Autophagy and senescence in cancer therapy
Adv Cancer Res. 2021;150:1-74. doi: 10.1016/bs.acr.2021.01.002. Epub 2021 Mar 12.ABSTRACTTumor cells can undergo diverse responses to cancer therapy. While apoptosis represents the most desirable outcome, tumor cells can alternatively undergo autophagy and senescence. Both autophagy and senescence have the potential to make complex contributions to tumor cell survival via both cell autonomous and cell non-autonomous pathways. The induction of autophagy and senescence in tumor cells, preclinically and clinically, either individually or concomitantly, has generated interest in the utilization of autophagy modulating and seno...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Nipa H Patel Sarah Bloukh Enas Alwohosh Ahmad Alhesa Tareq Saleh David A Gewirtz Source Type: research

Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
Adv Cancer Res. 2021;150:113-145. doi: 10.1016/bs.acr.2021.02.001. Epub 2021 Mar 8.ABSTRACTBoth senescence and autophagy have been strongly linked to aging and also cancer development. Numerous molecular, cellular, and physiological changes are known to correlate with an increasing age, yet our understanding of what underlies these changes or how they combine to give rise to the various pathologies associated with aging is still unclear. Levels of autophagy activity are known to decrease with advancing age, in a variety of organisms including mammals. Whereas senescent cells are known to accumulate in our bodies with age. ...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Andrew R J Young Liam D Cassidy Masashi Narita Source Type: research

Autophagy and senescence: Insights from normal and cancer stem cells
Adv Cancer Res. 2021;150:147-208. doi: 10.1016/bs.acr.2021.01.005. Epub 2021 Mar 30.ABSTRACTAutophagy is a fundamental cellular process, which allows cells to adapt to metabolic stress through the degradation and recycling of intracellular components to generate macromolecular precursors and produce energy. Autophagy is also critical in maintaining cellular/tissue homeostasis, as well preserving immunity and preventing human disease. Deregulation of autophagic processes is associated with cancer, neurodegeneration, muscle and heart disease, infectious diseases and aging. Research on a variety of stem cell types establish t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarmistha Talukdar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research

The role of autophagy in escaping therapy-induced polyploidy/senescence
Adv Cancer Res. 2021;150:209-247. doi: 10.1016/bs.acr.2021.01.004. Epub 2021 Mar 11.ABSTRACTAutophagy is an evolutionarily conserved process necessary to maintain cell homeostasis in response to various forms of stress such as nutrient deprivation and hypoxia as well as functioning to remove damaged molecules and organelles. The role of autophagy in cancer varies depending on the stage of cancer. Cancer therapeutics can also simultaneously evoke cancer cell senescence and ploidy increase. Both cancer cell senescence and polyploidization are reversible by depolyploidization giving rise to the progeny. Autophagy activation m...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Magdalena Dudkowska Karolina Staniak Agnieszka Bojko Ewa Sikora Source Type: research

Autophagy and PTEN in DNA damage-induced senescence
We present experimental evidence obtained with tumor cells, with a prime focus on two models of cancer, prostate and lung. A better understanding of mechanisms associated with DNA damage-induced cellular senescence is central to fully exploit the potential of DNA-damaging agents against cancer.PMID:33858598 | DOI:10.1016/bs.acr.2021.01.006 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Arishya Sharma Alexandru Almasan Source Type: research

Cellular senescence and tumor promotion: Role of the Unfolded Protein Response
Adv Cancer Res. 2021;150:285-334. doi: 10.1016/bs.acr.2021.01.001. Epub 2021 Feb 16.ABSTRACTSenescence is a cellular state which can be viewed as a stress response phenotype implicated in various physiological and pathological processes, including cancer. Therefore, it is of fundamental importance to understand why and how a cell acquires and maintains a senescent phenotype. Direct evidence has pointed to the homeostasis of the endoplasmic reticulum whose control appears strikingly affected during senescence. The endoplasmic reticulum is one of the sensing organelles that transduce signals between different pathways in ord...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Olivier Pluquet Corinne Abbadie Source Type: research

