Editorial Board
Publication date: July 2019Source: Progress in Lipid Research, Volume 75Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - September 5, 2019 Category: Lipidology Source Type: research

Control of membrane lipid homeostasis by lipid-bilayer associated sensors: A mechanism conserved from bacteria to humans
Publication date: Available online 23 August 2019Source: Progress in Lipid ResearchAuthor(s): Diego de Mendoza, Marc PilonAbstractThe lipid composition of biological membranes is key for cell viability. Nevertheless, and despite their central role in cell function, our understanding of membrane physiology continues to lag behind most other aspects of cell biology. The maintenance of membrane properties in situations of environmental stress requires homeostatic sense-and-response mechanisms. For example, the balance between esterified saturated (SFAs) and unsaturated fatty acids (UFAs), is a key factor determining lipid pac...
Source: Progress in Lipid Research - August 24, 2019 Category: Lipidology Source Type: research

Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain
Publication date: Available online 21 August 2019Source: Progress in Lipid ResearchAuthor(s): Dušan Garić, Juan B. De Sanctis, Juhi Shah, Daciana Catalina Dumut, Danuta RadziochAbstractCeramides, the principal building blocks of all sphingolipids, have attracted the attention of many scientists around the world interested in developing treatments for cystic fibrosis, the most common genetic disease of Caucasians. Many years of fruitful research in this field have produced some fundamentally important, yet controversial results.Here, we aimed to summarize the current knowledge on the role of long- and very-long- cha...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Mammalian sphingoid bases: Biophysical, physiological and pathological properties
Publication date: Available online 22 August 2019Source: Progress in Lipid ResearchAuthor(s): A.C. Carreira, T.C. Santos, M.A. Lone, E. Zupančič, E. Lloyd-Evans, R.F.M. de Almeida, T. Hornemann, L.C. SilvaAbstractSphingoid bases encompass a group of long chain amino alcohols which form the essential structure of sphingolipids. Over the last years, these amphiphilic molecules were moving more and more into the focus of biomedical research due to their role as bioactive molecules. In fact, free sphingoid bases interact with specific receptors and target molecules and have been associated with numerous biological and physio...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Ceramide and sphingosine 1-phosphate in adipose dysfunction
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Zijian Fang, Susan Pyne, Nigel J. PyneAbstractThe increased adipose tissue mass of obese individuals enhances the risk of metabolic syndrome, type 2 diabetes and cardiovascular diseases. During pathological expansion of adipose tissue, multiple molecular controls of lipid storage, adipocyte turn-over and endocrine secretion are perturbed and abnormal lipid metabolism results in a distinct lipid profile. There is a role for ceramides and sphingosine 1-phosphate (S1P) in inducing adipose dysfunction. For instance, the alteration of ...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Lipidomic studies of membrane glycerolipids in plant leaves under heat stress
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Yasuhiro Higashi, Kazuki SaitoAbstractEnvironmental stresses cause membrane damage in terrestrial plants. Studies on the lipids obtained from these plants are required to understand their adaptation to climate change. Recently, a number of plant leaf lipidomic studies converged on the topic of chloroplastic glycerolipid remodeling and triacylglycerol production. In this review, we show that among various abiotic stresses, plant leaves under heat stress specifically increase the levels of galactolipids containing linoleate (18:2) i...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Ceramide synthases in cancer therapy and chemoresistance
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Sebastian Brachtendorf, Khadija El-Hindi, Sabine GröschAbstractDrug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity. In this review we sum up the cellular mechanisms regulated by CerS and the respective ceramides of specific chain length contributing to chemoresistance and how we can interfere w...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Health benefits of dietary marine DHA/EPA-enriched glycerophospholipids
Publication date: Available online 20 August 2019Source: Progress in Lipid ResearchAuthor(s): Tian-Tian Zhang, Jie Xu, Yu-Ming Wang, Chang-Hu XueAbstractA typical feature of marine foods is that they are rich in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which have formed a large-scale global industry. DHA/EPA phospholipids (PLs) are ubiquitous in marine foods and are the main DHA/EPA molecular forms in fish roe, shrimp and shellfish. Much attention has been focused on the bioavailability and health benefits that are influenced by the type and esterified form of dietary fatty acids. Recently, numerous find...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease
Publication date: Available online 21 August 2019Source: Progress in Lipid ResearchAuthor(s): Sudip Paul, Graeme I. Lancaster, Peter J. MeikleAbstractPlasmalogens are a class of membrane glycerophospholipids with unique properties. They contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and, typically, a polyunsaturated fatty acyl chain at the sn-2 position. Plasmalogens are critical for human health and have established roles in neuronal development, the immune response and as endogenous antioxidants. However, the mechanistic bases of these and other biological functions of plasmalogens...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

