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Specialty: Lipidology

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Total 122 results found since Jan 2013.

Prostaglandins and Other Lipid Mediators Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases
Publication date: Available online 5 November 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Jogen Atone, K Wagner, Kenji Hashimoto, Bruce HammockAbstractCytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects in inflammatory disorders. Endogenous EpFAs are further metabolized into corresponding diols by the soluble epoxide hydrolase (sEH). Through inhibition of sEH, many studies have demonstrated the cardioprotective and renoprotective effects of EpFAs; however, the role of sEH inhibition...
Source: Prostaglandins and Other Lipid Mediators - November 6, 2019 Category: Lipidology Source Type: research

Lipid management in people with peripheral artery disease
Purpose of review To summarize recent data on the role of dyslipidaemia and the benefit from managing this in people with disease of the abdominal aorta and its peripheral branches (peripheral artery disease, PAD). Recent findings Findings from the Further Cardiovascular Outcomes Research with Proprotein convertase subtilisin/kexin type 9 (PCSK9) Inhibition in Subjects with Elevated Risk (FOURIER) trial demonstrate the benefit of intensely lowering low-density lipoprotein-cholesterol (LDL-c) in people with PAD to substantially reduce the incidence of major cardiovascular events (MACE; myocardial infarction, stroke or ...
Source: Current Opinion in Lipidology - November 5, 2019 Category: Lipidology Tags: THERAPY AND CLINICAL TRIALS: Edited by Erik S.G. Stroes and Gerald F. Watts Source Type: research

Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases Research Articles
Sphingolipids contribute to the regulation of cell and tissue homeostasis, and disorders of sphingolipid metabolism lead to diseases such as inflammation, stroke, diabetes, and cancer. Sphingolipid metabolic pathways involve an array of enzymes that reside in specific subcellular organelles, resulting in the formation of many diverse sphingolipids with distinct molecular species based on the diversity of the ceramide (Cer) structure. In order to probe compartment-specific metabolism of sphingolipids in this study, we analyzed the Cer and SM species preferentially produced in the inner plasma membrane (PM), Golgi apparatus,...
Source: The Journal of Lipid Research - October 31, 2019 Category: Lipidology Authors: Sakamoto, W., Canals, D., Salamone, S., Allopenna, J., Clarke, C. J., Snider, J., Obeid, L. M., Hannun, Y. A. Tags: Research Articles Source Type: research

PCSK9 loss-of-function variants and Lp(a) phenotypes among black US adults Patient-Oriented and Epidemiological Research
The pharmacologic inhibition of proprotein convertase subtilisin-kexin type 9 (PCSK9) lowers lipoprotein (a) [Lp(a)] concentrations. However, the impact of genetic PCSK9 loss-of-function variants (LOFVs) on Lp(a) is uncertain. We determined the association of PCSK9 LOFVs with Lp(a) measures among black adults. Genotyping for PCSK9 LOFVs was conducted in 10,196 black Reasons for Geographic and Racial Differences in Stroke study participants. Among 241 participants with and 723 randomly selected participants without PCSK9 LOFVs, Lp(a) concentations, apo(a) kringle IV (KIV) repeats (a proxy for isoform size), and oxidized pho...
Source: The Journal of Lipid Research - October 31, 2019 Category: Lipidology Authors: Mefford, M. T., Marcovina, S. M., Bittner, V., Cushman, M., Brown, T. M., Farkouh, M. E., Tsimikas, S., Monda, K. L., Lopez, J. A. G., Muntner, P., Rosenson, R. S. Tags: Patient-Oriented and Epidemiological Research Source Type: research

Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D Patient-Oriented and Epidemiological Research
APOB, APOC3, and APOE and apolipoprotein-defined lipoprotein subclasses (ADLSs; based on qualitative apolipoprotein complement) have been associated with dyslipidemia and CVD. Our main objective was to define associations of serum apolipoproteins and ADLSs with "any CVD" and "major atherosclerotic cardiovascular events" (MACEs) in a prospective study of T1D. Serum apolipoproteins and ADLSs (14 biomarkers in total) were measured in sera (obtained between 1997 and 2000) from a subset (n = 465) of the Epidemiology of Diabetes Interventions and Complications cohort. Prospective associations of "any CVD" (myocardial infarction,...
Source: The Journal of Lipid Research - July 31, 2019 Category: Lipidology Authors: Basu, A., Bebu, I., Jenkins, A. J., Stoner, J. A., Zhang, Y., Klein, R. L., Lopes-Virella, M. F., Garvey, W. T., Budoff, M. J., Alaupovic, P., Lyons, T. J., the Diabetes Control Complications Trial/Epidemiology of Diabetes Interventions Complications Rese Tags: Patient-Oriented and Epidemiological Research Source Type: research

Survey of the Erythrocyte EPA+DHA Levels in the Heart Attack/Stroke Belt
ConclusionsIndividuals in the CVD “belt” had relatively low O3I levels. Since in other settings, a low O3I is associated with increased risk for CVD, this may be one factor contributing to the higher risk for CVD in this region of the US.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 14, 2019 Category: Lipidology Source Type: research

