Light-induced liposomes for cancer therapeutics
Publication date: Available online 15 July 2020Source: Progress in Lipid ResearchAuthor(s): Wenjie Chen, Ewa M. Goldys, Wei Deng (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - July 15, 2020 Category: Lipidology Source Type: research

Towards model-driven characterization and manipulation of plant lipid metabolism
Publication date: Available online 5 July 2020Source: Progress in Lipid ResearchAuthor(s): Sandra M. Correa, Alisdair R. Fernie, Zoran Nikoloski, Yariv Brotman (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - July 7, 2020 Category: Lipidology Source Type: research

Antitumor and hepatoprotective activity of natural and synthetic neo steroids
Publication date: Available online 27 June 2020Source: Progress in Lipid ResearchAuthor(s): Valery M. Dembitsky (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - June 29, 2020 Category: Lipidology Source Type: research

Influence of glycosphingolipids on cancer cell energy metabolism
Publication date: Available online 24 June 2020Source: Progress in Lipid ResearchAuthor(s): Nina Schömel, Gerd Geisslinger, Marthe-Susanna Wegner (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - June 26, 2020 Category: Lipidology Source Type: research

The memory of the fatty acid system
Publication date: Available online 24 June 2020Source: Progress in Lipid ResearchAuthor(s): Rainer H. Straub (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - June 24, 2020 Category: Lipidology Source Type: research

Molecular mechanisms for biosynthesis and assembly of nutritionally important very long chain polyunsaturated fatty acids in microorganisms
Publication date: Available online 12 June 2020Source: Progress in Lipid ResearchAuthor(s): Xiao Qiu, Xi Xie, Dauenpen Meesapyodsuk (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - June 13, 2020 Category: Lipidology Source Type: research

Structure, function, and regulation of thioesterases
Publication date: Available online 19 May 2020Source: Progress in Lipid ResearchAuthor(s): Crystall Swarbrick, Jeffrey D. Nanson, Edward I. Patterson, Jade K. Forwood (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - May 20, 2020 Category: Lipidology Source Type: research

Editorial Board
Publication date: April 2020Source: Progress in Lipid Research, Volume 78Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - May 14, 2020 Category: Lipidology Source Type: research

Fat taste signal transduction and its possible negative modulator components
Publication date: Available online 8 May 2020Source: Progress in Lipid ResearchAuthor(s): Shanmugamprema Deepankumar, Muthuswamy Karthi, Subramanian Gowtham, Ponnusamy Vinithra, Krishnan Vasanth, Subramaniam Selvakumar (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - May 10, 2020 Category: Lipidology Source Type: research

Maresin-1 resolution with RORα and LGR6
Publication date: Available online 30 April 2020Source: Progress in Lipid ResearchAuthor(s): Dong-Soon Im (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - May 1, 2020 Category: Lipidology Source Type: research

Squalene monooxygenase: a journey to the heart of cholesterol synthesis
Publication date: Available online 28 April 2020Source: Progress in Lipid ResearchAuthor(s): Ngee Kiat Chua, Hudson W. Coates, Andrew J. Brown (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - April 29, 2020 Category: Lipidology Source Type: research

Lipid droplets throughout the evolutionary tree
Publication date: Available online 27 April 2020Source: Progress in Lipid ResearchAuthor(s): Peter K. Lundquist, Kiran-Kumar Shivaiah, Roberto Espinoza-Corral (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - April 28, 2020 Category: Lipidology Source Type: research

Preference for dietary fat: From detection to disease
Publication date: Available online 25 April 2020Source: Progress in Lipid ResearchAuthor(s): Amira S. Khan, Russell Keast, Naim A. Khan (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - April 28, 2020 Category: Lipidology Source Type: research

Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death
Publication date: Available online 24 April 2020Source: Progress in Lipid ResearchAuthor(s): Shrawan K. Mishra, Yong-Guang Gao, Xianqiong Zou, Daniel J. Stephenson, Lucy Malinina, Edward H. Hinchcliffe, Charles E. Chalfant, Rhoderick E. Brown (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - April 25, 2020 Category: Lipidology Source Type: research

