Predictors of Atrial Fibrillation After Coronary Artery Bypass Grafting: A  Bayesian Analysis

Conclusions This prospective Bayesian analysis identified five independent preoperative predictors of POAF after isolated CABG with cardiopulmonary bypass: CHA2DS2-VASc score, severe obesity, preoperative β-blocker use, preoperative antiplatelet therapy, and renal failure. The main interest in the CHA2DS2-VASc score as a predictor of POAF is that it is a simple and widely used bedside tool. Patients with these independent predictors of POAF may constitute a target population to test preventive strategies, such as non-antiarrhythmic and antiarrhythmic drugs.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research

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AbstractThis is a letter to the Editor concerning the recently published article by Zerem et al. The paper described a 12yo female with multisystem mitochondrial disorder (MID) due to the compound heterozygous variants c.1963_1964dupAT and p.Ile382Met inOPA1 manifesting phenotypically with congenital nystagmus, developmental delay, visual impairment, gait ataxia, epilepsy, a stroke-like episode (SLE) with encephalopathy and vomiting, and hearing impairment. This interesting case could be more meaningful by providing more information about the treatment of the SLE/stroke-like lesion (SLL), about the morphological characteri...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
AbstractFat-mass and obesity-associated protein (Fto) plays important roles in energy metabolism. It also acts as a demethylase and is most abundantly found in the brain. In the present study, we examined the spatial and temporal changes of Fto immunoreactivity after five minutes of transient forebrain ischemia in the hippocampus. In the control group, Fto immunoreactivity was mainly observed in the nucleus of pyramidal cells in the CA1 and CA3 regions as well as the polymorphic layer, granule cell layer, and subgranular zone of the dentate gyrus. Fto immunoreactivity was transiently, but not significantly, increased in th...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
High blood pressure: A common diagnosis, that shows hardly any symptoms, but can be deadly. Hardened arteries and blood forced too hard against artery walls can lead to a heart attack or stroke. Fortunately, there are lifestyle improvements that can lower blood pressure and potentially save your life.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Abbott Laboratories has been wildly successful with its FreeStyle Libre continuous glucose monitor (CGM) since winning FDA approval in 2017, but it seems some investors and patients may be getting restless as the U.S. market waits for the second-generation of the blockbuster technology. We first noted some signs of impatience for Libre 2 in our coverage of Abbott's third-quarter earnings call in October. One reader commented on that article that "I don’t particularly care about investors becoming impatient, as a Freestyle Libre user I am growing impatie...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
ConclusionsThese findings suggest that MXYF inhibits autophagy after OGD/R-induced PC12 cell injury through the AMPK-mTOR pathway. Thus, MXYF might have therapeutic potential in treating ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionLig exerts renoprotective functions in an animal model of DN mediated by antioxidant action, inhibition of apoptosis, anti-inflammatory action, reduction of renal fibrosis, reduction of the proliferation of mesangial cells, inhibition of endotheliosis, inhibition of atherosclerosis and promotion of renal autophagy. The positive conclusion should be treated cautiously because of various methodological flaws. Further studies are recommended according to ARRIVE guidelines. The method of modeling with high-dose STZ should be avoided and improved STZ modeling schemes are recommended. Considering the large dosage range...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
TYPE 2 diabetes is a chronic condition that may require you to forgo your favourite treats to stave off the risks posed by rising blood sugar levels. Certain foods may seem healthy on the surface but contain hidden risks that can send blood sugar soaring, including a popular breakfast item.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
No abstract available
Source: Neurology Today - Category: Neurology Tags: For Your Patients Source Type: research
In this study, using a mouse model of ischemic strokevia transient middle cerebral artery occlusion (tMCAO), we found that Hes1 was induced following brain injury, and that siRNA-mediated knockdown of Hes1 increased the cerebral infarction and worsened the neurological outcome, suggesting that Hes1 knockdown exacerbates ischemic stroke. In addition, mechanistically, Hes1 knockdown promoted apoptosis and activated the PERK/eIF2 α/ATF4/CHOP signaling pathway after tMCAO. These results suggest that Hes1 knockdown promotes ER stress-induced apoptosis. Furthermore, inhibition of PERK with the specific inhibitor GSK2606414...
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
Publication date: Available online 22 January 2020Source: Food BioscienceAuthor(s): Chengcheng Zhao, Jing Miao, Xia Li, Xuetao Chen, Xinhui Mao, Ying Wang, Xiangmei Hua, Wenyuan GaoAbstractChaenomeles speciosa (CS) and Crataegus pinnatifida (CP) are two common Chinese fruits with health benefits. The effect of in vitro digestion on the chemical composition, antioxidant activity and α-glucosidase inhibitory activity of these two fruits, as well as the accessibilities of their active compounds were studied. The inhibitory effects on starch digestion of CS, CP and the 5 identified compounds also were measured. It was ob...
Source: Food Bioscience - Category: Food Science Source Type: research
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