase (LDH) reaction leading to a dose-dependent lactate production in primary human myotubes.PMID:37694284 | DOI:10.1152/ajpcell.00186.2023

Source: American Journal of Physiology. Cell Physiology - September 11, 2023 Category: Cytology Authors: Jennifer Maurer Xinjie Zhao Martin Irmler Anders Gudiksen Nanna S Pilmark Qi Li Thomas Goj Johannes Beckers Martin Hrab ě de Angelis Andreas Birkenfeld Andreas Peter Rainer Lehmann Henriette Pilegaard Kristian Karstoft Guowang Xu Cora Weigert Source Type: research