Filtered By:
Specialty: Cytology

This page shows you your search results in order of relevance. This is page number 10.

Order by Relevance | Date

Total 1150 results found since Jan 2013.

Structural mechanism of the dynein power stroke
Nature Cell Biology 16, 479 (2014). doi:10.1038/ncb2939 Authors: Jianfeng Lin, Kyoko Okada, Milen Raytchev, Maria C. Smith & Daniela Nicastro Dyneins are large microtubule motor proteins required for mitosis, intracellular transport and ciliary and flagellar motility. They generate force through a power-stroke mechanism, which is an ATP-consuming cycle of pre- and post-power-stroke conformational changes that cause relative motion between different dynein domains. However, key structural details of dynein’s force generation remain elusive. Here, using cryo-electron tomography of intact, active (that is, beati...
Source: Nature Cell Biology - April 13, 2014 Category: Cytology Authors: Jianfeng LinKyoko OkadaMilen RaytchevMaria C. SmithDaniela Nicastro Tags: Letter Source Type: research

The Use of ADSCs as a Treatment for Chronic Stroke.
Abstract Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagic-induced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, ...
Source: Cell Transplantation - May 17, 2014 Category: Cytology Authors: Chan TM, Harn HJ, Lin HP, Chiu SC, Lin PC, Wang HI, Ho LI, Chuu CP, Chiou TW, Hsieh AC, Chen YW, Ho WY, Lin SZ Tags: Cell Transplant Source Type: research

Relationship Between Procalcitonin Serum Levels and Functional Outcome in Stroke Patients.
Abstract To determine whether serum procalcitonin (PCT) levels at admission were associated with short-term functional outcome after acute ischemic stroke (AIS) in a cohort Chinese sample. We prospectively studied 378 patients with AIS who were admitted within 24 h after the onset of symptoms. PCT and NIH stroke scale (NIHSS) were measured at the time of admission. Short-term functional outcome was measured by modified Rankin scale (mRS) 90 days after admission. The results indicated that the serum PCT levels were significantly higher in AIS patients as compared to normal controls (P < 0.0001). In the 114 p...
Source: Cellular and Molecular Neurobiology - November 5, 2014 Category: Cytology Authors: Deng WJ, Shen RL, Li M, Teng JF Tags: Cell Mol Neurobiol Source Type: research

Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of Stroke.
Abstract The present study was designed to evaluate the beneficial effects of Withania somnifera (WS) pre-supplementation on middle cerebral artery occlusion (MCAO) model of ischemic stroke. Ischemic stroke was induced in the rats by inserting intraluminal suture for 90 min, followed by reperfusion injury for 24 h. The animals were assessed for locomotor functions (by neurological deficit scores, narrow beam walk and rotarod test), cognitive and anxiety-like behavioural functions (by morris water maze and elevated plus maze test). MCAO animals showed significant impairment in locomotor and cognitive functions. N...
Source: Cellular and Molecular Neurobiology - December 30, 2015 Category: Cytology Authors: Sood A, Kumar A, Dhawan DK, Sandhir R Tags: Cell Mol Neurobiol Source Type: research

Intravenous injection of clinical grade human MSCs after experimental stroke: functional benefit and microvascular effect.
Abstract Stroke is the leading cause of disability in adults. Many current clinical trials use an intravenous (IV) administration of human mesenchymal stromal/stem cells (hMSCs). This autologous graft requires a delay for ex vivo expansion of cells. We followed microvascular effects and mechanisms of action involved after an IV injection of hMSCs at a subacute phase of stroke. Rats underwent a transient middle cerebral artery occlusion (MCAo) or a surgery without occlusion (sham) at day 0 (D0). At D8, rats received an IV injection of 3 million hMSCs or PBSglutamine. In a longitudinal behavioral follow-up, we showe...
Source: Cell Transplantation - February 26, 2016 Category: Cytology Authors: Moisan A, Favre I, Rome C, De Fraipont F, Grillon E, Coquery N, Mathieu H, Mayan V, Naegele B, Hommel M, Richard MJ, Barbier EL, Remy C, Detante O Tags: Cell Transplant Source Type: research

Bone Marrow Stromal Cells Combined with Sodium Ferulate and n-butylidenephthalide Promote the Effect of Therapeutic Angiogenesis via Advancing Astrocyte-Derived Trophic Factors After Ischemic Stroke.
This study aimed to investigate whether combined BMSCs with SF and BP had better therapeutic effect in the treatment of stroke, and also the underlying molecular basis. The results showed that combination treatment notably reduced neurological injury after stroke and increased the expression of astrocyte-derived vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and von Willebrand factor-positive vascular density in ischemic boundary zone as evaluated by immunofluorescence staining. After treatment of BMSCs plus SF and BP, astrocytes showed increased expression of VEGF and BDNF by up-regula...
Source: Cell Transplantation - October 20, 2016 Category: Cytology Authors: Zhang Q, Chen ZW, Zhao YH, Liu BW, Liu NW, Ke CC, Tan HM Tags: Cell Transplant Source Type: research

MicroRNA: Relevance to Stroke Diagnosis, Prognosis and Therapy
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - January 8, 2017 Category: Cytology Authors: Hamed Mirzaei, Fatemeh Momeni, Leila Saadatpour, Amirhossein Sahebkar, Mohammad Goodarzi, Aria Masoudifar, Shirin Kouhpayeh, Hossein Salehi, Hamid Reza Mirzaei, Mahmoud Reza Jaafari Tags: REVIEW ARTICLE Source Type: research

