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Total 122 results found since Jan 2013.

Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke
Publication date: January 2016 Source:Prostaglandins & Other Lipid Mediators, Volume 122 Author(s): Hui Huang, Mohamed Al-Shabrawey, Mong-Heng Wang Arachidonic acid (AA) is metabolized by cyclooxygenase (COX) and cytochrome P450 (CYP) enzymes into eicosanoids, which are involved in cardiovascular diseases and stroke. Evidence has demonstrated the important functions of these eicosanoids in regulating cerebral vascular tone, cerebral blood flow, and autoregulation of cerebral circulation. Although COX-2 inhibitors have been suggested as potential treatments for stroke, adverse events, including an increased ris...
Source: Prostaglandins and Other Lipid Mediators - January 11, 2016 Category: Lipidology Source Type: research

Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project Patient-Oriented and Epidemiological Research
HDL-associated paraoxonase-1 (PON1) is an enzyme whose activity is associated with cerebrovascular disease. Common PON1 genetic variants have not been consistently associated with cerebrovascular disease. Rare coding variation that likely alters PON1 enzyme function may be more strongly associated with stroke. The National Heart, Lung, and Blood Institute Exome Sequencing Project sequenced the coding regions (exomes) of the genome for heart, lung, and blood-related phenotypes (including ischemic stroke). In this sample of 4,204 unrelated participants, 496 had verified, noncardioembolic ischemic stroke. After filtering, 28 ...
Source: The Journal of Lipid Research - May 28, 2014 Category: Lipidology Authors: Kim, D. S., Crosslin, D. R., Auer, P. L., Suzuki, S. M., Marsillach, J., Burt, A. A., Gordon, A. S., Meschia, J. F., Nalls, M. A., Worrall, B. B., Longstreth, W. T., Gottesman, R. F., Furlong, C. E., Peters, U., Rich, S. S., Nickerson, D. A., Jarvik, G. P Tags: Patient-Oriented and Epidemiological Research Source Type: research

Nonalcoholic Fatty Liver Disease in Patients with Acute Ischemic Stroke is associated with more severe stroke and worse outcome.
There is a paucity of data regarding the association between non alcoholic fatty liver disease (NAFLD) and acute ischemic stroke. Stroke is largely preventable, so that knowledge of risk factors is essential to achieve reductions in the stroke rate and resulting disease burden.
Source: Journal of Clinical Lipidology - May 10, 2017 Category: Lipidology Authors: Sabry M. Abdeldyem, Tarek Goda, Samy A. Khodeir, Sabry Abou saif, Sherief Abd-Elsalam Source Type: research

Admission LDL-cholesterol, statin pretreatment and early outcomes in acute ischemic stroke
Elevated LDL-cholesterol (LDL-C) levels increase the risk of stroke and vascular events. Initiation and maintenance of lipid-lowering therapy after acute ischemic stroke (AIS) appears to be guided by LDL-C levels.1 The EUROASPIRE III stroke-specific module shows that secondary prevention and risk factor control in patients after ischemic stroke need to be improved since about half of patients are not achieving target lipid levels defined in European guidelines.2 However, lower levels of LDL-C are paradoxically associated with increased mortality in ST elevation myocardial infarction patients.
Source: Journal of Clinical Lipidology - August 7, 2023 Category: Lipidology Authors: Joon-Tae Kim, Ji Sung Lee, Beom Joon Kim, Jihoon Kang, Keon-Joo Lee, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Kyungbok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung Tags: Original Research Source Type: research

Effects of Angiotensin II Type 1 receptor blocker and adiponectin on adipocyte dysfunction in stroke-prone spontaneously hypertensive rats
Conclusions: Our results indicate that candesartan protects against hypertension and adipocyte dysfunction in SHRSP. The induction of leptin expression appeared to be important factor in the inhibition of stroke lesions, whereas adiponectin was not a major regulator of blood pressure in SHRSP with genetic hypertension. Further studies are needed to elucidate the role of the renin--angiotensin system in adipose tissue dysfunction in relation to hypertensive end-organ damage.
Source: Lipids in Health and Disease - July 22, 2013 Category: Lipidology Authors: Kumiko TakemoriTakao InoueHiroyuki Ito Source Type: research

Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
This study aims to evaluate the effects of MetS and its components on the short-term prognosis of patients with acute ischemic stroke. Methods: Subjects with ischemic stroke of
Source: Lipids in Health and Disease - July 22, 2015 Category: Lipidology Authors: Liu LiuLixuan ZhanYisheng WangChengping BaiJianjun GuoQingyuan LinDonghai LiangEn Xu Source Type: research

