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Condition: Thrombosis
Procedure: Heart Valve Surgery

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Total 230 results found since Jan 2013.

Paradoxical Increase of Stroke in Patients with Defect of High Molecular Weight Multimers of the von Willebrand Factors following Transcatheter Aortic Valve Replacement.
CONCLUSION:  MLBCs and CT-ADP > 180 seconds were identified as predictors for ischemic stroke or TIA. The present study suggests that the defects of HMW multimers of the VWFs may contribute not only to bleeding events but also to thrombotic events. PMID: 32726854 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 28, 2020 Category: Hematology Authors: Matsushita K, Marchandot B, Trimaille A, Kibler M, Heger J, Peillex M, Hess S, Grunebaum L, Reydel A, Kindo M, Hoang MT, Sato C, De Poli F, Leddet P, Ohana M, Jesel L, Ohlmann P, Susen S, Morel O Tags: Thromb Haemost Source Type: research

Surgical left atrial appendage occlusion in patients with atrial fibrillation undergoing mechanical heart valve replacement.
CONCLUSIONS: Concomitant SLAAO and MHVR was associated with longer length of stay, and cardiopulmonary bypass time and aortic cross-clamp time, but was not associated with additional protective effects against thromboembolic events and mortality during the 14-month follow-up. PMID: 32740149 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - July 23, 2020 Category: General Medicine Authors: Zheng Y, Rao CF, Chen SP, He L, Hou JF, Zheng Z Tags: Chin Med J (Engl) Source Type: research

Novel oral anticoagulant vs. warfarin in elderly atrial fibrillation patients with normal, mid ‐range, and reduced left ventricular ejection fraction
ConclusionsIn elderly AF patients ≥65 years, using NOAC was associated with lower IS/SE compared with warfarin in normal and mid‐range LVEF but not in reduced LVEF. Using NOACs was associated with lower death compared with warfarin in normal LVEF.
Source: ESC Heart Failure - July 15, 2020 Category: Cardiology Authors: Victor Chien ‐Chia Wu, Chun‐Li Wang, Cheng‐Hung Lee, Yu‐Ling Chen, Hui‐Tzu Tu, Michael Wu, Chang‐Fu Kuo, Shao‐Wei Chen, Yu‐Tung Huang, Ming‐Shien Wen, Shang‐Hung Chang Tags: Original Research Article Source Type: research

Minimally invasive, simplified double ‐layer left atrial appendage closure
AbstractThe left atrial appendage (LAA) has been identified as a site of thrombus formation in the heart and as a source of embolism in patients with atrial fibrillation, leading to stroke. Studies suggest that LAA closure may reduce the risk for stroke and the need for anticoagulation; conversely, incomplete closure can increase the stroke risk almost 12 ‐fold. Because open heart surgery is associated with increased risk for subsequent stroke, surgeons generally prefer to close the LAA during heart surgery, as recommended in current atrial fibrillation management guidelines. Building on trends toward minimally invasive ...
Source: Journal of Cardiac Surgery - June 11, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Ahmed Alnajar, Corinne Aberle, Joseph Lamelas Tags: SURGICAL TECHNIQUE Source Type: research

Sinus of Valsalva Thrombosis Detected on Computed Tomography after Transcatheter Aortic Valve Replacement.
CONCLUSIONS: Cardiac CT after TAVR can detect sinus of Valsalva thrombosis, and attention should be paid to this potential source of subsequent systemic embolization. PMID: 32281322 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - April 14, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Landmark Phase 3 VOYAGER PAD Study of XARELTO ® (rivaroxaban) Plus Aspirin Shows Significant Benefit in Patients with Symptomatic Peripheral Artery Disease (PAD) after Lower-Extremity Revascularization
RARITAN, NJ, March 28, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the VOYAGER PAD study met its primary efficacy and principal safety endpoints, demonstrating the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily) plus aspirin (100 mg once daily) was superior to aspirin alone in reducing the risk of major adverse limb and cardiovascular (CV) events by 15 percent in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization, with similar rates of TIMI[1] major bleeding. VOYAGER PAD is the only study to show a significant benefit using...
Source: Johnson and Johnson - March 28, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Highlights Continued Commitment to Cardiovascular & Metabolic Healthcare Solutions with Late-Breaking Data at the First Fully Virtual American College of Cardiology Scientific Session
RARITAN, N.J., March 20, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that it will unveil late-breaking data from its leading cardiovascular and metabolism portfolio during the virtual American College of Cardiology’s 69th Annual Scientific Session together with the World Congress of Cardiology (ACC.20/WCC) on March 28-30, 2020. Notably, four late-breaking abstracts for XARELTO® (rivaroxaban) will be presented, including data from the Phase 3 VOYAGER PAD study in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization.Click to Tweet: Jan...
Source: Johnson and Johnson - March 20, 2020 Category: Pharmaceuticals Source Type: news