Elevated Plasma Homocysteine Level Increased the Risk of Early Renal Impairment in Acute Ischemic Stroke Patients.
In conclusion, patients with stroke and HHcy could be more prone to renal impairment. PMID: 28275883 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - March 7, 2017 Category: Cytology Authors: Chen J, Li G, Xu Z, Zhang C, Wang Y, Xie H, Shao Y, Peng L, Lu J, Yuan D Tags: Cell Mol Neurobiol Source Type: research

MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy
Stroke is a life‐threatening disease that accounts for a considerable burden of mortality in both developing and developed world. Identification of specific biomarkers for stroke and its outcomes can greatly contribute to improved care of patients. MicroRNAs (miRNAs) are known as novel biomarkers that could be used as diagnostic, prognostic, and therapeutic biomarkers. Various studies have shown that miRNAs have key roles in the pathogenesis of stroke, and its complications and outcomes. In addition, there is evidence showing that mesenchaymal stromal cell‐derived exosomes containing miRNAs can be used for monitoring a...
Source: Journal of Cellular Physiology - June 22, 2017 Category: Cytology Authors: Hamed Mirzaei, Fatemeh Momeni, Leila Saadatpour, Amirhossein Sahebkar, Mohammad Goodarzi, Aria Masoudifar, Shirin Kouhpayeh, Hossein Salehi, Hamid Reza Mirzaei, Mahmoud Reza Jaafari Tags: REVIEW ARTICLE Source Type: research

Ischemic stroke activates the VE-cadherin promoter and increases VE-cadherin expression in adult mice.
Authors: Nakano-Doi A, Sakuma R, Matsuyama T, Nakagomi T Abstract Endothelial cells (ECs) are a key component of the blood-brain barrier (BBB). Healthy ECs in the BBB form inter-endothelial junctions, including adherens junctions (AJs). Under pathological conditions, such as after ischemic stroke, the BBB may be functionally compromised. However, gene and protein expression patterns involving endothelial AJs have not been well studied. Because expression levels of endothelial AJs are considered to be related to BBB functionality, we investigated the expression pattern of a representative endothelial AJ marker, VE-c...
Source: Histology and Histopathology - December 6, 2017 Category: Cytology Tags: Histol Histopathol Source Type: research

Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF- κB pathway by targeting FOXO3.
Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-κB pathway by targeting FOXO3. Exp Cell Res. 2018 Apr 28;: Authors: Guo D, Ma J, Li T, Yan L Abstract Dysfunction of the microRNA (miR) network has been emerging as a main regulator in ischemic stroke. Recently, studies have linked the deregulation of miR-122 to ischemic stroke. However, the specific role and molecular mechanism of miR-122 in ischemic stroke remain to be further investigated. Here, we found that miR-122 was decreased in mouse N2A neuroblastoma (N2A) cells af...
Source: Experimental Cell Research - April 28, 2018 Category: Cytology Authors: Guo D, Ma J, Li T, Yan L Tags: Exp Cell Res Source Type: research

The combination of mannitol and temozolomide increases the effectiveness of stem cell treatment in a chronic stroke model
Discussion The combination drug treatment of mannitol and temozolomide allowed for the efficient delivery of hUC-MSC–derived microvesicles into the brain in a chronic stroke rat model. This attenuated behavioral deficits, likely by improving neural regeneration and angiogenesis. Thus, combination drug treatment of mannitol and temozolomide could be a novel therapeutic option for patients with chronic ischemic stroke.
Source: Cytotherapy - June 22, 2018 Category: Cytology Source Type: research

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: Implications for cerebral ischemic stroke.
Abstract Circular RNAs (circRNAs) are highly expressed in the central nervous system and are involved in the regulation of physiological and pathophysiological processes. However, the potential role of circRNAs in stroke remains largely unknown. Here, using a circRNA microarray, we showed that circular RNA Hectd1 (circHectd1) levels were significantly increased in ischemic brain tissues in transient middle cerebral artery occlusion (tMCAO) mouse stroke models and further validated this finding in plasma samples from acute ischemic stroke (AIS) patients. Knockdown of circHectd1 expression significantly decreased in...
Source: Autophagy - June 25, 2018 Category: Cytology Authors: Han B, Zhang Y, Zhang Y, Bai Y, Chen X, Huang R, Wu F, Leng S, Chao J, Zhang JH, Hu G, Yao H Tags: Autophagy Source Type: research

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection.
Abstract The blood-brain barrier (BBB) is a physical and biochemical barrier that precisely controls cerebral homeostasis. It also plays a central role in the regulation of blood-to-brain flux of endogenous and exogenous xenobiotics and associated metabolites. This is accomplished by molecular characteristics of brain microvessel endothelial cells such as tight junction protein complexes and functional expression of influx and efflux transporters. One of the pathophysiological features of ischemic stroke is disruption of the BBB, which significantly contributes to development of brain injury and subsequent neurolo...
Source: Am J Physiol Cell Ph... - June 27, 2018 Category: Cytology Authors: Abdullahi W, Tripathi D, Ronaldson PT Tags: Am J Physiol Cell Physiol Source Type: research

The combination of mannitol and temozolomide increases the effectiveness of stem cell treatment in a chronic stroke model
DiscussionThe combination drug treatment of mannitol and temozolomide allowed for the efficient delivery of hUC-MSC–derived microvesicles into the brain in a chronic stroke rat model. This attenuated behavioral deficits, likely by improving neural regeneration and angiogenesis. Thus, combination drug treatment of mannitol and temozolomide could be a novel therapeutic option for patients with chronic ischemic stroke.
Source: Cytotherapy - July 5, 2018 Category: Cytology Source Type: research