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Total 1150 results found since Jan 2013.

The combination of mannitol and temozolomide increases the effectiveness of stem cell treatment in a chronic stroke model
DiscussionThe combination drug treatment of mannitol and temozolomide allowed for the efficient delivery of hUC-MSC–derived microvesicles into the brain in a chronic stroke rat model. This attenuated behavioral deficits, likely by improving neural regeneration and angiogenesis. Thus, combination drug treatment of mannitol and temozolomide could be a novel therapeutic option for patients with chronic ischemic stroke.
Source: Cytotherapy - July 10, 2018 Category: Cytology Source Type: research

MiR-298 Exacerbates Ischemia/Reperfusion Injury Following Ischemic Stroke by Targeting Act1
Conclusions: Upregulation of miR-298 following ischemic stroke promotes brain injuryin vitro and vivo by inhibiting the Act1/JNK/NF- κB signaling cascade and the downstream autophagy pathway. Therapeutic strategies that target miR-298 could be beneficial for the treatment of ischemic stroke.Cell Physiol Biochem 2018;48:528 –539
Source: Cellular Physiology and Biochemistry - July 18, 2018 Category: Cytology Source Type: research

Mesenchymal Stem Cells Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research.
Abstract Exogenous stem cell therapy (SCT) has been recognized recently as a promising neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem cells (MSCs) are the primary source of stem cells used in the majority of both pre-clinical and clinical studies in stroke. In the absence of evidence-based guidelines on the use of SCT in stroke patients, understanding the progress of MSC research across published studies will assist researchers and clinicians in better achieving success in translating research. We conducted a systematic review on published literature using MSCs in both pre-cli...
Source: Cell Transplantation - October 22, 2018 Category: Cytology Authors: Zheng H, Zhang B, Chhatbar PY, Dong Y, Alawieh A, Lowe F, Hu X, Feng W Tags: Cell Transplant Source Type: research

Bridging Therapy Versus Direct Mechanical Thrombectomy in Patients with Acute Ischemic Stroke due to Middle Cerebral Artery Occlusion: A Clinical-Histological Analysis of Retrieved Thrombi.
In conclusion, there was no difference in the functional outcomes between the direct MT and bridging therapy groups. However, randomized trials are needed to elucidate the high ratio of cardioembolism subtype in our group of patients. The histological MCA thrombus composition differed between cardioembolism and large-artery atherosclerosis, and this finding provides valuable information on the underlying pathogenesis and thrombus origin. PMID: 30654640 [PubMed - as supplied by publisher]
Source: Cell Transplantation - January 18, 2019 Category: Cytology Authors: Gong L, Zheng X, Feng L, Zhang X, Dong Q, Zhou X, Wang H, Zhang X, Shu Z, Zhao Y, Liu X Tags: Cell Transplant Source Type: research

The role of endogenous tissue-type plasminogen activator in neuronal survival after ischemic stroke: friend or foe?
Abstract Endogenous protease tissue-type plasminogen activator (tPA) has highly efficient fibrinolytic activity and its recombinant variants alteplase and tenecteplase are established as highly effective thrombolytic drugs for ischemic stroke. Endogenous tPA is constituted of five functional domains through which it interacts with a variety of substrates, binding proteins and receptors, thus having enzymatic and cytokine-like effects to act on all cell types of the brain. In the past 2 decades, numerous studies have explored the clinical relevance of endogenous tPA in neurological diseases, especially in ischemic...
Source: Cellular and Molecular Life Sciences : CMLS - January 17, 2019 Category: Cytology Authors: Zhu J, Wan Y, Xu H, Wu Y, Hu B, Jin H Tags: Cell Mol Life Sci Source Type: research

