Filtered By:
Specialty: Cytology
This page shows you your search results in order of relevance. This is page number 19.
Order by Relevance | Date
Total 1150 results found since Jan 2013.
In Vitro Model for Ischemic Stroke: Functional Analysis of Vascular Smooth Muscle Cells
Cell Mol Neurobiol. 2021 May 25. doi: 10.1007/s10571-021-01103-5. Online ahead of print.ABSTRACTThe Neurovascular Unit (NVU) is formed by vascular and neural cells controlling the cerebral hyperaemia. All the components are anatomically and functionally linked to each other, resulting in a highly efficient regulation of the cerebral blood flow, which, when interrupted, can lead to stroke. An ischemic stroke (IS) is the most common type of stroke with high rates of morbidity, mortality and disability. Therefore, it is of extreme importance to protect the functional and structural integrity of the NVU in patients with IS, un...
Source: Cellular and Molecular Neurobiology - May 25, 2021 Category: Cytology Authors: Melissa Mariana Claudio Roque Gra ça Baltazar Elisa Cairrao Source Type: research
Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke
This study was approved by the Laboratory Animal Care and Use Committee of the First Affiliated Hospital of Zhengzhou University (approval No. 201709276S) on September 27, 2017.PMID:34269220 | DOI:10.4103/1673-5374.314319
Source: Cell Research - July 16, 2021 Category: Cytology Authors: Yao-Hua Ma Wen-Jing Deng Zhi-Yi Luo Jing Jing Peng-Wei Pan Yao-Bing Yao Yan-Bo Fang Jun-Fang Teng Source Type: research
Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway
In conclusion, PRDX6 secreted by Schwann-like cell protects neuron against focal cerebral ischemia, SCLC-CM might be a new effective early intervention for ischemic stroke.PMID:34482185 | DOI:10.1016/j.tice.2021.101635
Source: Tissue and Cell - September 5, 2021 Category: Cytology Authors: Bin Tang Wei Ni Jiqin Zhou Yating Ling Dongdong Niu Xiaorui Lu Tianyan Chen Murugan Ramalingam Jiabo Hu Source Type: research
Clinical neurorestorative cell therapies for stroke
Prog Brain Res. 2021;265:231-247. doi: 10.1016/bs.pbr.2021.06.006. Epub 2021 Aug 13.ABSTRACTClinical neurorestorative cell therapies for stroke have been explored for over 20 years. Majority cell therapies have shown neurorestorative effects for stroke on non-double-blind studies. In this review, we summarize types of cell transplantation, transplanted routes, therapeutic time windows, dosage, results of exploring trials or clinical studies, results of multicenter, double-blind or observing-blind, randomized, placebo-controlled clinical trials. The clinical application prospects of majority cell therapies for stroke need t...
Source: Cell Research - September 25, 2021 Category: Cytology Authors: Hongyun Huang Gengsheng Mao Lin Chen Hari Shanker Sharma Source Type: research
MicroRNA miR-21 Decreases Post-stroke Brain Damage in Rodents
Transl Stroke Res. 2021 Nov 18. doi: 10.1007/s12975-021-00952-y. Online ahead of print.ABSTRACTDue to their role in controlling translation, microRNAs emerged as novel therapeutic targets to modulate post-stroke outcomes. We previously reported that miR-21 is the most abundantly induced microRNA in the brain of rodents subjected to preconditioning-induced cerebral ischemic tolerance. We currently show that intracerebral administration of miR-21 mimic decreased the infarct volume and promoted better motor function recovery in adult male and female C57BL/6 mice subjected to transient middle cerebral artery occlusion. The miR...
Source: Cell Research - November 19, 2021 Category: Cytology Authors: Mary S Lopez Kahlilia C Morris-Blanco Nancy Ly Carly Maves Robert J Dempsey Raghu Vemuganti Source Type: research
Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell Function and Alleviates Ischemic Stroke by Upregulating NOTCH3
Neurochem Res. 2022 Mar 22. doi: 10.1007/s11064-022-03544-w. Online ahead of print.ABSTRACTTo investigate the function of hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) and Notch receptor 3 (NOTCH3) in ischemic stroke. Stroke models were established by middle cerebral artery occlusion (MCAO) and oxygen glucose deprivation (OGD) in rats and rat brain microvascular endothelial cells (BMVECs), respectively. Neurological deficit evaluation and 2,3,5-triphenyltetrazolium chloride staining were used to assess cerebral injury. The expression of HEY1 and NOTCH3 was manipulated using gain and loss of function appr...
Source: Cell Research - March 22, 2022 Category: Cytology Authors: Tingting Zhu Hongxi Chen Cuihong He Xiaojuan Liu Source Type: research
The Bridge Between Ischemic Stroke and Gut Microbes: Short-Chain Fatty Acids
Cell Mol Neurobiol. 2022 Mar 28. doi: 10.1007/s10571-022-01209-4. Online ahead of print.ABSTRACTShort-chain fatty acids (SCFAs) are monocarboxylates produced by the gut microbiota (GM) and result from the interaction between diet and GM. An increasing number of studies about the microbiota-gut-brain axis (MGBA) indicated that SCFAs may be a crucial mediator in the MGBA, but their roles have not been fully clarified. In addition, there are few studies directly exploring the role of SCFAs as a potential regulator of microbial targeted interventions in ischemic stroke, especially for clinical studies. This review summarizes t...
Source: Cellular and Molecular Neurobiology - March 29, 2022 Category: Cytology Authors: Zongwei Fang Mingrong Chen Jiafen Qian Chunhua Wang Jinhua Zhang Source Type: research
Preclinical Studies of Neural Stem/Progenitor Cell Therapy for Ischemic Stroke: A Systematic Review
CONCLUSION: Most of the preclinical studies reported statistically significant effects and very few adverse reactions. Transplantation of NSPCs for ischemic stroke still needs to be optimized for several key factors. A standardized treatment outcome assessment could ease the translation of evidence in clinical settings.PMID:35410620 | DOI:10.2174/1574888X17666220410221905
Source: Cell Research - April 12, 2022 Category: Cytology Authors: Mengze Zhang Kan Wang Chunran Xue Chong Xie Ze Wang Yaying Song Haojun Yu Yong Hao Yangtai Guan Source Type: research
Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke
This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke.PMID:35551643 | DOI:10.1186/s13287-022-02876-2
Source: Cell Research - May 13, 2022 Category: Cytology Authors: Li Zhou Huimin Zhu Xue Bai Jiagui Huang Yue Chen Jun Wen Xuemei Li Bowen Wu Yongjun Tan Mingfen Tian Jiangxia Ren Mengxia Li Qin Yang Source Type: research
A Narrative Review on the Non-Pharmacologic Interventions in Post-Stroke Depression
Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022.ABSTRACTStroke is a major cause of death and disability globally. Post-stroke depression (PSD) is a major driver for poor recovery and poor quality of life with extra burden for the patient and the caregiver. We have previously shown the inflammatory basis of PSD with associated bioenergetic failure, disruption of the blood-brain barrier, cell death, and persistent maladapted inflammation, making the PSD a norm rather than the exception, highlighting the unmet need for therapeutic intervention in PSD across the recovery trajectory...
Source: Cell Research - July 14, 2022 Category: Cytology Authors: Tissa Wijeratne Carmela Sales Chanith Wijeratne Source Type: research
