tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke.

Conclusions: Our findings suggest that immune invasion of the neurovascular unit represents a previously unrecognized mechanism underlying tPA-mediated brain hemorrhage, which can be overcome by precise immune modulation during thrombolytic therapy.
PMID: 33070717 [PubMed - as supplied by publisher]

Source: Circulation Research - October 19, 2020 Category: Cardiology Authors: Shi K, Zou M, Jia DM, Shi S, Yang X, Liu Q, Dong J, Sheth KN, Wang X, Shi FD Tags: Circ Res Source Type: research