Berberine Facilitates Angiogenesis Against Ischemic Stroke Through Modulating Microglial Polarization via AMPK Signaling.
In conclusion, BBR treatment improves functional recovery and promotes angiogenesis following tMCAO via AMPK-dependent microglial M2 polarization. PMID: 31020571 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - April 23, 2019 Category: Cytology Authors: Zhu J, Cao D, Guo C, Liu M, Tao Y, Zhou J, Wang F, Zhao Y, Wei J, Zhang Y, Fang W, Li Y Tags: Cell Mol Neurobiol Source Type: research

Matrix metalloproteinases and ADAMs in stroke.
Abstract Stroke is a leading cause of death and disability worldwide. However, after years of in-depth research, the pathophysiology of stroke is still not fully understood. Increasing evidence shows that matrix metalloproteinases (MMPs) and "a disintegrin and metalloproteinase" (ADAMs) participate in the neuro-inflammatory cascade that is triggered during stroke but also in recovery phases of the disease. This review covers the involvement of these proteins in brain injury following cerebral ischemia which has been widely studied in recent years, with efforts to modulate this group of proteins in neuroprotective ...
Source: Cellular and Molecular Life Sciences : CMLS - June 4, 2019 Category: Cytology Authors: Montaner J, Ramiro L, Simats A, Hernández-Guillamon M, Delgado P, Bustamante A, Rosell A Tags: Cell Mol Life Sci Source Type: research

Detection of Crossed Cerebellar Diaschisis by Intravoxel Incoherent Motion MR Imaging in Subacute Ischemic Stroke.
Abstract Intravoxel incoherent motion has received extensive attention in brain studies for its potential as a non-invasive magnetic resonance perfusion method. However, studies on intravoxel incoherent motion imaging and crossed cerebellar diaschisis detection are relatively scarce. The aim of our study was to evaluate the feasibility of using intravoxel incoherent motion imaging in crossed cerebellar diaschisis diagnosis in subacute ischemic stroke patients by comparing results from intravoxel incoherent motion imaging, single-photon emission computed tomography, and arterial spin-labeling perfusion methods. In ...
Source: Cell Transplantation - June 13, 2019 Category: Cytology Authors: Wang J, Suo S, Zu J, Zhu W, Pan L, Song S, Li Y, Li L, Chen Z, Xu J Tags: Cell Transplant Source Type: research

Heat shock protein 27 as a neuroprotective biomarker and a suitable target for stem cell therapy and pharmacotherapy in ischemic stroke.
This article is protected by copyright. All rights reserved. PMID: 31502740 [PubMed - as supplied by publisher]
Source: Cell Biology International - September 9, 2019 Category: Cytology Authors: Behdarvandy M, Karimian M, Atlasi MA, Tameh AA Tags: Cell Biol Int Source Type: research

Urokinase Plasminogen Activator: A Potential Thrombolytic Agent for Ischaemic Stroke.
Abstract Stroke continues to be one of the leading causes of mortality and morbidity worldwide. Restoration of cerebral blood flow by recombinant plasminogen activator (rtPA) with or without mechanical thrombectomy is considered the most effective therapy for rescuing brain tissue from ischaemic damage, but this requires advanced facilities and highly skilled professionals, entailing high costs, thus in resource-limited contexts urokinase plasminogen activator (uPA) is commonly used as an alternative. This literature review summarises the existing studies relating to the potential clinical application of uPA in is...
Source: Cellular and Molecular Neurobiology - September 23, 2019 Category: Cytology Authors: Kadir RRA, Bayraktutan U Tags: Cell Mol Neurobiol Source Type: research

LncRNA MEG8 Attenuates Cerebral Ischemia After Ischemic Stroke Through Targeting miR-130a-5p/VEGFA Signaling.
Abstract MEG8 is involved in ischemia stroke, however, its role in ischemia stroke remains unknown. The current research aimed to investigate the effects and mechanisms of MEG8 in ischemic stroke. Mouse brain microvascular endothelial cells (BMECs) were treated by oxygen-glucose deprivation (OGD). Then, the expressions of MEG8 and miR-130a-5p were detected by quantitative reverse transcription-polymerase chain reaction (q-PCR). Cell counting kit-8 (CCK-8), wound-healing, tube formation, Western blot, and q-PCR assays were performed to detect the effects of MEG8 and miR-130a-5p on cell viability, migration, and ang...
Source: Cellular and Molecular Neurobiology - July 4, 2020 Category: Cytology Authors: Sui S, Sun L, Zhang W, Li J, Han J, Zheng J, Xin H Tags: Cell Mol Neurobiol Source Type: research

