Effect of Vitamin B12 Levels on the Association Between Folic Acid Treatment and CKD Progression: A Post Hoc Analysis of a Folic Acid Interventional Trial

Publication date: Available online 16 October 2019Source: American Journal of Kidney DiseasesAuthor(s): Youbao Li, J. David Spence, Xiaobin Wang, Yong Huo, Xiping Xu, Xianhui QinRationale &ObjectiveIn populations with folic acid fortification or supplementation, the main nutritional determinant of total homocysteine levels is vitamin B12 (B12) status. We aimed to evaluate the modifying effect of B12 levels on the association between folic acid treatment and chronic kidney disease (CKD) progression.Study DesignA post hoc analysis of an interventional trial.Setting &ParticipantsThis is a post hoc analysis of 1,374 hypertensive adults with mild to moderate CKD and B12 measurements at baseline from the kidney disease substudy of the China Stroke Primary Prevention Trial (CSPPT), conducted in 20 communities in Jiangsu province in China, a region with low folate consumption.InterventionsAssignments to a double-blinded daily treatment of enalapril, 10 mg, and folic acid, 0.8 mg; or enalapril, 10 mg, alone.OutcomesThe primary outcome was progression of CKD (defined as a decrease in estimated glomerular filtration rate [eGFR] ≥ 30% and to a level of 
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research

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