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Specialty: Lipidology

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Total 122 results found since Jan 2013.

Effects of fatty and lean fish intake on stroke risk: a meta-analysis of prospective cohort studies
Fish intake has been postulated to reduce the risk of stroke. However, whether the beneficial effect of fish are mainly linked to fat content, as a source of omega-3 polyunsaturated fatty acids, remains unclea...
Source: Lipids in Health and Disease - November 23, 2018 Category: Lipidology Authors: Zhi-Zhen Qin, Jia-Ying Xu, Guo-Chong Chen, Yu-Xia Ma and Li-Qiang Qin Tags: Research Source Type: research

Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids
Publication date: November 2018Source: Prostaglandins & Other Lipid Mediators, Volume 139Author(s): Reheman Adili, Megan Hawley, Michael HolinstatAbstractThrombosis is the most common underlying pathology responsible for morbidity and mortality in cardiovascular disease (CVD). Platelet adhesion, activation, and aggregation play central roles in hemostasis; however, the same process may also cause thrombosis and vessel occlusion at the site of ruptured atherosclerotic lesions leading to heart attack and stroke. ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) are an essential component of the platelet phospholipid membrane...
Source: Prostaglandins and Other Lipid Mediators - October 4, 2018 Category: Lipidology Source Type: research

Stroke and dyslipidemia: clinical risk factors in the telestroke versus non-telestroke
Clinical risk factors related to not administering thrombolysis to acute ischemic stroke patients with incidence dyslipidemia is not clear. This issue was investigated in telestroke and non-telestroke settings.
Source: Lipids in Health and Disease - September 27, 2018 Category: Lipidology Authors: Jordan Gainey, Brice Blum, Bekah Bowie, Keiko Cooley, Lee Madeline, Ervin Lowther Ervin and Thomas I. Nathaniel Tags: Research Source Type: research

Low LDL-C and risk of hemorrhagic stroke in Chinese adults
It is well-established that higher LDL and total cholesterol are associated with increased risk of atherosclerotic cardiovascular disease (ASCVD), that is, coronary heart disease (CHD) and ischemic stroke events, and that cholesterol-lowering by statins and other therapies reduce ASCVD risk. However, the picture is less clear for the 10% to 20% of strokes that are hemorrhagic rather than ischemic. A meta-analysis of observational studies shows that lower levels of LDL-C and total cholesterol are associated with higher risk of hemorrhagic strokes (HS), and with intracranial hemorrhage (ICH), a subset of HS.
Source: Journal of Clinical Lipidology - September 1, 2018 Category: Lipidology Authors: Rachel H. Mackey Tags: Editorial Source Type: research

Cardiovascular oncology: exploring the effects of targeted cancer therapies on atherosclerosis
Purpose of review Targeted cancer therapies have revolutionized the treatment of cancer in the past decade, but cardiovascular toxicity is a rising problem in cancer patients. Here we discuss the effects of targeted cancer therapies on atherosclerosis. Increasing the awareness of these adverse effects will promote the development of evidence-based preventive strategies in the emerging field of cardiovascular oncology. Recent findings Vascular endothelial growth factor inhibitors, immunomodulatory imide drugs, tyrosine kinase inhibitors and immune checkpoint inhibitors are successfully used as treatment for many types ...
Source: Current Opinion in Lipidology - August 31, 2018 Category: Lipidology Tags: ATHEROSCLEROSIS: CELL BIOLOGY AND LIPOPROTEINS: Edited by Mohamad Navab and Menno de Winther Source Type: research

Fatty acid transporting proteins: Roles in brain development, aging, and stroke
Publication date: Available online 21 April 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne StetlerAbstractPolyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-co...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 10, 2018 Category: Lipidology Source Type: research

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases
Publication date: Available online 10 March 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Grace Y. Sun, Agnes Simonyi, Kevin L. Fritsche, Dennis Y. Chuang, Mark Hannink, Zezong Gu, C. Michael Greenlief, Jeffrey K. Yao, James C. Lee, David Q. BeversdorfAbstractDocosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca2+-independent...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 10, 2018 Category: Lipidology Source Type: research

Fatty acid transporting proteins: Roles in brain development, aging, and stroke
Publication date: Available online 21 April 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne StetlerAbstractPolyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-co...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 5, 2018 Category: Lipidology Source Type: research

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases
Publication date: Available online 10 March 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Grace Y. Sun, Agnes Simonyi, Kevin L. Fritsche, Dennis Y. Chuang, Mark Hannink, Zezong Gu, C. Michael Greenlief, Jeffrey K. Yao, James C. Lee, David Q. BeversdorfAbstractDocosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca2+-independent...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 5, 2018 Category: Lipidology Source Type: research

