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Specialty: Neurology
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Total 51210 results found since Jan 2013.
Sleep duration and risk of stroke and coronary heart disease: a 9-year community-based prospective study of 0.5 million Chinese adults
There is uncertainty about the optimum sleep duration for risk of different subtypes of stroke and ischaemic heart disease.
Source: BMC Neurology - September 14, 2023 Category: Neurology Authors: Yiping Chen, Christiana Kartsonaki, Robert Clarke, Yu Guo, Huaidong Du, Canqing Yu, Ling Yang, Pei Pei, Rebecca Stevens, Sushila Burgess, Yujie Hua, Junshi Chen, Jun Lv, Liming Li and Zhengming Chen Tags: Research article Source Type: research
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
AbstractActivated microglia play dual roles in ischemic stroke (IS) according to its polarization states. Herein, we investigated the function of circPTP4A2 in regulating microglia polarization in IS. IS models were established by MACO/R and OGD/R treatment. TTC staining was employed to detect cerebral infarct size. Cell vitality was measured using CCK-8 assay. CD16 and CD206 levels were examined using flow cytometry. The interactions between circPTP4A2, miR-20b-5p, and YTHDF1 were analyzed by dual-luciferase reporter gene, RIP, or RNA pull-down assays. circPTP4A2 was upregulated in IS patients. circPTP4A2 knockdown allevi...
Source: NeuroMolecular Medicine - September 14, 2023 Category: Neurology Source Type: research
Aspiration thrombectomy with the Penumbra System for patients with stroke and late onset to treatment: a subset analysis of the COMPLETE registry
ConclusionFor patients with AIS due to anterior circulation LVO and with late onset to treatment, aspiration thrombectomy with the Penumbra System appears to be safe and effective. The rates of good functional outcome and all-cause mortality from this study compared favorably with those rates from the medical management arms of the DAWN and DEFUSE-3 studies.Clinical trial registrationhttps://www.clinicaltrials.gov, NCT03464565.
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research
Development and validation of a nomogram for the risk prediction of malignant cerebral edema after acute large hemispheric infarction involving the anterior circulation
ConclusionOur nomogram based on LASSO-logistic regression is accurate and useful for the early prediction of MCE after LHI. This model can serve as a precise and practical tool for clinical decision-making in patients with LHI who may require aggressive therapeutic approaches.
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research
Predictors of failure of early neurological improvement in early time window following endovascular thrombectomy: a multi-center study
ConclusionDiabetes mellitus history, pre-stroke mRS, longer last known well-to-puncture time, lack of modified thrombolysis in cerebral infarction = 3, and the number of mechanical thrombectomy passes are the predictors of FENI. Future large-scale studies are required to validate these findings.
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
AbstractActivated microglia play dual roles in ischemic stroke (IS) according to its polarization states. Herein, we investigated the function of circPTP4A2 in regulating microglia polarization in IS. IS models were established by MACO/R and OGD/R treatment. TTC staining was employed to detect cerebral infarct size. Cell vitality was measured using CCK-8 assay. CD16 and CD206 levels were examined using flow cytometry. The interactions between circPTP4A2, miR-20b-5p, and YTHDF1 were analyzed by dual-luciferase reporter gene, RIP, or RNA pull-down assays. circPTP4A2 was upregulated in IS patients. circPTP4A2 knockdown allevi...
Source: NeuroMolecular Medicine - September 14, 2023 Category: Neurology Source Type: research
Characteristics and outcomes of unknown onset stroke: The Japan Stroke Data Bank
This study aimed to investigate and describe the characteristics and clinical outcomes of patients with UOS.
Source: Journal of the Neurological Sciences - September 13, 2023 Category: Neurology Authors: Shinichi Wada, Sohei Yoshimura, Kazunori Toyoda, Michikazu Nakai, Yusuke Sasahara, Kaori Miwa, Junpei Koge, Akiko Ishigami, Masayuki Shiozawa, Kuniaki Ogasawara, Takanari Kitazono, Shigeru Nogawa, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Kazuo Minematsu, Ma Source Type: research
Web-based psychoeducational interventions for managing cognitive impairment –a systematic review
ConclusionWeb-based cognitive intervention programs are a new approach to rehabilitation and patient education. The evidence, although scarce, shows that web-based interventions are feasible and support subjective cognitive functioning. However, the literature to date is extremely limited and the quality of the studies is weak. More research with high-quality study designs is needed.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=257315, identifier: CRD42021257315.
