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Condition: Thrombosis
Procedure: Coronary Artery Bypass Graft

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Total 89 results found since Jan 2013.

Hybrid Coronary Revascularization The Best of 2 Worlds? ∗
As early as 1997, Michael Mack’s essay discussed the outlook for the possibility of hybrid revascularization with the emergence of minimally invasive coronary surgery combining the off-pump and minimally invasive direct coronary artery bypass (MIDCAB) techniques with percutaneous coronary intervention (PCI) to a non-left anterior descending (LAD) artery target (1). Since that time, coronary surgery and PCI technology have evolved even more. Off-pump coronary artery bypass surgery and MIDCAB surgery have been established in clinical practice and, with the development of drug-eluting stents, a new era of PCI was born. Desp...
Source: Journal of the American College of Cardiology - July 18, 2016 Category: Cardiology Source Type: research

Real ‐World Multicenter Registry of Patients with Severe Coronary Artery Calcification Undergoing Orbital Atherectomy
ConclusionIn the largest real‐world study of patients who underwent orbital atherectomy, including high‐risk patients who were not surgical candidates as well as those with very complex coronary anatomy, acute and short‐term adverse clinical event rates were low. A randomized clinical trial is needed to identify the ideal treatment strategy for patients with severe CAC.
Source: Journal of Interventional Cardiology - June 29, 2016 Category: Cardiology Authors: Michael S. Lee, Evan Shlofmitz, Barry Kaplan, Dragos Alexandru, Perwaiz Meraj, Richard Shlofmitz Tags: Original Investigation Source Type: research

A comparison of red blood cell transfusion utilization between anti ‐factor Xa and activated partial thromboplastin monitoring in patients receiving unfractionated heparin
ConclusionAnti‐Xa was associated with a significant reduction in RBC transfusions when compared to patients monitored by aPTT alone.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 30, 2016 Category: Hematology Authors: K.W. Belk, M. Laposata, C. Craver Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

A comparison of red blood cell transfusion utilization between anti-factor Xa and activated partial thromboplastin monitoring in patients receiving unfractionated heparin.
CONCLUSION: Anti-Xa was associated with a significant reduction in RBC transfusions when compared to patients monitored by aPTT alone. This article is protected by copyright. All rights reserved. PMID: 27543785 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 19, 2016 Category: Hematology Authors: Belk KW, Laposata M, Craver C Tags: J Thromb Haemost Source Type: research

Twenty ‐five year outcomes following composite graft aortic root replacement
ConclusionsComposite graft aortic root replacement is associated with low operative risk, excellent long‐term survival, and low incidence of reoperation and late events.
Source: Journal of Cardiac Surgery - November 30, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Salvior C.M. Mok, Wei ‐Guo Ma, Ahmed Mansour, Paris Charilaou, Alan S. Chou, Sven Peterss, Maryann Tranquilli, Bulat A. Ziganshin, John A. Elefteriades Tags: Original Article Source Type: research

Predictors of Atrial Fibrillation After Coronary Artery Bypass Grafting: A  Bayesian Analysis
Conclusions This prospective Bayesian analysis identified five independent preoperative predictors of POAF after isolated CABG with cardiopulmonary bypass: CHA2DS2-VASc score, severe obesity, preoperative β-blocker use, preoperative antiplatelet therapy, and renal failure. The main interest in the CHA2DS2-VASc score as a predictor of POAF is that it is a simple and widely used bedside tool. Patients with these independent predictors of POAF may constitute a target population to test preventive strategies, such as non-antiarrhythmic and antiarrhythmic drugs.
Source: The Annals of Thoracic Surgery - December 18, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research

Cangrelor reduces the risk of ischemic complications in patients with single and multi-vessel disease undergoing PCI: insights from the CHAMPION PHOENIX Trial
Conclusion In the CHAMPION-PHOENIX trial, MVD and SVD patients had similar ischemic outcomes at 48hours and 30days. Cangrelor consistently reduced ischemic complications in both SVD and MVD patients without a significant increase in GUSTO severe bleeding. Clinical Perspectives. What's known? Cangrelor is a novel, intravenous, potent, and rapidly-acting P2Y12 inhibitor, that has been demonstrated to reduce the rate of ischemic events at 48hours in patients who received PCI compared with clopidogrel. What's new? In contrast to prior studies, we found that in this modern cohort, patients with SVD and MVD had a similar risk of...
Source: American Heart Journal - March 9, 2017 Category: Cardiology Source Type: research

Cangrelor reduces the risk of ischemic complications in patients with single-vessel and multi-vessel disease undergoing percutaneous coronary intervention: Insights from the CHAMPION PHOENIX trial
Conclusion In the CHAMPION PHOENIX trial, MVD and SVD patients had similar ischemic outcomes at 48hours and 30days. Cangrelor consistently reduced ischemic complications in both SVD and MVD patients without a significant increase in GUSTO severe bleeding. Clinical perspectives What's known? Cangrelor is a novel, intravenous, potent, and rapidly acting P2Y12 inhibitor that has been demonstrated to reduce the rate of ischemic events at 48hours in patients who received PCI compared with clopidogrel. What's new? In contrast to prior studies, we found that in this modern cohort, patients with SVD and MVD had a similar risk of i...
Source: American Heart Journal - April 18, 2017 Category: Cardiology Source Type: research

