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Condition: Thrombosis
Procedure: Coronary Artery Bypass Graft

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Total 89 results found since Jan 2013.

Plasma Ceramides: A Novel Predictor of Major Adverse Cardiovascular Events After Coronary Angiography.
CONCLUSIONS: Elevated plasma concentrations of ceramides are independently associated with major adverse cardiovascular events in patients with and without coronary artery disease. PMID: 29903731 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 14, 2018 Category: Cardiology Authors: Meeusen JW, Donato LJ, Bryant SC, Baudhuin LM, Berger PB, Jaffe AS Tags: Arterioscler Thromb Vasc Biol Source Type: research

One-year efficacy and safety of routine prasugrel in patients with acute coronary syndromes treated with percutaneous coronary intervention: results of the prospective rijnmond collective cardiology research study.
CONCLUSIONS: In routine practice, a tailored approach of prasugrel prescription in ACS patients undergoing PCI, resulted in low ischaemic and low bleeding rates up to 1 year post PCI. PMID: 29931649 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - June 21, 2018 Category: Cardiology Authors: Yetgin T, Boersma E, Smits PC, de Vries AG, Huijskens E, Zijlstra F, van der Linden MMJM, van Geuns RJM, CCR Study Investigators Tags: Neth Heart J Source Type: research

Patients with atrial fibrillation and coronary artery disease – Double trouble
Publication date: March 2018Source: Advances in Medical Sciences, Volume 63, Issue 1Author(s): Ewelina Michniewicz, Elżbieta Mlodawska, Paulina Lopatowska, Anna Tomaszuk-Kazberuk, Jolanta MalyszkoAbstractCoronary artery disease (CAD) is the most common cardiovascular disease while atrial fibrillation (AF) is the most common cardiac arrhythmia. Both diseases share associated risk factors – hypertension, diabetes mellitus, sleep apnea, obesity and smoking. Moreover, inflammation plays a causative role in both diseases. The prevalence of CAD in patients with AF is from 17% to 46.5% while the prevalence of AF among patients...
Source: Advances in Medical Sciences - July 5, 2018 Category: Biomedical Science Source Type: research

Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.
CONCLUSION:  We identified the association of a genetic polymorphism in the intergenic region of SPRY2 with a decreased incidence of thrombocytopenia after CABG surgery. Because SPRY2-an endogenous receptor tyrosine kinase inhibitor-is present in platelets and modulates essential signalling pathways, these findings support a role for SPRY2 as a novel modulator of platelet responses after cardiac surgery. PMID: 30103242 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 13, 2018 Category: Hematology Authors: Karhausen JA, Qi W, Smeltz AM, Li YJ, Shah SH, Kraus WE, Mathew JP, Podgoreanu MV, Kertai MD, Duke Perioperative Genetics Safety Outcomes (PEGASUS) Investigative Team Tags: Thromb Haemost Source Type: research

Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial
Publication date: Available online 25 August 2018Source: The LancetAuthor(s): Marco Valgimigli, Enrico Frigoli, Sergio Leonardi, Pascal Vranckx, Martina Rothenbühler, Matteo Tebaldi, Ferdinando Varbella, Paolo Calabrò, Stefano Garducci, Paolo Rubartelli, Carlo Briguori, Giuseppe Andó, Maurizio Ferrario, Ugo Limbruno, Roberto Garbo, Paolo Sganzerla, Filippo Russo, Marco Nazzaro, Alessandro Lupi, Bernardo CorteseSummaryBackgroundThe Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox (MATRIX) programme was designed to assess the comparative safety and effectiveness of ra...
Source: The Lancet - August 25, 2018 Category: General Medicine Source Type: research

Cannabis Use Disorder and Perioperative Outcomes in Major Elective Surgeries A Retrospective Cohort Analysis
Conclusions An active cannabis use disorder is associated with an increased perioperative risk of myocardial infarction.Editor ’s PerspectiveWhat We Already Know about This TopicCannabis is known to have cardiovascular and psychoactive effectsThe association between active cannabis use disorder and postoperative outcomes remains unclearWhat This Article Tells Us That Is NewIn the United States, administrative data demonstrate that cannabis use disorder has increased in prevalence from 2010 to 2015Active cannabis use disorder is not associated with a change in overall perioperative morbidity, mortality, length of stay, or...
Source: Anesthesiology - March 10, 2020 Category: Anesthesiology Source Type: research

Blood lactate predicts survival after percutaneous implantation of extracorporeal life support for refractory cardiac arrest or cardiogenic shock complicating acute coronary syndrome: insights from the CareGem registry
AbstractRefractory cardiogenic shock (RCS) or refractory cardiac arrest (RCA) complicating acute coronary syndrome (ACS) is associated with extremely high mortality rate. Veno-arterial extracorporeal life support (VA-ECLS) represents a valuable therapeutic option to stabilize patients ’ condition before or at the time of emergency revascularization. We analyzed 29 consecutive patients with RCS or RCA complicating ACS, and implanted with VA-ECLS in two centers who have adopted a similar, structured approach to ECLS implantation. Data were collected from January 2010 to December 2015 and ECLS had to be percutaneously impla...
Source: Internal and Emergency Medicine - August 8, 2020 Category: Emergency Medicine Source Type: research

