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Condition: Heart Attack
Procedure: Coronary Artery Bypass Graft

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Total 1114 results found since Jan 2013.

Vorapaxar in Acute Coronary Syndrome Patients Undergoing Coronary Artery Bypass Graft Surgery Subgroup Analysis From the TRACER Trial (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome)
ConclusionsIn non–ST-segment elevation acute coronary syndrome patients undergoing CABG, vorapaxar was associated with a significant reduction in ischemic events and no significant increase in major CABG-related bleeding. These data show promise for protease-activated receptor 1 antagonism in patients undergoing CABG and warrant confirmatory evidence in randomized trials. (Trial to Assess the Effects of SCH 530348 in Preventing Heart Attack and Stroke in Patients With Acute Coronary Syndrome [TRA·CER] [Study P04736AM3]; NCT00527943)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - March 17, 2014 Category: Cardiology Source Type: research

CABG versus PCI in diabetic patients with multivessel disease after risk stratification by the SYNTAX score: A pooled analysis of the SYNTAX and FREEDOM trials
The 2010 European guidelines for myocardial revascularization indicate coronary artery bypass grafting (CABG) as a class I recommendation for patients with stable coronary multivessel disease (MVD), regardless of the angiographic burden reflected by the SYNTAX score . In contrast, percutaneous coronary intervention (PCI) is contraindicated (class III) in patients with MVD and intermediate to high (>22) SYNTAX score, while it is considered reasonable (class IIa) in patients with MVD and low (0–22) SYNTAX score. Recently, in the 2013 European guidelines on the management of patients with diabetes mellitus, PCI for MVD has ...
Source: International Journal of Cardiology - April 3, 2014 Category: Cardiology Authors: Davide Capodanno, Piera Capranzano, Corrado Tamburino Tags: Letters to the Editor Source Type: research

Angiographic success and procedural complications in patients undergoing retrograde percutaneous coronary chronic total occlusion interventions: A weighted meta-analysis of 3482 patients from 26 studies
Conclusions: Retrograde CTO PCI is associated with high procedural success rate and acceptable risk for procedural complications.
Source: International Journal of Cardiology - April 25, 2014 Category: Cardiology Authors: Abdallah El Sabbagh, Vishal G. Patel, Omar M. Jeroudi, Tesfaldet T. Michael, Mohammed E. Alomar, Owen Mogabgab, Eric Fuh, Michele Roesle, Bavana V. Rangan, Shuaib Abdullah, Jeffrey L. Hastings, Jerrold Grodin, Dharam J. Kumbhani, Dimitrios Alexopoulos, Pa Tags: Reviews Source Type: research

Comparison of bypass surgery and drug-eluting stenting in diabetic patients with left main and/or multivessel disease: A systematic review and meta-analysis of randomized and nonrandomized studies.
CONCLUSIONS: CABG for patients with diabetes mellitus and LM and/or MVD had advantages over PCI-DES in all-cause death, nonfatal MI, and repeat revascularization, but the substantial disadvantage in nonfatal stroke. The high-selected patients (RCTs) risked a higher mortality than the real-world patients (OCTs). PMID: 24846507 [PubMed - as supplied by publisher]
Source: Cardiology Journal - May 20, 2014 Category: Cardiology Authors: Huang F, Lai W, Chan C, Peng H, Zhang F, Zhou Y, Teng S, Huang Z Tags: Cardiol J Source Type: research

Coronary artery bypass grafting versus drug‐eluting stents in patients with severe coronary artery disease and diabetes mellitus: a systematic review and meta‐analysis
ConclusionsFor patients with diabetes mellitus and severe coronary artery disease, CABG was superior to DES in that it significantly improve overall and MACCE‐free survival rate and reduce incidences of myocardial infarction and repeat revascularization in the long‐term follow‐up, although it was associated with more perioperative risks and a higher incidence of stroke. Therefore, CABG should remain the gold standard for these patients.
Source: Journal of Diabetes - June 3, 2014 Category: Endocrinology Authors: Yi‐cheng Wu, Ting‐wei Su, Jian‐feng Zhang, Wei‐feng Shen, Guang Ning, Ye Kong Tags: Original Article Source Type: research

Clinical implications of new-onset left bundle branch block after transcatheter aortic valve replacement: analysis of the PARTNER experience
Conclusion Persistent, new-onset LBBB occurred in 10.5% of patients without intraventricular baseline conduction who underwent TAVR in the PARTNER experience. New LBBB was not associated with death, repeat hospitalization, stroke, or myocardial infarction at 1 year, but was associated with a higher rate of PPI and failure of left ventricular ejection fraction to improve.
Source: European Heart Journal - June 21, 2014 Category: Cardiology Authors: Nazif, T. M., Williams, M. R., Hahn, R. T., Kapadia, S., Babaliaros, V., Rodes-Cabau, J., Szeto, W. Y., Jilaihawi, H., Fearon, W. F., Dvir, D., Dewey, T. M., Makkar, R. R., Xu, K., Dizon, J. M., Smith, C. R., Leon, M. B., Kodali, S. K. Tags: TAVI Source Type: research

Does off-pump coronary revascularization confer superior organ protection in re-operative coronary artery surgery? a meta-analysis of observational studies
Off-pump coronary artery bypass surgery (OPCAB) has been hypothesised to be beneficial in the high-risk patient population undergoing re-operative coronary artery bypass graft surgery (CABG). In addition, this technique has been demonstrated to provide subtle benefits in end-organ function including heart, lungs and kidney. The aims of this study were to assess whether OPCAB is associated with a lower incidence of major adverse cardiovascular and cerebrovascular events (MACCE) and other adverse outcomes in re-operative coronary surgery. Twelve studies, incorporating 3471 patients were identified by systematic literature re...
Source: Journal of Cardiothoracic Surgery - June 24, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Amir SepehripourLeanne HarlingHutan AshrafianRoberto CasulaThanos Athanasiou Source Type: research

