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Specialty: Cytology

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Total 1150 results found since Jan 2013.

IRF4 is a novel mediator for neuronal survival in ischaemic stroke
Zhang, D-P Liu & H Li
Source: Cell Death and Differentiation - February 7, 2014 Category: Cytology Authors: S GuoZ-Z LiD-S JiangY Y LuY LiuL GaoS-M ZhangH LeiL-H ZhuX-D ZhangD-P LiuH Li Tags: IRF4 SRF ischaemic stroke neuronal survival Source Type: research

Sex differences in neuroinflammation and neuroprotection in ischemic stroke.
Abstract Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post-stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, larg...
Source: Cell Research - November 23, 2016 Category: Cytology Authors: Spychala MS, Honarpisheh P, McCullough LD Tags: J Neurosci Res Source Type: research

Enhanced recovery from chronic ischemic injury by bone marrow cells in a rat model of ischemic stroke.
This study provides valuable insights into the effect of BMC transplantation in the chronic ischemic brain, which lead to the development of effective therapy for chronic stroke patients who currently lack satisfactory therapeutic options. PMID: 24152766 [PubMed - as supplied by publisher]
Source: Cell Transplantation - October 22, 2013 Category: Cytology Authors: Yoo J, Seo JJ, Eom JH, Hwang DY Tags: Cell Transplant Source Type: research

New Insights into Stroke Prevention and Treatment: Gut Microbiome
Cell Mol Neurobiol. 2021 Feb 26. doi: 10.1007/s10571-021-01047-w. Online ahead of print.ABSTRACTStroke, a lethal neurological disease, accounts for a grave economic burden on society. Despite extensive basic and clinical studies on stroke prevention, a precise effective treatment approach for stroke at this stage remains unavailable. The majority of our body's gut microbiota plays a vital role in food digestion, immune regulation, and nervous system development, which is highly associated with the development of some diseases. Multiple clinical studies have documented variation in the composition of gut microbiota between ...
Source: Cellular and Molecular Neurobiology - February 26, 2021 Category: Cytology Authors: Linna Zhao Liji Yang Yuying Guo Jie Xiao Junping Zhang Shixin Xu Source Type: research

A Score of Low-Grade Inflammation for Predicting Stroke Recurrence in Patients with Ischemic Stroke
CONCLUSION: This study showed that an elevated LGI score was associated with a higher risk of stroke recurrence, independent of other vascular risk factors.PMID:34548807 | PMC:PMC8449639 | DOI:10.2147/JIR.S328383
Source: Cell Research - September 22, 2021 Category: Cytology Authors: Min Wu Xiaohao Zhang Jingjing Chen Mingming Zha Kang Yuan Kangmo Huang Yi Xie Jianzhong Xue Xinfeng Liu Source Type: research

Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke
Neurochem Res. 2022 Jun 8. doi: 10.1007/s11064-022-03628-7. Online ahead of print.ABSTRACTStroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repos...
Source: Cell Research - June 8, 2022 Category: Cytology Authors: Tayebeh Noori Samira Shirooie Antoni Sureda Eduardo Sobarzo-Sanchez Ahmad Reza Dehpour Marianela Sald ías Esra K üpeli Akkol Source Type: research

Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence.
Abstract The identification of the mechanisms predisposing to stroke may improve its preventive and therapeutic strategies in patients with essential hypertension. The role of macroautophagy/autophagy in the development of hypertension-related stroke needs to be clarified. We hypothesized that a defective autophagy may favor hypertension-related spontaneous stroke by promoting mitochondrial dysfunction. We studied autophagy in the stroke-prone spontaneously hypertensive (SHRSP) rat, which represents a clinically relevant model of stroke associated with high blood pressure. We assessed autophagy, mitophagy and NAD+...
Source: Autophagy - November 2, 2019 Category: Cytology Authors: Forte M, Bianchi F, Cotugno M, Marchitti S, De Falco E, Raffa S, Stanzione R, di Nonno F, Chimenti I, Palmerio S, Pagano F, Petrozza V, Micaloni A, Madonna M, Relucenti M, Torrisi MR, Frati G, Volpe M, Rubattu S, Sciarretta S Tags: Autophagy Source Type: research

