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Should we liberalize potassium intake in CKD? No, we should not
Although a high dietary sodium (Na) intake has dominated our understanding of pathophysiology of hypertension, the moderating effects of a dietary potassium (K) intake on blood pressure (BP) are less appreciated. K depletion in normotensive men can increase BP,1 supplementation of K among normotensive women can modestly lower 24-hour ambulatory BP,2 and in those with untreated hypertension3 or among those with hypertension and hypokalemia provoked by diuretics, K supplementation can lower BP.4 A cluster randomized trial from 600 villages in China in people with a history of previous stroke (72.6%) or a history of hypertens...
Source: Kidney International - September 20, 2022 Category: Urology & Nephrology Authors: Rajiv Agarwal Tags: Controversies in Nephrology Source Type: research

Association of acute kidney disease with the prognosis of ischemic stroke in the Third China National Stroke Registry
Acute kidney disease (AKD) evolves a spectrum of acute and subacute kidney disease requiring a global strategy to address. The present study aimed to explore the impact of AKD on the prognosis of ischemic stroke.
Source: BMC Nephrology - May 18, 2022 Category: Urology & Nephrology Authors: Yilun Zhou, Dongxue Wang, Hao Li, Yuesong Pan, Xianglong Xiang, Yu Wu, Xuewei Xie, Xianwei Wang, Yang Luo, Xia Meng, Jinxi Lin, Hong Wang, Yong Huo, Kunihiro Matsushita, Jing Chen, Fan Fan Hou & hellip; Tags: Research Source Type: research

Association of Urine Albumin-Creatinine Ratio and Cystatin C-Based Estimated GFR with Outcomes in Patients with Ischemic Stroke
Conclusions: Both decreased eGFRcys and albuminuria are independent risk factors for all-cause death and poststroke disability. Combining the two markers is useful for improving risk stratification even in those without chronic kidney disease.
Source: Kidney and Blood Pressure Research - February 7, 2022 Category: Urology & Nephrology Source Type: research

Association of Urine Albumin-Creatinine Ratio and Cystatin C –Based Estimated GFR with Outcomes in Patients with Ischemic Stroke
Background/Aims: Data about the independent and combined effects of cystatin C based estimated glomerular filtration rate (eGFRcys) and albuminuria on the risk of poor outcome in stroke patients is limited. The aim was to elucidate how these two renal markers affect the clinical outcomes after ischemic stroke separately and jointly. Methods: The study subjects consisted of 10,197 patients with ischemic stroke from the third China National Stroke Registry (CNSR-III). The study outcomes were all-cause mortality, post stroke disability, recurrence of stroke and cardiocerebral vascular disease (CVD) composite events. Cox prop...
Source: Kidney and Blood Pressure Research - February 7, 2022 Category: Urology & Nephrology Source Type: research

Benign prostatic hyperplasia and cardiovascular risk: a prospective study among Chinese men
ConclusionIn Chinese men, BPH was associated with higher risks of CVD, heart disease and stroke, particularly among men aged  <  60 years.
Source: World Journal of Urology - August 23, 2021 Category: Urology & Nephrology Source Type: research

Premature Stroke Secondary to Severe Hypertension Results from Liddle Syndrome Caused by a Novel SCNN1B Mutation
Conclusions:We identified a novelSCNN1B mutation (c.1849C#x3e;A) in a family affected by LS. Patients with LS, especially those with severe hypertension, should be alert for the occurrence of premature stroke. Timely diagnosis using genetic testing and tailored treatment with amiloride can help LS patients to avoid severe complications.Kidney Blood Press Res
Source: Kidney and Blood Pressure Research - July 22, 2020 Category: Urology & Nephrology Source Type: research

High Neutrophil/Lymphocyte Ratio as an Independent Risk Factor for the First Occurrence of Stroke in Peritoneal Dialysis Patients.
CONCLUSION: High NLR was an independent risk factor for the first occurrence of stroke in PD patients. PMID: 32655023 [PubMed - in process]
Source: Iranian Journal of Kidney Diseases - July 14, 2020 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Association of Serum Uromodulin with Death, Cardiovascular Events, and Kidney Failure in CKD.
CONCLUSIONS: Higher serum uromodulin is independently associated with lower risk for mortality, cardiovascular events, and kidney failure in white patients with CKD. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Deutsches Register für Klinische Studien (DRKS; German national database of clinical studies), DRKS00003971. PMID: 32291270 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - April 13, 2020 Category: Urology & Nephrology Authors: Steubl D, Schneider MP, Meiselbach H, Nadal J, Schmid MC, Saritas T, Krane V, Sommerer C, Baid-Agrawal S, Voelkl J, Kotsis F, Köttgen A, Eckardt KU, Scherberich JE, GCKD Study Investigators Tags: Clin J Am Soc Nephrol Source Type: research