Patients with atrial fibrillation and coronary artery disease – Double trouble
Publication date: March 2018 Source:Advances in Medical Sciences, Volume 63, Issue 1 Author(s): Ewelina Michniewicz, Elżbieta Mlodawska, Paulina Lopatowska, Anna Tomaszuk-Kazberuk, Jolanta Malyszko Coronary artery disease (CAD) is the most common cardiovascular disease while atrial fibrillation (AF) is the most common cardiac arrhythmia. Both diseases share associated risk factors – hypertension, diabetes mellitus, sleep apnea, obesity and smoking. Moreover, inflammation plays a causative role in both diseases. The prevalence of CAD in patients with AF is from 17% to 46.5% while the prevalence of AF among patients with...
Source: Advances in Medical Sciences - August 17, 2017 Category: Biomedical Science Source Type: research

Patients with atrial fibrillation and coronary artery disease - Double trouble.
Abstract Coronary artery disease (CAD) is the most common cardiovascular disease while atrial fibrillation (AF) is the most common cardiac arrhythmia. Both diseases share associated risk factors - hypertension, diabetes mellitus, sleep apnea, obesity and smoking. Moreover, inflammation plays a causative role in both diseases. The prevalence of CAD in patients with AF is from 17% to 46.5% while the prevalence of AF among patients with CAD is low and it is estimated from 0.2% to 5%. AF is a well-established factor of poor short- and long-term prognosis in patients with acute myocardial infarction (AMI) and is associ...
Source: Advances in Medical Sciences - August 14, 2017 Category: Biomedical Science Authors: Michniewicz E, Mlodawska E, Lopatowska P, Tomaszuk-Kazberuk A, Malyszko J Tags: Adv Med Sci Source Type: research

Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study
ConclusionAt one year, clinical outcomes with the SYNTAX-II strategy were associated with improved clinical results compared to the PCI performed in comparable patients from the original SYNTAX-I trial. Longer term follow-up is awaited and a randomized clinical trial with contemporary CABG is warranted.ClinicalTrials.gov IdentifierNCT02015832
Source: European Heart Journal - August 26, 2017 Category: Cardiology Source Type: research

Outcomes of primary percutaneous coronary intervention in acute myocardial infarction due to unprotected left main thrombosis: The Asia ‐Pacific Left Main ST‐Elevation Registry (ASTER)
ConclusionsSTEMI from culprit unprotected left main coronary artery stenosis is associated with significant mortality and morbidity. Emergency PCI provides an important treatment option in this high‐risk group, but in‐hospital mortality remains high.
Source: Journal of Interventional Cardiology - November 16, 2017 Category: Cardiology Authors: Jonathan Yap, Gagan D. Singh, Jung ‐Sun Kim, Krishan Soni, Kelvin Chua, Alvin Neo, Choong Hou Koh, Ehrin J. Armstrong, Stephen W. Waldo, Kendrick A. Shunk, Reginald I. Low, Myeong‐Ki Hong, Yangsoo Jang, Khung Keong Yeo Tags: ORIGINAL INVESTIGATION Source Type: research

Dual antiplatelet therapy at discharge: Antiplatelet practice patterns after coronary artery bypass grafting, surgical anecdote is driving standard of care
Thrombosis and platelet aggregation are key pathogenic mechanisms in acute coronary syndromes (ACS). Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor has been demonstrated to reduce death from cardiovascular causes, nonfatal myocardial infarction, and stroke after ACS.1-3 These large randomized controlled trials studied heterogeneous populations of patients with ACS treated with medical therapy, percutaneous coronary intervention, or coronary bypass grafting (CABG). The data supporting DAPT after CABG are less robust and limited to observational studies, subgroup analyses, and smaller randomized studies ...
Source: The Journal of Thoracic and Cardiovascular Surgery - November 8, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Mark Helmers, Pavan Atluri Tags: Editorial commentary Source Type: research

Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia.
CONCLUSIONS: ARC was significantly associated with future MACE in Japanese patients with heterozygous FH. ARC may start to develop, on average, at 17.4 and 19.7 years of age in males and females, respectively, with heterozygous FH. PMID: 29321389 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - January 14, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Left Atrial Appendage Occlusion for Prevention of Thromboembolic Events
More than 600  000 patients in the United States undergo cardiac operations each year, including coronary artery bypass graft operations, valve repair or replacement procedures, or other more complex operations. Patients with atrial fibrillation (AF) who undergo these procedures are at risk for postoperative th romboembolic complications, with the left atrial appendage being a common site of thrombus formation. Occlusion of the left atrial appendage may reduce the risk of thromboembolic stroke and can be performed intraoperatively at the time of cardiac operations. The most common surgical approaches to ac hieve left atr...
Source: JAMA - January 23, 2018 Category: General Medicine Source Type: research