Comparison of Associations of Outcomes After Stroke With Estimated GFR Using Chinese Modifications of the MDRD Study and CKD-EPI Creatinine Equations: Results From the China National Stroke Registry

Background: The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine equation estimates glomerular filtration rate (GFR) more precisely than the MDRD (Modification of Diet in Renal Disease) Study equation. The risk implications of this equation have been compared with the MDRD Study equation in different demographic and clinical characteristics. However, whether a Chinese modification of this equation performs better than a Chinese modification of the MDRD Study equation in risk prediction in Chinese patients with stroke is unknown.Study Design: Prospective cohort study, China National Stroke Registry.Setting & Participants: 15,791 consecutive patients with stroke enrolled from September 2007 to August 2008; follow-up time, 1 year.Predictor: Estimated GFR (eGFR) and eGFR categories computed using Chinese modifications of the MDRD Study and CKD-EPI creatinine equations.Outcomes: All-cause mortality, recurrent stroke, stroke disability, combined end point of stroke or death.Measurements: GFR was estimated by Chinese modifications of the MDRD Study (eGFRMDRD(CN)) and CKD-EPI (eGFRCKD-EPI(CN)) equations.Results: The median value for eGFRCKD-EPI(CN) was higher than that for eGFRMDRD(CN) (87.3 vs 82.5 mL/min/1.73m2; P

Source: American Journal of Kidney Diseases - October 7, 2013 Category: Urology & Nephrology Authors: Xianwei Wang, Yang Luo, Yilong Wang, Chunxue Wang, Xingquan Zhao, David Wang, Liping Liu, Gaifen Liu, Yongjun Wang, China National Stroke Registry Investigators Tags: Pathogenesis and Treatment of Kidney Disease Source Type: research