Kidney dysfunction is associated with risk of cardiovascular events in middle-aged and elderly population with hypertension: A  5-year community-based cohort study in China
.
CONCLUSION: Moderate to severe kidney dysfunction was an independent risk predictor of CVD events. Among subjects with hypertension or poorly controlled blood pressure level, the presence of CKD significantly increased the risks of CVD events and stroke.
. PMID: 31983380 [PubMed - as supplied by publisher]
Source: Clinical Nephrology - January 26, 2020 Category: Urology & Nephrology Authors: Gu X, Fang X, Ji X, Tang Z, Wang C, Guan S, Wu X, Liu H, Zhang Z Tags: Clin Nephrol Source Type: research

Effect of Vitamin B12 Levels on the Association Between Folic Acid Treatment and CKD Progression: A Post Hoc Analysis of a Folic Acid Interventional Trial
ConclusionsFolic acid treatment was associated with a greater reduction in the odds of CKD progression among patients with mild to moderate CKD and higher B12 levels.FundingGovernment funding (National Key Research and Development Program of China).
Source: American Journal of Kidney Diseases - October 17, 2019 Category: Urology & Nephrology Source Type: research

Serum lipoprotein(a) and risk of hemorrhagic stroke among incident peritoneal dialysis patients: a large study from a single center in China.
Conclusions: Among patients with incident PD, a higher serum Lp(a) level may predict a lower risk of hemorrhagic stroke. PMID: 31498021 [PubMed - in process]
Source: Renal Failure - September 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Favorable Renal Outcomes after Intravenous Thrombolytic Therapy for Acute Ischemic Stroke: Clinical Implication of Kidney ‐Brain axis
Nephrology,Volume 0, Issue ja, -Not available-.
Source: Nephrology - October 18, 2018 Category: Urology & Nephrology Authors: Teng ‐Hsiang Chang, Ping‐Fang Chiu, Chun‐Chieh Tsai, Chin‐Hua Chang, Chia‐Lin Wu, Chew‐Teng Kor, Jhao‐Rong Li, Cheng‐Ling Kuo, Ching‐Shan Huang, Cheng‐Chung Chu, Chih‐Ming Lin, Chia‐Chu Chang Source Type: research

Association of arterial stiffness and central hemodynamics with moderately reduced glomerular filtration rate in Chinese middle-aged and elderly community residents: a cross-sectional analysis
Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognos...
Source: BMC Nephrology - May 2, 2018 Category: Urology & Nephrology Authors: Shihui Fu, Yi Guo, Leiming Luo and Ping Ye Tags: Research article Source Type: research

Factors Associated with Chronic Kidney Disease and Their Clinical Utility in Primary Care Clinics in a Multi-Ethnic Southeast Asian Population
Conclusions: CKD prevalence in our Southeast Asian population is high and under-documented even in high-risk patients. Our findings highlight factors associated with CKD, and the predictive value of hypertension, diabetes, and advancing age as EHR-based screening targets for CKD. Our results also suggest that complementary educational efforts will be needed to increase physician detection and optimize the management of CKD, especially in high risk and marginalized groups across all clinics in Singapore, and possibly in the region.Nephron
Source: Nephron - December 15, 2017 Category: Urology & Nephrology Source Type: research

Comparison of Associations of Outcomes After Stroke With Estimated GFR Using Chinese Modifications of the MDRD Study and CKD-EPI Creatinine Equations: Results From the China National Stroke Registry
Background: The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine equation estimates glomerular filtration rate (GFR) more precisely than the MDRD (Modification of Diet in Renal Disease) Study equation. The risk implications of this equation have been compared with the MDRD Study equation in different demographic and clinical characteristics. However, whether a Chinese modification of this equation performs better than a Chinese modification of the MDRD Study equation in risk prediction in Chinese patients with stroke is unknown.Study Design: Prospective cohort study, China National Stroke Registry.Set...
Source: American Journal of Kidney Diseases - October 7, 2013 Category: Urology & Nephrology Authors: Xianwei Wang, Yang Luo, Yilong Wang, Chunxue Wang, Xingquan Zhao, David Wang, Liping Liu, Gaifen Liu, Yongjun Wang, China National Stroke Registry Investigators Tags: Pathogenesis and Treatment of Kidney Disease Source Type: research