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Cancer: Squamous Cell Carcinoma
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Total 19037 results found since Jan 2013.
ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023225. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) commonly has aggressive properties and a poor prognosis. Investigating the molecular mechanisms underlying the progression of ESCC is crucial for developing effective therapeutic strategies. Here, by performing transcriptome sequencing in ESCC and adjacent normal tissues, we find that E74-like transcription factor 4 (ELF4) is the main upregulated transcription factor in ESCC. The results of the immunohistochemistry show that ELF4 is overexpressed in ESCC tissues and is signific...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aiping Xu Mingchuang Sun Zhaoxing Li Yuan Chu Kang Fang Yunwei Zhang Jingjing Lian Li Zhang Tao Chen Meidong Xu Source Type: research
Crosstalk between PD-L1 and Jak2-Stat3/ MAPK-AP1 signaling promotes oral cancer progression, invasion and therapy resistance
CONCLUSIONS: PD-L1 was regulated mainly by the Jak2-Stat3/ MAPK-AP1 pathway, and besides the routine immunological functions, it supports OSCC survival, invasion, and therapy resistance. PD-L1 can be used as an indicator of severity and can be targeted along with Jak2-Stat3/ MAPK-AP1 for a better outcome OSCC.PMID:37678027 | DOI:10.1016/j.intimp.2023.110894
Source: International Immunopharmacology - September 7, 2023 Category: Allergy & Immunology Authors: Arpita Jha Manzar Alam Tanushree Kashyap Nidhi Nath Anjali Kumari Kamdeo K Pramanik Siddavaram Nagini Rajakishore Mishra Source Type: research
"Squamous cell carcinoma developed in a trichilemmal cyst, an incidental finding"
Actas Dermosifiliogr. 2023 Sep 5:S0001-7310(23)00690-7. doi: 10.1016/j.ad.2023.05.032. Online ahead of print.NO ABSTRACTPMID:37678632 | DOI:10.1016/j.ad.2023.05.032
Source: Actas Dermo-Sifiliograficas - September 7, 2023 Category: Dermatology Authors: J P érez Wilson G Coulon C Whittle A Castro Source Type: research
ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023225. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) commonly has aggressive properties and a poor prognosis. Investigating the molecular mechanisms underlying the progression of ESCC is crucial for developing effective therapeutic strategies. Here, by performing transcriptome sequencing in ESCC and adjacent normal tissues, we find that E74-like transcription factor 4 (ELF4) is the main upregulated transcription factor in ESCC. The results of the immunohistochemistry show that ELF4 is overexpressed in ESCC tissues and is signific...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aiping Xu Mingchuang Sun Zhaoxing Li Yuan Chu Kang Fang Yunwei Zhang Jingjing Lian Li Zhang Tao Chen Meidong Xu Source Type: research
The level of macrophage migration inhibitory factor is negatively correlated with the efficacy of PD-1 blockade immunotherapy combined with chemotherapy as a neoadjuvant therapy for esophageal squamous cell carcinoma
CONCLUSION: Baseline MIF levels were negatively correlated with neoadjuvant therapy efficacy. Thus, MIF may serve as a predictive biomarker for this therapy. The accuracy of the prediction could be improved if the serum concentration of MIF is measured again after the patient received several weeks of treatment.PMID:37678132 | DOI:10.1016/j.tranon.2023.101775
Source: Translational Oncology - September 7, 2023 Category: Cancer & Oncology Authors: Liangliang Wu Yiming Gao Shengzhi Xie Wan Ye Yasushi Uemura Rong Zhang Yanju Yu Jinfeng Li Man Chen Qiyan Wu Pengfei Cui Hongyu Liu Shuai Mu Yilan Li Lingxiong Wang Chunxi Liu Jiahui Li Lijun Zhang Shunchang Jiao Guoqing Zhang Tianyi Liu Source Type: research
The role of microbiota in esophageal squamous cell carcinoma: A review of the literature
In conclusion, esophageal dysbiosis is associated with ESCC progression and chemoresistance. Screening the oral and esophageal microbiota is a potential diagnostic tool for predicting ESCC development or drug-resistance. Repairing esophageal dysbiosis is a novel treatment for ESCC. Clinical trials with probiotics in addition to current chemotherapy are warranted to study the therapeutic effects.
