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Total 36609 results found since Jan 2013.
Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC
Mol Cell Proteomics. 2023 Sep 14:100647. doi: 10.1016/j.mcpro.2023.100647. Online ahead of print.ABSTRACTThe NFE2L2(NRF2) oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a mass spectrometry (MS)-based targeted proteomics assay based on internal standard triggered parallel reaction monitoring (IS-PRM) to quantify 69 NRF2 pathway components and targets, as well as 21 proteins of broad clinical si...
Source: Molecular and Cellular Proteomics : MCP - September 16, 2023 Category: Molecular Biology Authors: Nathan T Wamsley Emily M Wilkerson Li Guan Kyle M LaPak Travis P Schrank Brittany J Holmes Robert W Sprung Petra Erdmann Gilmore Sophie P Gerndt Ryan S Jackson Randal C Paniello Patrik Pipkorn Sidharth V Puram Jason T Rich Reid R Townsend Jos é P Zevallo Source Type: research
Primary melanoma of female urethra: A case diagnosed in Ouagadougou
We report a case of primary melanoma of a female urethra diagnosed at a non-metastatic stage in a 48-year-old patient with a history of breast carcinoma treated with radiotherapy and hormone therapy. The patient was consulting for dysuria, hematuria, and perineal pain. The clinical examination found a prolapsed and black mass, developed at the expense of the urethra and located at the anterosuperior part of the vulva. The mass biopsy revealed a proliferation of fusiform and globular cells loaded with black pigment expressing the anti-HMB 45 and PS 100 antibodies. The extension assessment showed an absence of secondary loca...
Source: Annales de Pathologie - September 16, 2023 Category: Pathology Authors: Aim é Sosthène Ouedraogo Franck Auguste Hermann Ad émayali Ido Ibrahim Savadogo Souleymane Ouattara Rakiswend é Alexis Ouedraogo A ïda Sandrine Ouedraogo Assita Sanou-Lamien Olga M Lompo Source Type: research
Differentiating Keratoacanthoma From Squamous Cell Carcinoma: Are We Losing the Battle or Our Bearings? - Comment on "Intralesional Methotrexate for Keratoacanthomas: A Case Series"
Actas Dermosifiliogr. 2023 Sep 14:S0001-7310(23)00734-2. doi: 10.1016/j.ad.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37716500 | DOI:10.1016/j.ad.2023.08.010
Source: Actas Dermo-Sifiliograficas - September 16, 2023 Category: Dermatology Authors: P L ópez Sanz Miriam Fern ández-Parrado Eduardo Escario Travesedo Source Type: research
Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC
Mol Cell Proteomics. 2023 Sep 14:100647. doi: 10.1016/j.mcpro.2023.100647. Online ahead of print.ABSTRACTThe NFE2L2(NRF2) oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a mass spectrometry (MS)-based targeted proteomics assay based on internal standard triggered parallel reaction monitoring (IS-PRM) to quantify 69 NRF2 pathway components and targets, as well as 21 proteins of broad clinical si...
Source: Molecular and Cellular Proteomics : MCP - September 16, 2023 Category: Molecular Biology Authors: Nathan T Wamsley Emily M Wilkerson Li Guan Kyle M LaPak Travis P Schrank Brittany J Holmes Robert W Sprung Petra Erdmann Gilmore Sophie P Gerndt Ryan S Jackson Randal C Paniello Patrik Pipkorn Sidharth V Puram Jason T Rich Reid R Townsend Jos é P Zevallo Source Type: research
NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity
Toxicol Appl Pharmacol. 2023 Sep 14;477:116688. doi: 10.1016/j.taap.2023.116688. Online ahead of print.ABSTRACTChemical modifications in messenger RNA (mRNA) regulate gene expression and play critical roles in stress responses and diseases. Recently we have shown that N6-methyladenosine (m6A), the most abundant mRNA modification, promotes the repair of UVB-induced DNA damage by regulating global genome nucleotide excision repair (GG-NER). However, the roles of other mRNA modifications in the UVB-induced damage response remain understudied. N4-acetylcytidine (ac4C) is deposited in mRNA by the RNA-binding acetyltransferase N...
