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Total 2594 results found since Jan 2013.

The Effect of Swallowing Action Observation Therapy on Resting fMRI in Stroke Patients with Dysphagia
CONCLUSION: Action observation therapy can affect the excitability of certain brain regions. The changes in brain function brought about by this treatment may help to further understand the potential mechanism of network remodeling of swallowing function.PMID:37124873 | PMC:PMC10147521 | DOI:10.1155/2023/2382980
Source: Neural Plasticity - May 1, 2023 Category: Neurology Authors: Ming Zeng Zhongli Wang Xuting Chen Meifang Shi Meihong Zhu Jingmei Ma Yunhai Yao Yao Cui Hua Wu Jie Shen Lingfu Xie Jianming Fu Xudong Gu Source Type: research

The charlotte large artery occlusion endovascular therapy outcome score compares favorably to the critical area perfusion score for prognostication before basilar thrombectomy
Late window endovascular thrombectomy (EVT) trials enrolled patients presenting with an internal carotid artery (ICA) or proximal middle cerebral artery (MCA) occlusion using computed tomography perfusion (CTP) or magnetic resonance imaging perfusion selection criteria.1,2 Radiographic1 or clinical mismatch2 was required for inclusion in these landmark studies. Although perfusion imaging is not always used for patient selection in early window anterior circulation thrombectomy,3 CTP ischemic core volume is independently associated with functional outcome improvement in the 0-6-hour time window when good endovascular reperfusion is achieved.
Source: Journal of Stroke and Cerebrovascular Diseases - April 28, 2023 Category: Neurology Authors: Rahul R. Karamchandani, Sagar Satyanarayana, Hongmei Yang, Jeremy B. Rhoten, Dale Strong, Sam Singh, Jonathan D. Clemente, Gary Defilipp, Manuel Hazim, Nikhil M. Patel, Joe Bernard, William R. Stetler, Jonathan M. Parish, Thomas A. Blackwell, Jeremy J. He Source Type: research

A case of ischemic stroke associated with protein-losing gastroenteropathy and protein S deficiency
We report a 24-year-old woman who developed acute dysarthria and right hemiplegia 4 months after delivering her first baby by cesarean section. Diffusion-weighted magnetic resonance imaging showed a high-intensity signal in the left anterior cerebral artery territory and middle cerebral artery territory.
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2023 Category: Neurology Authors: Kazuki Kimoto, Tomohisa Nezu, Eiichi Nomura, Shiro Aoki, Tomohito Kawano, Riho Katsumata, Megumi Nonaka, Yusuke Yoshida, Ryo Yuge, Hirofumi Maruyama Tags: Case Report Source Type: research

Repurposing the KCa3.1 Blocker Senicapoc for Ischemic Stroke
AbstractSenicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition and genetic deletion of KCa3.1 reduces infarction and improves neurologic recovery in rodents by attenuating neuroinflammation. Here we evaluated the potential of repurposing senicapoc for ischemic stroke. In cultured microglia, senicapoc inhibited KCa3.1 currents with an IC50 of 7  nM, reduced Ca2+ signaling induced by the purinergic agonist ATP, suppressed express...
Source: Translational Stroke Research - April 24, 2023 Category: Neurology Source Type: research

Electrocardiogram properties and risk of covert brain infarction and other magnetic resonance imaging abnormalities in a stroke ‐free population
ConclusionsOur study found that ECG abnormalities were related to presence of CBIs, white matter hyperintensity, and sulcal atrophy on MRI in a stroke-free relderly population. Specifically, those with left axis deviation had an increased risk of presence of CBIs.
Source: Brain and Behavior - April 17, 2023 Category: Neurology Authors: Fan Gao, Chen Chen, Fude Liu, Jianfeng Han Tags: ORIGINAL ARTICLE Source Type: research

Twenty-four-hour ambulatory blood pressure variability and association with ischemic stroke subtypes in the subacute stage
ConclusionThe results of this study indicate a discrepancy in blood pressure variability among different ischemic stroke subtypes during the subacute stage. Higher systolic blood pressure and systolic blood pressure variability during the 24 h, daytime, and nighttime, and nighttime diastolic blood pressure were independent predictors for large-artery atherosclerosis stroke. Increased nighttime diastolic BPV was an independent risk factor for cardioembolic stroke.
Source: Frontiers in Neurology - April 17, 2023 Category: Neurology Source Type: research