Functional diversity of glycerolipid acylhydrolases in plant metabolism and physiology
Publication date: Available online 21 August 2019Source: Progress in Lipid ResearchAuthor(s): Kun Wang, Timothy P. Durrett, Christoph BenningAbstractMost current knowledge about plant lipid metabolism has focused on the biosynthesis of lipids and their transport between different organelles. However, lipid composition changes during development and in response to environmental cues often go beyond adjustments of lipid biosynthesis. When lipids have to be removed to adjust the extent of membranes during down regulation of photosynthesis, or lipid composition has to be adjusted to alter the biophysical properties of membrane...
Source: Progress in Lipid Research - August 22, 2019 Category: Lipidology Source Type: research

The biogenesis of lipid droplets: Lipids take center stage
Publication date: Available online 24 July 2019Source: Progress in Lipid ResearchAuthor(s): Mingming Gao, Xun Huang, Bao-Liang Song, Hongyuan YangAbstractLipid droplets (LDs) are multi-functional cellular organelles that store energy, and regulate many aspects of cell physiology. However, our understanding of the biogenesis of LDs remains very limited. Originating from the endoplasmic reticulum (ER), LDs are highly unique organelles in that each LD is bounded by a monolayer of amphipathic lipids. Recent progress has unveiled critical roles of non-bilayer lipids in LD formation. For instance, non-bilayer lipids such as lyso...
Source: Progress in Lipid Research - July 26, 2019 Category: Lipidology Source Type: research

Mammalian sphingoid bases: Biophysical, physiological and pathological properties
Publication date: Available online 25 May 2019Source: Progress in Lipid ResearchAuthor(s): A.C. Carreira, T.C. Santos, M.A. Lone, E. Zupančič, E. Lloyd-Evans, R.F.M. de Almeida, T. Hornemann, L.C. SilvaAbstractSphingoid bases encompass a group of long chain amino alcohols which form the essential structure of sphingolipids. Over the last years, these amphiphilic molecules were moving more and more into the focus of biomedical research due to their role as bioactive molecules. In fact, free sphingoid bases interact with specific receptors and target molecules and have been associated with numerous biological and physiolog...
Source: Progress in Lipid Research - May 26, 2019 Category: Lipidology Source Type: research

Functional diversity of glycerolipid acylhydrolases in plant metabolism and physiology
Publication date: Available online 9 May 2019Source: Progress in Lipid ResearchAuthor(s): Kun Wang, Timothy P. Durrett, Christoph BenningAbstractMost current knowledge about plant lipid metabolism has focused on the biosynthesis of lipids and their transport between different organelles. However, lipid composition changes during development and in response to environmental cues often go beyond adjustments of lipid biosynthesis. When lipids have to be removed to adjust the extent of membranes during down regulation of photosynthesis, or lipid composition has to be adjusted to alter the biophysical properties of membranes, o...
Source: Progress in Lipid Research - May 10, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: April 2019Source: Progress in Lipid Research, Volume 74Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - April 24, 2019 Category: Lipidology Source Type: research

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease
Publication date: Available online 8 April 2019Source: Progress in Lipid ResearchAuthor(s): Sudip Paul, Graeme I. Lancaster, Peter J. MeikleAbstractPlasmalogens are a class of membrane glycerophospholipids with unique properties. They contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and, typically, a polyunsaturated fatty acyl chain at the sn-2 position. Plasmalogens are critical for human health and have established roles in neuronal development, the immune response and as endogenous antioxidants. However, the mechanistic bases of these and other biological functions of plasmalogens a...
Source: Progress in Lipid Research - April 9, 2019 Category: Lipidology Source Type: research

