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Human albumin aggravates cerebral edema by disrupting the blood ‑brain barrier in a rat model of ischemic stroke
Acta Neurobiol Exp (Wars). 2022;82(3):284-294. doi: 10.55782/ane-2022-027.ABSTRACTCerebral edema and elevated intracranial pressure (ICP) are common complications observed following ischemic stroke. Osmotherapy has been used as a foundation to manage ICP induced by cerebral edema, and albumin is one of the most commonly used osmotic agents. The present study aimed to explore whether albumin lowered ICP by reducing cerebral edema when albumin elevated the colloid osmotic pressure (COP) of plasma. Sprague‑Dawley rats that underwent middle cerebral artery occlusion were used to assess COP and ICP. Magnetic resonance imaging...
Source: Acta Neurobiologiae Experimentalis - October 10, 2022 Category: Neurology Authors: Chunchang Li Shiying Zhang Xin Jiang Zhuo Li Yiqin Zhang Xusheng Li Hongguang Ding Hongke Zeng Source Type: research