Lipid-based biomarkers for CVD, COPD, and aging – A translational perspective
Publication date: Available online 25 April 2020Source: Progress in Lipid ResearchAuthor(s): Kim Ekroos, Oksana Lavrynenko, Bjoern Titz, Calin Pater, Julia Hoeng, Nikolai V. Ivanov (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - April 25, 2020 Category: Lipidology Source Type: research

Regulation of coenzyme A levels by degradation: the ‘Ins and Outs’
Publication date: Available online 29 March 2020Source: Progress in Lipid ResearchAuthor(s): Philippe Naquet, Evan W. Kerr, Schuyler D. Vickers, Roberta Leonardi (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - March 31, 2020 Category: Lipidology Source Type: research

Editorial Board
Publication date: January 2020Source: Progress in Lipid Research, Volume 77Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - January 11, 2020 Category: Lipidology Source Type: research

A global perspective on the crosstalk between saturated fatty acids and Toll-like receptor 4 in the etiology of inflammation and insulin resistance
Publication date: Available online 20 December 2019Source: Progress in Lipid ResearchAuthor(s): Bin Li, Joseph C.K. Leung, Loretta Y.Y. Chan, Wai Han Yiu, Sydney C.W. TangAbstractObesity is featured by chronic systemic low-grade inflammation that eventually contributes to the development of insulin resistance. Toll-like receptor 4 (TLR4) is an important mediator that triggers the innate immune response by activating inflammatory signaling cascades. Human, animal and cell culture studies identified saturated fatty acids (SFAs), the dominant non-esterified fatty acid (NEFA) in the circulation of obese subjects, as non-microb...
Source: Progress in Lipid Research - December 22, 2019 Category: Lipidology Source Type: research

The (endo)cannabinoid signaling in female reproduction: What are the latest advances?
Publication date: Available online 18 December 2019Source: Progress in Lipid ResearchAuthor(s): Sandra Cecconi, Cinzia Rapino, Valentina Di Nisio, Gianna Rossi, Mauro MaccarroneAbstractCannabis extracts like marijuana have the highest consumption rate worldwide. Yet, their societal acceptance as recreational and therapeutic drugs could represent a serious hazard to female human reproduction, because cannabis ingredients [termed (phyto)cannabinoids] can perturb an endogenous system of lipid signals known as endocannabinoids. Accumulated evidence on animal models and humans has demonstrated a crucial role of these endogenous...
Source: Progress in Lipid Research - December 19, 2019 Category: Lipidology Source Type: research

Mammalian phospholipase D: Function, and therapeutics
Publication date: Available online 9 December 2019Source: Progress in Lipid ResearchAuthor(s): M.I. McDermott, Y. Wang, M.J.O. Wakelam, V.A. BankaitisAbstractDespite being discovered over 60 years ago, the precise role of Phospholipase D (PLD) is still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of glycerophospholipids producing phosphatidic acid and the free headgroup. PLD family members are found in organisms ranging from viruses, and bacteria to plants, and mammals, and they display a range of substrate specificities, are regulated by a diverse range of molecules, and have been imp...
Source: Progress in Lipid Research - December 10, 2019 Category: Lipidology Source Type: research

The highly unnatural fatty acid profile of cells in culture
Publication date: Available online 3 December 2019Source: Progress in Lipid ResearchAuthor(s): Paul L. ElseAbstractThe fatty acid profile of cells in culture are unlike any natural cell with twice the monounsaturated (MUFA) and half the polyunsaturated fatty acids (PUFA) of natural cells (Mol%). This is not due to cell lines primarily being derived from cancers but due to limited access to lipid and inability to make PUFA de novo as vertebrate cells. Classic culture methods use media with 10% serum (the only exogenous source of lipid). Fetal bovine serum (FBS), the serum of choice has a low level of lipid and cholesterol c...
Source: Progress in Lipid Research - December 4, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: October 2019Source: Progress in Lipid Research, Volume 76Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - November 15, 2019 Category: Lipidology Source Type: research

