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Specialty: Cardiology
Therapy: Thrombolytic Therapy

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Total 54 results found since Jan 2013.

Shorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke
CONCLUSIONS: Among older patients with stroke treated with either IVT only or IVT+EVT, shorter DTN times are associated with better long-term functional outcomes and lower mortality. These findings support further efforts to accelerate thrombolytic administration in all eligible patients, including EVT candidates.PMID:37199147 | DOI:10.1161/CIRCULATIONAHA.123.064053
Source: Circulation - May 18, 2023 Category: Cardiology Authors: Shumei Man Nicole Solomon Brian Mac Grory Brooke Alhanti Ken Uchino Jeffrey L Saver Eric E Smith Ying Xian Deepak L Bhatt Lee H Schwamm Muhammad Shazam Hussain Gregg C Fonarow Source Type: research

Specificity and sensitivity of the SeLECT score in predicting late seizures in patients undergoing intravenous thrombolytic treatment and the effect of diabetes mellitus and leukoaraiosis
CONCLUSION: We found that DM was an independent risk factor for late seizures after stroke in a patient group receiving thrombolytic therapy, and late seizures after stroke were less frequent in patients with leukoaraiosis.PMID:37059430 | DOI:10.1055/s-0043-1767764
Source: Atherosclerosis - April 14, 2023 Category: Cardiology Authors: Yasemin Din ç Aylin Bican Demir G üven Özkaya Mustafa Bakar Source Type: research

The impact of blood pressure variation on mortality and symptomatic intracerebral hemorrhage in acute stroke patients after thrombolysis
In conclusion, in-hospital systolic (SD, SV and CV) and diastolic (SV, SD) BPV profiles were associated with death and sICH in stroke patients after rt-PA therapy.
Source: Blood Pressure Monitoring - May 13, 2022 Category: Cardiology Tags: Clinical Methods and Pathophysiology Source Type: research

tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke.
Conclusions: Our findings suggest that immune invasion of the neurovascular unit represents a previously unrecognized mechanism underlying tPA-mediated brain hemorrhage, which can be overcome by precise immune modulation during thrombolytic therapy. PMID: 33070717 [PubMed - as supplied by publisher]
Source: Circulation Research - October 19, 2020 Category: Cardiology Authors: Shi K, Zou M, Jia DM, Shi S, Yang X, Liu Q, Dong J, Sheth KN, Wang X, Shi FD Tags: Circ Res Source Type: research

Ultrasound- Guided Sono- Photomechanic Combination Therapy Of Abdominal Aorta Atherothrombosis Accompanied By Simultaneously Plga- Based Encapsulated Tpa Nanoparticles And Pesda Microbubbles Administration
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a hamster model of abdominal aorta atherothrombotic stenosis and the subsequent investigating the feasibility of sono- photomechanic combination thrombolytic therapy accompanied by simultaneously PLGA- based encapsulated tPA nanoparticles and microbubbles administration in this model.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research

B- Mode Ultrasound- Guided Catheter- Based Q-Switched Nd: Yag Laser- Mediated Inertial Cavitation Therapy Of Embolic Artery Accompanied By Simultaneously Streptokinase And Pesda Microbubbles Administration
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. The aim of this study was to generate a rabbit model of femoral artery thromboembolism occlusion and the subsequent investigating the feasibility of Q-switched Nd: YAG laser thrombolytic therapy accompanied by simultaneously intravenous streptokinase and PESDA microbubbles administration in this model.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research

Multimode Computed-Tomography-Guided Thrombolysis under a Prolonged Time Window in Acute Ischemic Stroke Patients with Atrial Fibrillation.
Authors: Yang Y, Sun W, Li D, Li XY, Wang XT, Li SC, Zhao HJ, Zhang JB Abstract Atrial fibrillation (AF) is an independent risk factor for intracranial hemorrhage in patients receiving recombinant-tissue-type plasminogen activator (rt-PA) thrombolytic therapy. Research showed that patients with acute ischemic stroke (AIS) could benefit from multimode computed-tomography- (CT-) guided intravenous thrombolysis over 4.5 hours. The medical data of patients with AIS in our center were retrospectively reviewed, and the data of the multimode CT-guided thrombolytic therapy or nonthrombolytic therapy within different time w...
Source: International Heart Journal - July 2, 2019 Category: Cardiology Tags: Int Heart J Source Type: research