Source: Frontiers in Neurology - September 13, 2023 Category: Neurology Source Type: research
Treatment of Stroke at a Delayed Timepoint with a Repurposed Drug Targeting Sigma 1 Receptors
In this study, we hypothesized that oral oxeladin citrate would stimulate BDNF secretion and improve stroke outcomes when administered to male rats starting 48 h after transient middle cerebral artery occlusion. Oxeladin did not alter blood clotting and crossed the blood brain barrier within 30 min of oral administration. Rats underwent 90 min of transient middle cerebral artery occlusion. Forty-eight hours later rats began receiving daily oxeladin (13 5 mg/kg) for 11 days. Oxeladin significantly improved neurological function on days 3, 7, and 14 following MCAO. Infarct size was not altered by a single dose, but the...
Source: Translational Stroke Research - September 13, 2023 Category: Neurology Source Type: research
Corticospinal tract: a new hope for the treatment of post-stroke spasticity
AbstractStroke is the third leading cause of death and disability worldwide. Post-stroke spasticity (PSS) is the most common complication of stroke but represents only one of the many manifestations of upper motor neuron syndrome. As an upper motor neuron, the corticospinal tract (CST) is the only direct descending motor pathway that innervates the spinal motor neurons and is closely related to the recovery of limb function in patients with PSS. Therefore, promoting axonal remodeling in the CST may help identify new therapeutic strategies for PSS. In this review, we outline the pathological mechanisms of PSS, specifically ...
Source: Acta Neurologica Belgica - September 13, 2023 Category: Neurology Source Type: research
Prediction of stress-related gastrointestinal bleeding in patients with aneurysmal subarachnoid hemorrhage using caudate Hounsfield unit value in ASPECT score
ConclusionAmong aSAH patients, lower right caudate HU values indicated a higher risk of developing SRGB. Our findings provide further evidence for the relationship between the gastrointestinal system and the brain.
Source: Frontiers in Neurology - September 13, 2023 Category: Neurology Source Type: research
Case report: Fatal ischemic stroke induced by unruptured traumatic intracranial vertebral artery dissection
Intracranial vertebral artery dissection (IVAD) is rare and potentially fatal due to the risk of secondary subarachnoid hemorrhage once ruptured. Unruptured traumatic IVAD is even rarer and can result in ischemic stroke, yet mostly benign when timely diagnosed. Herein, we present an uncommon case of a patient who underwent a fatal ischemic stroke induced by unruptured traumatic IVAD. The patient was symptomatic soon after being physically assaulted but left untreated until acute deterioration for multiple brain infarctions occurred, secondary to IVAD-induced cerebellar stroke. Fifteen days later, he died, regardless of an ...
Source: Frontiers in Neurology - September 12, 2023 Category: Neurology Source Type: research
Prognostic value of contrast staining on dual-energy CT after endovascular therapy in acute ischemic stroke: a meta-analysis
Contrast staining (CS) on dual-energy CT (DECT) is common after endovascular therapy (EVT) in acute ischemic stroke (AIS). We performed a meta-analysis to investigate the prognostic significance of CS detected...
Source: BMC Neurology - September 12, 2023 Category: Neurology Authors: Fan Yang, Yi Zeng, Fei Zhu and Xiaoyan Hu Tags: Research Source Type: research
Synergy-based functional electrical stimulation and robotic-assisted for retraining reach-to-grasp in stroke: a study protocol for a randomized controlled trial
Stroke survivors have long-term upper limb impairment, which impacts the quality of life (QOL) and social reintegration, but there is lack of effective therapeutic strategies and novel technologies. Customized...
Source: BMC Neurology - September 12, 2023 Category: Neurology Authors: Huan-xia Zhou, Jun Hu, Rui-sheng Yun, Zhong-zhi Zhao, Ming-hui Lai, Li-hui-zi Sun and Kai-liang Luo Tags: Study Protocol Source Type: research
Personalised simulation of hemodynamics in cerebrovascular disease: lessons learned from a study of diagnostic accuracy
In this study, we performed the first quantitative validation of a simulation-based precision medicine framework to assess cerebral hemodynamics in patients with ICAD against clinical standard perfusion imaging. In a retrospective analysis, we used a 0-dimensional simulation model to detect brain areas that are hemodynamically vulnerable to subsequent stroke. The main outcome measures were sensitivity, specificity, and area under the receiver operating characteristics curve (ROC AUC) of the simulation to identify brain areas vulnerable to subsequent stroke as defined by quantitative measurements of relative mean transit ti...
Source: Frontiers in Neurology - September 12, 2023 Category: Neurology Source Type: research