Eighteen‑carbon trans fatty acids and inflammation in the context of atherosclerosis
Publication date: October 2019Source: Progress in Lipid Research, Volume 76Author(s): Carina A. Valenzuela, Ella J. Baker, Elizabeth A. Miles, Philip C. CalderAbstractEndothelial dysfunction is a pro-inflammatory state characterized by chronic activation of the endothelium, which leads to atherosclerosis and cardiovascular disease (CVD). Intake of trans fatty acids (TFAs) is associated with an increased risk of CVD. This risk is usually associated with industrial TFAs (iTFAs) rather than ruminant TFAs (rTFAs); however it is not clear how specific TFA isomers differ in their biological activity and mechanisms of action with...
Source: Progress in Lipid Research - November 3, 2019 Category: Lipidology Source Type: research

Galectin-3 modulation of T-cell activation: mechanisms of membrane remodelling
Publication date: Available online 1 November 2019Source: Progress in Lipid ResearchAuthor(s): Rebecca C. Gilson, Sachith D. Gunasinghe, Ludger Johannes, Katharina GausAbstractGalectin-3 (Gal3) is a multifaceted protein which belongs to a family of lectins and binds β-galactosides. Gal3 expression is altered in many types of cancer, with increased expression generally associated with poor prognosis. Although the mechanisms remain unknown, Gal3 has been implicated in several biological processes involved in cancer progression, including suppression of T cell-mediated immune responses. Extracellular Gal3 binding to the ...
Source: Progress in Lipid Research - November 2, 2019 Category: Lipidology Source Type: research

Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion
Publication date: Available online 15 October 2019Source: Progress in Lipid ResearchAuthor(s): Adam H. Metherel, Richard P. BazinetAbstractN-3 polyunsaturated fatty acids (PUFA) and the numerous families of lipid mediators derived from them collectively regulate numerous biological processes. The mechanisms by which n-3 PUFA regulate biological processes begins with an understanding of the n-3 biosynthetic pathway that starts with alpha-linolenic acid (18:3n-3) and is commonly thought to end with the production of docosahexaenoic acid (DHA, 22:6n-3). However, our understanding of this pathway is not as complete as previous...
Source: Progress in Lipid Research - October 16, 2019 Category: Lipidology Source Type: research

The lipid metabolism in THRAUSTOCHYTRIDS
We describe the different pathways involved in lipid and fatty acid syntheses, emphasizing their specificity, and we report on the recent efforts aimed to engineer their lipid metabolism. (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - September 7, 2019 Category: Lipidology Source Type: research

ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review
Publication date: Available online 6 September 2019Source: Progress in Lipid ResearchAuthor(s): Xiaojun Feng, Lei Zhang, Suowen Xu, Ai-zong ShenAbstractATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis. Mendelian randomization of large human cohorts has validated ACLY as a promising target for low-density-lipoprotein-cholesterol (LDL-C) lowering and cardiovascular protection. Among current ACLY inhibitors, Bempedoic acid (ETC-1002) is a first-in-class, prodrug-based direct competitive inhibitor of ACLY w...
Source: Progress in Lipid Research - September 7, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: July 2019Source: Progress in Lipid Research, Volume 75Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - September 5, 2019 Category: Lipidology Source Type: research

Control of membrane lipid homeostasis by lipid-bilayer associated sensors: A mechanism conserved from bacteria to humans
Publication date: Available online 23 August 2019Source: Progress in Lipid ResearchAuthor(s): Diego de Mendoza, Marc PilonAbstractThe lipid composition of biological membranes is key for cell viability. Nevertheless, and despite their central role in cell function, our understanding of membrane physiology continues to lag behind most other aspects of cell biology. The maintenance of membrane properties in situations of environmental stress requires homeostatic sense-and-response mechanisms. For example, the balance between esterified saturated (SFAs) and unsaturated fatty acids (UFAs), is a key factor determining lipid pac...
Source: Progress in Lipid Research - August 24, 2019 Category: Lipidology Source Type: research

Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain
Publication date: Available online 21 August 2019Source: Progress in Lipid ResearchAuthor(s): Dušan Garić, Juan B. De Sanctis, Juhi Shah, Daciana Catalina Dumut, Danuta RadziochAbstractCeramides, the principal building blocks of all sphingolipids, have attracted the attention of many scientists around the world interested in developing treatments for cystic fibrosis, the most common genetic disease of Caucasians. Many years of fruitful research in this field have produced some fundamentally important, yet controversial results.Here, we aimed to summarize the current knowledge on the role of long- and very-long- cha...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Mammalian sphingoid bases: Biophysical, physiological and pathological properties
Publication date: Available online 22 August 2019Source: Progress in Lipid ResearchAuthor(s): A.C. Carreira, T.C. Santos, M.A. Lone, E. Zupančič, E. Lloyd-Evans, R.F.M. de Almeida, T. Hornemann, L.C. SilvaAbstractSphingoid bases encompass a group of long chain amino alcohols which form the essential structure of sphingolipids. Over the last years, these amphiphilic molecules were moving more and more into the focus of biomedical research due to their role as bioactive molecules. In fact, free sphingoid bases interact with specific receptors and target molecules and have been associated with numerous biological and physio...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Ceramide and sphingosine 1-phosphate in adipose dysfunction
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Zijian Fang, Susan Pyne, Nigel J. PyneAbstractThe increased adipose tissue mass of obese individuals enhances the risk of metabolic syndrome, type 2 diabetes and cardiovascular diseases. During pathological expansion of adipose tissue, multiple molecular controls of lipid storage, adipocyte turn-over and endocrine secretion are perturbed and abnormal lipid metabolism results in a distinct lipid profile. There is a role for ceramides and sphingosine 1-phosphate (S1P) in inducing adipose dysfunction. For instance, the alteration of ...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Lipidomic studies of membrane glycerolipids in plant leaves under heat stress
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Yasuhiro Higashi, Kazuki SaitoAbstractEnvironmental stresses cause membrane damage in terrestrial plants. Studies on the lipids obtained from these plants are required to understand their adaptation to climate change. Recently, a number of plant leaf lipidomic studies converged on the topic of chloroplastic glycerolipid remodeling and triacylglycerol production. In this review, we show that among various abiotic stresses, plant leaves under heat stress specifically increase the levels of galactolipids containing linoleate (18:2) i...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Ceramide synthases in cancer therapy and chemoresistance
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Sebastian Brachtendorf, Khadija El-Hindi, Sabine GröschAbstractDrug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity. In this review we sum up the cellular mechanisms regulated by CerS and the respective ceramides of specific chain length contributing to chemoresistance and how we can interfere w...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Health benefits of dietary marine DHA/EPA-enriched glycerophospholipids
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Tian-Tian Zhang, Jie Xu, Yu-Ming Wang, Chang-Hu XueAbstractA typical feature of marine foods is that they are rich in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which have formed a large-scale global industry. DHA/EPA phospholipids (PLs) are ubiquitous in marine foods and are the main DHA/EPA molecular forms in fish roe, shrimp and shellfish. Much attention has been focused on the bioavailability and health benefits that are influenced by the type and esterified form of dietary fatty acids. Recently, numerous find...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease
Publication date: Available online 21 August 2019Source: Progress in Lipid ResearchAuthor(s): Sudip Paul, Graeme I. Lancaster, Peter J. MeikleAbstractPlasmalogens are a class of membrane glycerophospholipids with unique properties. They contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and, typically, a polyunsaturated fatty acyl chain at the sn-2 position. Plasmalogens are critical for human health and have established roles in neuronal development, the immune response and as endogenous antioxidants. However, the mechanistic bases of these and other biological functions of plasmalogens...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Functional diversity of glycerolipid acylhydrolases in plant metabolism and physiology
Publication date: Available online 21 August 2019Source: Progress in Lipid ResearchAuthor(s): Kun Wang, Timothy P. Durrett, Christoph BenningAbstractMost current knowledge about plant lipid metabolism has focused on the biosynthesis of lipids and their transport between different organelles. However, lipid composition changes during development and in response to environmental cues often go beyond adjustments of lipid biosynthesis. When lipids have to be removed to adjust the extent of membranes during down regulation of photosynthesis, or lipid composition has to be adjusted to alter the biophysical properties of membrane...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