Twenty-year epidemiologic study on LDL-C levels in relation to the risks of atherosclerotic event, hemorrhagic stroke, and cancer death among young and middle-aged population in China
Lowering elevated low-density lipoprotein cholesterol (LDL-C) levels is a key strategy in primary prevention of atherosclerotic cardiovascular disease (ASCVD), but the optimal LDL-C level is not well established in Chinese.
Source: Journal of Clinical Lipidology - June 26, 2018 Category: Lipidology Authors: Xingguang Zhang, Jing Liu, Miao Wang, Yue Qi, Jiayi Sun, Jun Liu, Ying Wang, Yongchen Hao, Yan Li, Mengge Zhou, Dong Zhao Tags: Original Article Source Type: research

Twenty-year epidemiologic study on LDL cholesterol levels in relation to the risks of atherosclerotic event, hemorrhagic stroke, and cancer death among young and middle-aged population in China
Lowering elevated low-density lipoprotein cholesterol (LDL-C) level is a key strategy in primary prevention of atherosclerotic cardiovascular disease (ASCVD), but the optimal LDL-C level is not well established in Chinese.
Source: Journal of Clinical Lipidology - June 26, 2018 Category: Lipidology Authors: Xingguang Zhang, Jing Liu, Miao Wang, Yue Qi, Jiayi Sun, Jun Liu, Ying Wang, Yongchen Hao, Yan Li, Mengge Zhou, Dong Zhao Tags: Original Research Source Type: research

Polymorphism of CONNEXIN37 gene is a risk factor for ischemic stroke in Han Chinese population
Stroke has a high fatality and disability rate, and is one of the main burdens to human health. It is thus very important to identify biomarkers for the development of effective approaches for the prevention a...
Source: Lipids in Health and Disease - April 10, 2018 Category: Lipidology Authors: Hong Li, Shasha Yu, Rui Wang, Zhaoqing Sun, Xinghu Zhou, Liqiang Zheng, Zhihua Yin and Yingxian Sun Tags: Research Source Type: research

Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques Patient-Oriented and Epidemiological Research
Patients with diabetes are at higher risk of developing carotid artery stenosis and resultant stroke. Arachidonoyl phospholipids affect plaque inflammation and vulnerability, but whether diabetic patients have unique carotid artery phospholipidomic profiles is unknown. We performed a comprehensive paired analysis of phospholipids in extracranial carotid endarterectomy (CEA) plaques of matched diabetic and nondiabetic patients and analyzed mass spectrometry-derived profiles of three phospholipids, plasmenyl-phosphatidylethanolamine (pPE), phosphatidylserine (PS), and phosphatidylinositol (PI), in maximally (MAX) and minimal...
Source: The Journal of Lipid Research - April 1, 2018 Category: Lipidology Authors: Zayed, M. A., Hsu, F.-F., Patterson, B. W., Yan, Y., Naim, U., Darwesh, M., De Silva, G., Yang, C., Semenkovich, C. F. Tags: Patient-Oriented and Epidemiological Research Source Type: research

DOCK7-ANGPTL3 SNPs and their haplotypes with serum lipid levels and the risk of coronary artery disease and ischemic stroke
Little is known about the association of the dedicator of cytokinesis 7 (DOCK7 rs1748195) and angiopoietin like 3 (ANGPTL3 rs12563308) single nucleotide polymorphisms (SNPs) and their haplotypes with serum lipid ...
Source: Lipids in Health and Disease - February 17, 2018 Category: Lipidology Authors: Wei-Jun Li, Rui-Xing Yin, Xiao-Li Cao, Wu-Xian Chen, Feng Huang and Jin-Zhen Wu Tags: Research Source Type: research

Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis Research Articles
Inhibiting the glutamate/cystine antiporter system xc–, a key antioxidant defense machinery in the CNS, could trigger a novel form of regulated necrotic cell death, ferroptosis. The underlying mechanisms of system xc–-dependent cell demise were elucidated using primary oligodendrocytes (OLs) treated with glutamate to block system xc– function. Pharmacological analysis revealed ferroptosis as a major contributing factor to glutamate-initiated OL death. A sphingolipid profile showed elevations of ceramide species and sphingosine that were preventable by inhibiting of an acid sphingomyelinase (ASM) activity....
Source: The Journal of Lipid Research - February 1, 2018 Category: Lipidology Authors: Novgorodov, S. A., Voltin, J. R., Gooz, M. A., Li, L., Lemasters, J. J., Gudz, T. I. Tags: Research Articles Source Type: research