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Specialty: Lipidology
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Total 122 results found since Jan 2013.
Association between single nucleotide polymorphism rs9534275 and the risk of coronary artery disease and ischemic stroke
The present study was to detect the association of single nucleotide polymorphism (SNP) in the breast susceptibility gene 2 (BRCA2) and the risk of coronary artery disease (CAD) and ischemic stroke (IS).
Source: Lipids in Health and Disease - October 5, 2017 Category: Lipidology Authors: Liu Miao, Rui-Xing Yin, Shuo Yang, Feng Huang, Wu-Xian Chen and Xiao-Li Cao Tags: Research Source Type: research
Circulating inflammation-resolving lipid mediators RvD1 and DHA are decreased in patients with acutely symptomatic carotid disease
Conclusions A circulating pro-inflammatory lipid profile, characterized by high AA:RvD1 and AA:DHA, is associated with acutely symptomatic carotid disease and stroke.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 27, 2017 Category: Lipidology Source Type: research
Synthesis and Identification of AceDoxyPC, a Protectin-Containing Structured Phospholipid, Using Liquid Chromatography/Mass Spectrometry
AbstractFatty acids have many health benefits in a great variety of diseases ranging from cardiovascular to cerebral diseases. For instance, docosahexaenoic acid (DHA), which is highly enriched in brain phospholipids, plays a major role in anti-inflammatory or neuroprotective pathways. Its effects are thought to be due, in part, to its conversion into derived mediators such as protectins. 1-Lyso,2-docosahexaenoyl-glycerophosphocholine (LysoPtdCho-DHA) is one of the physiological carrier of DHA to the brain. We previously synthesized a structured phosphatidylcholine to mimic 1-lyso,2-docosahexaenoyl-glycerophosphocholine, n...
Source: Lipids - August 3, 2017 Category: Lipidology Source Type: research
Adiponectin, lipids and atherosclerosis
Purpose of review: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases.
Recent findings: This narrative review discusses the associations of adiponectin with obesity-...
Source: Current Opinion in Lipidology - July 14, 2017 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research
The association of lipid metabolism relative gene polymorphisms and ischemic stroke in Han and Uighur population of Xinjiang
The present study is aimed to evaluate difference of lipid metabolism related gene single nucleotide polymorphisms (SNPs) with ischemic stroke (IS) in Han and Uighur population of Xinjiang, China.
Source: Lipids in Health and Disease - June 17, 2017 Category: Lipidology Authors: Yun-hua Yue, Ling-yun Liu, Liang Hu, You-mei Li, Jie-ping Mao, Xiao-ying Yang and Na-mu Dila Source Type: research
Nonalcoholic Fatty Liver Disease in Patients with Acute Ischemic Stroke is associated with more severe stroke and worse outcome.
There is a paucity of data regarding the association between non alcoholic fatty liver disease (NAFLD) and acute ischemic stroke. Stroke is largely preventable, so that knowledge of risk factors is essential to achieve reductions in the stroke rate and resulting disease burden.
Source: Journal of Clinical Lipidology - May 10, 2017 Category: Lipidology Authors: Sabry M. Abdeldyem, Tarek Goda, Samy A. Khodeir, Sabry Abou saif, Sherief Abd-Elsalam Source Type: research
Intensive Lifestyle Interventions Decrease Stroke Risk Factors In 18 Days In Patients With Carotid Stenosis
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Source: Journal of Clinical Lipidology - May 1, 2017 Category: Lipidology Authors: Francisco Ramirez, Neil Nedley Source Type: research
Propofol-Induced Hypertriglyceridemia as a Cause of Stroke
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Source: Journal of Clinical Lipidology - May 1, 2017 Category: Lipidology Authors: Matthew Weiss Source Type: research
Fatty Acid Transporting Proteins: Roles in Brain Development, Aging, and Stroke
Publication date: Available online 21 April 2017 Source:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) Author(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne Stetler Polyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 21, 2017 Category: Lipidology Source Type: research
Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways
Atherosclerosis is a common cardiovascular disease that causes myocardial infarction, heart failure, and stroke. Increased oxidized low density lipoprotein (ox-LDL) in the sub-endothelium is the characteristic...
Source: Lipids in Health and Disease - April 13, 2017 Category: Lipidology Authors: Yansheng Yao, Yanbing Wang, Yibo Zhang and Chang Liu Source Type: research
Docosahexaenoic acid (DHA): an essential nutrient and a nutraceutical for brain health and diseases
Publication date: Available online 10 March 2017 Source:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) Author(s): Grace Y. Sun, Agnes Simonyi, Kevin L. Fritsche, Dennis Y. Chuang, Mark Hannink, Zezong Gu, C. Michael Greenlief, Jeffrey K. Yao, James C. Lee, David Q. Beversdorf Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca2+-independ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - March 10, 2017 Category: Lipidology Source Type: research
Lipoprotein(a): new insights from modern genomics
Purpose of review: Lipoprotein(a) [Lp(a)] is the strongest independent genetic risk factor for both myocardial infarction and aortic stenosis. It has also been associated with other forms of atherosclerotic cardiovascular disease (CVD) including ischemic stroke. Its levels are genetically determined and remain fairly stable throughout life. Elevated Lp(a), above 50 mg/dl, affects one in five individuals worldwide.
Recent findings: Herein, we review the recent epidemiologic and genetic evidence supporting the causal role of Lp(a) in CVD, highlight recommendations made by European and Canadian guidelines regarding Lp(a) a...
Source: Current Opinion in Lipidology - March 10, 2017 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial Patient-Oriented and Epidemiological Research
The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from the China Stroke Primary Prevention Trial. Plasma lipid levels and total leukocyte, neutrophil, and lymphocyte counts were determined according to standard methods. Peripheral differential leukocyte counts were consistently and positively associated with serum total cholesterol (TC), LDL cholesterol (LDL-C), and TG levels (all ...
Source: The Journal of Lipid Research - December 31, 2016 Category: Lipidology Authors: Liu, Y., Kong, X., Wang, W., Fan, F., Zhang, Y., Zhao, M., Wang, Y., Wang, Y., Wang, Y., Qin, X., Tang, G., Wang, B., Xu, X., Hou, F. F., Gao, W., Sun, N., Li, J., Venners, S. A., Jiang, S., Huo, Y. Tags: Patient-Oriented and Epidemiological Research Source Type: research
Ischemic Stroke in a Young Adult with Extremely Elevated Lipoprotein(a): a Case Report and Review of Literature
Source: Journal of Clinical Lipidology - July 8, 2016 Category: Lipidology Authors: Dharshan Lakshminarayan, Tarec K. Elajami, Suresh Devabhaktuni, Francine K. Welty Source Type: research
Genetic susceptibility to cerebrovascular disease
Purpose of review: Cerebrovascular disease (CeVD) remains a major cause of death and a leading cause of disability worldwide. CeVD is a complex and multifactorial disease caused by the interaction of vascular risk factors, environment, and genetic factors. In the present article, we discussed genetic susceptibility to CeVD, with particular emphasis on genetic studies of the associations between lipid traits and CeVD.
Recent findings: Several animal and clinical studies clearly defined genetic predisposition to atherosclerosis and CeVD, and particularly to ischemic stroke. Recent evidence has shown that traditional vascula...
Source: Current Opinion in Lipidology - March 10, 2016 Category: Lipidology Tags: GENETICS AND MOLECULAR BIOLOGY: Edited by Robert A. Hegele Source Type: research
