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Total 51210 results found since Jan 2013.

Transradial versus transfemoral access for mechanical thrombectomy in acute ischemic stroke: A retrospective cohort study
The objective of this study was  to compare procedural and clinical outcomes in patients with acute ischemic stroke (AIS) treated via transradial access (TRA) mechanical thrombectomy (MT) versus conventional transfemoral access (TFA).
Source: Journal of Stroke and Cerebrovascular Diseases - August 31, 2023 Category: Neurology Authors: Leonard H. Verhey, Andres Restrepo Orozco, Marion Oliver, Leah Lyons, Andrea P. Sewell, Jenny P-C Tsai, Paul Mazaris, Muhib Khan, Justin A. Singer Source Type: research

Factors associated with hemorrhagic transformation after endovascular treatment despite early recanalization
To identify new factors associated with hemorrhagic transformation (HT) despite early recanalization in patients with acute ischemic stroke treated with mechanical thrombectomy.
Source: Journal of the Neurological Sciences - August 30, 2023 Category: Neurology Authors: Antonio Ciacciarelli, Agostino Tessitore, Giulia Fiume, Carmelo Tiberio Curr ò, Alessandra Coglitore, Anna Gardin, Fabrizio Giammello, Francesco Grillo, Mirta Longo, Enrico Mormina, Concetto Fabio Vecchio, Davide Vicari, Rosa Fortunata Musolino, Antonio Source Type: research

Diagnosis of atrial fibrillation in young patients with ischemic stroke: A systematic review and meta-analysis
The recommended cardiac rhythm evaluation to determine the etiology of ischemic stroke (IS) is similar in all patients regardless of their age and includes an electrocardiogram and at least a 24-hour heart rhythm monitoring. However, it is known that the main causes of IS vary according to patients ’ age. There is a higher preponderance of arterial dissections and patent foramen ovale in younger patients, while atrial fibrillation (AF) is more common in older patients.
Source: Journal of Stroke and Cerebrovascular Diseases - August 30, 2023 Category: Neurology Authors: Joana V ítor, Gonçalo V. Bonifácio, Ana Catarina Fonseca Source Type: research

Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
In this study, we investigated the expression and activati on of inflammasome components in protoplasmic and fibrous astrocytes under ischemic conditions. We found that both protoplasmic and fibrous astrocytes expressed a differential increase in inflammasome protein components, and that their activation promoted maturation of IL-1β and IL-18, and secretio n of IL-1β, as well as initiating apoptotic and pyroptotic cell death. Pharmacological inhibition of caspase-1 decreased expression of cleaved caspase-1 and production of mature IL-1β, and protected against inflammasome-mediated apoptotic and pyroptotic cell death. Ov...
Source: NeuroMolecular Medicine - August 30, 2023 Category: Neurology Source Type: research

Comparison of three measures for insomnia in ischemic stroke patients: Pittsburgh sleep quality index, insomnia severity index, and Athens insomnia scale
ConclusionEach of the three questionnaires has advantages and disadvantages when assessing insomnia. In the evaluation of insomnia in IS patients, the best questionnaire selection should be made according to the purpose of clinical evaluation and considering the sensitivity and specificity.
Source: Frontiers in Neurology - August 30, 2023 Category: Neurology Source Type: research

Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
In this study, we investigated the expression and activati on of inflammasome components in protoplasmic and fibrous astrocytes under ischemic conditions. We found that both protoplasmic and fibrous astrocytes expressed a differential increase in inflammasome protein components, and that their activation promoted maturation of IL-1β and IL-18, and secretio n of IL-1β, as well as initiating apoptotic and pyroptotic cell death. Pharmacological inhibition of caspase-1 decreased expression of cleaved caspase-1 and production of mature IL-1β, and protected against inflammasome-mediated apoptotic and pyroptotic cell death. Ov...
Source: NeuroMolecular Medicine - August 30, 2023 Category: Neurology Source Type: research

Dysregulated Genes and Signaling Pathways in the Formation and Rupture of Intracranial Aneurysm
AbstractIntracranial aneurysm (IA) has the potential to rupture. Despite scientific advances, we are still not in a position to screen patients for IA and identify those at risk of rupture. It is critical to comprehend the molecular basis of disease to facilitate the development of novel diagnostic strategies. We used transcriptomics to identify the dysregulated genes and understand their role in the disease biology. In particular, RNA-Seq was performed in tissue samples of controls, unruptured IA, and ruptured IA. Dysregulated genes (DGs) were identified and analyzed to understand the functional aspects of molecules. Subs...
Source: Translational Stroke Research - August 30, 2023 Category: Neurology Source Type: research

Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury by down-regulating miR-155-5p
CONCLUSION: Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury by regulating the YY1/p53/miR-155-5p axis.PMID:37642006 | DOI:10.2174/1567202620666230828092916
Source: Current Neurovascular Research - August 29, 2023 Category: Neurology Authors: Xuejing Li Ying Wang Xiang Zhou Hui Wang Jiang Xu Source Type: research

Prediction of hospitalization time and independence level with functional outcomes for patients with acute stroke: a retrospective study
The objective of this study was to develop predictive models for estimating the length of stay (LOS) with standardized clinical outcome measures (Functional Independence Measure, Trunk Impairment Scale, Postural Assessment Scale for Stroke Patients, Fugl Meyer Assessment Scale, and Functional Ambulation Category) during acute care setting.METHODS: One hundred sixty-nine patients were included in the retrospective study. Predictors chosen for the LOS included scores of functional outcome measures at admission. We used Spearman's rank correlation coefficients to calculate correlations among clinical outcome measures and LOS,...
Source: Neurological Research - August 29, 2023 Category: Neurology Authors: Asalet Ayb üke Güp Özge Ipek Dongaz Dilara Özen Oruk Emrah Emre Deveci Banu Bayar K ılıçhan Bayar Source Type: research

Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury by down-regulating miR-155-5p
CONCLUSION: Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury by regulating the YY1/p53/miR-155-5p axis.PMID:37642006 | DOI:10.2174/1567202620666230828092916
Source: Current Neurovascular Research - August 29, 2023 Category: Neurology Authors: Xuejing Li Ying Wang Xiang Zhou Hui Wang Jiang Xu Source Type: research

Prediction of hospitalization time and independence level with functional outcomes for patients with acute stroke: a retrospective study
The objective of this study was to develop predictive models for estimating the length of stay (LOS) with standardized clinical outcome measures (Functional Independence Measure, Trunk Impairment Scale, Postural Assessment Scale for Stroke Patients, Fugl Meyer Assessment Scale, and Functional Ambulation Category) during acute care setting.METHODS: One hundred sixty-nine patients were included in the retrospective study. Predictors chosen for the LOS included scores of functional outcome measures at admission. We used Spearman's rank correlation coefficients to calculate correlations among clinical outcome measures and LOS,...
Source: Neurological Research - August 29, 2023 Category: Neurology Authors: Asalet Ayb üke Güp Özge Ipek Dongaz Dilara Özen Oruk Emrah Emre Deveci Banu Bayar K ılıçhan Bayar Source Type: research

Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury by down-regulating miR-155-5p
CONCLUSION: Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury by regulating the YY1/p53/miR-155-5p axis.PMID:37642006 | DOI:10.2174/1567202620666230828092916
Source: Current Neurovascular Research - August 29, 2023 Category: Neurology Authors: Xuejing Li Ying Wang Xiang Zhou Hui Wang Jiang Xu Source Type: research