The biogenesis of lipid droplets: Lipids take center stage
Publication date: Available online 24 July 2019Source: Progress in Lipid ResearchAuthor(s): Mingming Gao, Xun Huang, Bao-Liang Song, Hongyuan YangAbstractLipid droplets (LDs) are multi-functional cellular organelles that store energy, and regulate many aspects of cell physiology. However, our understanding of the biogenesis of LDs remains very limited. Originating from the endoplasmic reticulum (ER), LDs are highly unique organelles in that each LD is bounded by a monolayer of amphipathic lipids. Recent progress has unveiled critical roles of non-bilayer lipids in LD formation. For instance, non-bilayer lipids such as lyso...
Source: Progress in Lipid Research - July 26, 2019 Category: Lipidology Source Type: research

Mammalian sphingoid bases: Biophysical, physiological and pathological properties
Publication date: Available online 25 May 2019Source: Progress in Lipid ResearchAuthor(s): A.C. Carreira, T.C. Santos, M.A. Lone, E. Zupančič, E. Lloyd-Evans, R.F.M. de Almeida, T. Hornemann, L.C. SilvaAbstractSphingoid bases encompass a group of long chain amino alcohols which form the essential structure of sphingolipids. Over the last years, these amphiphilic molecules were moving more and more into the focus of biomedical research due to their role as bioactive molecules. In fact, free sphingoid bases interact with specific receptors and target molecules and have been associated with numerous biological and physiolog...
Source: Progress in Lipid Research - May 26, 2019 Category: Lipidology Source Type: research

Functional diversity of glycerolipid acylhydrolases in plant metabolism and physiology
Publication date: Available online 9 May 2019Source: Progress in Lipid ResearchAuthor(s): Kun Wang, Timothy P. Durrett, Christoph BenningAbstractMost current knowledge about plant lipid metabolism has focused on the biosynthesis of lipids and their transport between different organelles. However, lipid composition changes during development and in response to environmental cues often go beyond adjustments of lipid biosynthesis. When lipids have to be removed to adjust the extent of membranes during down regulation of photosynthesis, or lipid composition has to be adjusted to alter the biophysical properties of membranes, o...
Source: Progress in Lipid Research - May 10, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: April 2019Source: Progress in Lipid Research, Volume 74Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - April 24, 2019 Category: Lipidology Source Type: research

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease
Publication date: Available online 8 April 2019Source: Progress in Lipid ResearchAuthor(s): Sudip Paul, Graeme I. Lancaster, Peter J. MeikleAbstractPlasmalogens are a class of membrane glycerophospholipids with unique properties. They contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and, typically, a polyunsaturated fatty acyl chain at the sn-2 position. Plasmalogens are critical for human health and have established roles in neuronal development, the immune response and as endogenous antioxidants. However, the mechanistic bases of these and other biological functions of plasmalogens a...
Source: Progress in Lipid Research - April 9, 2019 Category: Lipidology Source Type: research

Ceramide synthases in cancer therapy and chemoresistance
Publication date: Available online 4 April 2019Source: Progress in Lipid ResearchAuthor(s): Sebastian Brachtendorf, Khadija El-Hindi, Sabine GröschAbstractDrug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity. In this review we sum up the cellular mechanisms regulated by CerS and the respective ceramides of specific chain length contributing to chemoresistance and how we can interfere w...
Source: Progress in Lipid Research - April 5, 2019 Category: Lipidology Source Type: research

Ceramide and sphingosine 1-phosphate in adipose dysfunction
Publication date: Available online 2 April 2019Source: Progress in Lipid ResearchAuthor(s): Zijian Fang, Susan Pyne, Nigel J. PyneAbstractThe increased adipose tissue mass of obese individuals enhances the risk of metabolic syndrome, type 2 diabetes and cardiovascular diseases. During pathological expansion of adipose tissue, multiple molecular controls of lipid storage, adipocyte turn-over and endocrine secretion are perturbed and abnormal lipid metabolism results in a distinct lipid profile. There is a role for ceramides and sphingosine 1-phosphate (S1P) in inducing adipose dysfunction. For instance, the alteration of ce...
Source: Progress in Lipid Research - April 2, 2019 Category: Lipidology Source Type: research

Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain
Publication date: Available online 12 March 2019Source: Progress in Lipid ResearchAuthor(s): Dušan Garić, Juan B. De Sanctis, Juhi Shah, Daciana Catalina Dumut, Danuta RadziochAbstractCeramides, the principal building blocks of all sphingolipids, have attracted the attention of many scientists around the world interested in developing treatments for cystic fibrosis, the most common genetic disease of Caucasians. Many years of fruitful research in this field have produced some fundamentally important, yet controversial results.Here, we aimed to summarize the current knowledge on the role of long- and very-long- chai...
Source: Progress in Lipid Research - March 14, 2019 Category: Lipidology Source Type: research

Plant-based sterols and stanols in health & disease: “Consequences of human development in a plant-based environment?”
Publication date: Available online 26 February 2019Source: Progress in Lipid ResearchAuthor(s): J. Plat, S. Baumgartner, T. Vanmierlo, D. Lütjohann, K.L. Calkins, D.G. Burrin, G. Guthrie, C. Thijs, A.A. Te Velde, Vreugdenhil ACE, R. Sverdlov, J. Garssen, K. Wouters, E.A. Trautwein, T.G. Wolfs, C. van Gorp, M.T. Mulder, N.P. Riksen, A.K. Groen, R.P. MensinkAbstractDietary plant sterols and stanols as present in our diet and in functional foods are well-known for their inhibitory effects on intestinal cholesterol absorption, which translates into lower low-density lipoprotein cholesterol concentrations. However, emergin...
Source: Progress in Lipid Research - February 27, 2019 Category: Lipidology Source Type: research

Metabolic engineering for enhanced oil in biomass
Publication date: Available online 26 February 2019Source: Progress in Lipid ResearchAuthor(s): Thomas Vanhercke, John M. Dyer, Robert T. Mullen, Aruna Kilaru, Md. Mahbubur Rahman, James R. Petrie, Allan G. Green, Olga Yurchenko, Surinder P. SinghAbstractThe world is hungry for energy. Plant oils in the form of triacylglycerol (TAG) are one of the most reduced storage forms of carbon found in nature and hence represent an excellent source of energy. The myriad of applications for plant oils range across foods, feeds, biofuels, and chemical feedstocks as a unique substitute for petroleum derivatives. Traditionally, plant oi...
Source: Progress in Lipid Research - February 26, 2019 Category: Lipidology Source Type: research

Human milk fat substitutes: Past achievements and current trends
Publication date: Available online 20 February 2019Source: Progress in Lipid ResearchAuthor(s): Wei Wei, Qingzhe Jin, Xingguo WangAbstractThe first commercial infant formula, invented in 1867, contained lipids mainly from cow’s milk. We now know that human milk fat differs from the milk fat of other mammals and even more from vegetable oils. Human milk fat is one of the most complex natural lipid mixtures with a unique fatty acid composition, distribution, and numerous complex lipids. Therefore, to mimic human milk fat, human milk fat substitutes (HMFSs) have been produced through the enzymatic/chemical modification ...
Source: Progress in Lipid Research - February 21, 2019 Category: Lipidology Source Type: research

Hsp70 interactions with membrane lipids regulate cellular functions in health and disease
Publication date: Available online 30 January 2019Source: Progress in Lipid ResearchAuthor(s): Zsolt Balogi, Gabrielle Multhoff, Thomas Kirkegaard Jensen, Emyr Lloyd-Evans, Tetsumori Yamashima, Marja Jäättelä, John L. Harwood, László VíghAbstractBeyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates endocytosis, counteracts apoptotic mechanisms, sustains survival pathways or represents a signal that can...
Source: Progress in Lipid Research - January 30, 2019 Category: Lipidology Source Type: research

The lipid biochemistry of eukaryotic algae
Publication date: Available online 28 January 2019Source: Progress in Lipid ResearchAuthor(s): Yonghua Li-Beisson, Jay J. Thelen, Eric Fedosejevs, John L. HarwoodAbstractAlgal lipid metabolism fascinates both scientists and entrepreneurs due to the large diversity of fatty acyl structures that algae produce. Algae have therefore long been studied as sources of genes for novel fatty acids; and, due to their superior biomass productivity, algae are also considered a potential feedstock for biofuels. However, a major issue in a commercially viable “algal oil-to-biofuel” industry is the high production cost, becaus...
Source: Progress in Lipid Research - January 29, 2019 Category: Lipidology Source Type: research