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Gelatin-based 3D biomimetic scaffolds platform potentiates culture of cancer stem cells in esophageal squamous cell carcinoma
Biomaterials. 2023 Sep 11;302:122323. doi: 10.1016/j.biomaterials.2023.122323. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are crucial for tumorigenesis, metastasis, and therapy resistance in esophageal squamous cell carcinoma (ESCC). To further elucidate the mechanism underlying characteristics of CSCs and develop CSCs-targeted therapy, an efficient culture system that could expand and maintain CSCs is needed. CSCs reside in a complex tumor microenvironment, and three-dimensional (3D) culture systems of biomimetic scaffolds are expected to better support the growth of CSCs by recapitulating the biophysical prop...
Source: Biomaterials - September 17, 2023 Category: Materials Science Authors: Yenan Wu Haiwei Liang Aiping Luo Yong Li Zhiqiang Liu Xin Li Wenxin Li Kaini Liang Junyang Li Zhihua Liu Yanan Du Source Type: research
Electrochemotherapy for multiple cutaneous tumors in immunosuppressed patients
CONCLUSION: In immunocompromised patients, electrochemotherapy is an effective and safe therapeutic option for non-melanoma skin tumors. In order to provide more ideal management for this special sub-group, prevention, multidisciplinary approach and optimized immunosuppressive therapy is essential. Orv Hetil. 2023; 164(37): 1462-1468.PMID:37717236 | DOI:10.1556/650.2023.32852
Source: Orvosi Hetilap - September 17, 2023 Category: General Medicine Authors: Petra R ózsa D óra Ágoston Edit Szederk ényi Henriette Ócsai Eszter Balt ás G ábor Vass Lajos Kem ény Judit Ol áh Erika Kis Source Type: research
Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress
Biomed Pharmacother. 2023 Sep 15;167:115518. doi: 10.1016/j.biopha.2023.115518. Online ahead of print.ABSTRACTHead and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results have been reported for in vivo applications. Consequently, an alternative administration route is needed to improve bioavailability and establish the optimal dosage of melatonin for cancer treatment. On the other hand, the use of patient-derived tumor models has transformed the field of drug research because they reflect the heterogenei...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2023 Category: Drugs & Pharmacology Authors: Laura Martinez-Ruiz Javier Florido C ésar Rodriguez-Santana Alba L ópez-Rodríguez Ana Guerra-Librero Beatriz I Fern ández-Gil Patricia Garc ía-Tárraga Jos é Manuel Garcia-Verdugo Felix Oppel Holger Sudhoff David S ánchez-Porras Amadeo Ten-Steve Jo Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Molecular Biology Reports - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Differentiating Keratoacanthoma From Squamous Cell Carcinoma: Are We Losing the Battle or Our Bearings? - Comment on "Intralesional Methotrexate for Keratoacanthomas: A Case Series"
Actas Dermosifiliogr. 2023 Sep 14:S0001-7310(23)00734-2. doi: 10.1016/j.ad.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37716500 | DOI:10.1016/j.ad.2023.08.010
Source: Actas Dermo-Sifiliograficas - September 16, 2023 Category: Dermatology Authors: P L ópez Sanz Miriam Fern ández-Parrado Eduardo Escario Travesedo Source Type: research
Primary melanoma of female urethra: A case diagnosed in Ouagadougou
We report a case of primary melanoma of a female urethra diagnosed at a non-metastatic stage in a 48-year-old patient with a history of breast carcinoma treated with radiotherapy and hormone therapy. The patient was consulting for dysuria, hematuria, and perineal pain. The clinical examination found a prolapsed and black mass, developed at the expense of the urethra and located at the anterosuperior part of the vulva. The mass biopsy revealed a proliferation of fusiform and globular cells loaded with black pigment expressing the anti-HMB 45 and PS 100 antibodies. The extension assessment showed an absence of secondary loca...
Source: Annales de Pathologie - September 16, 2023 Category: Pathology Authors: Aim é Sosthène Ouedraogo Franck Auguste Hermann Ad émayali Ido Ibrahim Savadogo Souleymane Ouattara Rakiswend é Alexis Ouedraogo A ïda Sandrine Ouedraogo Assita Sanou-Lamien Olga M Lompo Source Type: research
Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):1-8. doi: 10.14715/cmb/2023.69.8.1.ABSTRACTCutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further risk stratification and search for new prognostic targets for CM are of positive clinical significance. PANoptosis is defined as an inflammatory programmed cell death mediated by the PANoptosome complex and cannot be characterized by pyroptosis, apoptosis or necroptosis alone. Although PANoptosis is closely associated with many diseases including cancer, it has not been reported in CM. Combined with GTEx and TCGA database, we extracted 14 PANopto...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Like Zhong Wenkang Qian Wangang Gong Li Zhu Xu Wang Source Type: research
Inhibitory Effect of Fingolimod on Head and Neck Squamous Cell Carcinoma and Its Mechanism: Gene Set Enrichment Analysis
This study aimed to clarify the therapeutic effect of Fingolimod on head and neck squamous cell carcinoma (HNSC) and initially explore its mechanism through data mining, clinical sample analysis and basic experiments. The normalized Enrichment Score (NES) of Fingolimod in tumor tissues was obtained by SwissTargetPrediction and The Cancer Genome Atlas (TCGA) database. IC50 (50% inhibitory concentration) of Fingolimod for HNSC was verified based on the Genomics of Drug Sensitivity in Cancer (GDSC) database. SCC9 cells were cultured in vitro for the application of Fingolimod. Cell proliferation was determined by the Cell Coun...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Lemeng Chang Chunhua Xie Kaiping Chou Qingnan Meng Lihui Zhao Source Type: research
Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC
Mol Cell Proteomics. 2023 Sep 14:100647. doi: 10.1016/j.mcpro.2023.100647. Online ahead of print.ABSTRACTThe NFE2L2(NRF2) oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a mass spectrometry (MS)-based targeted proteomics assay based on internal standard triggered parallel reaction monitoring (IS-PRM) to quantify 69 NRF2 pathway components and targets, as well as 21 proteins of broad clinical si...