Source: Thoracic Cancer - September 7, 2023 Category: Cancer & Oncology Authors: Hsueh ‐Chien Chiang,
Michael Hughes,
Wei‐Lun Chang Tags: REVIEW Source Type: research
Significant risk of second primary cancer among laryngeal squamous cell carcinoma patients even after 20 years
Conclusion: Patients with LSCC as primary cancer have a 60% excess risk for an SPC, especially for tobacco-associated cancers, remaining significantly elevated even decades after treatment.PMID:37672344 | DOI:10.1080/0284186X.2023.2254482
Source: Acta Oncologica - September 6, 2023 Category: Cancer & Oncology Authors: Rayan Nikkil ä Elli Hirvonen Aaro Haapaniemi Laura Tapiovaara Janne Pitk äniemi Nea Malila Antti M äkitie Source Type: research
Socioeconomic position and the pre-diagnostic interval among patients diagnosed with head and neck squamous cell carcinoma - a population-based study from DAHANCA
CONCLUSION: The interval from symptom onset to diagnosis and consultation patterns were similar across SEP groups. Still, socioeconomic differences in stage at diagnosis were observed for some - but not all - subsites.PMID:37672036 | DOI:10.1080/0284186X.2023.2254478
Source: Acta Oncologica - September 6, 2023 Category: Cancer & Oncology Authors: Maja Halgren Olsen Thomas Maltesen Pernille Lassen Trille Kristina Kjaer J ørgen Johansen Hanne Primdahl Elo Andersen Claus Andrup Kristensen Maria Andersen Mohammad Farhadi Jens Overgaard Susanne Oksbjerg Dalton Source Type: research
Significant risk of second primary cancer among laryngeal squamous cell carcinoma patients even after 20 years
Conclusion: Patients with LSCC as primary cancer have a 60% excess risk for an SPC, especially for tobacco-associated cancers, remaining significantly elevated even decades after treatment.PMID:37672344 | DOI:10.1080/0284186X.2023.2254482
Source: Acta Oncologica - September 6, 2023 Category: Cancer & Oncology Authors: Rayan Nikkil ä Elli Hirvonen Aaro Haapaniemi Laura Tapiovaara Janne Pitk äniemi Nea Malila Antti M äkitie Source Type: research
Socioeconomic position and the pre-diagnostic interval among patients diagnosed with head and neck squamous cell carcinoma - a population-based study from DAHANCA
CONCLUSION: The interval from symptom onset to diagnosis and consultation patterns were similar across SEP groups. Still, socioeconomic differences in stage at diagnosis were observed for some - but not all - subsites.PMID:37672036 | DOI:10.1080/0284186X.2023.2254478
Source: Acta Oncologica - September 6, 2023 Category: Cancer & Oncology Authors: Maja Halgren Olsen Thomas Maltesen Pernille Lassen Trille Kristina Kjaer J ørgen Johansen Hanne Primdahl Elo Andersen Claus Andrup Kristensen Maria Andersen Mohammad Farhadi Jens Overgaard Susanne Oksbjerg Dalton Source Type: research
5-Fluorouracil and Anti-EGFR antibody scaffold chitosan-stabilized Pickering emulsion: Formulations, physical characterization, in-vitro studies in NCL-H226 cells, and in-vivo investigations in Wistar rats for the augmented therapeutic effects against squamous cell carcinoma
Int J Biol Macromol. 2023 Sep 4:126716. doi: 10.1016/j.ijbiomac.2023.126716. Online ahead of print.ABSTRACTThis research seeks to optimize a chitosan-stabilized Pickering emulsion (PE) containing 5-fluorouracil (5-FU) as a potential Squamous Cell Carcinoma therapy. The 5-Fluorouracil was also thoroughly analysed using UV spectrophotometry and RP-HPLC, demonstrating exceptional linearity, sensitivity, precision, and robustness. The techniques of characterization revealed Pickering emulsion (PE) morphology, solid-like gel properties, successful encapsulation, and promising anticancer effects. FTIR was used to validate the ef...
Source: International Journal of Biological Macromolecules - September 6, 2023 Category: Biochemistry Authors: Sankha Bhattacharya Prafull Shinde Amit Page Satyam Sharma Source Type: research
Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations
Am J Hum Genet. 2023 Aug 29:S0002-9297(23)00283-5. doi: 10.1016/j.ajhg.2023.08.007. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a very poor prognosis. Genome-wide association studies (GWASs) of ESCC in predominantly East Asian populations indicate a substantial genetic contribution to its etiology, but no genome-wide studies have been done in populations of African ancestry. Here, we report a GWAS in 1,686 African individuals with ESCC and 3,217 population-matched control individuals to investigate its genetic etiology. We identified a geno...
Source: Cancer Control - September 6, 2023 Category: Cancer & Oncology Authors: Wenlong Carl Chen Jean-Tristan Brandenburg Ananyo Choudhury Mahtaab Hayat Dhriti Sengupta Yaniv Swiel Chantal Babb de Villiers Lucien Ferndale Colleen Aldous Cassandra C Soo Sang Lee Charles Curtis Rob Newton Tim Waterboer Freddy Sitas Debbie Bradshaw Chr Source Type: research
Genomic and Transcriptomic Landscape of an Oral Squamous Cell Carcinoma Mouse Model for Immunotherapy
Cancer Immunol Res. 2023 Sep 5. doi: 10.1158/2326-6066.CIR-23-0133. Online ahead of print.ABSTRACTThe immune checkpoint inhibitor (ICI), anti-programmed death-1 (anti-PD-1), has shown moderate efficacy in some patients with head and neck squamous cell carcinoma (HNSCC). Because of this, it is imperative to establish a mouse tumor model to explore mechanisms of antitumor immunity and to develop novel therapeutic options. Here, we examined the 4-nitroquinoline-1-oxide (4NQO)-induced oral squamous cell carcinoma (OSCC) model for genetic aberrations, transcriptomic profiles, and immune cell composition at different pathologica...
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Yi-Mei Lee Chia-Lang Hsu Yu-Hsin Chen Da-Liang Ou Chiun Hsu Ching-Ting Tan Source Type: research