Assessing the performance of monocyte to high-density lipoprotein ratio for predicting ischemic stroke: insights from a population-based Chinese cohort
Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged measure of inflammation and oxidative stress and has been used to predict multiple cardiovascular abnormalities, but data rela...
Source: Lipids in Health and Disease - May 30, 2019 Category: Lipidology Authors: Hao-Yu Wang, Wen-Rui Shi, Xin Yi, Ya-Ping Zhou, Zhi-Qin Wang and Ying-Xian Sun Tags: Research Source Type: research

Use of lipoprotein(a) in clinical practice: A biomarker whose time has come —A scientific statement from the National Lipid Association. Don P. Wilson, MD, on behalf of the Writing group
Lipoprotein(a) [Lp(a)] is a well-recognized, independent risk factor for atherosclerotic cardiovascular disease, with elevated levels estimated to be prevalent in 20% of the population. Observational and genetic evidence strongly support a causal relationship between high plasma concentrations of Lp(a) and increased risk of atherosclerotic cardiovascular disease –related events, such as myocardial infarction and stroke, and valvular aortic stenosis. In this scientific statement, we review an array of evidence-based considerations for testing of Lp(a) in clinical practice and the utilization of Lp(a) levels to inform trea...
Source: Journal of Clinical Lipidology - May 16, 2019 Category: Lipidology Authors: Don P. Wilson, Terry A. Jacobson, Peter H. Jones, Marlys L. Koschinsky, Catherine J. McNeal, B ørge G. Nordestgaard, Carl E. Orringer Tags: Original Research Source Type: research

Use of lipoprotein(a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association. Don P. Wilson, MD, on behalf of the Writing group
Lipoprotein(a) [Lp(a)] is a well-recognized, independent risk factor for atherosclerotic cardiovascular disease, with elevated levels estimated to be prevalent in 20% of the population. Observational and genetic evidence strongly support a causal relationship between high plasma concentrations of Lp(a) and increased risk of atherosclerotic cardiovascular disease –related events, such as myocardial infarction and stroke, and valvular aortic stenosis. In this scientific statement, we review an array of evidence-based considerations for testing of Lp(a) in clinical practice and the utilization of Lp(a) levels to inform trea...
Source: Journal of Clinical Lipidology - May 16, 2019 Category: Lipidology Authors: Don P. Wilson, Terry A. Jacobson, Peter H. Jones, Marlys L. Koschinsky, Catherine J. McNeal, B ørge G. Nordestgaard, Carl E. Orringer Tags: Original Research Source Type: research

A functional variant rs12904 in the miR-200c binding site was associated with a decreased risk of ischemic stroke
Genome-wide association study (GWAS) identified chromosome 12p13 rs12425791 and rs11833579 as susceptibility loci of ischemic stroke (IS) in a European population. However, conflicting results were obtained in...
Source: Lipids in Health and Disease - May 10, 2019 Category: Lipidology Authors: Zhi-Neng Zeng, Ling-Ling Liu, Yong-Ling He, Xiang Shi and Ye-Sheng Wei Tags: Research Source Type: research

PCSK9 inhibition in patients with and without prior myocardial infarction or ischemic stroke: A pooled analysis of nine randomized-controlled studies of alirocumab
Patients with prior cardiovascular events are at very high risk of recurrent events and may benefit from low-density lipoprotein cholesterol (LDL-C) lowering beyond that achieved with maximally tolerated statins.
Source: Journal of Clinical Lipidology - April 8, 2019 Category: Lipidology Authors: Eric Bruckert, Dean J. Kereiakes, Michael J. Koren, Michael J. Louie, Alexia Letierce, Kathryn Miller, Christopher P. Cannon Source Type: research

Sex difference in the incidence of stroke and its corresponding influence factors: results from a follow-up 8.4 years of rural China hypertensive prospective cohort study
Few studies investigate sex difference in stroke incidence in rural China hypertensive population.
Source: Lipids in Health and Disease - March 25, 2019 Category: Lipidology Authors: Yali Wang, Yue Dai, Jia Zheng, Yanxia Xie, Rongrong Guo, Xiaofan Guo, Guozhe Sun, Zhaoqing Sun, Yingxian Sun and Liqiang Zheng Tags: Research Source Type: research

Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4  years follow-up study
Studies have shown that non-traditional lipid profiles have a better association with stroke than traditional blood lipids in clinical applications, other studies have drawn different conclusions.
Source: Lipids in Health and Disease - January 8, 2019 Category: Lipidology Authors: Jia Zheng, Zhaoqing Sun, Xingang Zhang, Zhao Li, Xiaofan Guo, Yanxia Xie, Yingxian Sun and Liqiang Zheng Tags: Research Source Type: research

The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi ’an, China
Serum lipids [total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG)] are risk factors for stroke, but the relationships between...
Source: Lipids in Health and Disease - January 5, 2019 Category: Lipidology Authors: Beiyu Zhao, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Yu Jiang, Jin Wang, Kang Huo, Meiying Deng, Jingyi Wang and Qiumin Qu Tags: Research Source Type: research

Association between MEG3/miR-181b polymorphisms and risk of ischemic stroke
Recent evidence suggests that long non-coding RNAs (lncRNAs) are key regulators in the pathological process of ischemic stroke (IS). Maternally expressed gene 3 (MEG3) was observed to be up-regulated in IS, ac...
Source: Lipids in Health and Disease - December 22, 2018 Category: Lipidology Authors: Xuemei Han, Zhaoshi Zheng, Chunhui Wang and Libo Wang Tags: Research Source Type: research