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Specialty: Lipidology

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Total 122 results found since Jan 2013.

Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans Thematic Reviews
Epidemiological, genetic association, and Mendelian randomization studies have provided strong evidence that lipoprotein (a) [Lp(a)] is an independent causal risk factor for CVD, including myocardial infarction, stroke, peripheral arterial disease, and calcific aortic valve stenosis. Lp(a) levels >50 mg/dl are highly prevalent (20% of the general population) and are overrepresented in patients with CVD and aortic stenosis. These data support the notion that Lp(a) should be a target of therapy for CVD event reduction and to reduce progression of aortic stenosis. However, effective therapies to specifically reduce plasma ...
Source: The Journal of Lipid Research - March 1, 2016 Category: Lipidology Authors: Graham, M. J., Viney, N., Crooke, R. M., Tsimikas, S. Tags: Thematic Reviews Source Type: research

Blood lipid levels, statin therapy and the risk of intracerebral hemorrhage
Dyslipidemia has been proven to play an important role in the occurrence and development of the ischemic stroke and lipid-lowering therapy could significantly decrease the risk of the ischemic stroke. However,...
Source: Lipids in Health and Disease - March 1, 2016 Category: Lipidology Authors: Yingxu Ma, Zhaokai Li, Liang Chen and Xiangping Li Source Type: research

Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke
Publication date: January 2016 Source:Prostaglandins & Other Lipid Mediators, Volume 122 Author(s): Hui Huang, Mohamed Al-Shabrawey, Mong-Heng Wang Arachidonic acid (AA) is metabolized by cyclooxygenase (COX) and cytochrome P450 (CYP) enzymes into eicosanoids, which are involved in cardiovascular diseases and stroke. Evidence has demonstrated the important functions of these eicosanoids in regulating cerebral vascular tone, cerebral blood flow, and autoregulation of cerebral circulation. Although COX-2 inhibitors have been suggested as potential treatments for stroke, adverse events, including an increased ris...
Source: Prostaglandins and Other Lipid Mediators - January 11, 2016 Category: Lipidology Source Type: research

Determination of serum brassicasterol in spontaneously hypertensive rats stroke ‐prone fed a high‐ergosterol diet by ultra performance liquid chromatography
A method for the determination of ergosterol, brassicasterol, and cholesterol has been developed by ultra performance liquid chromatography with ultraviolet detection (UPLC‐UV). Using an ODS column and a mobile phase of acetonitrile‐water (95:5, v/v), we found that the peak area was linearly related to the amount of sterols injected, ranging from 1.5 to 100 μmol/L (r ≥ 0.998), except for cholesterol (2.5–400 μmol/L). Repeated injection showed that the relative standard deviation (RSD) at 50 μmol/L of sterols was less than 7.1% (intra‐day, n = 6) and 13% (inter‐day, n = 3). Ergosterol and br...
Source: European Journal of Lipid Science and Technology - October 12, 2015 Category: Lipidology Authors: Takaaki Ohtsubo, Ryo Kageyama, Yuji Koseki, Junya Hagi, Akira Kotani, Kazuhiro Yamamoto, Fumiyo Kusu, Tsuyoshi Miura, Hideki Hakamata Tags: Research Article Source Type: research

Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case–control study
Background: The v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B gene (MAFB) has been associated with serum lipid levels in the Eurpean population, but little is known about such association in the Chinese population or in atherosclerosis-related patients. Therefore, the purpose of the present study was to assess the association of the single nucleotide polymorphisms (SNPs) in the MAFB and serum lipid levels and the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Chinese population. Methods: A total of 1,065 unrelated patients (CAD, 525 and IS, 540) and 539 healthy controls were recruite...
Source: Lipids in Health and Disease - July 25, 2015 Category: Lipidology Authors: Qian YangRui-Xing YinYi-Jiang ZhouXiao-Li CaoTao GuoWu-Xian Chen Source Type: research

Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
This study aims to evaluate the effects of MetS and its components on the short-term prognosis of patients with acute ischemic stroke. Methods: Subjects with ischemic stroke of
Source: Lipids in Health and Disease - July 22, 2015 Category: Lipidology Authors: Liu LiuLixuan ZhanYisheng WangChengping BaiJianjun GuoQingyuan LinDonghai LiangEn Xu Source Type: research

Optimized Extraction of 2‐Arachidonyl Glycerol and Anandamide from Aortic Tissue and Plasma for Quantification by LC‐MS/MS
In this study, we investigated several sample preparation options for the LC‐MS quantification of AEA and 2‐AG from plasma and aortic tissue. The extractions considered included liquid‐liquid (LLE), solid‐phase (SPE), and supported‐liquid (SLE). Some extraction protocols yielded high analyte recovery and prevention of 1‐AG/2‐AG isomerization. Our results indicate that a liquid‐liquid extraction using toluene yields the highest recovery for both analytes, coupled with low ionization suppression in the mass spectrometer. This extraction and corresponding LC‐MS/MS assay provides a simple, high throughput mec...
Source: European Journal of Lipid Science and Technology - June 23, 2015 Category: Lipidology Authors: Christopher Garst, Makenzie Fulmer, Doug Thewke, Stacy Brown Tags: Short Communication Source Type: research

