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Specialty: Lipidology

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Total 122 results found since Jan 2013.

Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability
Purpose of reviewAtherosclerotic plaque rupture and subsequent acute events, such as myocardial infarction and stroke, contribute to the majority of cardiovascular-related deaths. Calcification has emerged as a significant predictor of cardiovascular morbidity and mortality, challenging previously held notions that calcifications stabilize atherosclerotic plaques. In this review, we address this discrepancy through recent findings that not all calcifications are equivalent in determining plaque stability. Recent findingsThe risk associated with calcification is inversely associated with calcification density. As opposed to...
Source: Current Opinion in Lipidology - October 1, 2014 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Andrew Newby and Yury Miller Source Type: research

Collagen and related extracellular matrix proteins in atherosclerotic plaque development
Purpose of reviewThe structure, composition and turnover of the extracellular matrix (ECM) as well as cell-matrix interactions are crucial in the developing atherosclerotic plaque. There is a need for further insight into specific proteins in the ECM and their functions in the developing plaque, and during the last few years a number of publications have highlighted this very important field of research. These novel findings will be addressed in the present review. Recent findingsThis review covers literature focused on collagen and ECM proteins interacting with collagen, and what their roles may be in plaque development. ...
Source: Current Opinion in Lipidology - October 1, 2014 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Andrew Newby and Yury Miller Source Type: research

Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies
Conclusion: The results indicate an overall risk reduction of all-cause mortality (11%), cardiovascular mortality (12%), cardiovascular events (9%), and stroke (17%) when comparing the top versus bottom third of MUFA, olive oil, oleic acid, and MUFA:SFA ratio. MUFA of mixed animal and vegetable sources per se did not yield any significant effects on these outcome parameters. However, only olive oil seems to be associated with reduced risk. Further research is necessary to evaluate specific sources of MUFA (i.e. plant vs. animal) and cardiovascular risk.
Source: Lipids in Health and Disease - October 1, 2014 Category: Lipidology Authors: Lukas SchwingshacklGeorg Hoffmann Source Type: research

Priority Paper Evaluation: Reverse epidemiology in ischemic stroke: high cholesterol as a predictor of improved survival in stroke patients
Clinical Lipidology April 2014, Vol. 9, No. 2, Pages 135-139.
Source: Future Medicine: Clinical Lipidology - June 11, 2014 Category: Lipidology Tags: article Source Type: research

Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project Patient-Oriented and Epidemiological Research
HDL-associated paraoxonase-1 (PON1) is an enzyme whose activity is associated with cerebrovascular disease. Common PON1 genetic variants have not been consistently associated with cerebrovascular disease. Rare coding variation that likely alters PON1 enzyme function may be more strongly associated with stroke. The National Heart, Lung, and Blood Institute Exome Sequencing Project sequenced the coding regions (exomes) of the genome for heart, lung, and blood-related phenotypes (including ischemic stroke). In this sample of 4,204 unrelated participants, 496 had verified, noncardioembolic ischemic stroke. After filtering, 28 ...
Source: The Journal of Lipid Research - May 28, 2014 Category: Lipidology Authors: Kim, D. S., Crosslin, D. R., Auer, P. L., Suzuki, S. M., Marsillach, J., Burt, A. A., Gordon, A. S., Meschia, J. F., Nalls, M. A., Worrall, B. B., Longstreth, W. T., Gottesman, R. F., Furlong, C. E., Peters, U., Rich, S. S., Nickerson, D. A., Jarvik, G. P Tags: Patient-Oriented and Epidemiological Research Source Type: research

Comparison of Lipid Profiles and BMI by Age Groups in Acute Ischemic Stroke*
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Source: Journal of Clinical Lipidology - May 1, 2014 Category: Lipidology Authors: Demetrios Doukas, Mauro Montevecchi, Michael Schneck, John Barron, Binh An Phan Tags: Abstracts Source Type: research

Pharmacological lipid modification therapy following stroke: an update
Clinical Lipidology , February 2014, Vol. 9, No. 1, Pages 83-89.
Source: Future Medicine: Clinical Lipidology - February 7, 2014 Category: Lipidology Tags: article Source Type: research

Two lipids in the diet, rather than cholesterol, are responsible for heart failure and stroke
Clinical Lipidology , Ahead of Print, Pages 1-16.
Source: Future Medicine: Clinical Lipidology - January 29, 2014 Category: Lipidology Tags: article Source Type: research

Lack of association between lipoprotein(a) genetic variants and subsequent cardiovascular events in Chinese Han patients with coronary artery disease after percutaneous coronary intervention
Conclusions: Our data did not support a relationship between genetic LPA variants (rs6415084 and rs3798220) and subsequent cardiovascular events after PCI in Chinese Han CAD patients.
Source: Lipids in Health and Disease - August 27, 2013 Category: Lipidology Authors: Zhi-Gen LiGuang LiYing-Ling ZhouZhu-Jun ChenJun-Qing YangYing ZhangShuo SunShi-Long Zhong Source Type: research

Effects of Angiotensin II Type 1 receptor blocker and adiponectin on adipocyte dysfunction in stroke-prone spontaneously hypertensive rats
Conclusions: Our results indicate that candesartan protects against hypertension and adipocyte dysfunction in SHRSP. The induction of leptin expression appeared to be important factor in the inhibition of stroke lesions, whereas adiponectin was not a major regulator of blood pressure in SHRSP with genetic hypertension. Further studies are needed to elucidate the role of the renin--angiotensin system in adipose tissue dysfunction in relation to hypertensive end-organ damage.
Source: Lipids in Health and Disease - July 22, 2013 Category: Lipidology Authors: Kumiko TakemoriTakao InoueHiroyuki Ito Source Type: research

From the Editor: What is obesity?
The concern about the prevalence of obesity in the population of the United States (now around the world) has grown as our epidemiologic colleagues have pointed out the associated disease states such as dyslipidemia, high blood pressure, diabetes, myocardial infarction, and stroke. We now recognize it to be a disease entity unto itself with causative elements in both genetic and environmental realms. There seems to be general agreement that this disease is linked to an increase in adipose tissue generally but with issues of enhanced effect when the excess fat cells are located within the abdominal cavity or when there is a...
Source: Journal of Clinical Lipidology - June 5, 2013 Category: Lipidology Authors: W. Virgil Brown Tags: Foreword Source Type: research

Impact of Obesity and Healthy Eating Index on Coronary Heart Disease, Stroke, and Cardiovascular Disease Mortality in United States Adults*
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Source: Journal of Clinical Lipidology - May 1, 2013 Category: Lipidology Authors: Rohini J. Patel, Geeta Sikand, Christopher Patao, Nathan Wong Tags: Abstracts Source Type: research