Ceramide synthases in cancer therapy and chemoresistance
Publication date: Available online 4 April 2019Source: Progress in Lipid ResearchAuthor(s): Sebastian Brachtendorf, Khadija El-Hindi, Sabine GröschAbstractDrug resistance is one major reason for failure of cancer therapy. In the past 10 years, evidence emerged showing that ceramides of specific chain length, generated by six different ceramide synthases (CerS), are deregulated in different cancer types thereby influencing chemosensitivity. In this review we sum up the cellular mechanisms regulated by CerS and the respective ceramides of specific chain length contributing to chemoresistance and how we can interfere w...
Source: Progress in Lipid Research - April 5, 2019 Category: Lipidology Source Type: research

Ceramide and sphingosine 1-phosphate in adipose dysfunction
Publication date: Available online 2 April 2019Source: Progress in Lipid ResearchAuthor(s): Zijian Fang, Susan Pyne, Nigel J. PyneAbstractThe increased adipose tissue mass of obese individuals enhances the risk of metabolic syndrome, type 2 diabetes and cardiovascular diseases. During pathological expansion of adipose tissue, multiple molecular controls of lipid storage, adipocyte turn-over and endocrine secretion are perturbed and abnormal lipid metabolism results in a distinct lipid profile. There is a role for ceramides and sphingosine 1-phosphate (S1P) in inducing adipose dysfunction. For instance, the alteration of ce...
Source: Progress in Lipid Research - April 2, 2019 Category: Lipidology Source Type: research

Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain
Publication date: Available online 12 March 2019Source: Progress in Lipid ResearchAuthor(s): Dušan Garić, Juan B. De Sanctis, Juhi Shah, Daciana Catalina Dumut, Danuta RadziochAbstractCeramides, the principal building blocks of all sphingolipids, have attracted the attention of many scientists around the world interested in developing treatments for cystic fibrosis, the most common genetic disease of Caucasians. Many years of fruitful research in this field have produced some fundamentally important, yet controversial results.Here, we aimed to summarize the current knowledge on the role of long- and very-long- chai...
Source: Progress in Lipid Research - March 14, 2019 Category: Lipidology Source Type: research

Plant-based sterols and stanols in health & disease: “Consequences of human development in a plant-based environment?”
Publication date: Available online 26 February 2019Source: Progress in Lipid ResearchAuthor(s): J. Plat, S. Baumgartner, T. Vanmierlo, D. Lütjohann, K.L. Calkins, D.G. Burrin, G. Guthrie, C. Thijs, A.A. Te Velde, Vreugdenhil ACE, R. Sverdlov, J. Garssen, K. Wouters, E.A. Trautwein, T.G. Wolfs, C. van Gorp, M.T. Mulder, N.P. Riksen, A.K. Groen, R.P. MensinkAbstractDietary plant sterols and stanols as present in our diet and in functional foods are well-known for their inhibitory effects on intestinal cholesterol absorption, which translates into lower low-density lipoprotein cholesterol concentrations. However, emergin...
Source: Progress in Lipid Research - February 27, 2019 Category: Lipidology Source Type: research

Metabolic engineering for enhanced oil in biomass
Publication date: Available online 26 February 2019Source: Progress in Lipid ResearchAuthor(s): Thomas Vanhercke, John M. Dyer, Robert T. Mullen, Aruna Kilaru, Md. Mahbubur Rahman, James R. Petrie, Allan G. Green, Olga Yurchenko, Surinder P. SinghAbstractThe world is hungry for energy. Plant oils in the form of triacylglycerol (TAG) are one of the most reduced storage forms of carbon found in nature and hence represent an excellent source of energy. The myriad of applications for plant oils range across foods, feeds, biofuels, and chemical feedstocks as a unique substitute for petroleum derivatives. Traditionally, plant oi...
Source: Progress in Lipid Research - February 26, 2019 Category: Lipidology Source Type: research

Human milk fat substitutes: Past achievements and current trends
Publication date: Available online 20 February 2019Source: Progress in Lipid ResearchAuthor(s): Wei Wei, Qingzhe Jin, Xingguo WangAbstractThe first commercial infant formula, invented in 1867, contained lipids mainly from cow’s milk. We now know that human milk fat differs from the milk fat of other mammals and even more from vegetable oils. Human milk fat is one of the most complex natural lipid mixtures with a unique fatty acid composition, distribution, and numerous complex lipids. Therefore, to mimic human milk fat, human milk fat substitutes (HMFSs) have been produced through the enzymatic/chemical modification ...
Source: Progress in Lipid Research - February 21, 2019 Category: Lipidology Source Type: research