Sphingolipids in cardiovascular diseases and metabolic disorders
Many investigations suggest the pivotal role of sphingolipids in the pathogenesis of lifestyle diseases such as myocardial infarction, hypertension, stroke, diabetes mellitus type 2 and obesity. Some studies suggest that sphingolipids are important factors in cellular signal transduction. They serve as biologically active components of cell membrane and are involved in many processes such as proliferation, maturation and apoptosis. Recently, ceramide and sphingosine-1-phomsphate has become the target of many investigations. Ceramide is generated in three metabolic pathways and many factors induce its production as a cellul...
Source: Lipids in Health and Disease - June 16, 2015 Category: Lipidology Authors: Sonia BorodziczKatarzyna CzarzastaMarek KuchAgnieszka Cudnoch-Jedrzejewska Source Type: research

Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: possible interaction with genes involved in 20-HETE and EETs metabolism
Conclusions Our data do not support a major role of ω-6 or ω-3 PUFA intakes on BP change over time, but suggest a possible interaction of ω-3 PUFA with the CYP4F2 V433M.
Source: Prostaglandins and Other Lipid Mediators - May 17, 2015 Category: Lipidology Source Type: research

Real-World Costs for First and Recurrent Events of Myocardial Infarction and Stroke in the Elderly Medicare Population
Dr. Becker has received a grant from Amgen Inc.
Source: Journal of Clinical Lipidology - May 1, 2015 Category: Lipidology Authors: David Becker, Pradeep Sharma, Meredith Kilgore, Nicole Yurgin Source Type: research

PIPs in neurological diseases
This article analyses recent progress in this area and explains how PIP lipids are involved, to varying degrees, in almost every class of neurological disease. This article is part of a Special Issue entitled Brain Lipids.
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 13, 2015 Category: Lipidology Source Type: research

Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain
Publication date: January 2015 Source:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), Volume 92 Author(s): M. Lagarde , M. Hachem , N. Bernoud-Hubac , M. Picq , E. Véricel , M. Guichardant 1-acetyl,2-docosahexaenoyl-glycerophosphocholine (AceDoPC) has been made to prevent docosahexaenoyl (DHA) to move to the sn-1 position as it rapidly does when present in 1-lyso,2-docosahexaenoyl-GPC (lysoPC-DHA), an efficient DHA transporter to the brain. When incubated with human blood, AceDoPC behaves closer to lysoPC-DHA than PC-DHA in terms of binding to plasma albumin and lipoproteins, and DHA incorporation into p...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 2, 2015 Category: Lipidology Source Type: research

Dual effects of the non-esterified fatty acid receptor ‘GPR40’ for human health
Publication date: Available online 20 January 2015 Source:Progress in Lipid Research Author(s): Tetsumori Yamashima G protein-coupled receptor 40 (GPR40), a receptor for diverse non-esterified fatty acids, is expressed predominantly in the wide variety of neurons of the central nervous system and ß-cells in the pancreatic islets. Since deorphanization of GPR40 in 2003, the past decade has seen major advances in our understanding of its role in the insulin secretion. However, there is still a great deal to be elucidated about the role of GPR40 in the brain, because the latter shows the most abundant GPR40 mRNA expression...
Source: Progress in Lipid Research - January 29, 2015 Category: Lipidology Source Type: research

Dual effects of the fatty acid receptor ‘GPR40’ for human health
Publication date: Available online 20 January 2015 Source:Progress in Lipid Research Author(s): Tetsumori Yamashima Free fatty acid receptor ‘GPR40’ is expressed predominantly in the wide variety of neurons of the central nervous system and ß-cells in the pancreatic islets. Since its deorphanization in 2003, the past decade has seen major advances in our understanding of its role in insulin secretion. In contrast, there is still a great deal to be learned about the relationship between GPR40 and brain, despite the most abundant mRNA expression. Since GPR40 is expressed also in the hypothalamus, ‘brain-lipid sensin...
Source: Progress in Lipid Research - January 26, 2015 Category: Lipidology Source Type: research

n-3 PUFA Induce Microvascular Protective Changes During Ischemia/Reperfusion
Abstract Ischemia/reperfusion (I/R) injury can occur in consequence of myocardial infarction, stroke and multiple organ failure, the most prevalent cause of death in critically ill patients. I/R injury encompass impairment of endothelial dependent relaxation, increase in macromolecular permeability and leukocyte-endothelium interactions. Polyunsaturated fatty acids (n-3 PUFA), such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) found in fish oil have several anti-inflammatory properties and their potential benefits against I/R injury were investigated using the hamster cheek pouch ...
Source: Lipids - October 26, 2014 Category: Lipidology Source Type: research