The COMPASS trial: practical considerations for application after coronary artery bypass surgery
Purpose of review We review the cardiovascular outcomes for people using anticoagulation strategies (COMPASS) trial with particular emphasis on patients with a history of remote coronary artery bypass grafting (CABG) and those who were enrolled 4–14 days after CABG. We provide practical guidance for selecting patients with the greatest potential to benefit who have acceptable bleeding risk. In particular, we address concerns about postoperative bleeding and discuss the relative merits of rivaroxaban and aspirin versus P2Y12 inhibition and aspirin. Recent findings The COMPASS trial demonstrated that rivaroxaban and a...
Source: Current Opinion in Cardiology - August 13, 2020 Category: Cardiology Tags: COMPLEX ISSUES IN CORONARY REVASCULARIZATION: Edited by Bobby Yanagawa and Subodh Verma Source Type: research

Net Adverse Clinical Events With Antiplatelet Therapy in Acute Coronary Syndromes
Clopidogrel, prasugrel, and ticagrelor are oral platelet P2Y12 receptor inhibitors that decrease the risk of platelet-mediated coronary artery thrombosis. Clinical guidelines have recommended ticagrelor or prasugrel over clopidogrel in combination with aspirin as dual antiplatelet therapy (DAPT) for 1 year after acute coronary syndrome (ACS), whether or not percutaneous coronary intervention (PCI) is performed. The ticagrelor recommendation was based on the Study of Platelet Inhibition and Patient Outcomes (PLATO) trial, which enrolled 18  624 patients with ACS and randomized them to receive DAPT with either clopidogrel ...
Source: JAMA - October 27, 2020 Category: General Medicine Source Type: research

Improved outcomes in CABG patients with atrial fibrillation associated with surgical left atrial appendage exclusion
ConclusionsConcomitant LAA exclusion via an epicardial closure device is associated with reduced CABG mortality, thromboembolic events, and readmissions in patients with pre ‐existing atrial fibrillation.
Source: Journal of Cardiac Surgery - January 24, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Edward G. Soltesz, Krish C. Dewan, Louise H. Anderson, Michael A. Ferguson, A. M. Gillinov Tags: ORIGINAL ARTICLE Source Type: research

Toward stroke ‐free coronary surgery: The role of the anaortic off‐pump bypass technique
AbstractSurgical coronary revascularization remains the preferred strategy in a significant portion of patients with coronary artery disease due to superior long ‐term outcomes. However, there is a significant risk of perioperative neurologic injury that has influenced guideline recommendations. These complications occur in 1%–5% of patients, ranging from overt neurologic deficits with permanent disability, to subtle cerebral defects noted on neuroimagin g that may result in slow cognitive and functional decline. The primary mechanism by which these events occur is thromboembolism from manipulation of the ascending aor...
Source: Journal of Cardiac Surgery - January 27, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Fabio Ramponi, Michael Seco, Russel John Legay Brereton, Mario F. L. Gaudino, John D. Puskas, Antonio M. Calafiore, Michael P. Vallely Tags: REVIEW ARTICLE Source Type: research

Improved outcomes in CABG patients with atrial fibrillation associated with surgical left atrial appendage exclusion
ConclusionsConcomitant LAA exclusion via an epicardial closure device is associated with reduced CABG mortality, thromboembolic events, and readmissions in patients with pre ‐existing atrial fibrillation.
Source: Journal of Cardiac Surgery - March 13, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Edward G. Soltesz, Krish C. Dewan, Louise H. Anderson, Michael A. Ferguson, A. M. Gillinov Tags: ORIGINAL ARTICLE Source Type: research

Toward stroke ‐free coronary surgery: The role of the anaortic off‐pump bypass technique
AbstractSurgical coronary revascularization remains the preferred strategy in a significant portion of patients with coronary artery disease due to superior long ‐term outcomes. However, there is a significant risk of perioperative neurologic injury that has influenced guideline recommendations. These complications occur in 1%–5% of patients, ranging from overt neurologic deficits with permanent disability, to subtle cerebral defects noted on neuroimagin g that may result in slow cognitive and functional decline. The primary mechanism by which these events occur is thromboembolism from manipulation of the ascending aor...
Source: Journal of Cardiac Surgery - March 13, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Fabio Ramponi, Michael Seco, Russel John Legay Brereton, Mario F. L. Gaudino, John D. Puskas, Antonio M. Calafiore, Michael P. Vallely Tags: REVIEW ARTICLE Source Type: research

Internal Mammary Artery and Its Resilience to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316256. doi: 10.1161/ATVBAHA.121.316256. Online ahead of print.ABSTRACTFueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic disease driven by a wide spectrum of factors, including cholesterol, pressure, and disturbed flow. Although all arterial beds encounter a similar atherogenic milieu, the development of atheromatous lesions occurs discontinuously across the vascular system. Indeed, the in...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Simon Kraler Peter Libby Paul C Evans Alexander Akhmedov Martin O Schmiady Michael Reinehr Giovanni G Camici Thomas F L üscher Source Type: research