Source: Molecular and Cellular Proteomics : MCP - September 16, 2023 Category: Molecular Biology Authors: Nathan T Wamsley Emily M Wilkerson Li Guan Kyle M LaPak Travis P Schrank Brittany J Holmes Robert W Sprung Petra Erdmann Gilmore Sophie P Gerndt Ryan S Jackson Randal C Paniello Patrik Pipkorn Sidharth V Puram Jason T Rich Reid R Townsend Jos é P Zevallo Source Type: research
Candida species as potential risk factors for oral squamous cell carcinoma: Systematic review and meta-analysis
Cancer Epidemiol. 2023 Sep 14;86:102451. doi: 10.1016/j.canep.2023.102451. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is considered a multifactorial disease and has been associated with microbial infections, although the association with Candida spp. is still controversial. This systematic review focused on clinical trials which evaluated the relation between oral Candida spp colonization and OSCC. PubMed; Scopus; Embase; Web of Science and Scientific Direct were assessed. Independent reviewers conducted the diagram steps. For data extraction the PRISMA protocol was followed. The quality analysis of ...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Camilla Olga Tasso T úlio Morandin Ferrisse Anal ú Barros de Oliveira Beatriz Ribeiro Ribas Janaina Habib Jorge Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity
Toxicol Appl Pharmacol. 2023 Sep 14:116688. doi: 10.1016/j.taap.2023.116688. Online ahead of print.ABSTRACTChemical modifications in messenger RNA (mRNA) regulate gene expression and play critical roles in stress responses and diseases. Recently we have shown that N6-methyladenosine (m6A), the most abundant mRNA modification, promotes the repair of UVB-induced DNA damage by regulating global genome nucleotide excision repair (GG-NER). However, the roles of other mRNA modifications in the UVB-induced damage response remain understudied. N4-acetylcytidine (ac4C) is deposited in mRNA by the RNA-binding acetyltransferase NAT10...
Source: Toxicology and Applied Pharmacology - September 16, 2023 Category: Toxicology Authors: Zizhao Yang Emma Wilkinson Yan-Hong Cui Haixia Li Yu-Ying He Source Type: research
Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
CONCLUSIONS: We have developed a GPCR-TME classifier that could predict the OS and immunotherapy response of patients with melanoma highly effectively based on multi-omics analysis.PMID:37716991 | DOI:10.1186/s40001-023-01346-6
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Kangjie Shen Qiangcheng Wang Lu Wang Yang Yang Min Ren Yanlin Li Zixu Gao Shaoluan Zheng Yiteng Ding Jiani Ji Chenlu Wei Tianyi Zhang Yu Zhu Jia Feng Feng Qin Yanwen Yang Chuanyuan Wei Jianying Gu Source Type: research
Nobiletin regulates invasion, migration and metastasis in hypopharyngeal squamous cell carcinoma
This study examined the effects of NOB on the proliferation, migration, and invasiveness of the FaDu cell line derived from hypopharyngeal squamous cell carcinoma. We determined protein kinase phosphorylation by western blot analysis, migration by Transwell assay, and metastatic potential by enzyme-linked immunosorbent assay of vascular endothelial growth factor. NOB inhibited cell proliferation by 40% at concentrations of 15 µM and 40 µM, and reduced migration and induced apoptosis at 50 µM by downregulating extracellular signal-regulated kinase, protein kinase B, and phosphoinositide 3-kinase. Our results suggest that...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Marisol Rosas-Mart ínez Jos é Antonio González Rosales Gloria Guti érrez-Venegas Source Type: research
Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):1-8. doi: 10.14715/cmb/2023.69.8.1.ABSTRACTCutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further risk stratification and search for new prognostic targets for CM are of positive clinical significance. PANoptosis is defined as an inflammatory programmed cell death mediated by the PANoptosome complex and cannot be characterized by pyroptosis, apoptosis or necroptosis alone. Although PANoptosis is closely associated with many diseases including cancer, it has not been reported in CM. Combined with GTEx and TCGA database, we extracted 14 PANopto...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Like Zhong Wenkang Qian Wangang Gong Li Zhu Xu Wang Source Type: research
