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Cancer: Squamous Cell Carcinoma
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Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
Cancers, Vol. 15, Pages 4539: Prognostic Value of Necroptosis-Related Genes Signature in Oral Squamous Cell Carcinoma
In conclusion, the high expression of NRG prognostic signature is associated with poor prognosis in OSCC, and HPRT1 can serve as a novel independent prognostic factor for OSCC.
Source: Cancers - September 13, 2023 Category: Cancer & Oncology Authors: Ke Huang Xiaoting Gu Huimei Xu Hui Li Mingxuan Shi Defang Wei Shiqi Wang Yao Li Bin Liu Yi Li Tags: Article Source Type: research
Definitive chemoradiation in vulvar squamous cell carcinoma: outcome and toxicity from an observational multicenter Italian study on vulvar cancer (OLDLADY 1.1)
CONCLUSION: In the context of CRT for LAVC, the present study reports encouraging results even if there is clearly room for further improvements, in terms of both treatment outcomes, toxicity and treatment interruption management.PMID:37700153 | DOI:10.1007/s11547-023-01712-8
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Gabriella Macchia Valentina Lancellotta Martina Ferioli Calogero Cas à Donato Pezzulla Brigida Pappalardi Concetta Laliscia Edy Ippolito Jacopo Di Muzio Alessandra Huscher Francesca Tortoreto Mariangela Boccardi Roberta Lazzari Anna Myriam Perrone France Source Type: research
Personalized Biomarker-Based Umbrella Trial for Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: KCSG HN 15-16 TRIUMPH Trial
CONCLUSION: To our knowledge, this study is the first biomarker-driven umbrella trial for platinum-refractory HNSCC using matched molecular targeted agents. We found that NGS-based genomic phenotyping was methodologically feasible and applicable.PMID:37699162 | DOI:10.1200/JCO.22.02786
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Bhumsuk Keam Min Hee Hong Seong Hoon Shin Seong Gu Heo Ji Eun Kim Hee Kyung Ahn Yun-Gyoo Lee Keon-Uk Park Tak Yun Keun-Wook Lee Sung-Bae Kim Sang-Cheol Lee Min Kyoung Kim Sang Hee Cho So Yeon Oh Sang-Gon Park Shinwon Hwang Byung-Ho Nam Sangwoo Kim Hye Ryu Source Type: research
Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing
CONCLUSIONS: Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. The mechanism by which GPRIN2, KCNJ12, and TEKT4 contribute to tumorigenesis is unclear, but our results suggest they may play an important role in NSCLC and it is worth investigating in future.PMID:37694353 | DOI:10.3233/CBM-220211
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Varsha Singh Amit Katiyar Prabhat Malik Sunil Kumar Anant Mohan Harpreet Singh Deepali Jain Source Type: research
Bioinformatics analysis of CUL2/4A/9 and its function in head and neck squamous cell carcinoma
CONCLUSION: These results suggest that the transcriptional levels of CUL2/4A/9 were upregulated and these genes could affect proliferation and migration of HNSCC cells. Therefore, CUL2/4A/9 could potentially function as novel independent biomarkers in HNSCC patients.PMID:37695034 | DOI:10.5603/EP.a2023.0029
Source: Endokrynologia Polska - September 11, 2023 Category: Endocrinology Authors: Bingqing Xu Ruohuang Wang Jisheng Zhang Lin Wang Xin Cui Fangyu Chai Xiaoyun Du Yan Jiang Source Type: research
A pH-Activatable Nanoprobe Labels Diverse Histologic Subtypes of Human Lung Cancer During Resection
CONCLUSIONS: This translational study demonstrates the feasibility of pegsitacianine as an IMI probe to label the two most common histologic subtypes of human lung cancer.PMID:37697109 | DOI:10.1007/s11307-023-01853-2
Source: Mol Biol Cell - September 11, 2023 Category: Molecular Biology Authors: Gregory Thomas Kennedy Feredun S Azari Ashley Chang Austin Chang Patrick Bou-Samra Charuhas Desphande Edward J Delikatny Evgeniy Eruslanov John C Kucharczuk David C Rice Sunil Singhal Source Type: research
Inhibition of microRNA-15b-5p Attenuates the Progression of Oral Squamous Cell Carcinoma via Modulating the < em > PTPN4 < /em > /STAT3 Axis Retraction
Cancer Manag Res. 2023 Sep 5;15:981-982. doi: 10.2147/CMAR.S438019. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.2147/CMAR.S272498.].PMID:37693220 | PMC:PMC10492538 | DOI:10.2147/CMAR.S438019
Source: Cell Research - September 11, 2023 Category: Cytology Source Type: research