Hsp70 interactions with membrane lipids regulate cellular functions in health and disease
Publication date: Available online 30 January 2019Source: Progress in Lipid ResearchAuthor(s): Zsolt Balogi, Gabrielle Multhoff, Thomas Kirkegaard Jensen, Emyr Lloyd-Evans, Tetsumori Yamashima, Marja Jäättelä, John L. Harwood, László VíghAbstractBeyond guarding the cellular proteome the major stress inducible heat shock protein Hsp70 has been shown to interact with lipids. Non-cytosolic Hsp70 stabilizes membranes during stress challenges and, in pathophysiological states, facilitates endocytosis, counteracts apoptotic mechanisms, sustains survival pathways or represents a signal that can...
Source: Progress in Lipid Research - January 30, 2019 Category: Lipidology Source Type: research

The lipid biochemistry of eukaryotic algae
Publication date: Available online 28 January 2019Source: Progress in Lipid ResearchAuthor(s): Yonghua Li-Beisson, Jay J. Thelen, Eric Fedosejevs, John L. HarwoodAbstractAlgal lipid metabolism fascinates both scientists and entrepreneurs due to the large diversity of fatty acyl structures that algae produce. Algae have therefore long been studied as sources of genes for novel fatty acids; and, due to their superior biomass productivity, algae are also considered a potential feedstock for biofuels. However, a major issue in a commercially viable “algal oil-to-biofuel” industry is the high production cost, becaus...
Source: Progress in Lipid Research - January 29, 2019 Category: Lipidology Source Type: research

Editorial Board
Publication date: January 2019Source: Progress in Lipid Research, Volume 73Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - January 15, 2019 Category: Lipidology Source Type: research

Phytol metabolism in plants
Publication date: Available online 7 January 2019Source: Progress in Lipid ResearchAuthor(s): Katharina Gutbrod, Jill Romer, Peter DörmannAbstractPhytol, the prenyl side chain of chlorophyll, is derived from geranylgeraniol by reduction of three double bonds. Recent results demonstrated that the conversion of geranylgeraniol to phytol is linked to chlorophyll synthesis, which is catalyzed by protein complexes associated with the thylakoid membranes. One of these complexes contains light harvesting chlorophyll binding like proteins (LIL3), enzymes of chlorophyll synthesis (protoporphyrinogen oxidoreductase, POR; chloro...
Source: Progress in Lipid Research - January 8, 2019 Category: Lipidology Source Type: research

Biochemical studies of membrane fusion at the single-particle level
Publication date: Available online 3 January 2019Source: Progress in Lipid ResearchAuthor(s): Zhiqi Tian, Jihong Gong, Michael Crowe, Ming Lei, Dechang Li, Baohua Ji, Jiajie DiaoAbstractTo study membrane fusion mediated by synaptic proteins, proteoliposomes have been widely used for in vitro ensemble measurements with limited insights into the fusion mechanism. Single-particle techniques have proven to be powerful in overcoming the limitations of traditional ensemble methods. Here, we summarize current single-particle methods in biophysical and biochemical studies of fusion mediated by soluble N-ethylmaleimide-sensitive fa...
Source: Progress in Lipid Research - January 4, 2019 Category: Lipidology Source Type: research

Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis
Publication date: Available online 4 December 2018Source: Progress in Lipid ResearchAuthor(s): Xiao-Hua Yu, Da-Wei Zhang, Xi-Long Zheng, Chao-Ke TangAbstractAtherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is removed by the reverse cholesterol transport (RCT) pathway, representing a major antiatherogenic mechanism. In addition to the RCT, other pathways are required for maintaining the whole-body cholesterol homeostasis. Thus, we propose a working model of integrated cholesterol transport, termed t...
Source: Progress in Lipid Research - December 6, 2018 Category: Lipidology Source Type: research

Enzymes of glycerol-3-phosphate pathway in triacylglycerol synthesis in plants: Function, biotechnological application and evolution
Publication date: Available online 4 December 2018Source: Progress in Lipid ResearchAuthor(s): Felipe dos Santos Maraschin, Franceli Rodrigues Kulcheski, Ana Lucia Anversa Segatto, Thomaz Stumpf Trenz, Ossman Barrientos-Diaz, Marcia Margis-Pinheiro, Rogerio Margis, Andreia Carina Turchetto-ZoletAbstractTriacylglycerols (TAG) are the major form of energy storage in plants. TAG are primarily stored in seeds and fruits, but vegetative tissues also possess a high capacity for their synthesis and storage. These storage lipids are essential to plant development, being used in seedling growth during germination, pollen developmen...
Source: Progress in Lipid Research - December 4, 2018 Category: Lipidology Source Type: research