Primary Prevention of Stroke is Strongly Correlated with Low-Density-Lipoprotein Cholesterol Reduction: A Meta-Regression Analysis
Statins have become the cornerstone of therapy for both primary and secondary prevention of cardiovascular (CV) and cerebrovascular diseases (CVD). Numerous studies and meta-analyses have documented these benefits independent of low-density-lipoprotein cholesterol (LDL-C) lowering. There are discrepant reports regarding the dependence of the stroke benefits on the baseline LDL-C levels. The relevance of LDL-C reduction from baseline in the era of pleiotropic benefits needs further exploration, especially, while comparing the primary stroke cohort with the secondary stroke prevention cohort.
Source: Journal of Clinical Lipidology - July 1, 2023 Category: Lipidology Authors: Samit Ghosal, Krishna G Seshadri Tags: Lipid Management in Special Populations Source Type: research

Fatty Acid Transporting Proteins: Roles in Brain Development, Aging, and Stroke
Publication date: Available online 21 April 2017 Source:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) Author(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne Stetler Polyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 21, 2017 Category: Lipidology Source Type: research

Fatty acid transporting proteins: Roles in brain development, aging, and stroke
Publication date: Available online 21 April 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne StetlerAbstractPolyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-co...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 5, 2018 Category: Lipidology Source Type: research

Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4  years follow-up study
Studies have shown that non-traditional lipid profiles have a better association with stroke than traditional blood lipids in clinical applications, other studies have drawn different conclusions.
Source: Lipids in Health and Disease - January 8, 2019 Category: Lipidology Authors: Jia Zheng, Zhaoqing Sun, Xingang Zhang, Zhao Li, Xiaofan Guo, Yanxia Xie, Yingxian Sun and Liqiang Zheng Tags: Research Source Type: research

The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population
Stroke is a sudden disorder of cerebral blood circulation. Many studies have illustrated that dyslipidemia, hypertension, diabetes, smoking and excessive drinking are the traditional risk factors for stroke. T...
Source: Lipids in Health and Disease - October 12, 2020 Category: Lipidology Authors: Yan Mao, Lin Yang, Qian Chen, Guoqing Li, Yao Sun, Jiamin Wu, Zichao Xiong, Yuanwei Liu, Haiyue Li, Jianfeng Liu and Yong Zhang Tags: Research Source Type: research

Determination of endogenous sphingolipid content in stroke rats and HT22 cells subjected to oxygen-glucose deprivation by LC ‒MS/MS
Stroke is the leading cause of death in humans worldwide, and its incidence increases every year. It is well documented that lipids are closely related to stroke. Analyzing the changes in lipid content in the ...
Source: Lipids in Health and Disease - January 25, 2023 Category: Lipidology Authors: Keqi Zeng, Xin Zhou, Wanyi Liu, Cong Nie and Yingfeng Zhang Tags: Research Source Type: research

Association of polymorphisms in the MAFB gene and the risk of coronary artery disease and ischemic stroke: a case–control study
Background: The v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B gene (MAFB) has been associated with serum lipid levels in the Eurpean population, but little is known about such association in the Chinese population or in atherosclerosis-related patients. Therefore, the purpose of the present study was to assess the association of the single nucleotide polymorphisms (SNPs) in the MAFB and serum lipid levels and the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Chinese population. Methods: A total of 1,065 unrelated patients (CAD, 525 and IS, 540) and 539 healthy controls were recruite...
Source: Lipids in Health and Disease - July 25, 2015 Category: Lipidology Authors: Qian YangRui-Xing YinYi-Jiang ZhouXiao-Li CaoTao GuoWu-Xian Chen Source Type: research

Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial Patient-Oriented and Epidemiological Research
The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from the China Stroke Primary Prevention Trial. Plasma lipid levels and total leukocyte, neutrophil, and lymphocyte counts were determined according to standard methods. Peripheral differential leukocyte counts were consistently and positively associated with serum total cholesterol (TC), LDL cholesterol (LDL-C), and TG levels (all ...
Source: The Journal of Lipid Research - December 31, 2016 Category: Lipidology Authors: Liu, Y., Kong, X., Wang, W., Fan, F., Zhang, Y., Zhao, M., Wang, Y., Wang, Y., Wang, Y., Qin, X., Tang, G., Wang, B., Xu, X., Hou, F. F., Gao, W., Sun, N., Li, J., Venners, S. A., Jiang, S., Huo, Y. Tags: Patient-Oriented and Epidemiological Research Source Type: research