Treatment of Simultaneous Thromboembolism of the Right and Left Coronary Arteries with Thrombus Aspiration in a Patient with a Prosthetic Mitral Valve.
Authors: Sığırcı S, Keskin K, Sezai Yıldız S, Aksan G, Bambul Sığırcı B, Orta Kılıçkesmez K Abstract Prosthetic heart valve thrombosis is a rare, difficult-to-treat condition that increases morbidity and mortality by leading to systemic embolism. Clinically, it presents mainly in the form of stroke, though an embolism be observed in many systems. Acute coronary syndrome, which is rarely observed in patients with a prosthetic heart valve, mostly occurs as non-ST segment elevation myocardial infarction (MI). There is no specific recommendation for the treatment of this condition. Revascularization succes...
Source: Journal of Heart Valve Disease - December 19, 2018 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Low Cholesterol Levels Increase Symptomatic Intracranial Hemorrhage Rates After Intravenous Thrombolysis: A Multicenter Cohort Validation Study.
CONCLUSIONS: This study supports the strong association between reduced LDL-C and increased SICH, but not for functional outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis. LDL-C level of ＜130 mg/dL is supposed to a candidate marker for predicting SICH within 24-36 h. PMID: 30464112 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - November 24, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Organizing stroke systems in the field for patients with suspected large vessel occlusion acute stroke.
Authors: Almekhlafi MA, Holodinsky JK, Hill MD, Kamal N, Goyal M Abstract INTRODUCTION: The dawn of endovascular stroke therapy has reshaped stroke care. Eligible patients need to be rushed to capable centers for intervention. This may entail bypassing closer hospitals that could confirm the diagnosis, administer thrombolytic therapy, then transfer patients for intervention. This has created a set of challenges: identifying endovascular candidates in the field, determining the best transport destination, and getting patients there quickly. Areas covered: This review provides a context for these emerging challenges....
Source: Expert Review of Cardiovascular Therapy - November 20, 2018 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

A Narrative Review on Thrombolytics in Advanced CKD: Is it an Evidence-Based Therapy?
ConclusionsThe impact of TT on the outcomes of advanced CKD patients is poorly understood to date, with scarce data available in current guidelines and conflicting results from observational studies. Until evidence-based data from RCTs will be obtained, the clinical challenge of maximizing benefits for this high-risk subgroup lays in the hands of practicing clinicians.
Source: Cardiovascular Drugs and Therapy - September 5, 2018 Category: Cardiology Source Type: research

Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
Abstract Poly(ADP-ribosyl)ation is an immediate cellular repair response to DNA damage and is catalyzed primarily by poly(ADP-ribose)polymerase-1 (PARP1), which is the most abundant of the 18 different PARP isoforms and accounts for more than 90% of the catalytic activity of PARP in the cell nucleus. Upon detection of a DNA strand break, PARP1 binds to the DNA, cleaves nicotinamide adenine dinucleotide between nicotinamide and ribose and then modifies the DNA nuclear acceptor proteins by formation of a bond between the protein and the ADP-ribose residue. This generates ribosyl-ribosyl linkages that act as a signal...
Source: Cardiovascular Toxicology - July 2, 2018 Category: Cardiology Authors: Henning RJ, Bourgeois M, Harbison RD Tags: Cardiovasc Toxicol Source Type: research

Full percutaneous biventricular support with two Impella pumps: the Bi ‐Pella approach
We report the first case of mechanical circulatory supported with Impella CP on the left and Impella RP on the right (Abiomed Inc., Danvers, MA) for acute biventricular failure due to suspected acute myocarditis in the context of thrombolytic therapy for ischaemic stroke.
Source: ESC Heart Failure - February 21, 2018 Category: Cardiology Authors: Federico Pappalardo, Anna Mara Scandroglio, Azeem Latib Tags: Case Report Source Type: research