mTOR as a senescence manipulation target: A forked road
Adv Cancer Res. 2021;150:335-363. doi: 10.1016/bs.acr.2021.02.002. Epub 2021 Mar 18.ABSTRACTCellular senescence, cancer and aging are highly interconnected. Among many important molecular machines that lie at the intersection of this triad, the mechanistic (formerly mammalian) target of rapamycin (mTOR) is a central regulator of cell metabolism, proliferation, and survival. The mTOR signaling cascade is essential to maintain cellular homeostasis in normal biological processes or in response to stress, and its dysregulation is implicated in the progression of many disorders, including age-associated diseases. Accordingly, t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarah Saoudaoui Monique Bernard Guillaume B Cardin Nicolas Malaquin Apostolos Christopoulos Francis Rodier Source Type: research

Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Adv Cancer Res. 2021;150:75-112. doi: 10.1016/bs.acr.2021.01.003. Epub 2021 Feb 22.ABSTRACTAutophagy and cellular senescence are two potent tumor suppressive mechanisms activated by various cellular stresses, including the expression of activated oncogenes. However, emerging evidence has also indicated their pro-tumorigenic activities, strengthening the case for the complexity of tumorigenesis. More specifically, tumorigenesis is a systemic process emanating from the combined accumulation of changes in the tumor support pathways, many of which cannot cause cancer on their own but might still provide excellent therapeutic t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Jaejin Kim Yeonghyeon Lee Kyeonghwan Roh Mi-Sung Kim Chanhee Kang Source Type: research

Preface
Adv Cancer Res. 2021;150:xiii-xviii. doi: 10.1016/S0065-230X(21)00041-5.NO ABSTRACTPMID:33858602 | DOI:10.1016/S0065-230X(21)00041-5 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: David A Gewirtz Paul B Fisher Source Type: research

Autophagy and senescence in cancer therapy
Adv Cancer Res. 2021;150:1-74. doi: 10.1016/bs.acr.2021.01.002. Epub 2021 Mar 12.ABSTRACTTumor cells can undergo diverse responses to cancer therapy. While apoptosis represents the most desirable outcome, tumor cells can alternatively undergo autophagy and senescence. Both autophagy and senescence have the potential to make complex contributions to tumor cell survival via both cell autonomous and cell non-autonomous pathways. The induction of autophagy and senescence in tumor cells, preclinically and clinically, either individually or concomitantly, has generated interest in the utilization of autophagy modulating and seno...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Nipa H Patel Sarah Bloukh Enas Alwohosh Ahmad Alhesa Tareq Saleh David A Gewirtz Source Type: research

Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
Adv Cancer Res. 2021;150:113-145. doi: 10.1016/bs.acr.2021.02.001. Epub 2021 Mar 8.ABSTRACTBoth senescence and autophagy have been strongly linked to aging and also cancer development. Numerous molecular, cellular, and physiological changes are known to correlate with an increasing age, yet our understanding of what underlies these changes or how they combine to give rise to the various pathologies associated with aging is still unclear. Levels of autophagy activity are known to decrease with advancing age, in a variety of organisms including mammals. Whereas senescent cells are known to accumulate in our bodies with age. ...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Andrew R J Young Liam D Cassidy Masashi Narita Source Type: research

Autophagy and senescence: Insights from normal and cancer stem cells
Adv Cancer Res. 2021;150:147-208. doi: 10.1016/bs.acr.2021.01.005. Epub 2021 Mar 30.ABSTRACTAutophagy is a fundamental cellular process, which allows cells to adapt to metabolic stress through the degradation and recycling of intracellular components to generate macromolecular precursors and produce energy. Autophagy is also critical in maintaining cellular/tissue homeostasis, as well preserving immunity and preventing human disease. Deregulation of autophagic processes is associated with cancer, neurodegeneration, muscle and heart disease, infectious diseases and aging. Research on a variety of stem cell types establish t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarmistha Talukdar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research