Delayed Treatment with Human Dental Pulp Stem Cells Accelerates Functional Recovery and Modifies Responses of Peri-Infarct Astrocytes Following Photothrombotic Stroke in Rats.
Abstract Dental pulp contains multipotent mesenchymal stem cells that improve outcomes when administered early after temporary middle cerebral artery occlusion in rats. To further assess the therapeutic potential of these cells, we tested whether functional recovery following stroke induced by photothrombosis could be modified by a delayed treatment that was initiated after the infarct attained maximal volume. Photothrombosis induces permanent focal ischemia resulting in tissue changes that better reflect key aspects of the many human strokes in which early restoration of blood flow does not occur. Human dental pu...
Source: Cell Transplantation - January 1, 2021 Category: Cytology Authors: Yew WP, Djukic ND, Jayaseelan JSP, Kaidonis X, Kremer KL, Choy FC, Woodman RJ, Koblar SA, Sims NR Tags: Cell Transplant Source Type: research

Microglia and bradykinin cross-talk in post-stroke cognitive impairment in diabetes.
Abstract Stroke is one of the leading causes of mortality and the leading cause of long-term disability worldwide. Although cognitive impairment is a common consequence of stroke, the underlying pathophysiological processes that lead to it are still poorly understood. Recently, more studies have shown evidence of the involvement of diabetes in producing a chronic neuroinflammatory state, which ultimately alters the recovery of function and cognition after stroke. To better understand the impact of diabetes on post-stroke recovery, here we highlight the recent insights on the role of diabetes in neuroinflammation, ...
Source: Am J Physiol Cell Ph... - January 27, 2021 Category: Cytology Authors: Barić A, Dobrivojević Radmilović M Tags: Am J Physiol Cell Physiol Source Type: research

Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats
This report investigates the role of PKa on hemorrhage and hypertension in stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP were fed with a high salt-containing stroke-prone diet to increase blood pressure and induce intracerebral hemorrhage. The roles of PKa on blood pressure, hemorrhage, and survival in SHRSP were examined in rats receiving a PKa inhibitor or plasma prekallikrein antisense oligonucleotide (PK ASO) compared with rats receiving control ASO. Effects on PKa on the proteolytic cleavage of atrial natriuretic peptide (ANP) were analyzed by tandem mass spectrometry. We show that SHRSP on high-salt die...
Source: Cell Research - July 9, 2021 Category: Cytology Authors: Jian Guan Allen C Clermont Loc-Duyen Pham Tuna Ustunkaya Alexey S Revenko A Robert MacLeod Edward P Feener Fabr ício Simão Source Type: research

Mice and Rats Exhibit Striking Inter-species Differences in Gene Response to Acute Stroke
Cell Mol Neurobiol. 2021 Aug 5. doi: 10.1007/s10571-021-01138-8. Online ahead of print.ABSTRACTNeuroprotection in acute stroke has not been successfully translated from animals to humans. Animal research on promising agents continues largely in rats and mice which are commonly available to researchers. However, controversies continue on the most suitable species to model the human situation. Generally, putative agents seem less effective in mice as compared with rats. We hypothesized that this may be due to inter-species differences in stroke response and that this might be manifest at a genetic level. Here we used whole-g...
Source: Cellular and Molecular Neurobiology - August 5, 2021 Category: Cytology Authors: Qiu Jing Wu Xiujun Sun Lucy Teves Diana Mayor Michael Tymianski Source Type: research