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
Publication date: Available online 22 November 2018Source: Progress in Lipid ResearchAuthor(s): Nikhlesh K. Singh, Gadiparthi N. RaoAbstract12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The in vitro studies have demonstrated the ability of 12/15-LOX metabolites in the expression of various genes and production of cytokine related to inflammation and resolution of inflammation....
Source: Progress in Lipid Research - November 23, 2018 Category: Lipidology Source Type: research

Plant lipids: Key players of plasma membrane organization and function
Publication date: Available online 19 November 2018Source: Progress in Lipid ResearchAuthor(s): Adiilah Mamode Cassim, Paul Gouguet, Julien Gronnier, Nelson Laurent, Véronique Germain, Magali Grison, Yohann Boutté, Patricia Gerbeau-Pissot, Françoise Simon-Plas, Sébastien MongrandAbstractThe plasma membrane (PM) is the biological membrane that separates the interior of all cells from the outside. The PM is constituted of a huge diversity of proteins and lipids. In this review, we will update the diversity of molecular species of lipids found in plant PM. We will further discuss how lipids govern ...
Source: Progress in Lipid Research - November 21, 2018 Category: Lipidology Source Type: research

Editorial Board
Publication date: October 2018Source: Progress in Lipid Research, Volume 72Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - November 14, 2018 Category: Lipidology Source Type: research

The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs
Publication date: Available online 17 September 2018Source: Progress in Lipid ResearchAuthor(s): Hartmut Kuhn, Lia Humeniuk, Nikita Kozlov, Sophie Roigas, Susan Adel, Dagmar HeydeckAbstractThe reaction specificity of lipoxygenases (ALOX) impacts the biological activity of these enzymes and also constitutes the decisive parameter for enzyme classification. ALOX15 orthologs, commonly known as 12/15-lipoxygenases, have recently been suggested to exhibit mainly arachidonic acid 12-lipoxygenating specificity in mammals ranked in evolution lower than gibbons and 15-lipoxygenating specificity in the higher ranking primates (Adel ...
Source: Progress in Lipid Research - September 17, 2018 Category: Lipidology Source Type: research

Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology
Publication date: Available online 6 September 2018Source: Progress in Lipid ResearchAuthor(s): Grace E. Lidgerwood, Stuart M. Pitson, Claudine Bonder, Alice PébayAbstractStem cells are unique in their ability to self-renew and differentiate into various cell types. Because of these features, stem cells are key to the formation of organisms and play fundamental roles in tissue regeneration and repair. Mechanisms controlling their fate are thus fundamental to the development and homeostasis of tissues and organs. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are bioactive phospholipids that play a wid...
Source: Progress in Lipid Research - September 7, 2018 Category: Lipidology Source Type: research

Properties, metabolism and roles of sulfogalactosylglycerolipid in male reproduction
Publication date: October 2018Source: Progress in Lipid Research, Volume 72Author(s): Nongnuj Tanphaichitr, Kessiri Kongmanas, Kym F. Faull, Julian Whitelegge, Federica Compostella, Naoko Goto-Inoue, James-Jules Linton, Brendon Doyle, Richard Oko, Hongbin Xu, Luigi Panza, Arpornrad SaewuAbstractSulfogalactosylglycerolipid (SGG, aka seminolipid) is selectively synthesized in high amounts in mammalian testicular germ cells (TGCs). SGG is an ordered lipid and directly involved in cell adhesion. SGG is indispensable for spermatogenesis, a process that greatly depends on interaction between Sertoli cells and TGCs. Spermatogenes...
Source: Progress in Lipid Research - August 31, 2018 Category: Lipidology Source Type: research

Properties, metabolisms and roles of sulfogalactosylglycerolipid in male reproduction
Publication date: Available online 25 August 2018Source: Progress in Lipid ResearchAuthor(s): Nongnuj Tanphaichitr, Kessiri Kongmanas, Kym F. Faull, Julian Whitelegge, Federica Compostella, Naoko Goto-Inoue, James-Jules Linton, Brendon Doyle, Richard Oko, Hongbin Xu, Luigi Panza, Arpornrad SaewuAbstractSulfogalactosylglycerolipid (SGG, aka seminolipid) is selectively synthesized in high amounts in mammalian testicular germ cells (TGCs). SGG is an ordered lipid and directly involved in cell adhesion. SGG is indispensable for spermatogenesis, a process that greatly depends on interaction between Sertoli cells and TGCs. Sperm...
Source: Progress in Lipid Research - August 25, 2018 Category: Lipidology Source Type: research