The Stroke-Induced Increase of Somatostatin-Expressing Neurons is Inhibited by Diabetes: A Potential Mechanism at the Basis of Impaired Stroke Recovery.
Abstract Type 2 diabetes (T2D) hampers recovery after stroke, but the underling mechanisms are mostly unknown. In a recently published study (Pintana et al. in Clin Sci (Lond) 133(13):1367-1386, 2019), we showed that impaired recovery in T2D was associated with persistent atrophy of parvalbumin+ interneurons in the damaged striatum. In the current work, which is an extension of the abovementioned study, we investigated whether somatostatin (SOM)+ interneurons are also affected by T2D during the stroke recovery phase. C57Bl/6j mice were fed with high-fat diet or standard diet (SD) for 12 months and subjected to 30...
Source: Cellular and Molecular Neurobiology - May 22, 2020 Category: Cytology Authors: Chiazza F, Pintana H, Lietzau G, Nyström T, Patrone C, Darsalia V Tags: Cell Mol Neurobiol Source Type: research

Delayed rFGF21 Administration Improves Cerebrovascular Remodeling and White Matter Repair After Focal Stroke in Diabetic Mice
This study aims to evaluate the potential effects of rFGF21 on cerebrovascular remodeling after T2DM stroke. Permanent distal middle cerebral artery occlusion was performed in heterozygous non-diabetic db/ + and homozygous diabetic db/db mice. Daily rFGF21 administration was initiated 1 week after stroke induction and maintained for up to 2 weeks thereafter. Multiple markers associated with post-stroke recovery, including angiogenesis, oligodendrogenesis, white matter integrity, and neurogenesis, were assessed up to 3 weeks after stroke. Our results showed an impairment in post-stroke vascular remodeling under T2DM conditi...
Source: Cell Research - September 15, 2021 Category: Cytology Authors: Yinghua Jiang Jinrui Han Yadan Li Yinga Wu Ning Liu Samuel X Shi Li Lin Jing Yuan Shusheng Wang Ming-Ming Ning Aaron S Dumont Xiaoying Wang Source Type: research

Decoding the Transcriptional Response to Ischemic Stroke in Obese and Non-obese Mice Brain
CONCLUSION: Hence, we concluded that obesity could affect the brain microenvironment at the transcriptome level and Stroke after obesity could lead to more changes in NOD-like receptor signaling pathway and monocyte infiltration, compared with non-obese Stroke.PMID:34702150 | DOI:10.2174/1567202618666210719150845
Source: Cell Research - October 27, 2021 Category: Cytology Authors: Jing Liang Ruiyao Hu Xin Wang Xinjing Liu Lulu Pei Mengke Tian Wenxian Sun Luyang Zhang Lan Ding Yuying Wang Yuming Xu Bo Song Source Type: research

Role of Ferroptosis in Stroke
Cell Mol Neurobiol. 2022 Jan 31. doi: 10.1007/s10571-022-01196-6. Online ahead of print.ABSTRACTStroke is a common and serious nervous system disease caused by the rupture or blockage of the cardiovascular system. It causes millions of deaths and disabilities every year, which is a huge burden on humanity. It may be induced by thrombosis, hypertension, hyperlipidemia, hyperglycemia, smoking, advanced age and so on. According to different causes, stroke can be generally divided into hemorrhagic stroke and ischemic stroke, whose pathogenesis and treatment are quite different. Ferroptosis is a new type of cell death first def...
Source: Cellular and Molecular Neurobiology - February 1, 2022 Category: Cytology Authors: Yunfei Xu Kexin Li Yao Zhao Lin Zhou Ying Liu Jie Zhao Source Type: research