The role of autophagy in escaping therapy-induced polyploidy/senescence
Adv Cancer Res. 2021;150:209-247. doi: 10.1016/bs.acr.2021.01.004. Epub 2021 Mar 11.ABSTRACTAutophagy is an evolutionarily conserved process necessary to maintain cell homeostasis in response to various forms of stress such as nutrient deprivation and hypoxia as well as functioning to remove damaged molecules and organelles. The role of autophagy in cancer varies depending on the stage of cancer. Cancer therapeutics can also simultaneously evoke cancer cell senescence and ploidy increase. Both cancer cell senescence and polyploidization are reversible by depolyploidization giving rise to the progeny. Autophagy activation m...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Magdalena Dudkowska Karolina Staniak Agnieszka Bojko Ewa Sikora Source Type: research

Autophagy and PTEN in DNA damage-induced senescence
We present experimental evidence obtained with tumor cells, with a prime focus on two models of cancer, prostate and lung. A better understanding of mechanisms associated with DNA damage-induced cellular senescence is central to fully exploit the potential of DNA-damaging agents against cancer.PMID:33858598 | DOI:10.1016/bs.acr.2021.01.006 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Arishya Sharma Alexandru Almasan Source Type: research

Cellular senescence and tumor promotion: Role of the Unfolded Protein Response
Adv Cancer Res. 2021;150:285-334. doi: 10.1016/bs.acr.2021.01.001. Epub 2021 Feb 16.ABSTRACTSenescence is a cellular state which can be viewed as a stress response phenotype implicated in various physiological and pathological processes, including cancer. Therefore, it is of fundamental importance to understand why and how a cell acquires and maintains a senescent phenotype. Direct evidence has pointed to the homeostasis of the endoplasmic reticulum whose control appears strikingly affected during senescence. The endoplasmic reticulum is one of the sensing organelles that transduce signals between different pathways in ord...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Olivier Pluquet Corinne Abbadie Source Type: research

mTOR as a senescence manipulation target: A forked road
Adv Cancer Res. 2021;150:335-363. doi: 10.1016/bs.acr.2021.02.002. Epub 2021 Mar 18.ABSTRACTCellular senescence, cancer and aging are highly interconnected. Among many important molecular machines that lie at the intersection of this triad, the mechanistic (formerly mammalian) target of rapamycin (mTOR) is a central regulator of cell metabolism, proliferation, and survival. The mTOR signaling cascade is essential to maintain cellular homeostasis in normal biological processes or in response to stress, and its dysregulation is implicated in the progression of many disorders, including age-associated diseases. Accordingly, t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarah Saoudaoui Monique Bernard Guillaume B Cardin Nicolas Malaquin Apostolos Christopoulos Francis Rodier Source Type: research

Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Adv Cancer Res. 2021;150:75-112. doi: 10.1016/bs.acr.2021.01.003. Epub 2021 Feb 22.ABSTRACTAutophagy and cellular senescence are two potent tumor suppressive mechanisms activated by various cellular stresses, including the expression of activated oncogenes. However, emerging evidence has also indicated their pro-tumorigenic activities, strengthening the case for the complexity of tumorigenesis. More specifically, tumorigenesis is a systemic process emanating from the combined accumulation of changes in the tumor support pathways, many of which cannot cause cancer on their own but might still provide excellent therapeutic t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Jaejin Kim Yeonghyeon Lee Kyeonghwan Roh Mi-Sung Kim Chanhee Kang Source Type: research

Preface
Adv Cancer Res. 2021;150:xiii-xviii. doi: 10.1016/S0065-230X(21)00041-5.NO ABSTRACTPMID:33858602 | DOI:10.1016/S0065-230X(21)00041-5 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: David A Gewirtz Paul B Fisher Source Type: research

Autophagy and senescence in cancer therapy
Adv Cancer Res. 2021;150:1-74. doi: 10.1016/bs.acr.2021.01.002. Epub 2021 Mar 12.ABSTRACTTumor cells can undergo diverse responses to cancer therapy. While apoptosis represents the most desirable outcome, tumor cells can alternatively undergo autophagy and senescence. Both autophagy and senescence have the potential to make complex contributions to tumor cell survival via both cell autonomous and cell non-autonomous pathways. The induction of autophagy and senescence in tumor cells, preclinically and clinically, either individually or concomitantly, has generated interest in the utilization of autophagy modulating and seno...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Nipa H Patel Sarah Bloukh Enas Alwohosh Ahmad Alhesa Tareq Saleh David A Gewirtz Source Type: research

Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
Adv Cancer Res. 2021;150:113-145. doi: 10.1016/bs.acr.2021.02.001. Epub 2021 Mar 8.ABSTRACTBoth senescence and autophagy have been strongly linked to aging and also cancer development. Numerous molecular, cellular, and physiological changes are known to correlate with an increasing age, yet our understanding of what underlies these changes or how they combine to give rise to the various pathologies associated with aging is still unclear. Levels of autophagy activity are known to decrease with advancing age, in a variety of organisms including mammals. Whereas senescent cells are known to accumulate in our bodies with age. ...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Andrew R J Young Liam D Cassidy Masashi Narita Source Type: research

Autophagy and senescence: Insights from normal and cancer stem cells
Adv Cancer Res. 2021;150:147-208. doi: 10.1016/bs.acr.2021.01.005. Epub 2021 Mar 30.ABSTRACTAutophagy is a fundamental cellular process, which allows cells to adapt to metabolic stress through the degradation and recycling of intracellular components to generate macromolecular precursors and produce energy. Autophagy is also critical in maintaining cellular/tissue homeostasis, as well preserving immunity and preventing human disease. Deregulation of autophagic processes is associated with cancer, neurodegeneration, muscle and heart disease, infectious diseases and aging. Research on a variety of stem cell types establish t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarmistha Talukdar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research

The role of autophagy in escaping therapy-induced polyploidy/senescence
Adv Cancer Res. 2021;150:209-247. doi: 10.1016/bs.acr.2021.01.004. Epub 2021 Mar 11.ABSTRACTAutophagy is an evolutionarily conserved process necessary to maintain cell homeostasis in response to various forms of stress such as nutrient deprivation and hypoxia as well as functioning to remove damaged molecules and organelles. The role of autophagy in cancer varies depending on the stage of cancer. Cancer therapeutics can also simultaneously evoke cancer cell senescence and ploidy increase. Both cancer cell senescence and polyploidization are reversible by depolyploidization giving rise to the progeny. Autophagy activation m...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Magdalena Dudkowska Karolina Staniak Agnieszka Bojko Ewa Sikora Source Type: research

Autophagy and PTEN in DNA damage-induced senescence
We present experimental evidence obtained with tumor cells, with a prime focus on two models of cancer, prostate and lung. A better understanding of mechanisms associated with DNA damage-induced cellular senescence is central to fully exploit the potential of DNA-damaging agents against cancer.PMID:33858598 | DOI:10.1016/bs.acr.2021.01.006 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Arishya Sharma Alexandru Almasan Source Type: research

Cellular senescence and tumor promotion: Role of the Unfolded Protein Response
Adv Cancer Res. 2021;150:285-334. doi: 10.1016/bs.acr.2021.01.001. Epub 2021 Feb 16.ABSTRACTSenescence is a cellular state which can be viewed as a stress response phenotype implicated in various physiological and pathological processes, including cancer. Therefore, it is of fundamental importance to understand why and how a cell acquires and maintains a senescent phenotype. Direct evidence has pointed to the homeostasis of the endoplasmic reticulum whose control appears strikingly affected during senescence. The endoplasmic reticulum is one of the sensing organelles that transduce signals between different pathways in ord...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Olivier Pluquet Corinne Abbadie Source Type: research

mTOR as a senescence manipulation target: A forked road
Adv Cancer Res. 2021;150:335-363. doi: 10.1016/bs.acr.2021.02.002. Epub 2021 Mar 18.ABSTRACTCellular senescence, cancer and aging are highly interconnected. Among many important molecular machines that lie at the intersection of this triad, the mechanistic (formerly mammalian) target of rapamycin (mTOR) is a central regulator of cell metabolism, proliferation, and survival. The mTOR signaling cascade is essential to maintain cellular homeostasis in normal biological processes or in response to stress, and its dysregulation is implicated in the progression of many disorders, including age-associated diseases. Accordingly, t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarah Saoudaoui Monique Bernard Guillaume B Cardin Nicolas Malaquin Apostolos Christopoulos Francis Rodier Source Type: research

Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Adv Cancer Res. 2021;150:75-112. doi: 10.1016/bs.acr.2021.01.003. Epub 2021 Feb 22.ABSTRACTAutophagy and cellular senescence are two potent tumor suppressive mechanisms activated by various cellular stresses, including the expression of activated oncogenes. However, emerging evidence has also indicated their pro-tumorigenic activities, strengthening the case for the complexity of tumorigenesis. More specifically, tumorigenesis is a systemic process emanating from the combined accumulation of changes in the tumor support pathways, many of which cannot cause cancer on their own but might still provide excellent therapeutic t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Jaejin Kim Yeonghyeon Lee Kyeonghwan Roh Mi-Sung Kim Chanhee Kang Source Type: research

Preface
Adv Cancer Res. 2021;150:xiii-xviii. doi: 10.1016/S0065-230X(21)00041-5.NO ABSTRACTPMID:33858602 | DOI:10.1016/S0065-230X(21)00041-5 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: David A Gewirtz Paul B Fisher Source Type: research

Autophagy and senescence in cancer therapy
Adv Cancer Res. 2021;150:1-74. doi: 10.1016/bs.acr.2021.01.002. Epub 2021 Mar 12.ABSTRACTTumor cells can undergo diverse responses to cancer therapy. While apoptosis represents the most desirable outcome, tumor cells can alternatively undergo autophagy and senescence. Both autophagy and senescence have the potential to make complex contributions to tumor cell survival via both cell autonomous and cell non-autonomous pathways. The induction of autophagy and senescence in tumor cells, preclinically and clinically, either individually or concomitantly, has generated interest in the utilization of autophagy modulating and seno...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Nipa H Patel Sarah Bloukh Enas Alwohosh Ahmad Alhesa Tareq Saleh David A Gewirtz Source Type: research

Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
Adv Cancer Res. 2021;150:113-145. doi: 10.1016/bs.acr.2021.02.001. Epub 2021 Mar 8.ABSTRACTBoth senescence and autophagy have been strongly linked to aging and also cancer development. Numerous molecular, cellular, and physiological changes are known to correlate with an increasing age, yet our understanding of what underlies these changes or how they combine to give rise to the various pathologies associated with aging is still unclear. Levels of autophagy activity are known to decrease with advancing age, in a variety of organisms including mammals. Whereas senescent cells are known to accumulate in our bodies with age. ...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Andrew R J Young Liam D Cassidy Masashi Narita Source Type: research

Autophagy and senescence: Insights from normal and cancer stem cells
Adv Cancer Res. 2021;150:147-208. doi: 10.1016/bs.acr.2021.01.005. Epub 2021 Mar 30.ABSTRACTAutophagy is a fundamental cellular process, which allows cells to adapt to metabolic stress through the degradation and recycling of intracellular components to generate macromolecular precursors and produce energy. Autophagy is also critical in maintaining cellular/tissue homeostasis, as well preserving immunity and preventing human disease. Deregulation of autophagic processes is associated with cancer, neurodegeneration, muscle and heart disease, infectious diseases and aging. Research on a variety of stem cell types establish t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarmistha Talukdar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research

The role of autophagy in escaping therapy-induced polyploidy/senescence
Adv Cancer Res. 2021;150:209-247. doi: 10.1016/bs.acr.2021.01.004. Epub 2021 Mar 11.ABSTRACTAutophagy is an evolutionarily conserved process necessary to maintain cell homeostasis in response to various forms of stress such as nutrient deprivation and hypoxia as well as functioning to remove damaged molecules and organelles. The role of autophagy in cancer varies depending on the stage of cancer. Cancer therapeutics can also simultaneously evoke cancer cell senescence and ploidy increase. Both cancer cell senescence and polyploidization are reversible by depolyploidization giving rise to the progeny. Autophagy activation m...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Magdalena Dudkowska Karolina Staniak Agnieszka Bojko Ewa Sikora Source Type: research