Lipid storage myopathies: Current treatments and future directions
Publication date: Available online 9 August 2018Source: Progress in Lipid ResearchAuthor(s): Emily R. Vasiljevski, Matthew A. Summers, David G. Little, Aaron SchindelerAbstractLipid storage myopathies (LSMs) are a heterogeneous group of genetic disorders that present with abnormal lipid storage in multiple body organs, typically muscle. Patients can clinically present with cardiomyopathy, skeletal muscle weakness, myalgia, and extreme fatigue. An early diagnosis is crucial, as some LSMs can be managed by simple nutraceutical supplementation. For example, high dosage l-carnitine is an effective intervention for patients wit...
Source: Progress in Lipid Research - August 10, 2018 Category: Lipidology Source Type: research

Editorial Board
Publication date: July 2018Source: Progress in Lipid Research, Volume 71Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - August 3, 2018 Category: Lipidology Source Type: research

Innovations in improving lipid production: Algal chemical genetics
Publication date: Available online 12 July 2018Source: Progress in Lipid ResearchAuthor(s): Nishikant Wase, Paul Black, Concetta DiRussoAbstractPerturbation of a biological system with small molecules to achieve a desired phenotype or activity is commonly referred as chemical genetics. In pharmaceutical discovery, this approach is most often employed in target-based screening but in plants systems the focus is primarily on phenotypic selection for commercially relevant phenotype generation such as crop improvement or disease and pathogen resistance. Likewise, algae are considered feedstock organisms for viable and sustaina...
Source: Progress in Lipid Research - July 13, 2018 Category: Lipidology Source Type: research

Editorial Board
Publication date: April 2018Source: Progress in Lipid Research, Volume 70Author(s): (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

Current trends to comprehend lipid metabolism in diatoms
Publication date: April 2018Source: Progress in Lipid Research, Volume 70Author(s): Nodumo Nokulunga Zulu, Krzysztof Zienkiewicz, Katharina Vollheyde, Ivo FeussnerAbstractDiatoms are the most dominant phytoplankton species in oceans and they continue to receive a great deal of attention because of their significant contributions in ecosystems and the environment. Due to triacylglycerol (TAG) profiles that are abundant in medium-chain fatty acids, diatoms have emerged to be better feed stocks for biofuel production, in comparison to the commonly studied green microalgal species (chlorophytes). Importantly, diatoms are also ...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

STAT3: The art of multi-tasking of metabolic and immune functions in obesity
Publication date: April 2018Source: Progress in Lipid Research, Volume 70Author(s): Wei Hu, Jianjun Lv, Mengzhen Han, Zhi Yang, Tian Li, Shuai Jiang, Yang YangAbstractSignal transducer and activator of transcription 3 (STAT3) is a transcription factor that has recently attracted increased attention. Accumulating studies have demonstrated that STAT3 plays an important role in various diseases, such as cancer and ischemic injury. In light of the distinctive effects of STAT3 on the regulation of metabolism and immune responses, we present the elaborate network of STAT3 in obesity. In this review, we first introduce the genera...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

Fat nucleosome: Role of lipids on chromatin
Publication date: April 2018Source: Progress in Lipid Research, Volume 70Author(s): Vinicius Fernandes, Kaian Teles, Camyla Ribeiro, Werner Treptow, Guilherme SantosAbstractStructural changes in chromatin regulate gene expression and define phenotypic outcomes. Molecules that bind to the nucleosome, the complex of DNA and histone proteins, are key modulators of chromatin structure. Most recently, the formation of condensed chromatin regions based on phase-separation in the cell, a basic physical mechanism, was proposed. Increased understanding of the mechanisms of interaction between chromatin and lipids suggest that small...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

