Lipid management in people with peripheral artery disease

Purpose of review To summarize recent data on the role of dyslipidaemia and the benefit from managing this in people with disease of the abdominal aorta and its peripheral branches (peripheral artery disease, PAD). Recent findings Findings from the Further Cardiovascular Outcomes Research with Proprotein convertase subtilisin/kexin type 9 (PCSK9) Inhibition in Subjects with Elevated Risk (FOURIER) trial demonstrate the benefit of intensely lowering low-density lipoprotein-cholesterol (LDL-c) in people with PAD to substantially reduce the incidence of major cardiovascular events (MACE; myocardial infarction, stroke or cardiovascular death) and major adverse limb events (MALE). Despite the evidence of substantial benefits from lowering LDL-c, the uptake of drug therapies to lower LDL-c remains sub-optimal in people with PAD. Summary Effective methods to educate physicians and patients on best medical management are needed. Further research is needed to examine the benefit of LDL-c lowering and other lipid therapies for PAD-specific problems like abdominal aortic aneurysm progression and walking impairment. Other novel lipid therapies, such as those that lower lipoprotein (a), maybe particularly beneficial to people with PAD given the evidence indicating high concentrations in this population and the high incidence of MACE in these individuals.
Source: Current Opinion in Lipidology - Category: Lipidology Tags: THERAPY AND CLINICAL TRIALS: Edited by Erik S.G. Stroes and Gerald F. Watts Source Type: research

Related Links:

STATINS are a type of medicine used to help lower the risk of heart problems caused by high cholesterol. As with all medications, side effects can occur when taking statins - but what are the most commonly reported symptoms you should know?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The Critical Care Resource Nurse Team (CCRNT) evolved from our traditional Rapid Response Team (RRT). The CCRNT is a unique paradigm created using the conceptual framework of the American Association of Critical Care Nursing Synergy Model for Patient Care. The goal of the CCRNT is to help align nurse competencies with patient needs. This team was seen as a much-needed strong clinical support by nursing leadership as large numbers of inexperienced new graduate registered nurses were hired and senior experienced nurses were leaving the workforce. The CCRNT supports 24/7 RRT, Code Blue, Code Stroke, Emergency Airway Response ...
Source: Dimensions of Critical Care Nursing - Category: Nursing Tags: Leadership DIMENSION Source Type: research
CNS Neurosci Ther. 2021 Dec 3. doi: 10.1111/cns.13763. Online ahead of print.ABSTRACTPostoperative neurological disorders, including postoperative delirium (POD), postoperative cognitive dysfunction (POCD), postoperative covert ischemic stroke, and hemorrhagic stroke, are challenging clinical problems in the emerging aged surgical population. These disorders can deteriorate functional outcomes and long-term quality of life after surgery, resulting in a substantial social and financial burden to the family and society. Understanding predisposing and precipitating factors may promote individualized preventive treatment for e...
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research
HIGH CHOLESTEROL describes having too much of a waxy substance, known as cholesterol, in your blood. This substance can cause your blood vessels to get blocked, putting you at a higher risk of heart problems and stroke. Luckily, eating healthy foods, including a small festive snack, can help lower your cholesterol levels.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
HIGH cholesterol is hard to pick up in the initial stages because it is rarely accompanied by symptoms. As fatty molecules gradually clog up arteries, however, complications are bound to occur. One sign in the back of the head may be indicative of high levels.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Background Cognitive impairment is prevalent in heart failure and is associated with higher mortality rates. The mechanism behind cognitive impairment in heart failure with preserved ejection fraction (HFpEF) has not been established. Objective The aim of this study was to evaluate associations between abnormal cardiac hemodynamics and cognitive impairment in individuals with HFpEF. Methods A secondary analysis of Atherosclerosis Risk in Communities (Atherosclerosis Risk in Communities) study data was performed. Participants free of stroke or dementia who completed in-person assessments at visit 5 were in...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
The AMAZE trial of left atrial appendage isolation, non-statin oral lipid lowering drugs, EHR alerts, non-MD care, and obesity are the topics John Mandrola, MD, discusses in this week ’s podcast.theheart.org on Medscape
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology Commentary Source Type: news
Conclusions: CoVS is associated with higher severity, poor outcome, and increased mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and baseline stroke severity are independent predictors of mortality.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Conclusions: In this study of patients admitted with dengue, neurological complications due to dengue were seen in 2.64%. Encephalopathy, encephalitis and syncope were the commonest manifestations, followed by acute symptomatic seizures, intracranial haemorrhage and GBS. The entire neuroaxis can be involved in dengue infection. To the best of our knowledge, this is the largest reported study of neurological complications of dengue.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Shalin Shah, Rajsrinivas Parthasarathy, Nishchint Jain, Vipul GuptaAnnals of Indian Academy of Neurology 2021 24(5):794-797
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
More News: Abdominal Aortic Aneurysm | Aortic Aneurysm | Cardiology | Cardiovascular | Cholesterol | Clinical Trials | Education | Heart | Heart Attack | Lipidology | Peripheral Vascular Disease (PVD) | Stroke