Virtual reality-induced motor function of the upper extremity and brain activation in stroke: study protocol for a randomized controlled trial
This study aims to provide high-quality evidence for the relationship between upper extremity motor function and brain activation in stroke. In addition, this is the first multimodal neuroimaging study that explores the evidence for neuroplasticity and associated upper motor function recovery after VR in stroke patients.Clinical trial registrationChinese Clinical Trial Registry, identifier: ChiCTR2200063425.
Source: Frontiers in Neurology - April 17, 2023 Category: Neurology Source Type: research

Stroke and cancer
Rev Neurol (Paris). 2023 Apr 4:S0035-3787(23)00891-3. doi: 10.1016/j.neurol.2023.03.009. Online ahead of print.ABSTRACTAssociation between stroke and cancer is well-established and has led to a growing literature over the past decades. Risk of ischemic and hemorrhagic stroke is increased among patients with newly diagnosed cancer and 5-10% of stroke patients bear an active cancer. All cancers are concerned, but hematological malignancy in childhood and adenocarcinoma from lung, digestive tract and pancreas in adults are most usually identified. Unique stroke mechanisms are dominated by hypercoagulation, a condition that ma...
Source: Revue Neurologique - April 6, 2023 Category: Neurology Authors: M Zuber Source Type: research

Development of a stroke risk score with MRI asymptomatic brain lesions attributes to evaluate prognostic vascular events
The use of a combination of stroke predictors, such as clinical factors and asymptomatic lesions on brain magnetic resonance imaging (MRI), may improve the accuracy of stroke risk prediction. Therefore, we attempted to develop a stroke risk score for healthy individuals.
Source: Journal of the Neurological Sciences - April 2, 2023 Category: Neurology Authors: Kenichi Iwasa, Keiichi Onoda, Masahiro Takamura, Hiroyuki Takayoshi, Shingo Mitaki, Shuhei Yamaguchi, Atsushi Nagai Source Type: research

Letter to editor: Is improved access to magnetic resonance imaging imperative for optimal ischemic stroke care?
We read the article “Is improved access to magnetic resonance imaging imperative for optimal ischemic stroke care?” [1] with great interest. The authors have presented a concise and informative summary of the use of MRI in ischemic stroke care, emphasizing its significance in diagnosis, management, and secondary pr evention. We appreciate the authors for presenting a comprehensive summary of the use of MRI in ischemic stroke care. However, we have certain points to make about the comparison of the MR scanners provided in this article.
Source: Journal of the Neurological Sciences - March 31, 2023 Category: Neurology Authors: Alex Panther Source Type: research

Culprit plaques of large parent arteries, rather than cerebral small vessel disease, contribute to early neurological deterioration in stroke patients with intracranial branch atheromatous disease
This study aimed to explore the association between culprit plaques of large parent arteries, neuroimaging markers of cerebral small vessel disease (CSVD), and the risk of early neurological deterioration (END) in stroke patients with BAD. Methods: A total of 97 stroke patients with BAD in the vascular territories of the lenticulostriate arteries or paramedian pontine arteries, diagnosed using high-resolution magnetic resonance imaging (HRMRI), were prospectively recruited in this observational study. A culprit plaque in the middle cerebral artery was defined as the only arterial plaque on the ipsilateral side of an infar...
Source: Cerebrovascular Diseases - March 30, 2023 Category: Neurology Source Type: research

Computed tomography versus short sequence magnetic resonance imaging in acute ischaemic stroke
It is undisputable that the acute management of stroke requires a fast and accurate diagnostic imaging modality. We read with interest and congratulate Kumar et al. on their article discussing the superiority and benefits of the use of magnetic resonance imaging (MRI) in acute ischaemic stroke (AIS) [1]. The authors suggest that MRI can improve the diagnostic accuracy of computed tomography (CT) negative AIS and allow better selection of patients for reperfusion therapies. Moreover, MRI may help avoid hospital admissions for patients with stroke mimics, facilitate earlier discharge, reduce overall hospital costs and play a...
Source: Journal of the Neurological Sciences - March 30, 2023 Category: Neurology Authors: Ho Lun Wong, Ashraf Nasim, Amit K.J. Mandal, Robert Davies, Constantinos G. Missouris Source Type: research

Assessing the influence of migraine on ischemic penumbra and on the prognosis of ischemic stroke: A prospective cohort study
CONCLUSION: Migraine is not associated with the absence of ischemic penumbra, the volume of the ischemic penumbra, or the stroke prognosis.PMID:36988078 | DOI:10.1111/head.14492
Source: Headache - March 29, 2023 Category: Neurology Authors: Felipe A A Oliveira Mario G Dourado-Filho Pedro A Sampaio Rocha-Filho Source Type: research