Thrombolysis for Acute Ischemic Stroke Following Transcatheter Aortic Valve Replacement: Case Report and Literature Review
Conclusion: Previously undescribed, we suggest that tPA should be considered for post-TAVR AIS patients who otherwise satisfy inclusion and exclusion criteria.
Source: The Neurologist - March 1, 2020 Category: Neurology Tags: Case Report/Case Series Source Type: research

Commentary: Subclinical valve thrombosis —Are all transcatheter aortic valves created equal?
Transcatheter aortic valve insertion (TAVI) technology presents new opportunities but also new challenges, including subclinical valve thrombosis (SCVT). In this edition of the Journal, Woldendorp and colleagues1 report a meta-analysis investigating SCVT after TAVI focusing on prevalence, predisposing factors, management, and consequences. Twelve studies that screened for SCVT using multidetector computed tomography (MDCT) were included comparing stroke risk between patients with SCVT and those without, as well as the effects of antiplatelet therapy and oral anticoagulation (OAC) on preventing SCVT.
Source: The Journal of Thoracic and Cardiovascular Surgery - February 20, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Sajiram Sarvananthan, Clifford William Barlow Tags: Commentary Source Type: research

Subclinical valve thrombosis in transcatheter aortic valve implantation: A systematic review and meta-analysis.
Recent high-resolution CT studies after transcatheter aortic valve insertion (TAVI) have reported high prevalence of subclinical valve thrombosis (SCVT), potentially contributing to increased risk of late stroke. We aimed to investigate SCVT after TAVI patients with focus on prevalence, predisposing factors, management, and potential sequelae.
Source: The Journal of Thoracic and Cardiovascular Surgery - February 18, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Kei Woldendorp, Mathew P. Doyle, Deborah Black, Martin Ng, Anthony Keech, Stuart Grieve, Paul G. Bannon Source Type: research

Valve-Sparing Root Replacement vs Composite Valve Grafting in Aortic Root Dilation: A Meta-Analysis
ConclusionsAortic valve sparing appears to be safe, and associated with reduced late mortality, thromboembolism/stroke and bleeding compared with composite valve grafting. Late durability is equivalent. Aortic valve sparing should be considered in patients with favorable aortic valve morphology.Graphical abstract
Source: The Annals of Thoracic Surgery - January 23, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research

Valve-Sparing Root Replacement vs Composite Valve Grafting in Aortic Root Dilation: A Meta-Analysis.
CONCLUSIONS: Aortic valve sparing appears to be safe, and associated with reduced late mortality, thromboembolism/stroke and bleeding compared with composite valve grafting. Late durability is equivalent. Aortic valve sparing should be considered in patients with favorable aortic valve morphology. PMID: 31981499 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - January 21, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Elbatarny M, Tam DY, Edelman JJ, Rocha RV, Chu MWA, Peterson MD, El-Hamamsy I, Appoo JJ, Friedrich JO, Boodhwani M, Yanagawa B, Ouzounian M, Canadian Thoracic Aortic Collaborative (CTAC) Investigators Tags: Ann Thorac Surg Source Type: research

Aortic valve calcification as a risk factor for major complications and reduced survival after transcatheter replacement
Aortic valve calcification is supposed to be a possible cause of embolic stroke or subclinical valve thrombosis after transcatheter aortic valve replacement (TAVR). We aimed to assess the role of aortic valve calcification in the occurrence of in-hospital clinical complications and survival after TAVR.
Source: Journal of Cardiovascular Computed Tomography - December 6, 2019 Category: Radiology Authors: Francesco Pollari, Wolfgang Hitzl, Ferdinand Vogt, Michela Cuomo, Johannes Schwab, Claudius S öhn, Jurij M. Kalisnik, Christian Langhammer, Thomas Bertsch, Theodor Fischlein, Steffen Pfeiffer Source Type: research

The Use of Embolic Protection Devices During Transcatheter Aortic Valve Implantation.
Authors: Shiyovich A, Kornowski R Abstract BACKGROUND: Aortic stenosis (AS) is a common valvular pathology and is increasing in prevalence. Severe symptomatic AS is associated with serious outcomes if left untreated. Transcatheter aortic valve implantation (TAVI) is an innovative modality, which has revolutionized the treatment of AS. With growing experience and technological upgrades, TAVI has become a valid alternative to surgical valve replacement. However, TAVI is associates with increase non-negligible risks of mortality, stroke, physical disability, and healthcare expenditures. Furthermore, imaging modalities...
Source: The Israel Medical Association Journal - September 24, 2019 Category: General Medicine Tags: Isr Med Assoc J Source Type: research