Clinical and Economic Burden in Patients with Diagnosis of Peripheral Arterial Disease in a Claims Database in Japan.
Abstract PURPOSE: The effect of peripheral arterial disease (PAD) among young and middle-aged adults can be significant, but no previous study has examined the prognosis and the associated health care cost of the disease in this population. We evaluated the clinical and economic burden of PAD in patients from a large claims database to clarify the effect of the disease on a relatively young working Japanese population. METHODS: Patients aged ≥45 and ≤64 years with first PAD diagnosis between 2005 and 2011 comprised the PAD cohort (n = 362); an age- and sex-matched non-PAD comparison cohort (n = 362) was a...
Source: Clinical Therapeutics - July 7, 2014 Category: Drugs & Pharmacology Authors: Hosaka A, Miyata T, Onishi Y, Liao L, Zhang Q Tags: Clin Ther Source Type: research

Abstract 132: The POWR Survey: Patient and Physician Perspectives on Outcomes Weighting in Revascularization. Session Title: Poster Session I
Conclusions: Patients and physicians agree on which outcomes are most (death and stroke)and least impactful (incision scar), but there is a lot of variability in between supporting the reporting of more adverse outcomes and not just those included in MACE.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Pandit, J. A., Gupta, V., Boyer, N., Ports, T. A., Yeghiazarians, Y., Boyle, A. J. Tags: Session Title: Poster Session I Source Type: research

Relation of Major Depression to Survival After Coronary Artery Bypass Grafting
In conclusion, we found a strong and significant association between depression and long-term survival in patients with established ischemic heart disease who underwent CABG. Depression was also associated with an increased risk for a combination of death or rehospitalization for heart failure, myocardial infarction, or stroke.
Source: The American Journal of Cardiology - June 20, 2014 Category: Cardiology Authors: Malin Stenman, Martin J. Holzmann, Ulrik Sartipy Tags: Coronary Artery Disease Source Type: research

Clinical outcomes of hybrid coronary revascularization versus coronary artery bypass surgery in patients with diabetes mellitus
Background: Hybrid coronary revascularization (HCR) involves minimally invasive left internal mammary artery to left anterior descending coronary artery grafting combined with percutaneous coronary intervention (PCI) of non–left anterior descending vessels. The safety and efficacy of HCR among diabetic patients are unknown.Methods: Patients with diabetes were included who underwent HCR at a US academic center between October 2003 and September 2013. These patients were matched 1:5 to similar patients treated with coronary artery bypass grafting (CABG) using a propensity score (PS)-matching algorithm. Conditional logistic...
Source: American Heart Journal - July 14, 2014 Category: Cardiology Authors: Ralf E. Harskamp, Patrick F. Walker, John H. Alexander, Ying Xian, Henry A. Liberman, Robbert J. de Winter, Thomas A. Vassiliades, Eric D. Peterson, John D. Puskas, Michael E. Halkos Tags: Diabetes and Metabolism Source Type: research

Eptifibatide infusion versus placebo in high risk patients with non-st segment elevation acute coronary syndromes managed with urgent coronary artery bypass graft surgery. a prospective multicenter randomized placebo-controlled clinical trial.
CONCLUSION: Preoperative use of eptifibatide vs. placebo is linked to significantly reduced 12--month MACCE rate in patients with NSTE--ACS requiring urgent CABG, while it simultaneously seems not to confer a greater risk of postoperative bleeding. PMID: 25394877 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - November 14, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Wilczynski M, Wybraniec MT, Milewski K, Sanak M, Wita K, Buldak L, Kondys M, Buszman P, Bochenek A Tags: J Cardiovasc Surg (Torino) Source Type: research

Coronary Revascularization in Diabetic Patients: A Systematic Review and Bayesian Network Meta-analysis.
CONCLUSION: Coronary artery bypass grafting seems to be the preferred revascularization technique in diabetics, especially if long-term survival is anticipated. However, because of residual uncertainties and increased risk for stroke with CABG, clinical judgment is required when choosing a revascularization technique in patients with diabetes. PRIMARY FUNDING SOURCE: Fonds de recherche du Québec-Santé. PMID: 25402514 [PubMed - in process]
Source: Annals of Internal Medicine - November 18, 2014 Category: Internal Medicine Authors: Tu B, Rich B, Labos C, Brophy JM Tags: Ann Intern Med Source Type: research

Coronary Artery Surgery Versus Percutaneous Coronary Intervention in Octogenarians: Long-Term Results
Conclusions In this real-world setting, surgical coronary revascularization remains the standard of care for patients with left main or multivessel disease. The long-term outcomes of current percutaneous coronary intervention technology in octogenarians are yet to be determined with adequately powered prospective randomized studies.
Source: The Annals of Thoracic Surgery - December 11, 2014 Category: Cardiovascular & Thoracic Surgery Source Type: research

Sequential Vein Bypass Grafting is Not Associated with an Increase of Either In-hospital or Mid-term Adverse Events in Off-pump Coronary Artery Bypass Grafting.
CONCLUSIONS: Compared to individual vein bypass grafting, sequential vein bypass grafting was not associated with an increase of either in-hospital or mid-term adverse events in patients undergoing off-pump CABG. PMID: 25563315 [PubMed - in process]
Source: Chinese Medical Journal - January 1, 2015 Category: Journals (General) Authors: Xiao F, Wang J, Wu H, Sun H Tags: Chin Med J (Engl) Source Type: research