Autophagy and PTEN in DNA damage-induced senescence
We present experimental evidence obtained with tumor cells, with a prime focus on two models of cancer, prostate and lung. A better understanding of mechanisms associated with DNA damage-induced cellular senescence is central to fully exploit the potential of DNA-damaging agents against cancer.PMID:33858598 | DOI:10.1016/bs.acr.2021.01.006 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Arishya Sharma Alexandru Almasan Source Type: research

Cellular senescence and tumor promotion: Role of the Unfolded Protein Response
Adv Cancer Res. 2021;150:285-334. doi: 10.1016/bs.acr.2021.01.001. Epub 2021 Feb 16.ABSTRACTSenescence is a cellular state which can be viewed as a stress response phenotype implicated in various physiological and pathological processes, including cancer. Therefore, it is of fundamental importance to understand why and how a cell acquires and maintains a senescent phenotype. Direct evidence has pointed to the homeostasis of the endoplasmic reticulum whose control appears strikingly affected during senescence. The endoplasmic reticulum is one of the sensing organelles that transduce signals between different pathways in ord...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Olivier Pluquet Corinne Abbadie Source Type: research

mTOR as a senescence manipulation target: A forked road
Adv Cancer Res. 2021;150:335-363. doi: 10.1016/bs.acr.2021.02.002. Epub 2021 Mar 18.ABSTRACTCellular senescence, cancer and aging are highly interconnected. Among many important molecular machines that lie at the intersection of this triad, the mechanistic (formerly mammalian) target of rapamycin (mTOR) is a central regulator of cell metabolism, proliferation, and survival. The mTOR signaling cascade is essential to maintain cellular homeostasis in normal biological processes or in response to stress, and its dysregulation is implicated in the progression of many disorders, including age-associated diseases. Accordingly, t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarah Saoudaoui Monique Bernard Guillaume B Cardin Nicolas Malaquin Apostolos Christopoulos Francis Rodier Source Type: research

Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Adv Cancer Res. 2021;150:75-112. doi: 10.1016/bs.acr.2021.01.003. Epub 2021 Feb 22.ABSTRACTAutophagy and cellular senescence are two potent tumor suppressive mechanisms activated by various cellular stresses, including the expression of activated oncogenes. However, emerging evidence has also indicated their pro-tumorigenic activities, strengthening the case for the complexity of tumorigenesis. More specifically, tumorigenesis is a systemic process emanating from the combined accumulation of changes in the tumor support pathways, many of which cannot cause cancer on their own but might still provide excellent therapeutic t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Jaejin Kim Yeonghyeon Lee Kyeonghwan Roh Mi-Sung Kim Chanhee Kang Source Type: research

Preface
Adv Cancer Res. 2021;150:xiii-xviii. doi: 10.1016/S0065-230X(21)00041-5.NO ABSTRACTPMID:33858602 | DOI:10.1016/S0065-230X(21)00041-5 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: David A Gewirtz Paul B Fisher Source Type: research

Autophagy and senescence in cancer therapy
Adv Cancer Res. 2021;150:1-74. doi: 10.1016/bs.acr.2021.01.002. Epub 2021 Mar 12.ABSTRACTTumor cells can undergo diverse responses to cancer therapy. While apoptosis represents the most desirable outcome, tumor cells can alternatively undergo autophagy and senescence. Both autophagy and senescence have the potential to make complex contributions to tumor cell survival via both cell autonomous and cell non-autonomous pathways. The induction of autophagy and senescence in tumor cells, preclinically and clinically, either individually or concomitantly, has generated interest in the utilization of autophagy modulating and seno...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Nipa H Patel Sarah Bloukh Enas Alwohosh Ahmad Alhesa Tareq Saleh David A Gewirtz Source Type: research

Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
Adv Cancer Res. 2021;150:113-145. doi: 10.1016/bs.acr.2021.02.001. Epub 2021 Mar 8.ABSTRACTBoth senescence and autophagy have been strongly linked to aging and also cancer development. Numerous molecular, cellular, and physiological changes are known to correlate with an increasing age, yet our understanding of what underlies these changes or how they combine to give rise to the various pathologies associated with aging is still unclear. Levels of autophagy activity are known to decrease with advancing age, in a variety of organisms including mammals. Whereas senescent cells are known to accumulate in our bodies with age. ...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Andrew R J Young Liam D Cassidy Masashi Narita Source Type: research

Autophagy and senescence: Insights from normal and cancer stem cells
Adv Cancer Res. 2021;150:147-208. doi: 10.1016/bs.acr.2021.01.005. Epub 2021 Mar 30.ABSTRACTAutophagy is a fundamental cellular process, which allows cells to adapt to metabolic stress through the degradation and recycling of intracellular components to generate macromolecular precursors and produce energy. Autophagy is also critical in maintaining cellular/tissue homeostasis, as well preserving immunity and preventing human disease. Deregulation of autophagic processes is associated with cancer, neurodegeneration, muscle and heart disease, infectious diseases and aging. Research on a variety of stem cell types establish t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarmistha Talukdar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research

The role of autophagy in escaping therapy-induced polyploidy/senescence
Adv Cancer Res. 2021;150:209-247. doi: 10.1016/bs.acr.2021.01.004. Epub 2021 Mar 11.ABSTRACTAutophagy is an evolutionarily conserved process necessary to maintain cell homeostasis in response to various forms of stress such as nutrient deprivation and hypoxia as well as functioning to remove damaged molecules and organelles. The role of autophagy in cancer varies depending on the stage of cancer. Cancer therapeutics can also simultaneously evoke cancer cell senescence and ploidy increase. Both cancer cell senescence and polyploidization are reversible by depolyploidization giving rise to the progeny. Autophagy activation m...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Magdalena Dudkowska Karolina Staniak Agnieszka Bojko Ewa Sikora Source Type: research

Autophagy and PTEN in DNA damage-induced senescence
We present experimental evidence obtained with tumor cells, with a prime focus on two models of cancer, prostate and lung. A better understanding of mechanisms associated with DNA damage-induced cellular senescence is central to fully exploit the potential of DNA-damaging agents against cancer.PMID:33858598 | DOI:10.1016/bs.acr.2021.01.006 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Arishya Sharma Alexandru Almasan Source Type: research

Cellular senescence and tumor promotion: Role of the Unfolded Protein Response
Adv Cancer Res. 2021;150:285-334. doi: 10.1016/bs.acr.2021.01.001. Epub 2021 Feb 16.ABSTRACTSenescence is a cellular state which can be viewed as a stress response phenotype implicated in various physiological and pathological processes, including cancer. Therefore, it is of fundamental importance to understand why and how a cell acquires and maintains a senescent phenotype. Direct evidence has pointed to the homeostasis of the endoplasmic reticulum whose control appears strikingly affected during senescence. The endoplasmic reticulum is one of the sensing organelles that transduce signals between different pathways in ord...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Olivier Pluquet Corinne Abbadie Source Type: research

mTOR as a senescence manipulation target: A forked road
Adv Cancer Res. 2021;150:335-363. doi: 10.1016/bs.acr.2021.02.002. Epub 2021 Mar 18.ABSTRACTCellular senescence, cancer and aging are highly interconnected. Among many important molecular machines that lie at the intersection of this triad, the mechanistic (formerly mammalian) target of rapamycin (mTOR) is a central regulator of cell metabolism, proliferation, and survival. The mTOR signaling cascade is essential to maintain cellular homeostasis in normal biological processes or in response to stress, and its dysregulation is implicated in the progression of many disorders, including age-associated diseases. Accordingly, t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarah Saoudaoui Monique Bernard Guillaume B Cardin Nicolas Malaquin Apostolos Christopoulos Francis Rodier Source Type: research

Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Adv Cancer Res. 2021;150:75-112. doi: 10.1016/bs.acr.2021.01.003. Epub 2021 Feb 22.ABSTRACTAutophagy and cellular senescence are two potent tumor suppressive mechanisms activated by various cellular stresses, including the expression of activated oncogenes. However, emerging evidence has also indicated their pro-tumorigenic activities, strengthening the case for the complexity of tumorigenesis. More specifically, tumorigenesis is a systemic process emanating from the combined accumulation of changes in the tumor support pathways, many of which cannot cause cancer on their own but might still provide excellent therapeutic t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Jaejin Kim Yeonghyeon Lee Kyeonghwan Roh Mi-Sung Kim Chanhee Kang Source Type: research

Preface
Adv Cancer Res. 2021;150:xiii-xviii. doi: 10.1016/S0065-230X(21)00041-5.NO ABSTRACTPMID:33858602 | DOI:10.1016/S0065-230X(21)00041-5 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: David A Gewirtz Paul B Fisher Source Type: research

Autophagy and senescence in cancer therapy
Adv Cancer Res. 2021;150:1-74. doi: 10.1016/bs.acr.2021.01.002. Epub 2021 Mar 12.ABSTRACTTumor cells can undergo diverse responses to cancer therapy. While apoptosis represents the most desirable outcome, tumor cells can alternatively undergo autophagy and senescence. Both autophagy and senescence have the potential to make complex contributions to tumor cell survival via both cell autonomous and cell non-autonomous pathways. The induction of autophagy and senescence in tumor cells, preclinically and clinically, either individually or concomitantly, has generated interest in the utilization of autophagy modulating and seno...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Nipa H Patel Sarah Bloukh Enas Alwohosh Ahmad Alhesa Tareq Saleh David A Gewirtz Source Type: research

Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
Adv Cancer Res. 2021;150:113-145. doi: 10.1016/bs.acr.2021.02.001. Epub 2021 Mar 8.ABSTRACTBoth senescence and autophagy have been strongly linked to aging and also cancer development. Numerous molecular, cellular, and physiological changes are known to correlate with an increasing age, yet our understanding of what underlies these changes or how they combine to give rise to the various pathologies associated with aging is still unclear. Levels of autophagy activity are known to decrease with advancing age, in a variety of organisms including mammals. Whereas senescent cells are known to accumulate in our bodies with age. ...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Andrew R J Young Liam D Cassidy Masashi Narita Source Type: research

Autophagy and senescence: Insights from normal and cancer stem cells
Adv Cancer Res. 2021;150:147-208. doi: 10.1016/bs.acr.2021.01.005. Epub 2021 Mar 30.ABSTRACTAutophagy is a fundamental cellular process, which allows cells to adapt to metabolic stress through the degradation and recycling of intracellular components to generate macromolecular precursors and produce energy. Autophagy is also critical in maintaining cellular/tissue homeostasis, as well preserving immunity and preventing human disease. Deregulation of autophagic processes is associated with cancer, neurodegeneration, muscle and heart disease, infectious diseases and aging. Research on a variety of stem cell types establish t...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Sarmistha Talukdar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research

The role of autophagy in escaping therapy-induced polyploidy/senescence
Adv Cancer Res. 2021;150:209-247. doi: 10.1016/bs.acr.2021.01.004. Epub 2021 Mar 11.ABSTRACTAutophagy is an evolutionarily conserved process necessary to maintain cell homeostasis in response to various forms of stress such as nutrient deprivation and hypoxia as well as functioning to remove damaged molecules and organelles. The role of autophagy in cancer varies depending on the stage of cancer. Cancer therapeutics can also simultaneously evoke cancer cell senescence and ploidy increase. Both cancer cell senescence and polyploidization are reversible by depolyploidization giving rise to the progeny. Autophagy activation m...
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Magdalena Dudkowska Karolina Staniak Agnieszka Bojko Ewa Sikora Source Type: research

Autophagy and PTEN in DNA damage-induced senescence
We present experimental evidence obtained with tumor cells, with a prime focus on two models of cancer, prostate and lung. A better understanding of mechanisms associated with DNA damage-induced cellular senescence is central to fully exploit the potential of DNA-damaging agents against cancer.PMID:33858598 | DOI:10.1016/bs.acr.2021.01.006 (Source: Advances in Cancer Research)
Source: Advances in Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Arishya Sharma Alexandru Almasan Source Type: research