Phytosterols and their derivatives: Structural diversity, distribution, metabolism, analysis, and health-promoting uses
Publication date: April 2018Source: Progress in Lipid Research, Volume 70Author(s): Robert A. Moreau, Laura Nyström, Bruce D. Whitaker, Jill K. Winkler-Moser, David J. Baer, Sarah K. Gebauer, Kevin B. HicksAbstractPhytosterols (plant sterols) occur in the cells of all plants. They are important structural components that stabilize the biological membranes of plants. Sterols can occur in the “free” unbound form or they can be covalently bound via an ester or glycosidic bond. Since our previous 2002 review on phytosterols and phytosterol conjugates, phytosterol glucosides have been found to be important stru...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health
Publication date: April 2018Source: Progress in Lipid Research, Volume 70Author(s): Manuel Rodriguez-Concepcion, Javier Avalos, M. Luisa Bonet, Albert Boronat, Lourdes Gomez-Gomez, Damaso Hornero-Mendez, M. Carmen Limon, Antonio J. Meléndez-Martínez, Begoña Olmedilla-Alonso, Andreu Palou, Joan Ribot, Maria J. Rodrigo, Lorenzo Zacarias, Changfu ZhuAbstractCarotenoids are lipophilic isoprenoid compounds synthesized by all photosynthetic organisms and some non-photosynthetic prokaryotes and fungi. With some notable exceptions, animals (including humans) do not produce carotenoids de novo but take them in ...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain
Publication date: July 2018Source: Progress in Lipid Research, Volume 71Author(s): Marc P. Baggelaar, Mauro Maccarrone, Mario van der SteltAbstract2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pa...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

Sphingolipid hydroxylation in mammals, yeast and plants – An integrated view
Publication date: July 2018Source: Progress in Lipid Research, Volume 71Author(s): Joaquim Trigo Marquês, H. Susana Marinho, Rodrigo F.M. de AlmeidaAbstractThis review is focused on sphingolipid backbone hydroxylation, a small but widespread structural feature with profound impact on membrane biophysical properties. We start by summarizing sphingolipid metabolism in mammalian cells, yeast and plants, focusing on how distinct hydroxylation patterns emerge in different eukaryotic kingdoms. Then, a comparison of the biophysical properties in membrane model systems and cellular membranes from diverse organisms is made. F...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

The phosphatidic acid paradox: Too many actions for one molecule class? Lessons from plants
Publication date: July 2018Source: Progress in Lipid Research, Volume 71Author(s): Igor Pokotylo, Volodymyr Kravets, Jan Martinec, Eric RuellandAbstractPhosphatidic acid (PA) is a simple phospholipid observed in most organisms. PA acts as a key metabolic intermediate and a second messenger that regulates many cell activities. In plants, PA is involved in numerous cell responses induced by hormones, stress inputs and developmental processes. Interestingly, PA production can be triggered by opposite stressors, such as cold and heat, or by hormones that are considered to be antagonistic, such as abscisic acid and salicylic ac...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

High density lipoprotein cholesterol and cancer: Marker or causative?
Publication date: July 2018Source: Progress in Lipid Research, Volume 71Author(s): Matteo Pirro, Biagio Ricciuti, Daniel J. Rader, Alberico L. Catapano, Amirhossein Sahebkar, Maciej BanachAbstractThe relationship between high-density lipoproteins (HDLs), HDL-cholesterol (HDLC) and cancer incidence and mortality is controversial. Although most studies conducted so far, including well-designed prospective studies and meta-analyses, have revealed a significant inverse association between HDL-C levels and cancer risk, several confounding factors and opposite results showing either a direct or an inverse association between HDL...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

Milk lipidomics: What we know and what we don't
Publication date: July 2018Source: Progress in Lipid Research, Volume 71Author(s): Zhiqian Liu, Simone Rochfort, Ben CocksAbstractBovine milk contains 3–5% of fat, of which the dominant portion (about 98%) is in the form of triacylglycerols, whereas polar lipids such as glycerophospholipids and sphingolipids are minor components (0.5–1%) of milk fat. Milk fat is thought to contain several thousand lipid species, making it the most complex material in nature in terms of lipid composition. Significant progress has been made in the past two decades in the identification and quantification of lipid species of milk ...
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research

Contemporary lipidomic analytics: opportunities and pitfalls
Discussion of the main sequences in a lipidomics workflow will be presented, including preparation of samples, accurate quantitation of lipid species and statistical modelling. (Source: Progress in Lipid Research)
Source: Progress in Lipid Research - July 10, 2018 Category: Lipidology Source Type: research