Source: Toxicology and Applied Pharmacology - September 16, 2023 Category: Toxicology Authors: Zizhao Yang Emma Wilkinson Yan-Hong Cui Haixia Li Yu-Ying He Source Type: research
Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):1-8. doi: 10.14715/cmb/2023.69.8.1.ABSTRACTCutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further risk stratification and search for new prognostic targets for CM are of positive clinical significance. PANoptosis is defined as an inflammatory programmed cell death mediated by the PANoptosome complex and cannot be characterized by pyroptosis, apoptosis or necroptosis alone. Although PANoptosis is closely associated with many diseases including cancer, it has not been reported in CM. Combined with GTEx and TCGA database, we extracted 14 PANopto...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Like Zhong Wenkang Qian Wangang Gong Li Zhu Xu Wang Source Type: research
Intracavitary cardiac metastasis of cervical squamous cell carcinoma with immune thrombocytopenia: a rare case report
We present the case of an adult patient diagnosed with cervical cancer and concurrent right ventricular cancer thrombus, accompanied by immune thrombocytopenia (ITP). The patient exhibited resistance to conventional ITP drugs, with suboptimal platelet response. However, upon achieving initial control of the tumor, the patient's platelet counts returned to normal. Notably, the addition of immune checkpoint inhibitors targeting PD-L1 resulted in effective tumor control, accompanied by sustained high platelet levels. Unfortunately, during subsequent anti-tumor therapy, the patient experienced a prolonged platelet rise time, r...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Ning Liu Deguan Lv Raydonna Rachel Schneider Hongyan Yang Mingyan Zhang Yanan Liu Meili Sun Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
Intratumoral Bacteria as Mediators of Cancer Immunotherapy Response
Cancer Res. 2023 Sep 15;83(18):2985-2986. doi: 10.1158/0008-5472.CAN-23-1857.ABSTRACTMultiple lines of evidence spanning from animal models to human clinical trials indicate that the microbiome influences cancer immunotherapy response. Whereas initial studies focused exclusively on the gastrointestinal (gut) microbiota-tumor axis, more recent studies have examined the possibility that bacteria located within tumor cells or within the tumor microenvironment mediate cancer treatment response. Strikingly, this phenomenon has been demonstrated in cancers that arise in anatomic locations that are traditionally thought to be dev...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Karen S Sfanos Source Type: research
Epiberberine suppresses the metastasis of head and neck squamous cell carcinoma cells by regulating the MMP-13 and JNK pathway
In conclusion, the present study demonstrates that epiberberine suppresses cell migration and invasion by regulating the JNK pathway and MMP-13. These results suggest that epiberberine could be a potential antimetastatic agent in HNSCC cells.PMID:37710409 | DOI:10.1111/jcmm.17954
Source: J Cell Mol Med - September 15, 2023 Category: Molecular Biology Authors: Hsin-Yu Ho Mu-Kuan Chen Chia-Chieh Lin Yu-Sheng Lo Yi-Ching Chuang Ming-Ju Hsieh Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: International Journal of Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
Epiberberine suppresses the metastasis of head and neck squamous cell carcinoma cells by regulating the MMP-13 and JNK pathway
In conclusion, the present study demonstrates that epiberberine suppresses cell migration and invasion by regulating the JNK pathway and MMP-13. These results suggest that epiberberine could be a potential antimetastatic agent in HNSCC cells.PMID:37710409 | DOI:10.1111/jcmm.17954
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hsin-Yu Ho Mu-Kuan Chen Chia-Chieh Lin Yu-Sheng Lo Yi-Ching Chuang Ming-Ju Hsieh Source Type: research
Multiple Primary Melanoma: Risk Factors Reviewed
Br J Dermatol. 2023 Sep 15:ljad343. doi: 10.1093/bjd/ljad343. Online ahead of print.NO ABSTRACTPMID:37713632 | DOI:10.1093/bjd/ljad343
Source: The British Journal of Dermatology - September 15, 2023 Category: Dermatology Authors: Remco van Doorn Source Type: research
Margin status in vulvovaginal melanoma: Management and oncologic outcomes of 50 cases
CONCLUSION: Preinvasive disease at the surgical margins may play an important role in local recurrence in patients with Stage I-II vulvovaginal melanoma. Patients with early (Stage 0) and advanced (Stage III) disease rarely recur locally and may not benefit from re-resection.PMID:37711973 | PMC:PMC10497797 | DOI:10.1016/j.gore.2023.101268
Source: Ann Oncol - September 15, 2023 Category: Cancer & Oncology Authors: Alli M Straubhar May P Chan Shitanshu Uppal Source Type: research
